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NTSQIWQELDRQVTAGRIPGYVAAVRRTGIGEVHASGRLSFDAGAPAMLSDTPFRITSLGKPLGAALTLA LIEDGVLGLDDEIRRWLPEFAEPAVLREVTGPLSDTGPADRPITVSHLLAMTAGWGMLLQDCPLQSGIDE REIGSGPVPPQMTGDEFVRRLAELPLAFQPGTGWLYDTPVKVLSVLLARAAGMPLGDLLAQRLTQPLGMT DTGFWTDADRLPAPYRPAGDGVEDIELPDGAFVRPPLFEDLSCGLVSTAPDLLRFFSAMADGGAPVLHPE SVRLMTTDQLTVDQRMQGLPILGPGVSWGLGVAVDVEAVSPWMAPGRWGWTGGSGTSAHVHPDGSVAVFL SQRELADAQDGFDDFWAAVSVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5065 | - | - | 100% (373) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_2658 | - | 4e-35 | 32.86% (350) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_1072 | - | 3e-18 | 27.71% (314) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1402c | - | 4e-42 | 36.50% (337) | hypothetical protein Mb1402c |
| M. gilvum PYR-GCK | Mflv_3749 | - | 8e-40 | 34.00% (350) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1367c | - | 3e-42 | 36.50% (337) | hypothetical protein Rv1367c |
| M. leprae Br4923 | MLBr_00119 | lipE | 3e-09 | 23.45% (388) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2833 | - | 6e-40 | 34.81% (362) | beta-lactamase |
| M. marinum M | MMAR_2187 | - | 2e-37 | 35.69% (339) | beta-lactamase |
| M. avium 104 | MAV_3395 | - | 2e-36 | 34.71% (363) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3040 | - | 8e-39 | 33.89% (357) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 3e-14 | 25.73% (342) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 1e-37 | 35.69% (339) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1402c|M.bovis_AF2122/97 --------------------------------------------------
Rv1367c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2187|M.marinum_M ---------------------------------------MNLDANQADIR
MUL_1772|M.ulcerans_Agy99 MGVARPRWRGPRAAWFAGARKPSDGRRLTRRPPAANLNPVNLDANQADIR
MAV_3395|M.avium_104 ---------------------------------------MTLDANSVSIR
Mflv_3749|M.gilvum_PYR-GCK ---------------------------------------MNLDRNKASIV
MSMEG_3040|M.smegmatis_MC2_155 ---------------------------------------MNLDGNQTSIR
MAB_2833|M.abscessus_ATCC_1997 ----------------------------------MAEPDSTFDAALAPIR
Mvan_5065|M.vanbaalenii_PYR-1 ---------------------------------------MNTSQIWQELD
TH_3520|M.thermoresistible__bu -----------MRAVRTLAALLLAVFAVSAGPSAAGQPPDLAAALDRAIE
MLBr_00119|M.leprae_Br4923 ----------MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATR
Mb1402c|M.bovis_AF2122/97 -------------MVWQREKLLQVNEIGY-------RDIDAGVP-MQRDT
Rv1367c|M.tuberculosis_H37Rv -------------MVWQREKLLQVNEIGY-------RDIDAGVP-MQRDT
MMAR_2187|M.marinum_M EVCDAGLLSGAVTVVWQHGEVLQVNEIGY-------RDVEAGLP-MQRDT
MUL_1772|M.ulcerans_Agy99 EVCDAGLLSGAVTVVWQHGEVLQVNEIGY-------RDVEAGLP-MQRDT
MAV_3395|M.avium_104 EVCDAGLLAGAVTMVWQRGELLQVNEIGY-------RDVEAGLP-MRRDT
Mflv_3749|M.gilvum_PYR-GCK DAIDAGLLAGAVTLVWHAGEVRQVNELGY-------RDVDAQLP-MQRDT
MSMEG_3040|M.smegmatis_MC2_155 EAIDAGLLAGAVTLVWQAGKVLQVNTLGH-------RDVEARLP-MQRDT
MAB_2833|M.abscessus_ATCC_1997 AAIDDRILAGAVTLVWQGGQLRHLGATGY-------RDIDAGLS-MAENT
Mvan_5065|M.vanbaalenii_PYR-1 RQVTAGRIPGYVAAVRRTG-IGEVHASGR-------LSFDAGAPAMLSDT
TH_3520|M.thermoresistible__bu LRLDQMGVPGAIVSLSIPGKIEYTRAFGV-------GDTATGTP-MLVDN
MLBr_00119|M.leprae_Br4923 HWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDT
: : * : : :.
