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MTLDTPSVSREADVADTNTTRRVAILGGNRIPFARADGAYAKASNQDMFTATLDGLADRFNLKGEKLDAV IGGAVLKHSRDFNLMRECVLGSSLSSATPAFDLQQACGTGLQAAIAAADGIARGRYEVAAAGGVDTASDA PIAFGDDLRRVLLGLRRAKSNVERLKLVGKLPAALGVEIPVNSEPRTGMSMGEHAAVTAKEMGVKRVDQD ELAAASHRNMAAAYDRGFFDDLVTPFLGLYRDNNLRADSSVEKLAKLRPVFGVRSGDATMTAGNSTPLTD GASVALLSSEEWAAEHSIPVLAYFVDGQTAAVDYVNGRDGLLMAPTYAVPRLLARNGLTLQDFDFYEIHE AFASVVLATLAAWKSDEYCKERLGLDKALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKA ETGKPVRGLISVCAAGGQGVTAILEA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0260 | - | - | 100% (446) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | 2e-44 | 31.13% (424) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2617 | - | 4e-40 | 30.30% (439) | acetyl-CoA acetyltransferases |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0249 | fadA2 | 0.0 | 84.26% (432) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_0411 | - | 0.0 | 93.53% (433) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv0243 | fadA2 | 0.0 | 84.26% (432) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02564 | fadA2 | 0.0 | 78.08% (447) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_4442c | - | 0.0 | 81.22% (442) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_0504 | fadA2 | 0.0 | 83.41% (434) | acetyl-CoA acyltransferase FadA2 |
| M. avium 104 | MAV_4915 | - | 0.0 | 83.84% (427) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_0373 | - | 0.0 | 88.50% (426) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0255 | - | 1e-33 | 26.51% (430) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_1167 | fadA2 | 0.0 | 83.41% (434) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0260|M.vanbaalenii_PYR-1 ---------MTLDTPSVSREADVADTNTTRRVAILGGNRIPFARADGAYA
Mflv_0411|M.gilvum_PYR-GCK ----------------------MADSKTARRVAILGGNRIPFARSDGAYA
MSMEG_0373|M.smegmatis_MC2_155 ----------------------MAN-ESRRRVAVLGGNRIPFARSDGAYA
MLBr_02564|M.leprae_Br4923 MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYA
MAV_4915|M.avium_104 -------------------------------MAVLGGNRIPFARSDGAYA
Mb0249|M.bovis_AF2122/97 ---------MAPAA--------KNTSQTRRRVAVLGGNRIPFARSDGAYA
Rv0243|M.tuberculosis_H37Rv ---------MAPAA--------KNTSQTRRRVAVLGGNRIPFARSDGAYA
MMAR_0504|M.marinum_M ---------MAPAA--------EKNAQTKRRVAVLGGNRIPFARSDGAYA
MUL_1167|M.ulcerans_Agy99 ---------MAPAA--------EKNAQTKRRVAVLGGNRIPFARSDGAYA
MAB_4442c|M.abscessus_ATCC_199 ---------MATSSARK-----SDASQGRRRVAVLGGNRIPFARSDGAYA
TH_0255|M.thermoresistible__bu ----------------------------MRETVIVEAVRTAVGKRNGALA
.:: . * ...: :** *
Mvan_0260|M.vanbaalenii_PYR-1 KASNQDMFTATLDGLADRFNLKGEKLDAVIGGAVLKHS-RDFNLMRECVL
