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TVYFIGAGPGAADLITLRGQRLLQSCPVCLYAGSIMPDDLLAYCPVEAKVVDTGPLTLEQIITELAAAHA AGHDVARLHSGDPSLYSALAEQCRRLDALGIGYEIVPGVPAFAAAAAALKREFTVPGVSQTVTLTRISTL STPMPPGEDLAALAKPGATLVLHLAAAQIDAIIPQLLAGGYRPETPAAVVAFASWPQQAVLRGTLSDIAA QMHNANITKTAVIVVGDVLAADGFTDSYLYSVARRGAH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2297 | cobM | - | 100% (249) | precorrin-4 C11-methyltransferase, CobM |
| M. ulcerans Agy99 | MUL_2114 | cysG | 5e-21 | 33.61% (238) | multifunctional enzyme siroheme synthase CysG |
| M. ulcerans Agy99 | MUL_2290 | cobI | 5e-07 | 29.26% (229) | bifunctional protein, CobI-CobJ fusion protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2097c | cobM | 1e-118 | 84.74% (249) | precorrin-4 C11-methyltransferase CobM |
| M. gilvum PYR-GCK | Mflv_0352 | - | 5e-59 | 50.41% (246) | precorrin-4 C11-methyltransferase |
| M. tuberculosis H37Rv | Rv2071c | cobM | 1e-118 | 84.34% (249) | precorrin-4 C11-methyltransferase CobM |
| M. leprae Br4923 | MLBr_02420 | hemD | 7e-06 | 24.11% (253) | putative uroporphyrin-III C-methyltransferase |
| M. abscessus ATCC 19977 | MAB_2196 | - | 1e-103 | 75.61% (246) | precorrin-4 C11-methyltransferase CobM |
| M. marinum M | MMAR_3053 | cobM | 1e-138 | 99.20% (249) | precorrin-4 C11-methyltransferase, CobM |
| M. avium 104 | MAV_2425 | cobM | 1e-114 | 82.45% (245) | precorrin-4 C11-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_3877 | cobM | 1e-113 | 81.71% (246) | precorrin-4 C11-methyltransferase |
| M. thermoresistible (build 8) | TH_0443 | cobM | 1e-117 | 83.33% (246) | Probable precorrin-4 C11-methyltransferase CobM |
| M. vanbaalenii PYR-1 | Mvan_0382 | - | 1e-54 | 49.19% (246) | uroporphyrin-III C/tetrapyrrole methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0352|M.gilvum_PYR-GCK ------------MN-HPVQFVGAGPGAADLLTVRAARLLADAGLVLYPGT
Mvan_0382|M.vanbaalenii_PYR-1 ------------MNDRAVQFVGAGPGAADLLTVRAARFLADAELVLYPGT
MUL_2297|M.ulcerans_Agy99 ---------------MTVYFIGAGPGAADLITLRGQRLLQSCPVCLYAGS
MMAR_3053|M.marinum_M ---------------MTVYFIGAGPGAADLITLRGQRLLQSCPVCLYAGS
Mb2097c|M.bovis_AF2122/97 ---------------MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGS
Rv2071c|M.tuberculosis_H37Rv ---------------MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGS
MAV_2425|M.avium_104 ---------------MTVYFIGAGPGAADLITVRGQRLLQSCPVCLYAGS
MSMEG_3877|M.smegmatis_MC2_155 ---------------MTVYFIGAGPGAADLITVRGQRLLGTCKVCLYAGS
TH_0443|M.thermoresistible__bu ---------VVGDETMTVYFIGAGPGAADLITVRGQRLLSRCPVCLYAGS
MAB_2196|M.abscessus_ATCC_1997 MEISSARSSVEHRKIMTVYFIGAGPGAADLITVRGQRILRQCSVCLYAGS
MLBr_02420|M.leprae_Br4923 MVGATMTTRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPD
: *:******..*:* :. .* . : :
Mflv_0352|M.gilvum_PYR-GCK YLD----------PDVLAHCSPSADLVDTGNLDLDTIVARLVDGH----R
Mvan_0382|M.vanbaalenii_PYR-1 YLD----------AAVLAHCSPDADLVDTENLDLDTIVARLVDGH----R
MUL_2297|M.ulcerans_Agy99 IMP----------DDLLAYCPVEAKVVDTGPLTLEQIITELAAAH----A
MMAR_3053|M.marinum_M IMP----------DDLLAYCPPEAKVVDTGPLTLEQIITELAAAH----A
Mb2097c|M.bovis_AF2122/97 IMP----------DDLLAQCPPGATIVDTGPLTLEQIVRKLADAD----A
Rv2071c|M.tuberculosis_H37Rv IMP----------DDLLAQCPPGATIVDTGPLTLEQIVRKLADAD----A
MAV_2425|M.avium_104 IMP----------DDLLALCPPDARIVDTGPLTLDQIITELSQAH----A
MSMEG_3877|M.smegmatis_MC2_155 IMP----------DDLLALCPPDAKVIDTGPLNLDQIIDELVAAD----E
TH_0443|M.thermoresistible__bu IMP----------DDLLALCPPDARIVDTGPLTLDQIVAELADAH----A
MAB_2196|M.abscessus_ATCC_1997 IMP----------DDLLAECPPGARVVDTGPLTLDAIIEEISAAD----A
MLBr_02420|M.leprae_Br4923 VPEPVLALIGKDLPPVSGPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMS
: . .. . : : : .
Mflv_0352|M.gilvum_PYR-GCK GGVAVVRLVSGDPSVYSAVSEQTRR-LDAAGVPWQVTPGVPAYAAAAARV
Mvan_0382|M.vanbaalenii_PYR-1 AGLRVVRLVSGDPSVYSALSEQTRR-LDAVRVPWEVTPGVPAYAAAAARV
MUL_2297|M.ulcerans_Agy99 AGHDVARLHSGDPSLYSALAEQCRR-LDALGIGYEIVPGVPAFAAAAAAL
MMAR_3053|M.marinum_M AGHDVARLHSGDPSLYSALAEQCRR-LDALGIGYEIVPGVPAFAAAAAAL
Mb2097c|M.bovis_AF2122/97 DGRDVARLHSGDPSLYSALAEQCRE-LDALGIGYEIVPGVPAFAAAAAAL
Rv2071c|M.tuberculosis_H37Rv DGRDVARLHSGDPSLYSALAEQCRE-LDALGIGYEIVPGVPAFAAAAAAL
MAV_2425|M.avium_104 AGHDVARLHSGDPSLYSALAEQCRR-LDALGIDYEIVPGVPAFAAAAAAL
MSMEG_3877|M.smegmatis_MC2_155 AGLDVARLHSGDPSIYSALAEQCRR-LDALGIGYEIVPGVPAFAAVAAAL
TH_0443|M.thermoresistible__bu RGLDVARLHSGDPAIYSALAEQCRR-LDALGIDYEIVPGVPAFAAAAAAL
MAB_2196|M.abscessus_ATCC_1997 EGLDVARLHSGDPSLYSAVAEQCRR-LDVLGIDHEIVPGVPAFAAAAAAL
MLBr_02420|M.leprae_Br4923 GGADIRPALGDPTEVAKTLTAEARSGVDVVRLVAGDPLTVDAVIAEVNAV
* : .. . : .::: : * :*. : * * * . :
Mflv_0352|M.gilvum_PYR-GCK GRELTVPLVAQSVVLTRTRARSTQMPDTE-----------SLAAFAATRA
Mvan_0382|M.vanbaalenii_PYR-1 GRELTVPLVAQSVVLTRTRQRSTVMPDTE-----------SLKAFAATRA
MUL_2297|M.ulcerans_Agy99 KREFTVPGVSQTVTLTRISTLSTPMPPGE-----------DLAALAKPGA
MMAR_3053|M.marinum_M KREFTVPGVSQTVTLTRISTLSTPMPPGE-----------DLAALAKPGA
Mb2097c|M.bovis_AF2122/97 KRELTVPGVAQTVTLTRVATLSTPMPPGE-----------DLAALARSRA
Rv2071c|M.tuberculosis_H37Rv KRELTVPGVAQTVTLTRVATLSTPIPPGE-----------DLAALARSRA
MAV_2425|M.avium_104 KRELTVPGVAQTVTLSRVATLSTAMPPGE-----------DLATLARTGG
MSMEG_3877|M.smegmatis_MC2_155 GRELTVPGVAQTVTLSRVATLSTAMPEGE-----------DLRTLSAPGA
TH_0443|M.thermoresistible__bu GRELTVPGVAQTVTLTRVATLSTAMPPGE-----------DLVTLSKPGA
MAB_2196|M.abscessus_ATCC_1997 GTELTVPGVAQTVTITRVSTLSTAMPEGE-----------DLRTLAAPGA
MLBr_02420|M.leprae_Br4923 ARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVADVRGDVDWEALAAAPG
: :. : : :* . . ::: . .
Mflv_0352|M.gilvum_PYR-GCK TLVLHLAITRIRELMAEIEG-DYGPDCPVVVVYRASQPQEIVLRGTVSDI
Mvan_0382|M.vanbaalenii_PYR-1 TLVLHLAITRIRELMAEIEP-EYGADCPVVVVYRASQPQELVLRGTVADI
MUL_2297|M.ulcerans_Agy99 TLVLHLAAAQIDAIIPQLLAGGYRPETPAAVVAFASWPQQAVLRGTLSDI
MMAR_3053|M.marinum_M TLVLHLAAAQIDAIVPQLLAGGYRPETPAAVVAFASWPQQAVLRGTLSDI
Mb2097c|M.bovis_AF2122/97 TLVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADI
Rv2071c|M.tuberculosis_H37Rv TLVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADI
MAV_2425|M.avium_104 TLVLQLAAAQIDSIVGQLLDNGRQSQTPCAVVAFASWPQETVLRGTLDDI
MSMEG_3877|M.smegmatis_MC2_155 TLVLHLAAAQIDNIVPQLIEGGYRPETPCAVVAFASWPQEVVLRGTLADI
TH_0443|M.thermoresistible__bu TLVLHLAAAQIDAIVPKLLEGGYRPETPCAVVAFASWPEQTVLRGTLADI
MAB_2196|M.abscessus_ATCC_1997 TLALHLAAAQIDTVAADLVAGGYPSDTPVAVVAYASWPSETILRGTLADI
MLBr_02420|M.leprae_Br4923 PLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVETTLEGL
.* *: : ::: : * .*. .: .: :. *: .:
Mflv_0352|M.gilvum_PYR-GCK ADAVESAG------LRQAAVILVGRALAGRPDP-------EAGESYLYDA
Mvan_0382|M.vanbaalenii_PYR-1 ADAVQEAG------LRQAAVILVGRALAGRPDP-------DAGESYLYDP
MUL_2297|M.ulcerans_Agy99 AAQMHNAN------ITKTAVIVVGDVLAADG----------FTDSYLYSV
MMAR_3053|M.marinum_M AAQMHNAN------ITKTAVIVVGDVLAADG----------FTDSYLYSV
Mb2097c|M.bovis_AF2122/97 AARMHDAK------ITRTAVIVVGDVLTAEG----------FTDSYLYSV
Rv2071c|M.tuberculosis_H37Rv AARMHDAK------ITRTAVIVVGDVLTAEG----------FTDSYLYSV
MAV_2425|M.avium_104 AAQMHDAH------ITKTAVIIVGDALTAGG----------FTDSYLYST
MSMEG_3877|M.smegmatis_MC2_155 AEQMHAAD------VTRTAVIVVGDVLAAEG----------FTDSYLYSA
TH_0443|M.thermoresistible__bu AEQMRQAG------ITKTAVIIVGDVLAAEG----------FTDSYLYSA
MAB_2196|M.abscessus_ATCC_1997 AGQLKEAA------VTKTAVIFVGKVLAAEG----------FTDSYLYSS
MLBr_02420|M.leprae_Br4923 ADSAVLVGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPR
* . : . *: :* .::. : *
Mflv_0352|M.gilvum_PYR-GCK SRDRSGRDR-----------------------------------------
Mvan_0382|M.vanbaalenii_PYR-1 ARDRSGRSS-----------------------------------------
MUL_2297|M.ulcerans_Agy99 ARRGAH--------------------------------------------
MMAR_3053|M.marinum_M ARRGAH--------------------------------------------
Mb2097c|M.bovis_AF2122/97 ARHGRYAQ------------------------------------------
Rv2071c|M.tuberculosis_H37Rv ARHGRYAQ------------------------------------------
MAV_2425|M.avium_104 GRARGSRH------------------------------------------
MSMEG_3877|M.smegmatis_MC2_155 TRRRGSRH------------------------------------------
TH_0443|M.thermoresistible__bu GRRRGSRH------------------------------------------
MAB_2196|M.abscessus_ATCC_1997 GRRRGASH------------------------------------------
MLBr_02420|M.leprae_Br4923 TKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW
:
Mflv_0352|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0382|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2297|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3053|M.marinum_M --------------------------------------------------
Mb2097c|M.bovis_AF2122/97 --------------------------------------------------
Rv2071c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2425|M.avium_104 --------------------------------------------------
MSMEG_3877|M.smegmatis_MC2_155 --------------------------------------------------
TH_0443|M.thermoresistible__bu --------------------------------------------------
MAB_2196|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02420|M.leprae_Br4923 VVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGEATADRVRAFGISPE
Mflv_0352|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0382|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2297|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3053|M.marinum_M --------------------------------------------------
Mb2097c|M.bovis_AF2122/97 --------------------------------------------------
Rv2071c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2425|M.avium_104 --------------------------------------------------
MSMEG_3877|M.smegmatis_MC2_155 --------------------------------------------------
TH_0443|M.thermoresistible__bu --------------------------------------------------
MAB_2196|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02420|M.leprae_Br4923 LVPAGEQSSLGLLDEFPPYDSVFDPVNRVLLPRADIATETLAEGLRGCGW
Mflv_0352|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0382|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2297|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3053|M.marinum_M --------------------------------------------------
Mb2097c|M.bovis_AF2122/97 --------------------------------------------------
Rv2071c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2425|M.avium_104 --------------------------------------------------
MSMEG_3877|M.smegmatis_MC2_155 --------------------------------------------------
TH_0443|M.thermoresistible__bu --------------------------------------------------
MAB_2196|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02420|M.leprae_Br4923 EIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFTSSSTVRNLVGIAGKP
Mflv_0352|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0382|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2297|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3053|M.marinum_M --------------------------------------------------
Mb2097c|M.bovis_AF2122/97 --------------------------------------------------
Rv2071c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2425|M.avium_104 --------------------------------------------------
MSMEG_3877|M.smegmatis_MC2_155 --------------------------------------------------
TH_0443|M.thermoresistible__bu --------------------------------------------------
MAB_2196|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02420|M.leprae_Br4923 HARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDALAEHVARLRAE
Mflv_0352|M.gilvum_PYR-GCK -------------
Mvan_0382|M.vanbaalenii_PYR-1 -------------
MUL_2297|M.ulcerans_Agy99 -------------
MMAR_3053|M.marinum_M -------------
Mb2097c|M.bovis_AF2122/97 -------------
Rv2071c|M.tuberculosis_H37Rv -------------
MAV_2425|M.avium_104 -------------
MSMEG_3877|M.smegmatis_MC2_155 -------------
TH_0443|M.thermoresistible__bu -------------
MAB_2196|M.abscessus_ATCC_1997 -------------
MLBr_02420|M.leprae_Br4923 GALPPPRKKSRRR