Mb1402c|M.bovis_AF2122/97 LFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGP
Rv1367c|M.tuberculosis_H37Rv LFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGP
MMAR_2187|M.marinum_M LFRIASMTKPVTVAAAMSMVDEGKMALRDPITRWAPELRDIRVLDDPHGP
MUL_1772|M.ulcerans_Agy99 LFRIASMTKPVTVAAAMSMVDEGKIALRDPITRWAPELRDIRVLDDPHGP
MAV_3395|M.avium_104 LFRIASMTKPVTVAAVMSLVDAGKLSLKDPVTRWAPELAGVRVLDDPHGP
Mflv_3749|M.gilvum_PYR-GCK IFRIASMTKPVTVAAAMSLVEEGRLSLTDRVATWLPELADMRVLAEPRGA
MSMEG_3040|M.smegmatis_MC2_155 IFRIASMTKPVTVAAAMALAEEGKFALADPVTAWLPELSNMRVLREPRGP
MAB_2833|M.abscessus_ATCC_1997 IFRIASMTKPIISAATMNLVDDGTIRLSDPITTWLPEFSDMRVLKNPEGP
Mvan_5065|M.vanbaalenii_PYR-1 PFRITSLGKPLGAALTLALIEDGVLGLDDEIRRWLPEFAEPAVLREVTGP
TH_3520|M.thermoresistible__bu HHRIGSVTKTFIGTAILQLADQGRIRLSDPISRYVEG-------------
MLBr_00119|M.leprae_Br4923 PFCAYSAAKAITATVVHMLVERGHFSLDDRVCEYLPTYTSYG--------
. * *.. : : : * : * * : :
Mb1402c|M.bovis_AF2122/97 LDRTHPARRAILIEDLLTHTSGLAYGFS----VSGPISRAYQRLPFG--Q
Rv1367c|M.tuberculosis_H37Rv LDRTHPARRAILIEDLLTHTSGLAYGFS----VSGPISRAYQRLPFG--Q
MMAR_2187|M.marinum_M LDRTHPTRRPILIEDLLTHTSGLAYSFS----VSGDISRAYMRLPFG--H
MUL_1772|M.ulcerans_Agy99 LDRTHPTRRPILIEDLLTHTSGLAYSFS----VSGDISRAYMRLPFG--H
MAV_3395|M.avium_104 LDRTHPLDRAILIEDLLTHTSGLAYGFS----VSGPISKAYMRLPFQ--H
Mflv_3749|M.gilvum_PYR-GCK LDRTVPAQRHITIEDLMTHRSGLAYMFS----VLGPLSDAYRKLPTR--Q
MSMEG_3040|M.smegmatis_MC2_155 LDQTVPARRPITFDDLMTHRSGMAYVFS----VLGPLASAYGKISQR--Q
MAB_2833|M.abscessus_ATCC_1997 LDDTFRAPRLITVEDLLTHRSGLTYDFI----STGPIAKAYHPLHTAAFR
Mvan_5065|M.vanbaalenii_PYR-1 LSDTGPADRPITVSHLLAMTAGWGMLLQDCPLQSGIDEREIGSGPVPPQM
TH_3520|M.thermoresistible__bu ----VPSGDVITLDMLARMRSGLADYTET-DEFVERLYRESPSGPDAFAV
MLBr_00119|M.leprae_Br4923 -------KHRTTIRHVLTHSAGVPFPTG----PRPDVTRADDHAYAQ---
. : :*
Mb1402c|M.bovis_AF2122/97 GPDVWLAALATLPLVHQPGDRVTYS--HAIDVLGVIVSRIEDAPLYQVID
Rv1367c|M.tuberculosis_H37Rv GPDVWLAALATLPLVHQPGDRVTYS--HAIDVLGVIVSRIEDAPLYQIID
MMAR_2187|M.marinum_M GSDAWLAELAALPLVHQPGERVTYS--HAIDLLGVIMSRIDDKPFYQVLD
MUL_1772|M.ulcerans_Agy99 GSDAWLAELAALPLVHQPGERVTYS--HAIDLLGVIMSRIDDKPFYQVLD
MAV_3395|M.avium_104 GPDAWLAELAKLPLVHQPGEKVTYS--HSIDLLGVIAARIEDKPFHQVLD
Mflv_3749|M.gilvum_PYR-GCK DQDRWLTELSALPLVHQPGERLTYS--HATDVLGIALSRIEGKPLSEVLA