Mflv_0411|M.gilvum_PYR-GCK QASNQDMFTAVLDGLADRFNLKGEKLDAVIGGAVLKHS-RDFNLMRECVL
MSMEG_0373|M.smegmatis_MC2_155 NASNQDMFTAALGGLIDRFNLAGEQLGAVIGGAVLKHS-RDFNLMRECVL
MLBr_02564|M.leprae_Br4923 EASNQDMFSAALSGLVDRFGLAGERLDMVIGGAVLKHS-RDFNLMRECVL
MAV_4915|M.avium_104 EASNQDMLTAALEGLVDRFGLAGERLGVVVGGAVLKHS-RDFNLTRECVL
Mb0249|M.bovis_AF2122/97 DASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHS-RDFNLMRECVL
Rv0243|M.tuberculosis_H37Rv DASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHS-RDFNLMRECVL
MMAR_0504|M.marinum_M EASNQDMFTAALAGLVDRFDLRGQRLGAVVGGAVLKHS-RDFNLMRECVL
MUL_1167|M.ulcerans_Agy99 EASNQDMFTAALAGLVDRFDLRGQRLGAVVGGAVLKHS-RDFNLMRECVL
MAB_4442c|M.abscessus_ATCC_199 NASNQDMLTAAITGASDRFNLKGERLGAVIAGAVLKLS-RDFNLTRESVL
TH_0255|M.thermoresistible__bu DVHAADLSAVVLSELVERAGIDPELIDDVIWGCVSQVGDQSSNIGRYAVL
.. *: :..: :* .: : :. *: *.* : . :. *: * .**
Mvan_0260|M.vanbaalenii_PYR-1 GSSLSSATPAFDLQQACGTGLQAAIAAADGIARGRYEVAAAGGVDTASDA
Mflv_0411|M.gilvum_PYR-GCK GSSLSSYTPAFDLQQACGTGLQSAIAAADGIARGRYDVAAAGGVDTASDA
MSMEG_0373|M.smegmatis_MC2_155 GSALSPYTPAFDIQQACGTGLQAAIAAADGIAAGRYESAAAGGVDTASDA
MLBr_02564|M.leprae_Br4923 GSQLSPYTPAFDLQQACATGLQAAIVAADGIAAGRYEVAVAGGVDTTSDV
MAV_4915|M.avium_104 GSQLSSYTPAFDLQQACGTGLQAAIAAAEGIAAGRYDVAAAGGVDTTSDA
Mb0249|M.bovis_AF2122/97 GSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
Rv0243|M.tuberculosis_H37Rv GSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
MMAR_0504|M.marinum_M GSELSPYTAACDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
MUL_1167|M.ulcerans_Agy99 GSELSPYTAACDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDP
MAB_4442c|M.abscessus_ATCC_199 GSPLSPYTQAFDLQQACGTGLQAAIVGADGIALGRYESVLAGGVDTTSDA
TH_0255|M.thermoresistible__bu AAGWPETIPGTTVNRACGSSQQALDFAVHAVMSGQQDVVVAGGVEVMS--
.: . . :::**.:. *: ....: *: : . ****:. *
Mvan_0260|M.vanbaalenii_PYR-1 PIAFGDDLRRVLLGLRRAKSNVERLKLVGKLPAALGVEIPVNSEPRTGMS
Mflv_0411|M.gilvum_PYR-GCK PIAFGDDLRKVLLGLRRAKSNVDRLKLVGKLPASLGVEIPVNSEPRTGMS
MSMEG_0373|M.smegmatis_MC2_155 PIAFGNDLRRVLLGLRRAKSNVDRLKLVGKLPASLGVEIPVNSEPRTGMS
MLBr_02564|M.leprae_Br4923 PISLGDNLRRNLLKLRRSKSNVQRLKLVGALPANIGVEIPANSEPRTGLS
MAV_4915|M.avium_104 PIGLGDNLRRTLLKLRRAKSNVQRLKLVGTLPATLGVEIPVNSEPRTGLS
Mb0249|M.bovis_AF2122/97 PIGLGDDLRRTLLKLRRSRSNVQRLKLVGTLPASLGVEIPANSEPRTGLS
Rv0243|M.tuberculosis_H37Rv PIGLGDDLRRTLLKLRRSRSNVQRLKLVGTLPASLGVEIPANSEPRTGLS
MMAR_0504|M.marinum_M PIGLGEDLRRTLLRLRRAKSNVHRLRLVGGLPANLGVEIPANSEPRTGLS
MUL_1167|M.ulcerans_Agy99 PIGLGEDLRRTLLRLRRAKSNVHRLRLVGGLPANLGVEIPANSEPRTGLS
MAB_4442c|M.abscessus_ATCC_199 PINFGDDLRHTLLAIRRAKDNVTRLKLLGKLPAALGVDIPQNGEPRTGLS
TH_0255|M.thermoresistible__bu ---------RVPLGAARATGMPYGPKVLERYDN-------------FGFN
: * *: . ::: *:.
