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MTERPDIRYPGPTLTTRLQWLLNAGPSDFMLAMSVASASLPVIGKHLEPLGALTAAGIWGTRHAPDFVGA LAKSLITPNDAERKKQERDCTNAVTEAALRDVVGPKDLEIEWPAAERTPPVWRMREHRRHVHRTSVRYGP RPTQLLDVWRRDDLPAEPAPVLIFVPGGAWVHGSRMLQGYALMSHLAERGWVCLSIDYRVAPHNPWPAHV ADVKTAIAWARANVDKFGGDRNFVAISGASAGGHLAALAGLTANDPEMQDELPEGSDTSVDAVVGIYGRY DWEDKSTVERVRFMDFLERVVVRRKFDRHPELFRKASPMARVHPEAPPFLVVHGTGDSVIPVAQAQSFVE RLRGVSRSVVGYVELPGAGHGFDMTDGARTGAASTAIGLFLNHIHRNRTLIGAKEVI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0227 | - | - | 100% (407) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0231 | - | 1e-70 | 48.36% (275) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | 1e-15 | 37.61% (117) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0226 | lipC | 1e-165 | 69.25% (400) | esterase LipC |
| M. gilvum PYR-GCK | Mflv_0440 | - | 0.0 | 87.80% (410) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0220 | lipC | 1e-165 | 69.25% (400) | esterase LipC |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2814 | - | 2e-13 | 35.92% (103) | lipase LipH |
| M. marinum M | MMAR_0463 | lipC | 1e-169 | 69.87% (395) | esterase LipC |
| M. avium 104 | MAV_4953 | - | 1e-160 | 66.16% (396) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_0289 | - | 1e-159 | 71.58% (366) | alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_2755 | - | 1e-166 | 65.00% (420) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_1112 | lipC | 1e-169 | 70.66% (392) | esterase LipC |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0227|M.vanbaalenii_PYR-1 MTERPDIRYPGPTLTTRLQWLLNAGPSDFMLAMSVASASLPVIGKHLEPL
Mflv_0440|M.gilvum_PYR-GCK MTERPDTRYPGPTLTTRLEWLLNAGPSDYMLALSVASASLPVIGKHLEPL
MSMEG_0289|M.smegmatis_MC2_155 -----------------------------------------MIGKHFEPL
Mb0226|M.bovis_AF2122/97 ---MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPL
Rv0220|M.tuberculosis_H37Rv ---MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPL
MMAR_0463|M.marinum_M MAATGPTTMSMTSMMSRVKWMLRARPADYLLAMSVAGASLPVVGKHLEPL
MUL_1112|M.ulcerans_Agy99 --------------MSRVKWMLRARPADYLLAMSVAGASLPVVGKHLEPL
MAV_4953|M.avium_104 ---------MAPGMTPYLKWLLRARPADYALAVSLAGASLPVVGRHLEPL
TH_2755|M.thermoresistible__bu ---MTVRPDGGSSAWLCARRLLRAGPADHLLALSAASGSLPIVGRHLEPL
MAB_2814|M.abscessus_ATCC_1997 --------------------------------MTATAGIDPIIVKILEAV
:: : ::.:
Mvan_0227|M.vanbaalenii_PYR-1 GALTAAGIWGTRHAPDFVGALAKSLITPNDAERK---KQERDCTNAVTEA
Mflv_0440|M.gilvum_PYR-GCK GALTAAGVWGARHAPDFVGALAKSLVAPNDVGKKEKQQQERDSTNAITQA
MSMEG_0289|M.smegmatis_MC2_155 GSMTAMSIWGLRHLPDFVAASAKSRLAPGAAAMR---REEREQTTAAAVA
Mb0226|M.bovis_AF2122/97 GGVTAIGVWGARHASDFLSATAKDLLTPGINEVR---RRDRASTQEVSVA
Rv0220|M.tuberculosis_H37Rv GGVTAIGVWGARHASDFLSATAKDLLTPGINEVR---RRDRASTQEVSVA
MMAR_0463|M.marinum_M GCVTAMGVWGARHTPEFFAARAKDLFTPGINVTR---QRDRDSTNEVSAA
MUL_1112|M.ulcerans_Agy99 GCVTAMGVWGARHTPEFVAARAKDLFTPGINVTR---QRDRDSTNEVSAA
MAV_4953|M.avium_104 AGLTAMGMWGARHAPEVISAATRDMFAPGGGDAR---RRDRESTQQVSLA
TH_2755|M.thermoresistible__bu GSAAAMSLWGFRHLPDFVGATVKSWLAPGSAELR---RRQREMTNEVSRQ
MAB_2814|M.abscessus_ATCC_1997 P---------------------IQLVSPDG--------------PQASRD
. .:*. :
Mvan_0227|M.vanbaalenii_PYR-1 ALRDVVGPK--------------DLEIEWPAAERTPPVWRMREHRRHVHR
Mflv_0440|M.gilvum_PYR-GCK ALRGLVSQK--------------DLEIEWPAAERTPPVWKMREHRRHVHR
MSMEG_0289|M.smegmatis_MC2_155 ALRNVVPPA--------------ELAAEWPAPQNLPPLWNVLEHRRSVYR
Mb0226|M.bovis_AF2122/97 ALRGIVSPD--------------DLAVEWPAPERTPPVCGALRHRRYVHR
Rv0220|M.tuberculosis_H37Rv ALRGIVSPD--------------DLAVEWPAPERTPPVCGALRHRRYVHR
MMAR_0463|M.marinum_M ALRGIVSTA--------------DLDVEWPAPQRTPPVCEAFRHRRYLHR
MUL_1112|M.ulcerans_Agy99 ALRGIVSTA--------------DLDVEWPAPQRTPPVCEAFRHRRYLHR
MAV_4953|M.avium_104 ALRGLVSAA--------------ELESQWPVAQRTPPIWDGVRRHRHLYR
TH_2755|M.thermoresistible__bu ALRGLLPADPAAPGASEVSSGSAGSALDWPAPDRVPPLWRMLQHRRHLYR
MAB_2814|M.abscessus_ATCC_1997 AYRAIATAR--------------------------PPWIEVANIEDRTIP
* * : ** . .
