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SKRPLRWLTEQITLAGMRPPISPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVA RRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGIDILINNAGRSIRRPLAESLERWH DVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAALSAVSRIIETEWG SQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPRWV NALMQRRNEQLNP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0547c | - | - | 100% (294) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1543 | - | 9e-50 | 46.12% (258) | fatty acyl-CoA reductase |
| M. tuberculosis H37Rv | Rv3391 | acrA1 | 1e-42 | 36.78% (242) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0561c | - | 1e-166 | 100.00% (294) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0026 | - | 1e-110 | 67.93% (290) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-14 | 29.02% (193) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3947 | - | 6e-89 | 60.00% (280) | short chain dehydrogenase |
| M. marinum M | MMAR_0894 | - | 1e-137 | 80.89% (293) | dehydrogenase |
| M. avium 104 | MAV_4597 | - | 1e-129 | 75.09% (293) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1073 | - | 1e-114 | 69.42% (291) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3707 | - | 2e-78 | 69.61% (204) | PUTATIVE oxidoreductase, short-chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0647 | - | 1e-137 | 80.89% (293) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0944 | - | 1e-110 | 67.59% (290) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0547c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0894|M.marinum_M --------------------------------------------------
MUL_0647|M.ulcerans_Agy99 --------------------------------------------------
MAV_4597|M.avium_104 --------------------------------------------------
MSMEG_1073|M.smegmatis_MC2_155 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3947|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Rv0547c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0894|M.marinum_M --------------------------------------------------
MUL_0647|M.ulcerans_Agy99 --------------------------------------------------
MAV_4597|M.avium_104 --------------------------------------------------
MSMEG_1073|M.smegmatis_MC2_155 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3947|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Rv0547c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0894|M.marinum_M --------------------------------------------------
MUL_0647|M.ulcerans_Agy99 --------------------------------------------------
MAV_4597|M.avium_104 --------------------------------------------------
MSMEG_1073|M.smegmatis_MC2_155 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3947|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Rv0547c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0894|M.marinum_M --------------------------------------------------
MUL_0647|M.ulcerans_Agy99 --------------------------------------------------
MAV_4597|M.avium_104 --------------------------------------------------
MSMEG_1073|M.smegmatis_MC2_155 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3947|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Rv0547c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0561c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0894|M.marinum_M --------------------------------------------------
MUL_0647|M.ulcerans_Agy99 --------------------------------------------------
MAV_4597|M.avium_104 --------------------------------------------------
MSMEG_1073|M.smegmatis_MC2_155 --------------------------------------------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK ----------------------------------------MRSSRKSASE
Mvan_0944|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3947|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Rv0547c|M.tuberculosis_H37Rv ----------------MSKRPL-RWLTEQITLAGMRP-------------
Mb0561c|M.bovis_AF2122/97 ----------------MSKRPL-RWLTEQITLAGMRP-------------
MMAR_0894|M.marinum_M ----------------MSKSPL-RRLTEQITLAGMRP-------------
MUL_0647|M.ulcerans_Agy99 ----------------MSKSPL-RRLTEQITLAGMRP-------------
MAV_4597|M.avium_104 ----------------MSKSPL-RRFADQLVLATMRP-------------
MSMEG_1073|M.smegmatis_MC2_155 ----------------MSKHPL-RRLTDNLFLASMRP-------------
TH_3707|M.thermoresistible__bu --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK VLLECEFGAGNRLRGVTSRNPL-RRLADQVVLTSMRP-------------
Mvan_0944|M.vanbaalenii_PYR-1 ---------------MTSRNPL-RRLADQVVLTSMRP-------------
MAB_3947|M.abscessus_ATCC_1997 ----------------MSKNSFGKRVSTTLARAAMQPF------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Rv0547c|M.tuberculosis_H37Rv --------PISPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGL
Mb0561c|M.bovis_AF2122/97 --------PISPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGL
MMAR_0894|M.marinum_M --------PIAPQLLVNRPPIKPVALDGKRVMITGASSGIGEAAAEQFAR
MUL_0647|M.ulcerans_Agy99 --------PIAPQLLVNRPPIKPVALDGKRVMITGASSGIGEAAAEQFAR
MAV_4597|M.avium_104 --------PMAPQVLVNRPLIKPVELAGKRVLLTGASSGIGEAAAEQFAR
MSMEG_1073|M.smegmatis_MC2_155 --------PVTDQLIQLRAARDAVDLTGKRVLITGASSGIGAAAARKFAE
TH_3707|M.thermoresistible__bu -----------------------VRADGR------ADQGLDAARX-----
Mflv_0026|M.gilvum_PYR-GCK --------PILPALLN-RPTRETIELRGKRVLLTGASSGIGEAAAEKLAR
Mvan_0944|M.vanbaalenii_PYR-1 --------PILPALLN-RPNRETIELKGKRVLLTGASSGIGEAAAEKLAR
MAB_3947|M.abscessus_ATCC_1997 --------PSLPLVRARLDPNYGAPIKGKRVLITGASSGIGEEAAYQFGK
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. *..*:.