Mvan_0260|M.vanbaalenii_PYR-1 MGEHAAVTAKEMGVKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFLG--
Mflv_0411|M.gilvum_PYR-GCK MGEHAAVTAKEMGVKRVDQDELAAASHRNMSAAYDRGFFDDLVSPFLG--
MSMEG_0373|M.smegmatis_MC2_155 MGEHAAVTAKAMGIKRVEQDELAAASHRNMAAAYDAGFFDDLVTPFLG--
MLBr_02564|M.leprae_Br4923 MGEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDDLVTPFLG--
MAV_4915|M.avium_104 MGEHQAITAKQMGITRVAQDELAAASHRNMAAAYDRGFFDDLVTPFLG--
Mb0249|M.bovis_AF2122/97 MGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLG--
Rv0243|M.tuberculosis_H37Rv MGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLG--
MMAR_0504|M.marinum_M MGDHAAITAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVTPFLG--
MUL_1167|M.ulcerans_Agy99 MGDHAAITAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVTPFLG--
MAB_4442c|M.abscessus_ATCC_199 MGEHAAITAKQAGVKRTEQDALAAASHQKMAAAYDRGFFDDLISPFLG--
TH_0255|M.thermoresistible__bu QGISAELIAERWNLSRTRLDEYSAQSHERAAAAQSSGAFKDQIVPVFTDD
* : *: .:.*. * :* **.. : * . * *.* : *.:
Mvan_0260|M.vanbaalenii_PYR-1 --LYRDNNLRADSSVEKLAKLRPVFGVRSGDATMTAGNSTPLTDGASVAL
Mflv_0411|M.gilvum_PYR-GCK --LYRDNNLRPDSSAEKLAKLKPVFGVRNGDATMTAGNSTPLTDGASVAL
MSMEG_0373|M.smegmatis_MC2_155 --VYRDNNLRADSSVEKLAKLKPVFGVKAGDATMTAGNSTPLTDGASVAL
MLBr_02564|M.leprae_Br4923 --LYRDDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGASVAL
MAV_4915|M.avium_104 --LYRDDNLRPDSSPEKLAKLRPVFGVKAGDATMTAGNSTPLTDGASVAL
Mb0249|M.bovis_AF2122/97 --LYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVAL
Rv0243|M.tuberculosis_H37Rv --LYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVAL
MMAR_0504|M.marinum_M --LYRDDNLRPNSSVEKLASLRPVFGVKAGDATMTAGNSTPLTDGASVAL
MUL_1167|M.ulcerans_Agy99 --LYRDDNLRPNSSVEKLASLRPVFGVKAGDATMTAGNSTPLTDGASVAL
MAB_4442c|M.abscessus_ATCC_199 --LYRDDNLRPNSSVEKLATLKPVFGVKHGDATMTAGNSTPLTDGASVAL
TH_0255|M.thermoresistible__bu AVVTEDEGIRRGTTVEKLATLKPAFTEN---GVIHAGNSSQISDGAAALL
: .*:.:* .: ****.*:*.* . ..: ****: ::***:. *
Mvan_0260|M.vanbaalenii_PYR-1 LSSEEWAAEHSIPVLAYFVDGQTAAVDYVNGRDGLLMAPTYAVPRLLARN
Mflv_0411|M.gilvum_PYR-GCK LSSEEWAAQHSIPVLAYLVDAETAAVDYVNGRDGLLMAPTYAVPRLLTRN
MSMEG_0373|M.smegmatis_MC2_155 LAGEDWAQARGLEPLAYFVDAETAAVDYVNGPDGLLMAPTYAVPRLLARN
MLBr_02564|M.leprae_Br4923 LATEQWVAAHSLTPFAYWVDAEIAAVDYVSGNDGLLMAPTYAVPRLLARN
MAV_4915|M.avium_104 LGTEEWAAAHSLTPLAYLVDAETAAVDYVNGRDGLLMAPTYAVPRLLARN
Mb0249|M.bovis_AF2122/97 LASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARN
Rv0243|M.tuberculosis_H37Rv LASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARN
MMAR_0504|M.marinum_M LSSEQWAQEHSLSPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARN
MUL_1167|M.ulcerans_Agy99 LSSEQWAQEHSLSPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARN
MAB_4442c|M.abscessus_ATCC_199 LSSEEWAAERNIPVLAYFVDGETAAVDYVNGPDGLLMAPTYAVPRLLARN
TH_0255|M.thermoresistible__bu VMTAETAVTLGLTPIVRYRAGAVTGADPVL----MLTGPIPATEKVLRKT
: : . .: :. . :..* * :* .* *. ::* :.
Mvan_0260|M.vanbaalenii_PYR-1 GLTLQDFDFYEIHEAFASVVLATLAAWKSDEYCKERLGLDKALGSIDRSK
Mflv_0411|M.gilvum_PYR-GCK GLTLQDFDYYEIHEAFASVVLATLAAWESDEYCKERLGLDKALGSIDRSK
MSMEG_0373|M.smegmatis_MC2_155 NLTLQDFDFYEIHEAFASVVLAHLQAWESDEYCKERLGLDKALGSIDRTK
MLBr_02564|M.leprae_Br4923 GLSFQDFDFYEIHEAFASVVLAHLQAWESEEYCRQCLGLDTALGPIDRSK
MAV_4915|M.avium_104 GLSLQDFDFYEIHEAFASVVLAHLQAWESEDYCKERLGLDAALGSIDRSK
Mb0249|M.bovis_AF2122/97 GLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSK
Rv0243|M.tuberculosis_H37Rv GLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSK
MMAR_0504|M.marinum_M GLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKQRLGLDAALGSIDRSK
MUL_1167|M.ulcerans_Agy99 GLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKQRLGLDAALGSIDRSK
MAB_4442c|M.abscessus_ATCC_199 GLTLQDFDFYEIHEAFASVVLATLQAWESADYCKERLGLDKPLGAIDRSK
TH_0255|M.thermoresistible__bu GLNIDDIGVFEVNEAFAPVPLAWQAETG-----------------ADPAK
.*.::*:. :*::****.* ** * :*
Mvan_0260|M.vanbaalenii_PYR-1 LNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKA---ETGKPVRGLISVC
Mflv_0411|M.gilvum_PYR-GCK LNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKK---QTGQPVRGLISVC
MSMEG_0373|M.smegmatis_MC2_155 LNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKK---STGRPVRGLISIC
MLBr_02564|M.leprae_Br4923 LNVNGSSLAAGHPFAATGGRILVQTAKQLAEQKATQKGCG-PMRALISVC
MAV_4915|M.avium_104 LNVNGSSLAAGHPFAATGGRILAQAAKQVAQRKAELKGADKPVRALISIC
Mb0249|M.bovis_AF2122/97 LNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKG-GGPLRGLISIC
Rv0243|M.tuberculosis_H37Rv LNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKG-GGPLRGLISIC
MMAR_0504|M.marinum_M LNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAERKGSAQPVRALISIC
MUL_1167|M.ulcerans_Agy99 LNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAERKGSAQPVRALISIC
MAB_4442c|M.abscessus_ATCC_199 LNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKKENGGTG-TYRGLISVC
TH_0255|M.thermoresistible__bu LNPLGGAIALGHPLGASGAVLMTRMVHHMR--------ANGIRYGLQTMC
** *.::* ***:.*:*. ::.: .::: .* ::*
Mvan_0260|M.vanbaalenii_PYR-1 AAGGQGVTAILEA--
Mflv_0411|M.gilvum_PYR-GCK AAGGQGVTAILEA--
MSMEG_0373|M.smegmatis_MC2_155 AAGGQGVAAILEA--
MLBr_02564|M.leprae_Br4923 AAGGQGVAVILEA--
MAV_4915|M.avium_104 AAGGQGVAAILEA--
Mb0249|M.bovis_AF2122/97 AAGGQGVAAILEA--
Rv0243|M.tuberculosis_H37Rv AAGGQGVAAILEA--
MMAR_0504|M.marinum_M AAGGQGVAAILEA--
MUL_1167|M.ulcerans_Agy99 AAGGQGVAAILEA--
MAB_4442c|M.abscessus_ATCC_199 AAGGQGVTAILEA--
TH_0255|M.thermoresistible__bu EGGGTANATVVELLA
.** . :.::*