Mvan_0227|M.vanbaalenii_PYR-1 TSVRYGPRPTQLLDVWRRDDLPAEPAPVLIFVPGGAWVHGSRMLQGYALM
Mflv_0440|M.gilvum_PYR-GCK TSVRYGPRPTQLLDVWRRDDVPAD-APVMIFVPGGAWVHGGRMLQGYALM
MSMEG_0289|M.smegmatis_MC2_155 TSVRYGDDPAQLLDVWRPKELPAQPAPVLLFVPGGAWVHGSRVLQGYALM
Mb0226|M.bovis_AF2122/97 RRVLYGDDPAQLLDVWRRKDMPTKPAPVLIFVPGGAWVHGSRAIQGYAVL
Rv0220|M.tuberculosis_H37Rv RRVLYGDDPAQLLDVWRRKDMPTKPAPVLIFVPGGAWVHGSRAIQGYAVL
MMAR_0463|M.marinum_M GGVHYGNSPAQVLDVWRRDDLPTEPAPVLIFVPGGAWIHGSRAIQGYALL
MUL_1112|M.ulcerans_Agy99 GGVHYGNSPAQVLDVWRRDDLPTEPAPVLIFVPGGAWIHGSRAIQGYALL
MAV_4953|M.avium_104 RAVHYGHHPAQVLDVWRRKDLPAQPAPVLIFVPGGAWVHGKSMGQGSALM
TH_2755|M.thermoresistible__bu GAVRYGDHTENVLDVWRRKDLPAQPAPVLIFVPGGAWVHGSRMLQGYALL
MAB_2814|M.abscessus_ATCC_1997 G-------PAGEIPVRIYSPAEGGVRPVFVLIHGGGWVIGDLDTHDAVAR
. : * . **:::: **.*: * :. .
Mvan_0227|M.vanbaalenii_PYR-1 SHLAERGWVCLSIDYRVAPHNPWPAHVADVKTAIAWARANVDKFGGDRNF
Mflv_0440|M.gilvum_PYR-GCK HHLAEMGWVCLSVEYRVAPHNPWPAHINDVKTAIAWARANVDKFGGNRDF
MSMEG_0289|M.smegmatis_MC2_155 SHLAQQGWVCLSVDYRVSPHHRWPRHIHDVKAAIAWARANVDKFGGDRHF
Mb0226|M.bovis_AF2122/97 SRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWARANVDKFGGDRNF
Rv0220|M.tuberculosis_H37Rv SRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWARANVDKFGGDRNF
MMAR_0463|M.marinum_M SRLAEQGWVCLSIDYRVAPHHRWPRHIHDVKAAIAWARANVDKFGGDRNF
MUL_1112|M.ulcerans_Agy99 SRLAEQGWVCLSIDYRVAPHHRWPRHIHDVKAAIAWARANVDKFGGDRNF
MAV_4953|M.avium_104 SRLAEQGWVCLAIDYRVAPHHRWPRHIVDVKTAIAWARANVDKFGGDRNF
TH_2755|M.thermoresistible__bu SHLAEQGWVCLSIDYRVAPQHPWPAHLTDVKTAIAWARANVDKFGGDRDF
MAB_2814|M.abscessus_ATCC_1997 AAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQWVHEHAAEIGGDPGR
. . * ::::**::*.: :* : * :*: *.: :. ::**:
Mvan_0227|M.vanbaalenii_PYR-1 VAISGASAGGHLAALAGLTANDPEMQDELPEGSDTSVDAVVGIYGRYDWE
Mflv_0440|M.gilvum_PYR-GCK VAIAGTSAGGHLAALAGLTANDPEMQGELPEGSDTSVDAVVGIYGRYDWE
MSMEG_0289|M.smegmatis_MC2_155 IAIAGCSAGGHLAALAGLTPNHPELQGDLPDGADTSVDAVVGIYGRYDWE
Mb0226|M.bovis_AF2122/97 IAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGRYDWE
Rv0220|M.tuberculosis_H37Rv IAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGRYDWE
MMAR_0463|M.marinum_M IAVAGCSAGGHLSALAGLTANDPDYQSELPEGSDTSVDAAVGIYGRYDWE
