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VVGSLISVGMPDAACDDGPGVPEAEELYMGFERIDDLLSEVTADGSLHGVAATVVGRDGVLYEGAAGDAK HDTMFRNASMTKAVATTAALQLVEQGRVDLDATVASLVPEFGELQVIDGFQGSEPVLRAPKTQATVRQLM NHTAGCGYHFLNGELLAYCEGQNFPNPLEGVKKSLSAPLVHDPGTVWEYGVSTDWLGMVVEAVSGQTLAD YLAEHVYGPLGMTDSTFDLTDEQRARLLPVRFRAPDGSLVATDLDLPAAPEWDAAGHGSYGTVADYGRFV RAWLDGGELDGTRILKEETVELALRDHLDGAPLPKKMEPAVPELSNPVELLDVPQGWGLGFHLYLIDLPG MRSAGSADWSGLFNSFFWIDRKAGIGAVIATQLLPFFDGKMVETILRFEATVYAELGAGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1072 | - | - | 100% (410) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_2658 | - | 2e-30 | 30.00% (330) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_5065 | - | 3e-18 | 27.71% (314) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1402c | - | 2e-26 | 28.18% (330) | hypothetical protein Mb1402c |
| M. gilvum PYR-GCK | Mflv_3473 | - | 0.0 | 82.28% (378) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1367c | - | 2e-26 | 28.18% (330) | hypothetical protein Rv1367c |
| M. leprae Br4923 | MLBr_00119 | lipE | 9e-11 | 25.99% (327) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2833 | - | 2e-30 | 30.06% (346) | beta-lactamase |
| M. marinum M | MMAR_2187 | - | 6e-27 | 27.49% (371) | beta-lactamase |
| M. avium 104 | MAV_3395 | - | 3e-28 | 28.73% (369) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3040 | - | 2e-29 | 29.97% (327) | beta-lactamase |
| M. thermoresistible (build 8) | TH_4016 | - | 4e-20 | 38.36% (159) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 2e-27 | 27.49% (371) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1072|M.vanbaalenii_PYR-1 -----------MVGSLISVGMPDAACDDGPGVPEAEELYMGFERIDDLLS
Mflv_3473|M.gilvum_PYR-GCK --------------------MSSLLCTS-----PARRYGMGFERIDDLLH
Mb1402c|M.bovis_AF2122/97 --------------------------------------------------
Rv1367c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2187|M.marinum_M ---------------------------------------MNLDANQADIR
MUL_1772|M.ulcerans_Agy99 MGVARPRWRGPRAAWFAGARKPSDGRRLTRRPPAANLNPVNLDANQADIR
MAV_3395|M.avium_104 ---------------------------------------MTLDANSVSIR
MSMEG_3040|M.smegmatis_MC2_155 ---------------------------------------MNLDGNQTSIR
MAB_2833|M.abscessus_ATCC_1997 ----------------------------------MAEPDSTFDAALAPIR
TH_4016|M.thermoresistible__bu --------------------------------------------VIGQVD
MLBr_00119|M.leprae_Br4923 ----------MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATR
Mvan_1072|M.vanbaalenii_PYR-1 EVTADGSLHGVAATVVGRDGVLYEGAAG------------------DAKH
Mflv_3473|M.gilvum_PYR-GCK RVTGDGSLHGVAATVVGRDGVLYEGASG------------------SATP
Mb1402c|M.bovis_AF2122/97 -------------MVWQREKLLQVNEIGYRDIDA----------GVPMQR
Rv1367c|M.tuberculosis_H37Rv -------------MVWQREKLLQVNEIGYRDIDA----------GVPMQR
MMAR_2187|M.marinum_M EVCDAGLLSGAVTVVWQHGEVLQVNEIGYRDVEA----------GLPMQR
MUL_1772|M.ulcerans_Agy99 EVCDAGLLSGAVTVVWQHGEVLQVNEIGYRDVEA----------GLPMQR
