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NLDANQADIREVCDAGLLSGAVTVVWQHGEVLQVNEIGYRDVEAGLPMQRDTLFRIASMTKPVTVAAAMS MVDEGKMALRDPITRWAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYM RLPFGHGSDAWLAELAALPLVHQPGERVTYSHAIDLLGVIMSRIDDKPFYQVLDERILGPAGMTDTGFFV STQAQRRAATMYRLDELDQLRHDVMGPPHVRPPSFCNAGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSP ESVRLMRTDRLSDEHKRHNFLGAPFWVGRGFGLNLSVVTDPAQSTPLFGPGGLGTFSWPGAYGTWWQADP GADLILLYLIQHCPDLSVNAAAAVAGNPGLAKLRTAQPRFVRRTYRALGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2187 | - | - | 100% (401) | beta-lactamase |
| M. marinum M | MMAR_5330 | lipE | 2e-10 | 24.93% (341) | lipase LipE |
| M. marinum M | MMAR_4623 | - | 3e-10 | 22.86% (315) | penicillin binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1402c | - | 0.0 | 86.47% (377) | hypothetical protein Mb1402c |
| M. gilvum PYR-GCK | Mflv_3749 | - | 1e-159 | 67.58% (401) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1367c | - | 0.0 | 86.21% (377) | hypothetical protein Rv1367c |
| M. leprae Br4923 | MLBr_00119 | lipE | 4e-08 | 23.41% (299) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2833 | - | 1e-102 | 49.25% (402) | beta-lactamase |
| M. avium 104 | MAV_3395 | - | 0.0 | 83.04% (401) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3040 | - | 1e-161 | 68.33% (401) | beta-lactamase |
| M. thermoresistible (build 8) | TH_0102 | - | 5e-40 | 75.26% (97) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1772 | - | 0.0 | 99.50% (401) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_2658 | - | 1e-164 | 69.58% (401) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3749|M.gilvum_PYR-GCK ---------------------------------------MNLDRNKASIV
Mvan_2658|M.vanbaalenii_PYR-1 ---------------------------------------MNLDRNKASIA
MSMEG_3040|M.smegmatis_MC2_155 ---------------------------------------MNLDGNQTSIR
TH_0102|M.thermoresistible__bu --------------------------------------------------
MMAR_2187|M.marinum_M ---------------------------------------MNLDANQADIR
MUL_1772|M.ulcerans_Agy99 MGVARPRWRGPRAAWFAGARKPSDGRRLTRRPPAANLNPVNLDANQADIR
Mb1402c|M.bovis_AF2122/97 --------------------------------------------------
Rv1367c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3395|M.avium_104 ---------------------------------------MTLDANSVSIR
MAB_2833|M.abscessus_ATCC_1997 ----------------------------------MAEPDSTFDAALAPIR
MLBr_00119|M.leprae_Br4923 ----------MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATR
Mflv_3749|M.gilvum_PYR-GCK DAIDAGLLAGAVTLVWHAGEVRQVNELGY--------RDVDAQLPMQRDT