MSMEG_3040|M.smegmatis_MC2_155 DQDRWLAEVAALPLAHQPGERLTYS--HSTDVLGIALSRIEGKPLSQVLS
MAB_2833|M.abscessus_ATCC_1997 EPDEWLAAIAALPLVYPPGERFHYS--HSTDVLGLLIARAAGLPLNTLLR
Mvan_5065|M.vanbaalenii_PYR-1 TGDEFVRRLAELPLAFQPGTGWLYD--TPVKVLSVLLARAAGMPLGDLLA
TH_3520|M.thermoresistible__bu TPRELVESAFARPLNFAPGSEFEYSN-TNTVLLGMVVERVSGVPLARYLQ
MLBr_00119|M.leprae_Br4923 ------QKLSELRPFYRPGLVHIYHALTWGPLMREIIWTATGKEIRDILA
. ** * :: . : :
Mb1402c|M.bovis_AF2122/97 ERVLGPAGMTDTGFYVSADAQRRAATMYRLDE------QDRLRHDVMG--
Rv1367c|M.tuberculosis_H37Rv ERVLGPAGMTDTGFYVSADAQRRAATMYRLDE------QDRLRHDVMG--
MMAR_2187|M.marinum_M ERILGPAGMTDTGFFVSTQAQRRAATMYRLDE------LDQLRHDVMG--
MUL_1772|M.ulcerans_Agy99 ERILGPAGMTDTGFFVSTQAQRRAATMYRLDE------LDQLRHDVMG--
MAV_3395|M.avium_104 ERVLGPAGMTDTGFFVSPQARHRAATMYSLDE------HSRLQHGVMG--
Mflv_3749|M.gilvum_PYR-GCK ERIFEPLGMTDTGFSVGSEGRRRAATMYQLDK------DGTLRHDVMG--
MSMEG_3040|M.smegmatis_MC2_155 ERVFEPLGMTDTGFSIGAAGRRRAATMYKLTA------ENTLTHDVMG--
MAB_2833|M.abscessus_ATCC_1997 QRILDPLGMNDTDFFVPEHKAARLARLYGLGD------DDTIVAADSGYL
Mvan_5065|M.vanbaalenii_PYR-1 QRLTQPLGMTDTGFWTDAD---RLPAPYRPAG------DGVEDIELPDG-
TH_3520|M.thermoresistible__bu DNIFGPVGLTQTSYPADGRLPAPYTHGYNQGP------DGAIVDTTLWN-
MLBr_00119|M.leprae_Br4923 AEILDPLGFRWTNFGVAEEDVPLVALSHATGRPLPPIIAAIFRKAIGGTV
.: * *: *.: . :
Mb1402c|M.bovis_AF2122/97 ---PPHVTPPSFCN---AGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSP
Rv1367c|M.tuberculosis_H37Rv ---PPHVTPPSFCN---AGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSP
MMAR_2187|M.marinum_M ---PPHVRPPSFCN---AGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSP
MUL_1772|M.ulcerans_Agy99 ---PPHVRPPSFCN---AGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSP
MAV_3395|M.avium_104 ---PPHVTPPAFCN---AGGGLWSSADDYLRFVRMLLGDGTIDGVRVLSE
Mflv_3749|M.gilvum_PYR-GCK ---PAPIVDPPFCT---GGAGLFSTVDDYLRFARMLLNGGTLDGTRVLSE
MSMEG_3040|M.smegmatis_MC2_155 ---PPPITDPPFCA---GGAGLFSTVDDYLVFARMLLGGGTVDGVRVLSE
MAB_2833|M.abscessus_ATCC_1997 --TAMPTSAPALCR---GGGALASTAHDYLTFARALLGGGQADGVRILSP
Mvan_5065|M.vanbaalenii_PYR-1 ----AFVRPPLFED---LSCGLVSTAPDLLRFFSAMADGG----APVLHP
TH_3520|M.thermoresistible__bu ---------PAWAD---AAGKIVSNVHDMRTWARALGSGALLRPDTHAER
MLBr_00119|M.leprae_Br4923 HEVIPYTNTPPFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRS
* . *.. : : ..