MAV_3395|M.avium_104 EVCDAGLLAGAVTMVWQRGELLQVNEIGYRDVEA----------GLPMRR
MSMEG_3040|M.smegmatis_MC2_155 EAIDAGLLAGAVTLVWQAGKVLQVNTLGHRDVEA----------RLPMQR
MAB_2833|M.abscessus_ATCC_1997 AAIDDRILAGAVTLVWQGGQLRHLGATGYRDIDA----------GLSMAE
TH_4016|M.thermoresistible__bu DAVAVRRLPGAVVQIGHAGEVVFRQAFGSRKLAGEPGPTGEPTPAEPMTE
MLBr_00119|M.leprae_Br4923 HWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDP--HDAEKIPVTT
: : *
Mvan_1072|M.vanbaalenii_PYR-1 DTMFRNASMTKAVA-TTAALQLVEQGRVDLDATVASLVPEFGELQVIDGF
Mflv_3473|M.gilvum_PYR-GCK NSMFRNASMTKAVA-TTGALQLVEQGRVDLDAPVSSIVPEFGELQVLEGF
Mb1402c|M.bovis_AF2122/97 DTLFRIASMTKPVT-VAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDA
Rv1367c|M.tuberculosis_H37Rv DTLFRIASMTKPVT-VAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDA
MMAR_2187|M.marinum_M DTLFRIASMTKPVT-VAAAMSMVDEGKMALRDPITRWAPELRDIRVLDDP
MUL_1772|M.ulcerans_Agy99 DTLFRIASMTKPVT-VAAAMSMVDEGKIALRDPITRWAPELRDIRVLDDP
MAV_3395|M.avium_104 DTLFRIASMTKPVT-VAAVMSLVDAGKLSLKDPVTRWAPELAGVRVLDDP
MSMEG_3040|M.smegmatis_MC2_155 DTIFRIASMTKPVT-VAAAMALAEEGKFALADPVTAWLPELSNMRVLREP
MAB_2833|M.abscessus_ATCC_1997 NTIFRIASMTKPII-SAATMNLVDDGTIRLSDPITTWLPEFSDMRVLKNP
TH_4016|M.thermoresistible__bu DTMFDLASLTKSLATTVAVLQLAEQGRLRVDDPVQSHLPEFN--------
MLBr_00119|M.leprae_Br4923 DTPFCAYSAAKAIT-ATVVHMLVERGHFSLDDRVCEYLPTYTSYG-----
:: * * :*.: . . :.: * . : : *
Mvan_1072|M.vanbaalenii_PYR-1 QGSEPVLRAPKTQATVRQLMNHTAGCGYHFLN-GELLAYCEGQNFP---N
Mflv_3473|M.gilvum_PYR-GCK DDGAPVLRAPRTQATVRQLMTHTAGCGYHFLN-ENLYRYCTEFGFP---D
Mb1402c|M.bovis_AF2122/97 AGPLDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFG--QG
Rv1367c|M.tuberculosis_H37Rv AGPLDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFG--QG
MMAR_2187|M.marinum_M HGPLDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYMRLPFG--HG
MUL_1772|M.ulcerans_Agy99 HGPLDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYMRLPFG--HG
MAV_3395|M.avium_104 HGPLDRTHPLDRAILIEDLLTHTSGLAYGFSVSGPISKAYMRLPFQ--HG
MSMEG_3040|M.smegmatis_MC2_155 RGPLDQTVPARRPITFDDLMTHRSGMAYVFSVLGPLASAYGKISQR--QD
MAB_2833|M.abscessus_ATCC_1997 EGPLDDTFRAPRLITVEDLLTHRSGLTYDFISTGPIAKAYHPLHTAAFRE
TH_4016|M.thermoresistible__bu ----PQHDPRRARVTLRMLLTHTSGIAGDLSLDGPWG-----LDRP---D
MLBr_00119|M.leprae_Br4923 ----------KHRTTIRHVLTHSAGVPFPTGPRPDVTRADDHAYAQ----
. ::.* :*
Mvan_1072|M.vanbaalenii_PYR-1 PLEGVKKSLSAPLVHDPGTVWEYG-VSTDWLG-MVVEAVSGQTLADYLAE
Mflv_3473|M.gilvum_PYR-GCK PFSGMKKSISAPLVHDPGTVWEYG-VNTDWLG-MVVEAVSGQTLGDYLTE
Mb1402c|M.bovis_AF2122/97 PDVWLAALATLPLVHQPGDRVTYS-HAIDVLG-VIVSRIEDAPLYQVIDE
Rv1367c|M.tuberculosis_H37Rv PDVWLAALATLPLVHQPGDRVTYS-HAIDVLG-VIVSRIEDAPLYQIIDE
MMAR_2187|M.marinum_M SDAWLAELAALPLVHQPGERVTYS-HAIDLLG-VIMSRIDDKPFYQVLDE
MUL_1772|M.ulcerans_Agy99 SDAWLAELAALPLVHQPGERVTYS-HAIDLLG-VIMSRIDDKPFYQVLDE
MAV_3395|M.avium_104 PDAWLAELAKLPLVHQPGEKVTYS-HSIDLLG-VIAARIEDKPFHQVLDE
MSMEG_3040|M.smegmatis_MC2_155 QDRWLAEVAALPLAHQPGERLTYS-HSTDVLG-IALSRIEGKPLSQVLSE
MAB_2833|M.abscessus_ATCC_1997 PDEWLAAIAALPLVYPPGERFHYS-HSTDVLG-LLIARAAGLPLNTLLRQ
TH_4016|M.thermoresistible__bu KAEGVRRALGAWVVHEPGRLFHYSDIGFILLG-AIVEKLTGEPLDVYVTE
MLBr_00119|M.leprae_Br4923 -----QKLSELRPFYRPGLVHIYHALTWGPLMREIIWTATGKEIRDILAA
: ** * * . : :
Mvan_1072|M.vanbaalenii_PYR-1 HVYGPLGMTDSTFDLTDEQR------------------------------
Mflv_3473|M.gilvum_PYR-GCK HVYRPLGMTDSTFAPSDEQR------------------------------
Mb1402c|M.bovis_AF2122/97 RVLGPAGMTDTGFYVSADAQ------------------------------
Rv1367c|M.tuberculosis_H37Rv RVLGPAGMTDTGFYVSADAQ------------------------------
MMAR_2187|M.marinum_M RILGPAGMTDTGFFVSTQAQ------------------------------
MUL_1772|M.ulcerans_Agy99 RILGPAGMTDTGFFVSTQAQ------------------------------
MAV_3395|M.avium_104 RVLGPAGMTDTGFFVSPQAR------------------------------
MSMEG_3040|M.smegmatis_MC2_155 RVFEPLGMTDTGFSIGAAGR------------------------------
MAB_2833|M.abscessus_ATCC_1997 RILDPLGMNDTDFFVPEHKA------------------------------
TH_4016|M.thermoresistible__bu NVFAPLGMADTRYLPVSKACGPIRMVGNAVVEDESAEPTPCGEDRWSTSL
MLBr_00119|M.leprae_Br4923 EILDPLGFRWTNFGVAEEDVPLVALSHATG--------------------
.: * *: : :
Mvan_1072|M.vanbaalenii_PYR-1 -ARLLPVRFRAPD-------GSLVATDLDLPAAPE-----WDAAGHGSYG
Mflv_3473|M.gilvum_PYR-GCK -ARLLPVHSRAAD-------GSLAPTDLDLPEAPQ-----WDAAGHGSYG
Mb1402c|M.bovis_AF2122/97 -RRAATMYRLDEQ-------DRLRHDVMGPPHVTP---PSFCNAGGGLWS
Rv1367c|M.tuberculosis_H37Rv -RRAATMYRLDEQ-------DRLRHDVMGPPHVTP---PSFCNAGGGLWS
MMAR_2187|M.marinum_M -RRAATMYRLDEL-------DQLRHDVMGPPHVRP---PSFCNAGGGLWS
MUL_1772|M.ulcerans_Agy99 -RRAATMYRLDEL-------DQLRHDVMGPPHVRP---PSFCNAGGGLWS
MAV_3395|M.avium_104 -HRAATMYSLDEH-------SRLQHGVMGPPHVTP---PAFCNAGGGLWS
MSMEG_3040|M.smegmatis_MC2_155 -RRAATMYKLTAE-------NTLTHDVMGPPPITD---PPFCAGGAGLFS
MAB_2833|M.abscessus_ATCC_1997 -ARLARLYGLGDD-------DTIVAADSGYLTAMPTSAPALCRGGGALAS
TH_4016|M.thermoresistible__bu RARIAPTSCDGDTPDLNPHRGRLLRGTVHDPTARR---MGGVSGSAGVFS
MLBr_00119|M.leprae_Br4923 -RPLPPIIAAIFR----KAIGGTVHEVIPYTNTPP--FLTTIVPSSNTVS
. . .
Mvan_1072|M.vanbaalenii_PYR-1 TVADYGRFVRAWLDGGELDGTRILKEETVELALRDHLDGAPLP-------
Mflv_3473|M.gilvum_PYR-GCK TVADYGRFVRAWLNDGELDGTRILKAETVELALRDHLDGAPLP-------
Mb1402c|M.bovis_AF2122/97 TADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLT------------
Rv1367c|M.tuberculosis_H37Rv TADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLT------------
MMAR_2187|M.marinum_M TADDYLRFVRLLLGDGTIDGVRVLSPESVRLMRTDRLS------------
MUL_1772|M.ulcerans_Agy99 TADDYLRFVRLLLGDGTIDGVRVLSPESVRLMRTDRLS------------
MAV_3395|M.avium_104 SADDYLRFVRMLLGDGTIDGVRVLSEESVRLMRTDRLT------------
MSMEG_3040|M.smegmatis_MC2_155 TVDDYLVFARMLLGGGTVDGVRVLSEESVRTMRTDRLT------------
MAB_2833|M.abscessus_ATCC_1997 TAHDYLTFARALLGGGQADGVRILSPESTQALRTNRLT------------
TH_4016|M.thermoresistible__bu TAADVGSYAQALLDRLAGRPSRFPLRRSTLQMMTSPQQPGHAPGQLDVAN
MLBr_00119|M.leprae_Br4923 TANELSRFAEIWLRGGELDGIRVLRSETLLGAVAECRR------------
:. : :.. * *. .: .
