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NDRAVQFVGAGPGAADLLTVRAARFLADAELVLYPGTYLDAAVLAHCSPDADLVDTENLDLDTIVARLVD GHRAGLRVVRLVSGDPSVYSALSEQTRRLDAVRVPWEVTPGVPAYAAAAARVGRELTVPLVAQSVVLTRT RQRSTVMPDTESLKAFAATRATLVLHLAITRIRELMAEIEPEYGADCPVVVVYRASQPQELVLRGTVADI ADAVQEAGLRQAAVILVGRALAGRPDPDAGESYLYDPARDRSGRSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0382 | - | - | 100% (257) | uroporphyrin-III C/tetrapyrrole methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2305 | - | 4e-20 | 32.37% (241) | uroporphyrin-III C-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0846 | - | 7e-08 | 25.69% (288) | uroporphyrinogen III synthase HEM4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2097c | cobM | 2e-56 | 50.81% (246) | precorrin-4 C11-methyltransferase CobM |
| M. gilvum PYR-GCK | Mflv_0352 | - | 1e-122 | 89.60% (250) | precorrin-4 C11-methyltransferase |
| M. tuberculosis H37Rv | Rv2071c | cobM | 5e-56 | 50.41% (246) | precorrin-4 C11-methyltransferase CobM |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2196 | - | 6e-58 | 50.00% (248) | precorrin-4 C11-methyltransferase CobM |
| M. marinum M | MMAR_3053 | cobM | 1e-55 | 49.59% (246) | precorrin-4 C11-methyltransferase, CobM |
| M. avium 104 | MAV_2425 | cobM | 3e-56 | 49.80% (251) | precorrin-4 C11-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_3877 | cobM | 2e-61 | 51.79% (251) | precorrin-4 C11-methyltransferase |
| M. thermoresistible (build 8) | TH_0443 | cobM | 3e-62 | 52.19% (251) | Probable precorrin-4 C11-methyltransferase CobM |
| M. ulcerans Agy99 | MUL_2297 | cobM | 1e-54 | 49.19% (246) | precorrin-4 C11-methyltransferase, CobM |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3877|M.smegmatis_MC2_155 ---------------MTVYFIGAGPGAADLITVRGQRLLGTCKVCLYAGS
TH_0443|M.thermoresistible__bu ---------VVGDETMTVYFIGAGPGAADLITVRGQRLLSRCPVCLYAGS
Mb2097c|M.bovis_AF2122/97 ---------------MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGS
Rv2071c|M.tuberculosis_H37Rv ---------------MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGS
MMAR_3053|M.marinum_M ---------------MTVYFIGAGPGAADLITLRGQRLLQSCPVCLYAGS
MUL_2297|M.ulcerans_Agy99 ---------------MTVYFIGAGPGAADLITLRGQRLLQSCPVCLYAGS
MAV_2425|M.avium_104 ---------------MTVYFIGAGPGAADLITVRGQRLLQSCPVCLYAGS
MAB_2196|M.abscessus_ATCC_1997 MEISSARSSVEHRKIMTVYFIGAGPGAADLITVRGQRILRQCSVCLYAGS
Mvan_0382|M.vanbaalenii_PYR-1 ------------MNDRAVQFVGAGPGAADLLTVRAARFLADAELVLYPGT
Mflv_0352|M.gilvum_PYR-GCK ------------MN-HPVQFVGAGPGAADLLTVRAARLLADAGLVLYPGT
.* *:*********:*:*. *:* . : **.*:
MSMEG_3877|M.smegmatis_MC2_155 IMPDDLLALCPPDAKVIDTGPLNLDQIIDELVAADEAGLDVARLHSGDPS
TH_0443|M.thermoresistible__bu IMPDDLLALCPPDARIVDTGPLTLDQIVAELADAHARGLDVARLHSGDPA
Mb2097c|M.bovis_AF2122/97 IMPDDLLAQCPPGATIVDTGPLTLEQIVRKLADADADGRDVARLHSGDPS
Rv2071c|M.tuberculosis_H37Rv IMPDDLLAQCPPGATIVDTGPLTLEQIVRKLADADADGRDVARLHSGDPS
MMAR_3053|M.marinum_M IMPDDLLAYCPPEAKVVDTGPLTLEQIITELAAAHAAGHDVARLHSGDPS
MUL_2297|M.ulcerans_Agy99 IMPDDLLAYCPVEAKVVDTGPLTLEQIITELAAAHAAGHDVARLHSGDPS
MAV_2425|M.avium_104 IMPDDLLALCPPDARIVDTGPLTLDQIITELSQAHAAGHDVARLHSGDPS
MAB_2196|M.abscessus_ATCC_1997 IMPDDLLAECPPGARVVDTGPLTLDAIIEEISAADAEGLDVARLHSGDPS
Mvan_0382|M.vanbaalenii_PYR-1 YLDAAVLAHCSPDADLVDTENLDLDTIVARLVDGHRAGLRVVRLVSGDPS
Mflv_0352|M.gilvum_PYR-GCK YLDPDVLAHCSPSADLVDTGNLDLDTIVARLVDGHRGGVAVVRLVSGDPS
: :** *. * ::** * *: *: .: .. * *.** ****:
MSMEG_3877|M.smegmatis_MC2_155 IYSALAEQCRRLDALGIGYEIVPGVPAFAAVAAALGRELTVPGVAQTVTL
TH_0443|M.thermoresistible__bu IYSALAEQCRRLDALGIDYEIVPGVPAFAAAAAALGRELTVPGVAQTVTL
Mb2097c|M.bovis_AF2122/97 LYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTL
Rv2071c|M.tuberculosis_H37Rv LYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTL
MMAR_3053|M.marinum_M LYSALAEQCRRLDALGIGYEIVPGVPAFAAAAAALKREFTVPGVSQTVTL
MUL_2297|M.ulcerans_Agy99 LYSALAEQCRRLDALGIGYEIVPGVPAFAAAAAALKREFTVPGVSQTVTL
MAV_2425|M.avium_104 LYSALAEQCRRLDALGIDYEIVPGVPAFAAAAAALKRELTVPGVAQTVTL
MAB_2196|M.abscessus_ATCC_1997 LYSAVAEQCRRLDVLGIDHEIVPGVPAFAAAAAALGTELTVPGVAQTVTI
Mvan_0382|M.vanbaalenii_PYR-1 VYSALSEQTRRLDAVRVPWEVTPGVPAYAAAAARVGRELTVPLVAQSVVL
Mflv_0352|M.gilvum_PYR-GCK VYSAVSEQTRRLDAAGVPWQVTPGVPAYAAAAARVGRELTVPLVAQSVVL
:***::** *.**. : ::.*****:**.** : *:*** *:*:*.:
MSMEG_3877|M.smegmatis_MC2_155 SRVATLSTAMPEGEDLRTLSAPGATLVLHLAAAQIDNIVPQLIEGGYRPE
TH_0443|M.thermoresistible__bu TRVATLSTAMPPGEDLVTLSKPGATLVLHLAAAQIDAIVPKLLEGGYRPE
Mb2097c|M.bovis_AF2122/97 TRVATLSTPMPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDGGYRPE
Rv2071c|M.tuberculosis_H37Rv TRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDGGYRPE
MMAR_3053|M.marinum_M TRISTLSTPMPPGEDLAALAKPGATLVLHLAAAQIDAIVPQLLAGGYRPE
MUL_2297|M.ulcerans_Agy99 TRISTLSTPMPPGEDLAALAKPGATLVLHLAAAQIDAIIPQLLAGGYRPE
MAV_2425|M.avium_104 SRVATLSTAMPPGEDLATLARTGGTLVLQLAAAQIDSIVGQLLDNGRQSQ
MAB_2196|M.abscessus_ATCC_1997 TRVSTLSTAMPEGEDLRTLAAPGATLALHLAAAQIDTVAADLVAGGYPSD
Mvan_0382|M.vanbaalenii_PYR-1 TRTRQRSTVMPDTESLKAFAATRATLVLHLAITRIRELMAEIEP-EYGAD
Mflv_0352|M.gilvum_PYR-GCK TRTRARSTQMPDTESLAAFAATRATLVLHLAITRIRELMAEIEG-DYGPD
:* ** :* *.* ::: . .**.*:** ::* : : .:
MSMEG_3877|M.smegmatis_MC2_155 TPCAVVAFASWPQEVVLRGTLADIAEQMHAADVTRTAVIVVGDVLAAEG-
TH_0443|M.thermoresistible__bu TPCAVVAFASWPEQTVLRGTLADIAEQMRQAGITKTAVIIVGDVLAAEG-
Mb2097c|M.bovis_AF2122/97 TPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEG-
Rv2071c|M.tuberculosis_H37Rv TPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEG-
MMAR_3053|M.marinum_M TPAAVVAFASWPQQAVLRGTLSDIAAQMHNANITKTAVIVVGDVLAADG-
MUL_2297|M.ulcerans_Agy99 TPAAVVAFASWPQQAVLRGTLSDIAAQMHNANITKTAVIVVGDVLAADG-
MAV_2425|M.avium_104 TPCAVVAFASWPQETVLRGTLDDIAAQMHDAHITKTAVIIVGDALTAGG-
MAB_2196|M.abscessus_ATCC_1997 TPVAVVAYASWPSETILRGTLADIAGQLKEAAVTKTAVIFVGKVLAAEG-
Mvan_0382|M.vanbaalenii_PYR-1 CPVVVVYRASQPQELVLRGTVADIADAVQEAGLRQAAVILVGRALAGRPD
Mflv_0352|M.gilvum_PYR-GCK CPVVVVYRASQPQEIVLRGTVSDIADAVESAGLRQAAVILVGRALAGRPD
* .** ** *.: ****: *** :. * : ::***.** .*:.
MSMEG_3877|M.smegmatis_MC2_155 --FTDSYLYSATRRRGSRH-
TH_0443|M.thermoresistible__bu --FTDSYLYSAGRRRGSRH-
Mb2097c|M.bovis_AF2122/97 --FTDSYLYSVARHGRYAQ-
Rv2071c|M.tuberculosis_H37Rv --FTDSYLYSVARHGRYAQ-
MMAR_3053|M.marinum_M --FTDSYLYSVARRGAH---
MUL_2297|M.ulcerans_Agy99 --FTDSYLYSVARRGAH---
MAV_2425|M.avium_104 --FTDSYLYSTGRARGSRH-
MAB_2196|M.abscessus_ATCC_1997 --FTDSYLYSSGRRRGASH-
Mvan_0382|M.vanbaalenii_PYR-1 PDAGESYLYDPARDRSGRSS
Mflv_0352|M.gilvum_PYR-GCK PEAGESYLYDASRDRSGRDR
:****. *