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MPHRFDKRTSVAGMRVFVTGGTGAIGGYAVPALIAAGHDVTAVARSDAKAAVLQRQGATAVKVSLFDRDA LTAAFRGHTAVVNLASSLPTPARFMLKSAWEECHRIRIQGSATVIDAALAAGVGRVVQESVAMIYRDGGA RWIDEDWPVDRYPIAAGNHGAEASNRRFGENGRDAVVLRFGFFYGPGAGHSETMMRLARRRVTFQAGKPG SYMSSIHLEDAAAAVVAALEAAPGTYNVVDDCPVTATQHSAAMAAAVGVRPWLTPPGRAALLLGDRATSM TRSLRVNNARLRAATPWRTRYPSVWDGYRAMVGAQGW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0427 | - | - | 100% (317) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_1926 | - | 2e-12 | 27.70% (296) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_5808 | - | 1e-10 | 28.21% (280) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2239 | - | 5e-09 | 28.37% (282) | hypothetical protein Mb2239 |
| M. gilvum PYR-GCK | Mflv_1635 | - | 1e-10 | 30.73% (192) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2216 | - | 5e-09 | 28.37% (282) | hypothetical protein Rv2216 |
| M. leprae Br4923 | MLBr_00860 | - | 7e-07 | 25.56% (266) | hypothetical protein MLBr_00860 |
| M. abscessus ATCC 19977 | MAB_2971c | - | 2e-11 | 26.25% (301) | putative oxidoreductase |
| M. marinum M | MMAR_3319 | - | 3e-10 | 25.84% (329) | dehydrogenase |
| M. avium 104 | MAV_0588 | - | 4e-12 | 31.11% (225) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4136 | - | 6e-14 | 27.07% (229) | dTDP-glucose 4,6-dehydratase |
| M. thermoresistible (build 8) | TH_0221 | - | 4e-14 | 29.33% (283) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2058 | - | 1e-09 | 28.37% (282) | hypothetical protein MUL_2058 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0427|M.vanbaalenii_PYR-1 --MPHRFDKRTSVAGMRVFVTGGTGAIGGYAVPALI--AAGHDVTAVAR-
MSMEG_4136|M.smegmatis_MC2_155 ---------------MRIFFAGASGLIGRHVLPLLI--DAGHTVGAMTR-
Mb2239|M.bovis_AF2122/97 --------MAN----AVVAIAGSSGLIGSALTAALR--AADHTVLRIVRR
Rv2216|M.tuberculosis_H37Rv --------MAN----AVVAIAGSSGLIGSALTAALR--AADHTVLRIVRR
MLBr_00860|M.leprae_Br4923 --------MAQASRKAVVAIAGSSGMIGSALAAALR--ANDHLVLRIVRR
TH_0221|M.thermoresistible__bu --------------MAVIAIAGSSGLIGSALVYALR--AADHRVLRIVRR
MAV_0588|M.avium_104 ---------------MRVLVTGASGGIGSAVVKELL--AAGHHVIGLAR-
Mflv_1635|M.gilvum_PYR-GCK ----------MPGNDVRCVVTGATGYIGGRLVPELL--ARGLQVRAMAR-
MAB_2971c|M.abscessus_ATCC_199 ---------------MRVLVTGGTGFVGGWTAKAMA--EAGHKVRFLVRK
MUL_2058|M.ulcerans_Agy99 -------------MGVAVAVTGPTGDIGISAVTALEREPAVASIVGMAR-
MMAR_3319|M.marinum_M MSEHEFDRPAPSLSGRTIFITGANGFIGRAMAARFR------ALGAVVRG
.:* .* :* : : :.*
Mvan_0427|M.vanbaalenii_PYR-1 ---SDAKAAVLQRQGATAVKVSLFDRDALTAAFRGHTAVVNLASSLPTPA
MSMEG_4136|M.smegmatis_MC2_155 ---TADKAGHLEASGALPIVCDVFDRPSLDHHVRAFAPDLLLHELTDLPD
Mb2239|M.bovis_AF2122/97 AP-ANSEELHWNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSL
Rv2216|M.tuberculosis_H37Rv AP-ANSEELHWNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSL
MLBr_00860|M.leprae_Br4923 TP-ANAEELHWNPESGEFDTDAITDVDAVVNLCGVNLGQRRWSGSFKQNL
TH_0221|M.thermoresistible__bu AP-ANPDELFWNPDSGEFDADRLRGVDAVVNLCGVNIGARRWSGSFKQQL
MAV_0588|M.avium_104 ---SEASAATVSGLGAEPLRGDIADLDVLQKAAVDTDGVAYLAFSHDFSD
Mflv_1635|M.gilvum_PYR-GCK -T-PSKLDRTEWRDRVEVVRGDLTEADSLTAAFNGADVVYYLVHSMGTSR
MAB_2971c|M.abscessus_ATCC_199 EARLHTTVATLGVDVSDYAVGDITDRASVEAALDGCDAVVHSAAMVSTDP
MUL_2058|M.ulcerans_Agy99 ---RPFDPAIYGWSKTTYQRGNILDRDAVDALVAQADVVVHLAFIKLGSR
MMAR_3319|M.marinum_M VDLAADPAGDVVAGDITRPETWAAGPTGLEGADTVIHTAALLGAAFPLKQ
:
Mvan_0427|M.vanbaalenii_PYR-1 R------FMLKSAWEECHR-IRIQGSATVIDAALAAGVGRVVQESVAMIY
MSMEG_4136|M.smegmatis_MC2_155 N------LKDLPADSALNARIRDEGTRNLIAATTELAKVKIVAQSVAWS-
Mb2239|M.bovis_AF2122/97 R------DSRITPTEVLSAAVADAGVATLINASAVGYYGNTKDRVVDEND
Rv2216|M.tuberculosis_H37Rv R------DSRITPTEVLSAAVADAGVATLINASAVGYYGNTKDRVVDEND
MLBr_00860|M.leprae_Br4923 R------DSRITPTEVLSAAVAEAGVKTFINASAVGYYGNTRDRVVDEND
TH_0221|M.thermoresistible__bu R------DSRITPTEVLTAAVVEAGVPVLVNASAVGVYGDTRDRAVDESA
MAV_0588|M.avium_104 VGDA--IADEARAIDALGAALADTGKPLVLASGTPARPGSVSTEDDPFIA
Mflv_1635|M.gilvum_PYR-GCK D--F--VAEERRSAHNVVEAAKKAGVRRIVYLSGLHPDRKELSRHLASRV
MAB_2971c|M.abscessus_ATCC_199 AEADRMMAINLEGTRNVLGAAVDRGLDPIVHVSSITALFRPGLETFAADL
MUL_2058|M.ulcerans_Agy99 AES--AQVNLQGARNVFEATVAARRPRRLVYTSSMAAYGYHSDNPAAITE
MMAR_3319|M.marinum_M A-----WHVNVLGTSRVLRAAIDAGVRRFVHFSSVAAYGFEFPDGADETY
.:
Mvan_0427|M.vanbaalenii_PYR-1 RDGGARWIDEDWPVDRYPIAAGNHGAEASNRRFGENGRDAVVLRFGFFYG
MSMEG_4136|M.smegmatis_MC2_155 ------------------MAPGKESAAVGVLEKSVLAVGGVVLRYGLIYG
Mb2239|M.bovis_AF2122/97 SAGTG------------FLAQLCVDWETATRPAQQSGARVVLARTGVVLS
Rv2216|M.tuberculosis_H37Rv SAGTG------------FLAQLCVDWETATRPAQQSGARVVLARTGVVLS
MLBr_00860|M.leprae_Br4923 RAGTG------------FLAQLCQDWEGATLPAQYAGTRVILARTGMVLA
TH_0221|M.thermoresistible__bu PPGQG------------FLARLCQDWEAATTPARQAGVRVVLARTGLVVS
MAV_0588|M.avium_104 DG---------------PLAGRGRTGQAVVELAGRGVRSAVVRLPRAVHD
Mflv_1635|M.gilvum_PYR-GCK EVGEILMQSGIETVVLQAGIVIGSGSASFEMVRHLTDRLPVMTTPKWVHN
MAB_2971c|M.abscessus_ATCC_199 PAAGGS----------DGYGQSKARVELYVRALQDSGAPVTITYPGMVLG
MUL_2058|M.ulcerans_Agy99 DVPARG------SPEHYYSEQKAQSEAELAKITEDSLLQVFVLRPCIVAG
MMAR_3319|M.marinum_M PVHVNG---------DVYTDTKVNSEAVVLAAHGAGEIDVTVIRPGDVWG
: .
Mvan_0427|M.vanbaalenii_PYR-1 PGA----------GHSETMMRLARR--RVTFQAGKPGSYMSSIHLEDAAA
MSMEG_4136|M.smegmatis_MC2_155 PGT----------YFERQLPPTPR------------------VHVDTAAV
Mb2239|M.bovis_AF2122/97 PAG----------GMLRRMRPLFSV--GLGARLGSGRQYMSWISLEDEVR
Rv2216|M.tuberculosis_H37Rv PAG----------GMLRRMRPLFSV--GLGARLGSGRQYMSWISLEDEVR
MLBr_00860|M.leprae_Br4923 QEA----------GVLSRMRPLFSF--ALGARIGNGRQYMSWISLEDEVR
TH_0221|M.thermoresistible__bu PSG----------GLLSRLRPLFAA--GLGARLGSGCQYMSWISLEDEVR
MAV_0588|M.avium_104 AGGR--------YGLAGILIQLARQR-GVSSFAGDGTQRWPAVHRDDAAA
Mflv_1635|M.gilvum_PYR-GCK KIQP--------ISISDVLHYLAEAA-TAEFGESRTWDIGGPDVMEYGDA
MAB_2971c|M.abscessus_ATCC_199 PPVG---------DQFGEAAEGVRWV-LLTRSVPGRSAAWLVVDVRDLAA
MUL_2058|M.ulcerans_Agy99 PHAYSLAEAMPCRQVPAPVRALSRVVPMLKPIVPDPGVPVQLVHHDDVAA
MMAR_3319|M.marinum_M PGS---------VWVRSPIAEMRKRT-GFPLPNGGNGIFSPVYIDNFVDG
Mvan_0427|M.vanbaalenii_PYR-1 AVVAALEAA--PGTYNVVDDCPVTATQHS--------AAMA-AAVG-VRP
MSMEG_4136|M.smegmatis_MC2_155 RTVEALDAP--SGVLTIVDE------------------------------
Mb2239|M.bovis_AF2122/97 ALQFAIAQPNLSGPVNLTGPAPVTNAEFT--------TAFG-RAVNRPTP
Rv2216|M.tuberculosis_H37Rv ALQFAIAQPNLSGPVNLTGPAPVTNAEFT--------TAFG-RAVNRPTP
MLBr_00860|M.leprae_Br4923 ALLFAISHQSLSGPLNLTGPAPVTNAEFT--------TAFG-RAINRPTP
TH_0221|M.thermoresistible__bu ALQRLLTDDALSGPVNLTGPAPVTNAEFT--------AALG-RALNRPAP
MAV_0588|M.avium_104 LFRLALEQAPAGSVLHAVGDEGVPLRAIA--------EVIG-RRLG----
Mflv_1635|M.gilvum_PYR-GCK MQGYADVAGLRRRVMVVLPFLTPTIASWW--------VGLV-TPIPSGLA
MAB_2971c|M.abscessus_ATCC_199 LHTALLEPSRGPRRYTAGGHR-LEVGELV--------DLLT-EAAGSAVL
MUL_2058|M.ulcerans_Agy99 AIALAATAPVPAGAYNIAADGVVTITDMA--------RALGGRPVRVPAA
MMAR_3319|M.marinum_M MVLAVSSDDAVGQIFNITDGKGVRCADFFGRMASMSDGTIHTLPIRVAAP
Mvan_0427|M.vanbaalenii_PYR-1 WLTPPGRAALLLGDRATSMTRSLRVNNARLRAATPWRTRYPSVWDGYRAM
MSMEG_4136|M.smegmatis_MC2_155 --------------------------------------------------
Mb2239|M.bovis_AF2122/97 LMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAGFQFHHNTIGEALGYA
Rv2216|M.tuberculosis_H37Rv LMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAGFQFHHNTIGEALGYA
MLBr_00860|M.leprae_Br4923 LMLPSFAVRAALGEFADEGLLIGQRAIPAALERAGFQFHHNTIGEALSYA
TH_0221|M.thermoresistible__bu WVLPGVAVRALLGEFAEEGVLAGQRVVPAALEAAGFGFRHNTIGAALAYA
MAV_0588|M.avium_104 -VPVESAPADAFGPLGQVFAVDQPSSSALTQRRFGWQPVGPGLLDDLETG
Mflv_1635|M.gilvum_PYR-GCK RPLVESLECDAICHEHDIDAVIPPPKGGLIGYREAVAKELRSEGGSSAGR
MAB_2971c|M.abscessus_ATCC_199 AVPVPDSLLRAAGTVMDQIGRYVPWETPMTEAGMQYYTQMPASDDTPSER
MUL_2058|M.ulcerans_Agy99 AASVASAAISRLPLVPPLLEWLHAVRQPVVMDTAKAKRELGWSPTHSSAE
MMAR_3319|M.marinum_M AAELLGSLLRRLGQKTDLSAGTMWLLNRPGTYSIEKAQKMLGYQPRVSIE
Mvan_0427|M.vanbaalenii_PYR-1 VGAQGW-------------------------------
MSMEG_4136|M.smegmatis_MC2_155 -------------------------------------
Mb2239|M.bovis_AF2122/97 TTRPG--------------------------------
Rv2216|M.tuberculosis_H37Rv TTRPG--------------------------------
MLBr_00860|M.leprae_Br4923 TTRPSQN------------------------------
TH_0221|M.thermoresistible__bu TAGPDAR------------------------------
MAV_0588|M.avium_104 VYPE---------------------------------
Mflv_1635|M.gilvum_PYR-GCK RHLLRFSPAASD-------------------------
MAB_2971c|M.abscessus_ATCC_199 ELGITYRDPRETLADTVVSLRAGRTTSKLWGLWPFSE
MUL_2058|M.ulcerans_Agy99 TLSALAAAI----------------------------
MMAR_3319|M.marinum_M EGMARVHEWARAERLI---------------------