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RIFFAGASGLIGRHVLPLLIDAGHTVGAMTRTADKAGHLEASGALPIVCDVFDRPSLDHHVRAFAPDLLL HELTDLPDNLKDLPADSALNARIRDEGTRNLIAATTELAKVKIVAQSVAWSMAPGKESAAVGVLEKSVLA VGGVVLRYGLIYGPGTYFERQLPPTPRVHVDTAAVRTVEALDAPSGVLTIVDE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4136 | - | - | 100% (194) | dTDP-glucose 4,6-dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0994 | - | 2e-06 | 51.11% (45) | putative NAD-dependent epimerase/dehydratase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2497 | - | 1e-05 | 32.48% (117) | RmlD substrate binding domain-containing protein |
| M. thermoresistible (build 8) | TH_0069 | - | 8e-05 | 31.48% (108) | nucleoside-diphosphate-sugar epimerase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0427 | - | 3e-14 | 27.07% (229) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4136|M.smegmatis_MC2_155 -------------MRIFFAGASGLIGRHVLPLLIDAGHTVGAMTR-TADK
Mvan_0427|M.vanbaalenii_PYR-1 MPHRFDKRTSVAGMRVFVTGGTGAIGGYAVPALIAAGHDVTAVAR-SDAK
TH_0069|M.thermoresistible__bu ---------MPDLPRCLVTGATGYIGGRLIPRLLDRGHPVQAMARNPEKL
MAB_0994|M.abscessus_ATCC_1997 -------------MRVFVTGASGFIGSAVVRELIDSGHTVTGLAR-SDSS
MAV_2497|M.avium_104 ----------MTANTVLVTGAFGQVGKRCTQLLLQRGRTVVAMDLRNDNT
:.:*. * :* *: *: * .:
MSMEG_4136|M.smegmatis_MC2_155 AGHLEASGAL-------PIVCDVFDRPSLDHHVRAFA--PDLLLHELTDL
Mvan_0427|M.vanbaalenii_PYR-1 AAVLQRQGAT-------AVKVSLFDRDALTAAFRGHT--AVVNLASSLPT
TH_0069|M.thermoresistible__bu AGAPWRDRVD-------VVQGDLTDGDSLTAAFAGVD--VVYYLVHSMGS
MAB_0994|M.abscessus_ATCC_1997 AAALTAAGAD-------VHRGSLDDLESLRAGAVAAD--GVAHLAFVHDF
MAV_2497|M.avium_104 AAVATELAAGGYPGTLIPAYTDLLDAEAVRDLVTAHQPDAVVHLAAVVSP
*. . .: * :: . *
MSMEG_4136|M.smegmatis_MC2_155 PDNLKDLPADSALNARIRDEGTRNLIAATTELAKVKIVAQSVAWS-----
Mvan_0427|M.vanbaalenii_PYR-1 PARFMLKSAWEECHR-IRIQGSATVIDAALAAGVGRVVQESVAMIYRDGG
TH_0069|M.thermoresistible__bu ADDFAAEEAR----------SAREVVAAARRTGVRRLVYLGGLHPPGTG-
MAB_0994|M.abscessus_ATCC_1997 ENYAEAVNAD---------KRAIATIGEALAGTERPFVVTSGLAGFGLG-
MAV_2497|M.avium_104 LSYRKPDLARRVNVG-----GTENLLAACTALPRPPLFLMASSAAVYGS-
* : : .. .
MSMEG_4136|M.smegmatis_MC2_155 --------------MAPGKESAAVGVLEKSVLAVGGVVLRYG---LIYGP
Mvan_0427|M.vanbaalenii_PYR-1 ARWIDEDWPVDRYPIAAGNHGAEASNRRFGENGRDAVVLRFG---FFYGP
TH_0069|M.thermoresistible__bu --------------LSTHLESRVEVGDILLDSGIETVVLQAG---IVIGS
MAB_0994|M.abscessus_ATCC_1997 ------RPLTEEDAAAPESPRLSEEALNLADRGVRVSAVRLAP--SVHGE
MAV_2497|M.avium_104 -----RNPYRQPERITPDTPVNPIDQYGQDKVLAEAAIRASGLPYALFRL
:. . .
MSMEG_4136|M.smegmatis_MC2_155 G-TYFERQLPPTPR-----------------VHVDTAAVRTVEALDAPS-
Mvan_0427|M.vanbaalenii_PYR-1 G-AGHSETMMRLARRR-VTFQAGKPGSYMSSIHLEDAAAAVVAALEAAP-
TH_0069|M.thermoresistible__bu GSASFEMIRHLTDRLP-VMTTPKWVRNRIQPIAVDDVLHYLAEAATAAVP
MAB_0994|M.abscessus_ATCC_1997 GDHGFVPRLIEIARAKGVSAYPGDGSNRWPAVHRLDAAHLFRLALENAPT
MAV_2497|M.avium_104 GGIISPDTHASINGDYLLLMRSMPSDNRMHAVDARDVALAFANGVDRAAT
* : . . .
MSMEG_4136|M.smegmatis_MC2_155 -------GVLTIVDE-----------------------------------
Mvan_0427|M.vanbaalenii_PYR-1 -------GTYNVVDDCP---VTATQHSAAMAAAVGVRPWLTPPGRAALLL
TH_0069|M.thermoresistible__bu GSRAWDVGGPDVLEYGE---AIQVYAEEAGRRRRVIVPLPWLTPRIASWW
MAB_0994|M.abscessus_ATCC_1997 G------SRLHGVAEDG---IPVRDIAEVIGRHLNLPVESVPLAQAFDHF
MAV_2497|M.avium_104 IS-----GKVLLIGGNESYVLTQRELEDAMMEAVGLGRLGPSASLPGNPA
. :
MSMEG_4136|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0427|M.vanbaalenii_PYR-1 GDRATSMTRSLRVN--NARLRAATPWRTRYPSVWDGYRAMVGAQGW----
TH_0069|M.thermoresistible__bu VGLVTPLPPGLAPPXPRCSATCRSPPSSSAPAWSRSGSGCSSAAS-----
MAB_0994|M.abscessus_ATCC_1997 GWLGGFFAMDLPATSVLTQERLG--WRPVQPGLIADLEKGHYFDE-----
MAV_2497|M.avium_104 DDRGWSFTGWYDTTEAQQLLDFQEHDWSQTVAWLAESQGRSRLALRLLGP
MSMEG_4136|M.smegmatis_MC2_155 ------------------------------------------
Mvan_0427|M.vanbaalenii_PYR-1 ------------------------------------------
TH_0069|M.thermoresistible__bu ------------------------------------------
MAB_0994|M.abscessus_ATCC_1997 ------------------------------------------
MAV_2497|M.avium_104 LLRPLLRTILIVQRRLEGRGPYADPWTLIEKKYGTAALATAD