Mvan_2658|M.vanbaalenii_PYR-1 EAIDAGLLAGAVTLVWQAGEVRQVNELGY--------RDVEARLPMQRDT
MSMEG_3040|M.smegmatis_MC2_155 EAIDAGLLAGAVTLVWQAGKVLQVNTLGH--------RDVEARLPMQRDT
TH_0102|M.thermoresistible__bu --------------------------------------------------
MMAR_2187|M.marinum_M EVCDAGLLSGAVTVVWQHGEVLQVNEIGY--------RDVEAGLPMQRDT
MUL_1772|M.ulcerans_Agy99 EVCDAGLLSGAVTVVWQHGEVLQVNEIGY--------RDVEAGLPMQRDT
Mb1402c|M.bovis_AF2122/97 -------------MVWQREKLLQVNEIGY--------RDIDAGVPMQRDT
Rv1367c|M.tuberculosis_H37Rv -------------MVWQREKLLQVNEIGY--------RDIDAGVPMQRDT
MAV_3395|M.avium_104 EVCDAGLLAGAVTMVWQRGELLQVNEIGY--------RDVEAGLPMRRDT
MAB_2833|M.abscessus_ATCC_1997 AAIDDRILAGAVTLVWQGGQLRHLGATGY--------RDIDAGLSMAENT
MLBr_00119|M.leprae_Br4923 HWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDT
Mflv_3749|M.gilvum_PYR-GCK IFRIASMTKPVTVAAAMSLVEEGRLSLTDRVATWLPELADMRVLAEPRGA
Mvan_2658|M.vanbaalenii_PYR-1 IFRIASMTKPVTVAAAMSLIDEGKLRLSDRIATWLPELADMRVLVDPRGG
MSMEG_3040|M.smegmatis_MC2_155 IFRIASMTKPVTVAAAMALAEEGKFALADPVTAWLPELSNMRVLREPRGP
TH_0102|M.thermoresistible__bu --------------------------------------------------
MMAR_2187|M.marinum_M LFRIASMTKPVTVAAAMSMVDEGKMALRDPITRWAPELRDIRVLDDPHGP
MUL_1772|M.ulcerans_Agy99 LFRIASMTKPVTVAAAMSMVDEGKIALRDPITRWAPELRDIRVLDDPHGP
Mb1402c|M.bovis_AF2122/97 LFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGP
Rv1367c|M.tuberculosis_H37Rv LFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGP
MAV_3395|M.avium_104 LFRIASMTKPVTVAAVMSLVDAGKLSLKDPVTRWAPELAGVRVLDDPHGP
MAB_2833|M.abscessus_ATCC_1997 IFRIASMTKPIISAATMNLVDDGTIRLSDPITTWLPEFSDMRVLKNPEGP
MLBr_00119|M.leprae_Br4923 PFCAYSAAKAITATVVHMLVERGHFSLDDRVCEYLPTYTSY---------
Mflv_3749|M.gilvum_PYR-GCK LDRTVPAQRHITIEDLMTHRSGLAYMFSVLGPLSDAYRKLPTR--QDQDR
Mvan_2658|M.vanbaalenii_PYR-1 LDRTVPAQRHITIEDLMTHRSGLAYMFSVLGPLSDAYRKLPTR--QDQDR
MSMEG_3040|M.smegmatis_MC2_155 LDQTVPARRPITFDDLMTHRSGMAYVFSVLGPLASAYGKISQR--QDQDR
TH_0102|M.thermoresistible__bu --------------------------------------------------
MMAR_2187|M.marinum_M LDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYMRLPFG--HGSDA
MUL_1772|M.ulcerans_Agy99 LDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYMRLPFG--HGSDA
Mb1402c|M.bovis_AF2122/97 LDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFG--QGPDV
Rv1367c|M.tuberculosis_H37Rv LDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFG--QGPDV
MAV_3395|M.avium_104 LDRTHPLDRAILIEDLLTHTSGLAYGFSVSGPISKAYMRLPFQ--HGPDA
MAB_2833|M.abscessus_ATCC_1997 LDDTFRAPRLITVEDLLTHRSGLTYDFISTGPIAKAYHPLHTAAFREPDE