Mvan_1072|M.vanbaalenii_PYR-1 ---KKMEPAVPELSNPVELLDVPQGWGLG-FHLYL-----IDLPGMRSAG
Mflv_3473|M.gilvum_PYR-GCK ---TKMEPTVPELAKAVELLPVPQGWGLG-FHLYH-----VDLPGMRSAG
Mb1402c|M.bovis_AF2122/97 -------DEQKRHSFLGAPFWVGRGFGLN-LSVVTDPAKSRPLFGPGGLG
Rv1367c|M.tuberculosis_H37Rv -------DEQKRHSFLGAPFWVGRGFGLN-LSVVTDPAKSRPLFGPGGLG
MMAR_2187|M.marinum_M -------DEHKRHNFLGAPFWVGRGFGLN-LSVVTDPAQSTPLFGPGGLG
MUL_1772|M.ulcerans_Agy99 -------DEHKRHNFLGAPFWVGRGFGLN-LSVVTDPVQSTPLFGPGGLG
MAV_3395|M.avium_104 -------EAQKRHNFLGAPYWVGRGFGLN-LSVVTDPARSIPLFGPGGVG
MSMEG_3040|M.smegmatis_MC2_155 -------PEQKQYPFLGAPFWVGRGFGLN-LSVVTDPAKSRQLFGPGGLG
MAB_2833|M.abscessus_ATCC_1997 -------PAQRRLPSFGIPYWTGRGFGLG-LSVVMDPNE-AALFGPGGTG
TH_4016|M.thermoresistible__bu KAAREAVLSASDDPLLAPDYPAVPGRDLRGFGWDIDTNQSRPRGSVFPVG
MLBr_00119|M.leprae_Br4923 --------LRPDFVVGLMPARWGTGFILG--------TNKFGPFGRNAPA
* * . .
Mvan_1072|M.vanbaalenii_PYR-1 SADWSGLFNSFFWIDRKAGIGAVIATQL-LPFFD-------------GKM
Mflv_3473|M.gilvum_PYR-GCK SGDWSGLFNSFFWIDRTAGIGGVIATQL-LPFFD-------------DTM
Mb1402c|M.bovis_AF2122/97 TFSWPGAYGTWWQADPSADLILLYLIQH-CPDLSVDAAAAVAGNPSLAKL
Rv1367c|M.tuberculosis_H37Rv TFSWPGAYGTWWQADPSADLILLYLIQH-CPDLSVDAAAAVAGNPSLAKL
MMAR_2187|M.marinum_M TFSWPGAYGTWWQADPGADLILLYLIQH-CPDLSVNAAAAVAGNPGLAKL
MUL_1772|M.ulcerans_Agy99 TFSWPGAYGTWWQADPGADLILLYLIQH-CPDLSVNAAAAVAGNPGLAKL
MAV_3395|M.avium_104 TFSWPGAYGTWWQADPTAELILIYLIQN-LPDLTVDAATAVAGNTSLAKL
MSMEG_3040|M.smegmatis_MC2_155 TFSWPGAYGTWWQADPSADLILIYLIQN-FPDLGVDAA-AIAGNTSLAKL
MAB_2833|M.abscessus_ATCC_1997 TFGWPGAFGTWWHADPKADAILMFLPQWRMPELDPKAALARTST---IRL
TH_4016|M.thermoresistible__bu SFGHTGFTGVTLWIDPGSDTYVVVLANVIHQPGGPP----------VAPL
MLBr_00119|M.leprae_Br4923 AFGHLGLVNIAIWADPQRSMAAGLISSG-KPGQDPN----------AGRY
: . * . * .
Mvan_1072|M.vanbaalenii_PYR-1 VETILRFEATVYAELGAGV
Mflv_3473|M.gilvum_PYR-GCK VETILAFEAAVYASL----
Mb1402c|M.bovis_AF2122/97 RTAQPKFVRRTYRALGL--
Rv1367c|M.tuberculosis_H37Rv RTAQPKFVRRTYRALGL--
MMAR_2187|M.marinum_M RTAQPRFVRRTYRALGL--
MUL_1772|M.ulcerans_Agy99 RTAQPRFVRRTYRALGL--
MAV_3395|M.avium_104 RTAQPRFVRTTYRALGL--
MSMEG_3040|M.smegmatis_MC2_155 QSAQPKFVRRTYQALDL--
MAB_2833|M.abscessus_ATCC_1997 QLLHVQFGQAVYAAL----
TH_4016|M.thermoresistible__bu SGRVATLAARALHLYGT--
MLBr_00119|M.leprae_Br4923 GALMNTITAEIPVH-----
: