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MTVPMTQLEVPDYDLGIRGKLVRTEKTVDPTRLAFCTILYGLSVVDEVSDTPVSNAGNGYPDARLVPDQS TRVALPWRPGTDAVIADMVGADGAPLAMSPRNSLRSLVDRYAELDLEPVLGFEYEFWLFQDREDPRRPLG STENAYSLSRIAESQSLATEFIDRMHAVGIEIEMFHTELGPGFFEFTMAPAPACQAADAAVRARQYLRDL CAERGLHASFMAKPFGDKSGAGGHVHSSLNRNGKNIFADDHGWLSAEAGHYLAGLLAGMADTTAMLNPYV NSFKRIDPEMFTPVHATYGHDDRSTACRLILNDAKSARVEHRRPGADASPYLVATALLAAGFLGLQENLT LPGSDAVPAPLPGDLTAAIDAFENSPWLPDLVGKAFCASFAATRRAEAQRYAQWLKTTITSWELTRHLEH Q
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0611 | - | - | 100% (421) | glutamate--ammonia ligase |
| M. vanbaalenii PYR-1 | Mvan_1603 | - | 5e-51 | 31.94% (432) | glutamate--ammonia ligase |
| M. vanbaalenii PYR-1 | Mvan_0612 | - | 1e-36 | 29.34% (392) | glutamate--ammonia ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2885c | glnA4 | 1e-36 | 28.92% (408) | glutamine synthetase |
| M. gilvum PYR-GCK | Mflv_1300 | - | 5e-35 | 29.30% (413) | glutamate--ammonia ligase |
| M. tuberculosis H37Rv | Rv2860c | glnA4 | 1e-36 | 28.92% (408) | glutamine synthetase |
| M. leprae Br4923 | MLBr_01631 | glnA2 | 8e-31 | 28.68% (380) | glutamine synthase class II |
| M. abscessus ATCC 19977 | MAB_1920 | - | 1e-35 | 29.55% (379) | glutamine synthetase |
| M. marinum M | MMAR_3294 | glnA2 | 7e-34 | 30.00% (380) | glutamine synthetase GlnA2 |
| M. avium 104 | MAV_3718 | glnA | 6e-43 | 31.95% (435) | glutamine synthetase catalytic domain |
| M. smegmatis MC2 155 | MSMEG_3827 | - | 1e-174 | 70.42% (426) | glutamine synthetase |
| M. thermoresistible (build 8) | TH_3396 | - | 4e-31 | 28.23% (379) | PUTATIVE glutamine synthetase, type I |
| M. ulcerans Agy99 | MUL_1335 | glnA2 | 6e-34 | 30.00% (380) | glutamine synthetase GlnA2 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3294|M.marinum_M -----------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKS
MUL_1335|M.ulcerans_Agy99 -----------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKS
MLBr_01631|M.leprae_Br4923 -----------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKS
TH_3396|M.thermoresistible__bu -----------------MDRQKEFVLRSLEERDIRFVRLWFTDVLGFLKS
MAB_1920|M.abscessus_ATCC_1997 -----------------MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKS
Mflv_1300|M.gilvum_PYR-GCK --------------------MPHDLAALAEQSGTRFILALFVDLRGKPCA
Mb2885c|M.bovis_AF2122/97 -------MTGPGSPPLAWTELERLVAAGD----VDTVIVAFTDMQGRLAG
Rv2860c|M.tuberculosis_H37Rv -------MTGPGSPPLAWTELERLVAAGD----VDTVIVAFTDMQGRLAG
MAV_3718|M.avium_104 MASEDSALTGSDTAMLSLAALDRLVAAGAPETRVDTVIVAFPDMQGRLVG
Mvan_0611|M.vanbaalenii_PYR-1 -------------------------------MTVPMTQLEVPDYDLGIRG
MSMEG_3827|M.smegmatis_MC2_155 -----------------------------MADHVAMTQLEVADYDLGLRG
. * .
MMAR_3294|M.marinum_M VAIAPAELEGAFEEG----------IGFDGSSIEGFARVS----ESDTVA
MUL_1335|M.ulcerans_Agy99 VAIAPAELEGAFEEG----------IGFDGSSIEGFARVS----ESDTVA
MLBr_01631|M.leprae_Br4923 VAIAPAELEGAFEEG----------IGFDGSSIEGFARVS----ESDTVA
TH_3396|M.thermoresistible__bu VAIAPAELEGAFEEG----------IGFDGSAIEGFARVS----EADMVA
MAB_1920|M.abscessus_ATCC_1997 VSIAPAELEGAFEEG----------IGFDGSSIEGFARVS----ESDTVA
Mflv_1300|M.gilvum_PYR-GCK KLVPVEAVDQLATEG----------VGFAGYAVGAMGQEPK---DPDLMA
Mb2885c|M.bovis_AF2122/97 KRISGRHFVDDIATRGVECCSYLLAVDVDLNTVPGYAMASWDTGYGDMVM
Rv2860c|M.tuberculosis_H37Rv KRISGRHFVDDIATRGVECCSYLLAVDVDLNTVPGYAMASWDTGYGDMVM
MAV_3718|M.avium_104 KRMDARLFVDEAAATGVECCGYLLAVDVDMNTVGGYAISGWDTGFGDLVM
Mvan_0611|M.vanbaalenii_PYR-1 KLVRTEKTVDPTRLAFCTILYGLSVVDEVSDTPVSNAGNG----YPDARL
MSMEG_3827|M.smegmatis_MC2_155 KLVRSSKTHGASGLAFCTILYGLSLIDDVTDTPFSNAANG----YPDAQL
: :. : . . *
MMAR_3294|M.marinum_M HPDPSTFQVLPWVTDAGHHHSARIFCDITMPDGSPSWADPRHVLRRQLTK
MUL_1335|M.ulcerans_Agy99 HPDPSTFQVLPWVTDAGHHHSARIFCDITMPDGSPSWADPRHVLRRQLIK
MLBr_01631|M.leprae_Br4923 HPDPSTFQILPWATTAGHHHSARMFCDITMPDGSSSWADPRHVLRRQLTK
TH_3396|M.thermoresistible__bu RPDPSTFQVLPWTGDSGKHYSARMFCDITMPDGSPSWADPRHVLRRQLAK
MAB_1920|M.abscessus_ATCC_1997 HPDPSTFQVLPWTTSAGKHHSARMFCDIKLPDGSPSWSDPRHVLRRQLAK
Mflv_1300|M.gilvum_PYR-GCK IPDPESFTPIPFIKEG----LAIVHCDPHVN-GKPWPYAPRVILKSLIQR
Mb2885c|M.bovis_AF2122/97 TPDLSTLRLIPWLPGT-----ALVIADLVWADGSEVAVSPRSILRRQLDR
Rv2860c|M.tuberculosis_H37Rv TPDLSTLRLIPWLPGT-----ALVIADLVWADGSEVAVSPRSILRRQLDR
MAV_3718|M.avium_104 RPDLSTLRRIPWLPGT-----ALVIADVVGADGSPVAVSPRAVLRRQLDR
Mvan_0611|M.vanbaalenii_PYR-1 VPDQSTRVALPWRPGT-----DAVIADMVGADGAPLAMSPRNSLRSLVDR
MSMEG_3827|M.smegmatis_MC2_155 VPDETTRVALPWRHGT-----DAVIAELVDEQGRPLEVSPRAVLAGLAAR
** : :*: : .: * ** * :
MMAR_3294|M.marinum_M ANELGFSCYVHPEIEFFLLNPGPEDG------TEPVPIDNAGYFDQAVHV
MUL_1335|M.ulcerans_Agy99 ANELGFSCYVHPEIEFFLLNPGPEDG------TEPVPIDNAGYFDQAVHV
MLBr_01631|M.leprae_Br4923 ANDLGFSCYVHPEIEFFLLKAGPEDGS----MPIPVPVDNAGYFDQAVHD
TH_3396|M.thermoresistible__bu AGDQGFTCYVHPEIEFFLLKPGPHDG------SPPVPADTSGYFDQSVHD
MAB_1920|M.abscessus_ATCC_1997 ASDLGFSCYVHPEIEFFLLKNLPDDG------TAPIPADDAGYFDQAVHE
Mflv_1300|M.gilvum_PYR-GCK CADAGFEPWVGAEVEYFLLRRNDDGSVS---VADAADTASQPCYDARGVT
Mb2885c|M.bovis_AF2122/97 LKARGLVADVATELEFIVFDQPYRQAWASGYRGLTPASDYNIDYAILASS
Rv2860c|M.tuberculosis_H37Rv LKARGLVADVATELEFIVFDQPYRQAWASGYRGLTPASDYNIDYAILASS
MAV_3718|M.avium_104 LAGRGLFADAATELEFMVFDEPYRQAWASGYRGLTPASDYNIDYAISASS
Mvan_0611|M.vanbaalenii_PYR-1 YAELDLEPVLGFEYEFWLFQDREDP--------RRPLGSTENAYSLSRIA
MSMEG_3827|M.smegmatis_MC2_155 YGELGLAPVLGYEYELWIFRDGEGTSPPI-LGGRPAHGRTENAYSLTRCA
.: * * :: :
MMAR_3294|M.marinum_M SASKFRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMT
MUL_1335|M.ulcerans_Agy99 SASKFRRHVIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMT
MLBr_01631|M.leprae_Br4923 SALNFRRHAIEALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMT
TH_3396|M.thermoresistible__bu TAPNFRRHAIEALEQMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMT
MAB_1920|M.abscessus_ATCC_1997 AAPNFRRHAIDALESMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMT
Mflv_1300|M.gilvum_PYR-GCK RMYDHLTSVSAAMNQLGWSNYANDHEDGNGQFEQNFKFAEALTTADRVIT
Mb2885c|M.bovis_AF2122/97 RMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEIGFRYDEALVTCDNHAI
Rv2860c|M.tuberculosis_H37Rv RMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEIGFRYDEALVTCDNHAI
MAV_3718|M.avium_104 RMEPLLRDIRRGMAGAGLRFESVKGECNRGQQEIGFRYDEALRTCDNHVI
Mvan_0611|M.vanbaalenii_PYR-1 ESQSLATEFIDRMHAVGIEIEMFHTELGPGFFEFTMAPAPACQAADAAVR
MSMEG_3827|M.smegmatis_MC2_155 EINDIATEFVNRMDQIGIEVEMFHAELGPGFFEFTLAPETALRATDNAAR
: * . * * * : * *
MMAR_3294|M.marinum_M FRYVIKEVALEEGVRATFMPKPFGQHAGSAMHTHMSLFEGDVNAFHSPDD
MUL_1335|M.ulcerans_Agy99 FRYVIKEVALEEGVRATFMPKPFGQHAGSAMHTHMSLFEGDVNAFHSPDD
MLBr_01631|M.leprae_Br4923 FRYVIKEVAIENGARASFMPKPFAQHPGSAMHTHMSLFEGDVNAFHSDDD
TH_3396|M.thermoresistible__bu FRYVVKQVAISDGVRASFMPKPFAEHPGSAMHTHMSLFEGDTNAFHSPDD
MAB_1920|M.abscessus_ATCC_1997 FRNVVKEVAIIDGVHATFMPKPFSDHPGSAMHTHMSLFEGDTNAFHNPDD
Mflv_1300|M.gilvum_PYR-GCK LRYLLSMIADERGMIATFMPKPFGDKTGNGLHFHLSLTSAGTPVFPAEDD
Mb2885c|M.bovis_AF2122/97 YKNGAKEIADQHGKSLTFMAK-YDEREGNSCHIHVSLRGTDGSAVFADSN
Rv2860c|M.tuberculosis_H37Rv YKNGAKEIADQHGKSLTFMAK-YDEREGNSCHIHVSLRGTDGSAVFADSN
MAV_3718|M.avium_104 YKNGAKEIADQHGKSLTFMAK-YDEREGNSCHVHLSLRDAQGGAAFADPS
Mvan_0611|M.vanbaalenii_PYR-1 ARQYLRDLCAERGLHASFMAKPFGDKSGAGGHVHSSLNRNGKNIFADDHG
MSMEG_3827|M.smegmatis_MC2_155 ARQYLRDLCAERGLHASFMAKPFADKSGAGGHVHSSLTRDGNNVFSDGAG
: :. * :**.* : :: * . * * ** .
MMAR_3294|M.marinum_M P--LQLSEVGKSFIAGILEHASEISAVTNQWVNSYKRLILGGEAPTAASW
MUL_1335|M.ulcerans_Agy99 P--LQLSEVGKSFIAGILEHASEISAVTNQWVNSYKRLILGGEAPTAASW
MLBr_01631|M.leprae_Br4923 P--LQLSDVGKSFIAGILEHASEISAVTNQWVNSYKRLVVGGEAPTTASW
TH_3396|M.thermoresistible__bu P--LQLSDVAKSFIAGILEHANEISAVTNQWVNSYKRLVHGGEAPTAASW
MAB_1920|M.abscessus_ATCC_1997 P--LQLSDVGKSFIAGILEHANEISAVTNQWVNSYKRLVQGGEAPTAASW
Mflv_1300|M.gilvum_PYR-GCK NRGLGLSDTAYGFIGGILEHACALQAVVGPTVNSYKRTG-AVATLSGASW
Mb2885c|M.bovis_AF2122/97 GP-HGMSSMFRSFVAGQLATLREFTLCYAPTINSYKRFADSSFAPTALAW
Rv2860c|M.tuberculosis_H37Rv GP-HGMSSMFRSFVAGQLATLREFTLCYAPTINSYKRFADSSFAPTALAW
MAV_3718|M.avium_104 RP-HGMSTMFCSFLAGLLATMADFTLFYAPNINSYKRFADESFAPTALAW
Mvan_0611|M.vanbaalenii_PYR-1 W----LSAEAGHYLAGLLAGMADTTAMLNPYVNSFKRIDPEMFTPVHATY
MSMEG_3827|M.smegmatis_MC2_155 A----LSAEGSRYLAGLLAGMADTSLMLNPHVNSYKRIDPEMFTPALANW
:* ::.* * :**:** : :
MMAR_3294|M.marinum_M GAANRSALVRVPMYTPHKTSSRRIEVRSPDSACNPYLAFAVLLAAGLRGV
MUL_1335|M.ulcerans_Agy99 GAANRSALVRVPMYTPHKTSSRRIEVRSPDSACNPYLAFAVLLAAGLRGV
MLBr_01631|M.leprae_Br4923 GAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLAFAVLLAAGLRGV
TH_3396|M.thermoresistible__bu GAANRSALVRVPMYTPHKASSRRVEVRSPDSACNPYLTFAVLLAAGLRGV
MAB_1920|M.abscessus_ATCC_1997 GAANRSALVRVPMYTPNKSSSRRIEVRSPDSACNPYLTYAVLLAAGLRGV
Mflv_1300|M.gilvum_PYR-GCK APRLPTYGGNDRTHYIRVPDGDRIEMRGGDGSANPYLAIAAALGAGLDGI
Mb2885c|M.bovis_AF2122/97 GLDNRTCALRVVGHG----QNIRVECRVPGGDVNQYLAVAALIAGGLYGI
Rv2860c|M.tuberculosis_H37Rv GLDNRTCALRVVGHG----QNIRVECRVPGGDVNQYLAVAALIAGGLYGI
MAV_3718|M.avium_104 GLDNRTCALRVVGHG----AHTRVECRVPGGDVNPYLAVAAIVAGGLYGI
Mvan_0611|M.vanbaalenii_PYR-1 GHDDRSTACRLILND---AKSARVEHRRPGADASPYLVATALLAAGFLGL
MSMEG_3827|M.smegmatis_MC2_155 GYDDRGTSARVILPD---AKSARVEHRRPGADASPYLVAAALLAAGLRGL
. . *:* * .. . **. :. :..*: *:
MMAR_3294|M.marinum_M EKGYVLGPQAEDNVWDLTPEERRTMGYRELPTSLDSALRAMESS---ELV
MUL_1335|M.ulcerans_Agy99 EKGYVLGPQAEDNVWDLTPEERRTMGYRELPTSLDSALRAMESS---ELV
MLBr_01631|M.leprae_Br4923 EKGYVLGPQAEDNVWDLTPEERLAMGYRELPTSLDSALGAMEVS---EFV
TH_3396|M.thermoresistible__bu EKGYVLGPEAEDNVWTLTPEERRAMGFKELPSSLGQALAEMERS---ELV
MAB_1920|M.abscessus_ATCC_1997 EQGYTLGPEAEDDVWGLTRAERQAMGYKELPSTLENALIAMEGS---ELV
Mflv_1300|M.gilvum_PYR-GCK KRSTDPGAVGQG------------VSTQPLPATLLHAVEAFETN---PVV
Mb2885c|M.bovis_AF2122/97 ERGLQLPEPCVGN-------AYQGADVERLPVTLADAAVLFEDS---ALV
Rv2860c|M.tuberculosis_H37Rv ERGLQLPEPCVGN-------AYQGADVERLPVTLADAAVLFEDS---ALV
MAV_3718|M.avium_104 EQGLALPEPCAGN-------AYRARGVGRLPATLAEAAALFEHS---ALA
Mvan_0611|M.vanbaalenii_PYR-1 QENLTLPGSDAVP--------------APLPGDLTAAIDAFENSPWLP--
MSMEG_3827|M.smegmatis_MC2_155 QEELPLPERDAEP--------------TELPGDLAGALAHFENSTWLP--
:. ** * * :* .
MMAR_3294|M.marinum_M A---EALGEHVFDFFLRNKRREWATYR----SHVTPYELSTYLSL-
MUL_1335|M.ulcerans_Agy99 A---EALGEHVFDFFLRNKRREWATYR----SHVTPYELSTYLSL-
MLBr_01631|M.leprae_Br4923 A---EALGEHVFDFFLRNKRAEWANYR----SHVSLYELKTYLSL-
TH_3396|M.thermoresistible__bu A---EALGEHVFDFFLRNKRAEWENYR----SHVTPYELKNYLSL-
MAB_1920|M.abscessus_ATCC_1997 A---EALGEHVFDFFLRNKRAEWARYR----SNVTPFELRAYLGL-
Mflv_1300|M.gilvum_PYR-GCK TGVLDAAGEGVASYFAAIKRDEFFAYH----SSVSPWEIDYYLTAF
Mb2885c|M.bovis_AF2122/97 R---EAFGEDVVAHYLNNARVELAAFN----AAVTDWERIRGFERL
Rv2860c|M.tuberculosis_H37Rv R---EAFGEDVVAHYLNNARVELAAFN----AAVTDWERIRGFERL
MAV_3718|M.avium_104 R---QVFGDDVVAHYLNNARVELAAFH----AAVTDWERMRGFERL
Mvan_0611|M.vanbaalenii_PYR-1 ----DLVGKAFCASFAATRRAEAQRYAQWLKTTITSWELTRHLEHQ
MSMEG_3827|M.smegmatis_MC2_155 ----DLLGKAFCTSYAATRRAELQRYEQWLRTTITDWELHRHLEHQ
: *. . : * * : : :: :* :