Rv0547c|M.tuberculosis_H37Rv HRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVE
Mb0561c|M.bovis_AF2122/97 HRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVE
MMAR_0894|M.marinum_M QGATVIAVARRKDLLDAVADRITTSGGVAMSAPCDISDLDAVDALVADVE
MUL_0647|M.ulcerans_Agy99 QGATVIAVARRKDLLDAVADRITTSGGVAMSAPCDISDLDAVDALVADVE
MAV_4597|M.avium_104 EGARVVVVARRKDLLDALAEGITRAGGEAIAMPCDISDLDAADALVADVQ
MSMEG_1073|M.smegmatis_MC2_155 RGARVIVVARRAELLDEVAGGITASGGDAKARPCDLTDLDAIDALVAEIE
TH_3707|M.thermoresistible__bu -------------------------GGTGRALACDLTDLDAIDELVLKIE
Mflv_0026|M.gilvum_PYR-GCK RGATVVAVARRQDLLDELVTRIADAGGDARAHACDLSDLDAVDELVATVE
Mvan_0944|M.vanbaalenii_PYR-1 RGATVVAVARRGDLLDDLVARITDAGGRARAHACDLSDLDAIDALVATVE
MAB_3947|M.abscessus_ATCC_1997 LGAKVIVVARREDLLAEVAARIIAEGGEAEAIACDLSDLDAIDKLVETVN
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
** . : . *::* * : :. :.
Rv0547c|M.tuberculosis_H37Rv KRIGGIDILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLA
Mb0561c|M.bovis_AF2122/97 KRIGGIDILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLA
MMAR_0894|M.marinum_M NRLGGVDILINNAGRSIRRPLAESLQRWHDVERTMVLNYYGPLRLIRGLA
MUL_0647|M.ulcerans_Agy99 NRLGGVDILINNAGRSIRRPLAESLQRWHDVERTMVLNYYGPLRLIRGLA
MAV_4597|M.avium_104 QQLGGVDILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGIA
MSMEG_1073|M.smegmatis_MC2_155 SDHGGLDILVNNAGHSIRRPLADSLERWHDIERTMTLNYYSPLRLIRGFA
TH_3707|M.thermoresistible__bu QDLGGVDILINNAGKSIRRPLAESLERWHDVERTMNLNYYAPLRLIRGLA
Mflv_0026|M.gilvum_PYR-GCK KDLGGIDILVNNAGRSIRRPLEESLERWHDVERTMTLNYYGPLRLIRGLA
Mvan_0944|M.vanbaalenii_PYR-1 DELGGVDILVNNAGRSIRRPLEESLDRWHDVERTMTLNYYGPLRLIRGLA
MAB_3947|M.abscessus_ATCC_1997 EKHGGVDILVNNAGRSIRRKTYESLDRWHDAERTMQLNYFSPLRLIRGFA
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGRFLDTPP--EEFDRVLAVNLGGVVNCCRAFG
* **::**** . :: .: :*.: :* . :. *.:.
Rv0547c|M.tuberculosis_H37Rv PGMLERGDGHIINVATWGVLSEASPLFSVYNASKAALSAVSRIIETEWGS
Mb0561c|M.bovis_AF2122/97 PGMLERGDGHIINVATWGVLSEASPLFSVYNASKAALSAVSRIIETEWGS
MMAR_0894|M.marinum_M PGMLERGDGHIINVTTWGVLSEASPLFSVYNASKAALSAVSRTIETEWGR
MUL_0647|M.ulcerans_Agy99 PGMLERGDGHIINVTTWGVLSEASPLFSVYNASKAALSAVSRTIETEWGR
MAV_4597|M.avium_104 PGMIERGDGHIINVSTWGVLSEASPLFAVYNASKAALSTVSRVVETEWGD
MSMEG_1073|M.smegmatis_MC2_155 PGMRERGAGHIINVSTWGVLSEASPLFSVYQASKAALSAVSRVIETEWGD
TH_3707|M.thermoresistible__bu PGMRE----------TWGVLSEASPLFSVYNASKAALTAVSRVVETEWSQ
Mflv_0026|M.gilvum_PYR-GCK PGMLARGDGHIINVSTWGVKTESPPLFGVYNASKAALSSVSRIIETEWSG
Mvan_0944|M.vanbaalenii_PYR-1 PGMLERGDGHVINVSTWGVKTESPPLFGVYNASKAALSSISRIMETEWAD
MAB_3947|M.abscessus_ATCC_1997 PGMVERRSGHIINVATWGVLTDVVPQFAVYNASKAALSTVSRIVDAEYGK
MLBr_00862|M.leprae_Br4923 QRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDA
: : . :..* :**** .* : :*
Rv0547c|M.tuberculosis_H37Rv QGVHSTTLYYPLVATPMIAPTKAYDGLP----ALTAAEAAEWMVTAARTR
Mb0561c|M.bovis_AF2122/97 QGVHSTTLYYPLVATPMIAPTKAYDGLP----ALTAAEAAEWMVTAARTR
MMAR_0894|M.marinum_M GGVHSTTLYYPLVATPMIAPTKAYSGMP----ALTPQEAAEWMITAARTR
MUL_0647|M.ulcerans_Agy99 GGVHSTTLYYPLVATPMIAPTKAYSGMP----ALTPQEAAEWMITAARTR
MAV_4597|M.avium_104 KGVHSTTLYYPLVATPMIAPTKAYQGVP----ALTPEEAGRWMITAARTR
MSMEG_1073|M.smegmatis_MC2_155 GGVHSTTLYYPLVDTPMIKPTRAFDGLP----ALSADEAADWMITAARHR
TH_3707|M.thermoresistible__bu FGVHSTTLFYPLVKTPMIAPTREYDNLP----ALSAEEAADWMISAARYR
Mflv_0026|M.gilvum_PYR-GCK RGVHATTLYYPLVKTPMIAPTRAYDGLP----GLSADEAAGWIVTAARHR
Mvan_0944|M.vanbaalenii_PYR-1 RGVHSTTLYYPLVKTPMIAPTRAYDGLP----GLSAEEAAGWIITAARHR
MAB_3947|M.abscessus_ATCC_1997 YNVHTTTLYFPLVRTPMIAPTEAYTNAA----ALTSAEAAEWMVLAARTR
MLBr_00862|M.leprae_Br4923 VGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYG
.* **: :: * :* .*. . :. *
Rv0547c|M.tuberculosis_H37Rv PVRIAPRVAVAVNALDSIGPRWVNALMQRRNEQLNP------------
Mb0561c|M.bovis_AF2122/97 PVRIAPRVAVAVNALDSIGPRWVNALMQRRNEQLNP------------
MMAR_0894|M.marinum_M PVRIAPRIALMAKALNTLGPRWVNTLMQQRDDQLNDR-----------
MUL_0647|M.ulcerans_Agy99 PVRIAPRIALMAKALNTLGPRWVNTLMQQRDDQLNDR-----------
MAV_4597|M.avium_104 PVRIAPRMAIAAKALDTFGPRWVNAVMQRQTVQPNREAGA--------
MSMEG_1073|M.smegmatis_MC2_155 PVQIAPRVAVGARALNAVAPGVVNAVMKRQSAQPDGVGRRPIFPAG--
TH_3707|M.thermoresistible__bu PIQIAPRMAVTARALNVVAPGVVNAVMKRQRIQP-------VFV----
Mflv_0026|M.gilvum_PYR-GCK PVSIAPRIAVTAHAINSVAPGAVDTIMKRQRMQPRD------------
Mvan_0944|M.vanbaalenii_PYR-1 PVSIAPRIAVTAHAINSIAPAAVDTIMKRQRMQPKD------------
MAB_3947|M.abscessus_ATCC_1997 VVRIAPRISVMSAATNAVAPDLVTRVARNGRETLG-------------
MLBr_00862|M.leprae_Br4923 PDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI
:* : . . *