MLBr_00119|M.leprae_Br4923 ------GKHRTTIRHVLTHSAGVPFPTGPRPDVTRADDHAYAQ-------
Mflv_3749|M.gilvum_PYR-GCK WLTELSALPLVHQPGERLTYSHATD--VLGIALSRIEGKPLSEVLAERIF
Mvan_2658|M.vanbaalenii_PYR-1 WLAELSALPLVHQPGERLTYSHATD--VLGIALSRIEGKPLSEVLSERVL
MSMEG_3040|M.smegmatis_MC2_155 WLAEVAALPLAHQPGERLTYSHSTD--VLGIALSRIEGKPLSQVLSERVF
TH_0102|M.thermoresistible__bu --------------------------------------------------
MMAR_2187|M.marinum_M WLAELAALPLVHQPGERVTYSHAID--LLGVIMSRIDDKPFYQVLDERIL
MUL_1772|M.ulcerans_Agy99 WLAELAALPLVHQPGERVTYSHAID--LLGVIMSRIDDKPFYQVLDERIL
Mb1402c|M.bovis_AF2122/97 WLAALATLPLVHQPGDRVTYSHAID--VLGVIVSRIEDAPLYQVIDERVL
Rv1367c|M.tuberculosis_H37Rv WLAALATLPLVHQPGDRVTYSHAID--VLGVIVSRIEDAPLYQIIDERVL
MAV_3395|M.avium_104 WLAELAKLPLVHQPGEKVTYSHSID--LLGVIAARIEDKPFHQVLDERVL
MAB_2833|M.abscessus_ATCC_1997 WLAAIAALPLVYPPGERFHYSHSTD--VLGLLIARAAGLPLNTLLRQRIL
MLBr_00119|M.leprae_Br4923 --QKLSELRPFYRPGLVHIYHALTWGPLMREIIWTATGKEIRDILAAEIL
Mflv_3749|M.gilvum_PYR-GCK EPLGMTDTGFSVGSEGRRRAATMYQLDK------DGTLRHDVMG-----P
Mvan_2658|M.vanbaalenii_PYR-1 GPLGMSDTGFHVGPTGRRRAATMYQLDA------DNTLRHDVMG-----P
MSMEG_3040|M.smegmatis_MC2_155 EPLGMTDTGFSIGAAGRRRAATMYKLTA------ENTLTHDVMG-----P
TH_0102|M.thermoresistible__bu --------------------------------------------------
MMAR_2187|M.marinum_M GPAGMTDTGFFVSTQAQRRAATMYRLDE------LDQLRHDVMG-----P
MUL_1772|M.ulcerans_Agy99 GPAGMTDTGFFVSTQAQRRAATMYRLDE------LDQLRHDVMG-----P
Mb1402c|M.bovis_AF2122/97 GPAGMTDTGFYVSADAQRRAATMYRLDE------QDRLRHDVMG-----P
Rv1367c|M.tuberculosis_H37Rv GPAGMTDTGFYVSADAQRRAATMYRLDE------QDRLRHDVMG-----P
MAV_3395|M.avium_104 GPAGMTDTGFFVSPQARHRAATMYSLDE------HSRLQHGVMG-----P
MAB_2833|M.abscessus_ATCC_1997 DPLGMNDTDFFVPEHKAARLARLYGLGD------DDTIVAADSGYL--TA
MLBr_00119|M.leprae_Br4923 DPLGFRWTNFGVAEEDVPLVALSHATGRPLPPIIAAIFRKAIGGTVHEVI
Mflv_3749|M.gilvum_PYR-GCK APIVDPPFCT---GGAGLFSTVDDYLRFARMLLNGGTLDGTRVLSEDSAM
Mvan_2658|M.vanbaalenii_PYR-1 APIVDPPFCT---GGAGLWSTVDDYLRFAQMLLAGGELDGVRVLSEESAM
MSMEG_3040|M.smegmatis_MC2_155 PPITDPPFCA---GGAGLFSTVDDYLVFARMLLGGGTVDGVRVLSEESVR
TH_0102|M.thermoresistible__bu --------------------------------------------------
MMAR_2187|M.marinum_M PHVRPPSFCN---AGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSPESVR
MUL_1772|M.ulcerans_Agy99 PHVRPPSFCN---AGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSPESVR
Mb1402c|M.bovis_AF2122/97 PHVTPPSFCN---AGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVR
Rv1367c|M.tuberculosis_H37Rv PHVTPPSFCN---AGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVR
MAV_3395|M.avium_104 PHVTPPAFCN---AGGGLWSSADDYLRFVRMLLGDGTIDGVRVLSEESVR
MAB_2833|M.abscessus_ATCC_1997 MPTSAPALCR---GGGALASTAHDYLTFARALLGGGQADGVRILSPESTQ
MLBr_00119|M.leprae_Br4923 PYTNTPPFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLL
Mflv_3749|M.gilvum_PYR-GCK SMRTDRLTAEQKRQDFLGAPFWIGRGFGLNLSVVTDPAKSRQLFGPGGLG
Mvan_2658|M.vanbaalenii_PYR-1 SMRADRLTDEQKRHDFLGAPFWIGRGFGLNLSVVTDPAKSRQLFGPGGVG
MSMEG_3040|M.smegmatis_MC2_155 TMRTDRLTPEQKQYPFLGAPFWVGRGFGLNLSVVTDPAKSRQLFGPGGLG
TH_0102|M.thermoresistible__bu ------------------MPFWLGRGFGLNLSVVTDPAQSQRLYGPGGPG
MMAR_2187|M.marinum_M LMRTDRLSDEHKRHNFLGAPFWVGRGFGLNLSVVTDPAQSTPLFGPGGLG
MUL_1772|M.ulcerans_Agy99 LMRTDRLSDEHKRHNFLGAPFWVGRGFGLNLSVVTDPVQSTPLFGPGGLG
Mb1402c|M.bovis_AF2122/97 LMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGPGGLG
Rv1367c|M.tuberculosis_H37Rv LMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGPGGLG
MAV_3395|M.avium_104 LMRTDRLTEAQKRHNFLGAPYWVGRGFGLNLSVVTDPARSIPLFGPGGVG
MAB_2833|M.abscessus_ATCC_1997 ALRTNRLTPAQRRLPSFGIPYWTGRGFGLGLSVVMDPNE-AALFGPGGTG
MLBr_00119|M.leprae_Br4923 GAVAECRR-LRPDFVVGLMPARWGTGFILGTNKFG-------PFGRNAPA
* * ** *. . . :* .. .
Mflv_3749|M.gilvum_PYR-GCK TFSWPGAYGTWWQADPSADVILIYLIQN-LPSMSVDVAAAIAGNTSLAKL
Mvan_2658|M.vanbaalenii_PYR-1 TFSWPGAYGTWWQADPSADVILIYLIQN-MPNLTADAAAAVAGNTSLAKL
MSMEG_3040|M.smegmatis_MC2_155 TFSWPGAYGTWWQADPSADLILIYLIQN-FPDLGVDAAA-IAGNTSLAKL
TH_0102|M.thermoresistible__bu TFSWPGAYGTWWQADPSADLILIYLIQN-FPTLGVDAAATIAGNTSLLKL
MMAR_2187|M.marinum_M TFSWPGAYGTWWQADPGADLILLYLIQH-CPDLSVNAAAAVAGNPGLAKL
MUL_1772|M.ulcerans_Agy99 TFSWPGAYGTWWQADPGADLILLYLIQH-CPDLSVNAAAAVAGNPGLAKL
Mb1402c|M.bovis_AF2122/97 TFSWPGAYGTWWQADPSADLILLYLIQH-CPDLSVDAAAAVAGNPSLAKL
Rv1367c|M.tuberculosis_H37Rv TFSWPGAYGTWWQADPSADLILLYLIQH-CPDLSVDAAAAVAGNPSLAKL
MAV_3395|M.avium_104 TFSWPGAYGTWWQADPTAELILIYLIQN-LPDLTVDAATAVAGNTSLAKL
MAB_2833|M.abscessus_ATCC_1997 TFGWPGAFGTWWHADPKADAILMFLPQWRMPELDPKAALARTST---IRL
MLBr_00119|M.leprae_Br4923 AFGHLGLVNIAIWADPQRSMAAGLISSG-KPGQDPNAGRYGALMNTITAE
:*. * . *** . : . * ... :
Mflv_3749|M.gilvum_PYR-GCK QTAQPKFVRSTYQALEL
Mvan_2658|M.vanbaalenii_PYR-1 QSAQPKFVRSTYQALDL
MSMEG_3040|M.smegmatis_MC2_155 QSAQPKFVRRTYQALDL
TH_0102|M.thermoresistible__bu QSVQPKFVRCTYQALDL
MMAR_2187|M.marinum_M RTAQPRFVRRTYRALGL
MUL_1772|M.ulcerans_Agy99 RTAQPRFVRRTYRALGL
Mb1402c|M.bovis_AF2122/97 RTAQPKFVRRTYRALGL
Rv1367c|M.tuberculosis_H37Rv RTAQPKFVRRTYRALGL
MAV_3395|M.avium_104 RTAQPRFVRTTYRALGL
MAB_2833|M.abscessus_ATCC_1997 QLLHVQFGQAVYAAL--
MLBr_00119|M.leprae_Br4923 IPVH-------------
: