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SDDSAAALYDVINRRRDTRREFTGEPVAGDVLQRVLLAAHAAPSVGMSQPWDFILVRSPQTLTTFRDHVA AERETFAGELSGERAETFGRIKIEGICESGLGIVVGYDPTRAGPQVLGRHAVPDAGLYSVVCAIQNLWLA ATVEGLGVGWVSFYREEFLRSLVGMPDHVRPVAWLCVGPVAELPDVPDLERFGWRARSSLETVLHQECYR AR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0381 | - | - | 100% (213) | cob(II)yrinic acid a,c-diamide reductase |
| M. vanbaalenii PYR-1 | Mvan_1732 | - | 1e-05 | 23.81% (189) | F420-0--gamma-glutamyl ligase |
| M. vanbaalenii PYR-1 | Mvan_3115 | - | 4e-05 | 24.53% (212) | nitroreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0314 | - | 4e-39 | 47.34% (188) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0353 | - | 1e-103 | 86.27% (204) | cob(II)yrinic acid a,c-diamide reductase |
| M. tuberculosis H37Rv | Rv0306 | - | 4e-39 | 47.34% (188) | putative oxidoreductase |
| M. leprae Br4923 | MLBr_00758 | - | 4e-08 | 22.75% (189) | F420-0--gamma-glutamyl ligase |
| M. abscessus ATCC 19977 | MAB_3351c | - | 2e-66 | 58.33% (204) | putative nitroreductase |
| M. marinum M | MMAR_0555 | - | 1e-40 | 50.00% (188) | oxidoreductase |
| M. avium 104 | MAV_4857 | bluB | 5e-41 | 48.45% (194) | cob(II)yrinic acid a,c-diamide reductase |
| M. smegmatis MC2 155 | MSMEG_6053 | bluB | 2e-38 | 46.39% (194) | cob(II)yrinic acid a,c-diamide reductase |
| M. thermoresistible (build 8) | TH_1748 | - | 3e-36 | 44.32% (185) | PUTATIVE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1218 | - | 5e-40 | 48.94% (188) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0381|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0353|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3351c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6053|M.smegmatis_MC2_155 --------------------------------------------------
TH_1748|M.thermoresistible__bu --------------------------------------------------
Mb0314|M.bovis_AF2122/97 --------------------------------------------------
Rv0306|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0555|M.marinum_M --------------------------------------------------
MUL_1218|M.ulcerans_Agy99 --------------------------------------------------
MAV_4857|M.avium_104 --------------------------------------------------
MLBr_00758|M.leprae_Br4923 MTSSDSHRSAPSPEHGTASTIEILPVAGLPEFRPGDDLSAALAAAAPWLR
Mvan_0381|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0353|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3351c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6053|M.smegmatis_MC2_155 --------------------------------------------------
TH_1748|M.thermoresistible__bu --------------------------------------------------
Mb0314|M.bovis_AF2122/97 --------------------------------------------------
Rv0306|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0555|M.marinum_M --------------------------------------------------
MUL_1218|M.ulcerans_Agy99 --------------------------------------------------
MAV_4857|M.avium_104 --------------------------------------------------
MLBr_00758|M.leprae_Br4923 DGDVVVVTSKVVSKCEGRLVPAPEDTRGRNELRRKLINDETIRVLARKGR
Mvan_0381|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0353|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3351c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6053|M.smegmatis_MC2_155 --------------------------------------------------
TH_1748|M.thermoresistible__bu --------------------------------------------------
Mb0314|M.bovis_AF2122/97 --------------------------------------------------
Rv0306|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0555|M.marinum_M --------------------------------------------------
MUL_1218|M.ulcerans_Agy99 --------------------------------------------------
MAV_4857|M.avium_104 --------------------------------------------------
MLBr_00758|M.leprae_Br4923 TLIIENGLGLVQAAAGVDGSNVGRGELALLPVNPDASAAVLRIGLRAMLG
Mvan_0381|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0353|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3351c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6053|M.smegmatis_MC2_155 --------------------------------------------------
TH_1748|M.thermoresistible__bu --------------------------------------------------
Mb0314|M.bovis_AF2122/97 --------------------------------------------------
Rv0306|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0555|M.marinum_M --------------------------------------------------
MUL_1218|M.ulcerans_Agy99 --------------------------------------------------
MAV_4857|M.avium_104 --------------------------------------------------
MLBr_00758|M.leprae_Br4923 VNVAVVITDTMGRAWRNGQTDVAIGAAGLAVLHNYSGAVDRYGNELVVTE
Mvan_0381|M.vanbaalenii_PYR-1 ----------------------------MSDDSAAALYDVINRR------
Mflv_0353|M.gilvum_PYR-GCK ----------------------------MS-AETAALYDVINRR------
MAB_3351c|M.abscessus_ATCC_199 ----------------------------------MDVYQAIATR------
MSMEG_6053|M.smegmatis_MC2_155 -----------------------MPRHAFSPSERQAVYRAITER------
TH_1748|M.thermoresistible__bu --------------------------------------------------
Mb0314|M.bovis_AF2122/97 ---------------------------MFSAPERRAVYRVIAER------
Rv0306|M.tuberculosis_H37Rv ---------------------------MFSAPERRAVYRVIAER------
MMAR_0555|M.marinum_M -----------------------MADYAFTAQERQAVYRVITER------
MUL_1218|M.ulcerans_Agy99 -----------------------MTDYAFTAQERQAVYRVLTER------
MAV_4857|M.avium_104 -----------------------MTGPAFSPQERRAVYRVISER------
MLBr_00758|M.leprae_Br4923 IAVADEVAAATDLVKGKLTAMPVAVVRGLSPTDDGSTAQHLLRNGPDDLF
Mvan_0381|M.vanbaalenii_PYR-1 ------------------RDTRREFTGEPVAGDVLQRVLLAAHAAPSVGM
Mflv_0353|M.gilvum_PYR-GCK ------------------RDTRREFTGAPTDDEVLERVLLAAHAAPSVGM
MAB_3351c|M.abscessus_ATCC_199 ------------------RDVRAEFTGQVVDDATLMKLLQAAHRAPSVGN
MSMEG_6053|M.smegmatis_MC2_155 ------------------RDMRQFVPGSTVSDEVLSRLLHAAHAAPSVGL
TH_1748|M.thermoresistible__bu --------------------MRRFIPGTTISDDVLKRLMHAAHAAPNVGL
Mb0314|M.bovis_AF2122/97 ------------------RDMRRFVPGGVVSEDVLARLLHAAHAAPSVGL
Rv0306|M.tuberculosis_H37Rv ------------------RDMRRFVPGGVVSEDVLARLLHAAHAAPSVGL
MMAR_0555|M.marinum_M ------------------RDMRRFVPGAMVPEDVLTRLLHAAHAAPNVGL
MUL_1218|M.ulcerans_Agy99 ------------------RDMRHFVPGAVVPEDVLTRLLHAAHAAPNVGL
MAV_4857|M.avium_104 ------------------RDMRRFVAGAVVDEQVLARLLAAAHAAPSVGL
MLBr_00758|M.leprae_Br4923 WLGTTEALELGRQQAQLLRRSVRQFSDEPIAAELIETAVAEALTAPAPHH
... : : * **
Mvan_0381|M.vanbaalenii_PYR-1 SQPWDFILVRSPQTLTTFRDHVAAERETFAGELSGERAETFGRIKIEGIC
Mflv_0353|M.gilvum_PYR-GCK SQPWDFVLVRSPETLRAFRDHVAGEREVFAAELSGERADVFDRIKIEGIC
MAB_3351c|M.abscessus_ATCC_199 SQPWDFVVIREPGMLDDFAAHVALQRQRFADSLPEGRRNTFDPIKIEGIR
MSMEG_6053|M.smegmatis_MC2_155 MQPWRFIRITDDTLRSRIHALVDEERVNTADALG-PRAQEFLALKVEGIR
TH_1748|M.thermoresistible__bu MQPWRFIRITDPDLRRAIHRLVDEERHHTAAALG-PRGEEFLALKVEGIL
Mb0314|M.bovis_AF2122/97 MQPWRFIRITDETLKRRIHALVDDERLLTAEALG-AREEEFLALKVEGIL
Rv0306|M.tuberculosis_H37Rv MQPWRFIRITDETLKRRIHALVDDERLLTAEALG-AREEEFLALKVEGIL
MMAR_0555|M.marinum_M MQPWRFIRITDTGLRRRIHTLVDEERALTAGALG-ERAEEFLALKVEGIL
MUL_1218|M.ulcerans_Agy99 MQPWRFIRITDTGLRRRIHTLVDEERALTAGALG-ERAEEFLALKVEGIL
MAV_4857|M.avium_104 MQPWRFIRITDAALRRRIHALVEQERPRTAAALG-ERAQEFLALKVEGIL
MLBr_00758|M.leprae_Br4923 TRPVRFVWLQTPAVRTRLLDRMADKWRLDLASDALPADAIAQRVARGQIL
:* *: : : : : : *
Mvan_0381|M.vanbaalenii_PYR-1 ESGLGIVVGYDP---TRAGPQVLGRHAVPDAGLYSVVCAIQNLWLAATVE
Mflv_0353|M.gilvum_PYR-GCK ESGLGIVVGYDP---TRGGPAVLGRHAIPDAGLYSVVCAIQNLWLAATAE
MAB_3351c|M.abscessus_ATCC_199 ESGTGVVVTYDH---GRGGPHILGRHTISDAGLFSAVLAIQNLWLAAVTE
MSMEG_6053|M.smegmatis_MC2_155 ECAELFVVALGE---GRER-HVFGRRTLPNMDLASVSCAIQNMWLAARAE
TH_1748|M.thermoresistible__bu ECAELLVVALGD---DRER-HIFGRRTMPDMDLASVSCAIQNLWLAARAE
Mb0314|M.bovis_AF2122/97 DCAELLVVALCD---RRGS-YIFGRRTLPQMDLASVSCAIQNLWLAARSE
Rv0306|M.tuberculosis_H37Rv DCAELLVVALCD---RRGS-YIFGRRTLPQMDLASVSCAIQNLWLAARSE
MMAR_0555|M.marinum_M ECAELMVVALRD---GRDG-HIFGRRTLPQMDLASVSCAIQNLWLAARAE
MUL_1218|M.ulcerans_Agy99 ECAELMVVALRD---GRDG-HIFGRRTLPQMDLASVSCAIQNLWLAARAE
MAV_4857|M.avium_104 ECAELLVVALGD---DRDK-HVFGRRTLPQMDLASVSCAIQNLWLAARAE
MLBr_00758|M.leprae_Br4923 YDAPEVIIPFMVPDGAHAYPDAARASAEHTMFIVAVGAAVQALLVALAVR
. .:: : : : :. *:* : :* .
Mvan_0381|M.vanbaalenii_PYR-1 GLGVGWVS--FYREEFLRSLVGMPDHVRPVAWLCVGPVAELPDVPDLERF
Mflv_0353|M.gilvum_PYR-GCK GLGVGWVS--FYREETLRSLVGMPDHVRPVAWLCVGPVADLPDVPDLERF
MAB_3351c|M.abscessus_ATCC_199 GIGVGWVS--FYEEQFLAELIDAPAHIRPIAWLCVGPVREFAERPDLERF
MSMEG_6053|M.smegmatis_MC2_155 GLGMGWVS--IFEPQPLAELLGMPDGAEPVAILCLGPVPEFPDRPVLEIE
TH_1748|M.thermoresistible__bu GLGMGWVS--LFEPRRLATLLDIPADAEPVAVLCLGPVPDFPDRPELEIE
Mb0314|M.bovis_AF2122/97 GLGMGWVS--LFDPQRLAALLAMPADAEPVAILCLGPVPEFPDRPALELD
Rv0306|M.tuberculosis_H37Rv GLGMGWVS--LFDPQRLAALLAMPADAEPVAILCLGPVPEFPDRPALELD
MMAR_0555|M.marinum_M GLGMGWVS--LFDPHRLADLLRMPDGAEPVAVLCLGPVPEFPQQPALELD
MUL_1218|M.ulcerans_Agy99 GLGMGWVS--LFDPHRLADLLRMPDGAEPVAVLCLGPVPEFPQQPALELD
MAV_4857|M.avium_104 GLGMGWVS--LFEPRPLAELLGLPDGAEPVAILCLGPVPEFPDRPALELD
MLBr_00758|M.leprae_Br4923 GLGSCWIGSTIFADDLVRAELELPADWEPLGAIAIG----YAHEP----T
*:* *:. :: : : * .*:. :.:* .. *
Mvan_0381|M.vanbaalenii_PYR-1 GWRARSSLETVLHQECYRAR-----------
Mflv_0353|M.gilvum_PYR-GCK GWQARRSLDTVVHRERYPEP-----------
MAB_3351c|M.abscessus_ATCC_199 GWRTGRPLEDAVHWGRYRA------------
MSMEG_6053|M.smegmatis_MC2_155 HWTTGRPLPEFVSENGWPEHASV--------
TH_1748|M.thermoresistible__bu NWTVGRPLDEFVSENGWTDSGARA-------
Mb0314|M.bovis_AF2122/97 GWAYARPLAEFVSENRWSYPSALATDHHHGE
Rv0306|M.tuberculosis_H37Rv GWAYARPLAEFVSENRWSYPSALATDHHHGE
MMAR_0555|M.marinum_M GWAVARPLPEFVSENRWDQP-----------
MUL_1218|M.ulcerans_Agy99 GWAVARPLPEFVSENRWDQP-----------
MAV_4857|M.avium_104 GWATPRPLAEFVCENRWAQPQLP--------
MLBr_00758|M.leprae_Br4923 DLREPVRVADLLLRK----------------
: :