Mb1402c|M.bovis_AF2122/97 ESVRLMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGP
Rv1367c|M.tuberculosis_H37Rv ESVRLMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGP
MMAR_2187|M.marinum_M ESVRLMRTDRLSDEHKRHNFLGAPFWVGRGFGLNLSVVTDPAQSTPLFGP
MUL_1772|M.ulcerans_Agy99 ESVRLMRTDRLSDEHKRHNFLGAPFWVGRGFGLNLSVVTDPVQSTPLFGP
MAV_3395|M.avium_104 ESVRLMRTDRLTEAQKRHNFLGAPYWVGRGFGLNLSVVTDPARSIPLFGP
Mflv_3749|M.gilvum_PYR-GCK DSAMSMRTDRLTAEQKRQDFLGAPFWIGRGFGLNLSVVTDPAKSRQLFGP
MSMEG_3040|M.smegmatis_MC2_155 ESVRTMRTDRLTPEQKQYPFLGAPFWVGRGFGLNLSVVTDPAKSRQLFGP
MAB_2833|M.abscessus_ATCC_1997 ESTQALRTNRLTPAQRRLPSFGIPYWTGRGFGLGLSVVMDPNE-AALFGP
Mvan_5065|M.vanbaalenii_PYR-1 ESVRLMTTDQLTVDQRMQGLP----ILGPGVSWGLGVAVDVEAVSPWMAP
TH_3520|M.thermoresistible__bu IHGGSSVVPGVDYSFAIFNAQGWLGHNGDIPGYATVVVYLPERDATLVVF
MLBr_00119|M.leprae_Br4923 ETLLG-AVAECRRLRPDFVVGLMPARWGTGFILGTNKFG-------PFGR
. * .
Mb1402c|M.bovis_AF2122/97 GGLGTFSWPGAYGTWWQADPSADLILLYLIQHCPDLSVDAAAAVAGNPSL
Rv1367c|M.tuberculosis_H37Rv GGLGTFSWPGAYGTWWQADPSADLILLYLIQHCPDLSVDAAAAVAGNPSL
MMAR_2187|M.marinum_M GGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDLSVNAAAAVAGNPGL
MUL_1772|M.ulcerans_Agy99 GGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDLSVNAAAAVAGNPGL
MAV_3395|M.avium_104 GGVGTFSWPGAYGTWWQADPTAELILIYLIQNLPDLTVDAATAVAGNTSL
Mflv_3749|M.gilvum_PYR-GCK GGLGTFSWPGAYGTWWQADPSADVILIYLIQNLPSMSVDVAAAIAGNTSL
MSMEG_3040|M.smegmatis_MC2_155 GGLGTFSWPGAYGTWWQADPSADLILIYLIQNFPDLGVD-AAAIAGNTSL
MAB_2833|M.abscessus_ATCC_1997 GGTGTFGWPGAFGTWWHADPKADAILMFLPQWR-MPELDPKAALAR-TST
Mvan_5065|M.vanbaalenii_PYR-1 G---RWGWTGGSGTSAHVHP-DGSVAVFLSQRELADAQDGFDDFWAAVSV
TH_3520|M.thermoresistible__bu VNSDVPEPHSAGQIAYVVTEMVTPEHIYELGPQPPQMLDEPAA-------
MLBr_00119|M.leprae_Br4923 NAPAAFGHLGLVNIAIWADPQRSMAAGLISSGKPGQDPNAGRYGALMNTI
. . :
Mb1402c|M.bovis_AF2122/97 AKLRTAQPKFVRRTYRALGL
Rv1367c|M.tuberculosis_H37Rv AKLRTAQPKFVRRTYRALGL
MMAR_2187|M.marinum_M AKLRTAQPRFVRRTYRALGL
MUL_1772|M.ulcerans_Agy99 AKLRTAQPRFVRRTYRALGL
MAV_3395|M.avium_104 AKLRTAQPRFVRTTYRALGL
Mflv_3749|M.gilvum_PYR-GCK AKLQTAQPKFVRSTYQALEL
MSMEG_3040|M.smegmatis_MC2_155 AKLQSAQPKFVRRTYQALDL
MAB_2833|M.abscessus_ATCC_1997 IRLQLLHVQFGQAVYAAL--
Mvan_5065|M.vanbaalenii_PYR-1 G-------------------
TH_3520|M.thermoresistible__bu --------------------
MLBr_00119|M.leprae_Br4923 TAEIPVH-------------