MUL_1112|M.ulcerans_Agy99 IAVAGCSAGGHLSALAGLTANDPDYQSELPEGSDTSVDAAVGIYGRYDWE
MAV_4953|M.avium_104 VAIAGCSAGGHLSALAGLTPDDPQYRGMLPEGADTSVDAVVGIYGRYDWE
TH_2755|M.thermoresistible__bu VAVAGCSAGGHLAALAGLTENDPDMQTELPEGSDTSVDAVVGVYGRYDWV
MAB_2814|M.abscessus_ATCC_1997 LAVGGDSAGGNLSAVMAQLARDNGIDLAFQVLWYPATTFDTTLPSMVENA
:*:.* ****:*:*: . . : .:. . : . :
Mvan_0227|M.vanbaalenii_PYR-1 DKSTVERVRFMDFLERVVVRRKFDRHPELFRKASPMARVHPEAPPFLVVH
Mflv_0440|M.gilvum_PYR-GCK DKSTVERVRFMDFLERVVVKRKFDKHPDVFRKASPMARIHSEAPPFLVIH
MSMEG_0289|M.smegmatis_MC2_155 DRSTVERERFVDFLERVVVKRSIERHPEIFRLASPIAQVHADAPPFLVVH
Mb0226|M.bovis_AF2122/97 DRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPFLVIH
Rv0220|M.tuberculosis_H37Rv DRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPFLVIH
MMAR_0463|M.marinum_M DRSTAERARFVDFLERVVVKRSIKRHPQVFRDASPVARVHTNAPPFLVIH
MUL_1112|M.ulcerans_Agy99 DRSTAERARFVDFLERVVVKRSIKRHPQVFRDASPVARVHTNAPPFLVIH
MAV_4953|M.avium_104 DRSTPERVRFVDFLERVVVRKSIARHPEVFRDASPIARVHRNAPPFLVIH
TH_2755|M.thermoresistible__bu DRSTAERVRFLDFLERVVVRKRLDRHPEVFHRASPMHRVHGDAPPFLLVH
MAB_2814|M.abscessus_ATCC_1997 EAPVLD-FKTVGALSKWYLG---DTNPATAGPTLVPARAENFEGLAPAFI
: .. : : :. *.: : :* : : .
Mvan_0227|M.vanbaalenii_PYR-1 GTGDSVIPVAQAQSFVERLRGVSRSVVGYVELPGAGHGFDMTDGARTGAA
Mflv_0440|M.gilvum_PYR-GCK GTGDSVIPVAQAQSFVERLRNVSRSVVGYVELPGAGHGFDMTDGARTGAA
MSMEG_0289|M.smegmatis_MC2_155 GSADTVIPVAQARSFVDRLGAASRAPVSYLELPGAGHGFDMTDGARTGAM
Mb0226|M.bovis_AF2122/97 GSRDCVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTGPT
Rv0220|M.tuberculosis_H37Rv GSRDCVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTGPT
MMAR_0463|M.marinum_M GSRDGVIPVAQARSFVERLRAVSRSLVAYVELPGAGHGFDLLDGARTGSA
MUL_1112|M.ulcerans_Agy99 GSRDGVIPVAQARSFVERLRAVSRSLVAYVELPGAGHGFDLLDGARTGSA
MAV_4953|M.avium_104 GSKDSVIPVEQARSFVERLRAVSHSTVGYLELPGAGHGYDLIDGERAGAA
TH_2755|M.thermoresistible__bu GSADTVIPVRQARDFADRLRSVSRSAVSYLELPGAGHGFDLLDGARTGSA
MAB_2814|M.abscessus_ATCC_1997 GTAQFDPLRDDGAKYAELLRDAG-VPVQLHNAPTLIHGY-LGYADIVPSA
*: : :. .:.: * .. * : * **: : . . .
Mvan_0227|M.vanbaalenii_PYR-1 STAIGLFLNHIHRNRTLIGAKEVI
Mflv_0440|M.gilvum_PYR-GCK ATAIGLFLNHIHRNRSLVGAKEVI
MSMEG_0289|M.smegmatis_MC2_155 ATAIGLFLKEIHRNRTRNTAKAVI
Mb0226|M.bovis_AF2122/97 AHAIALFLNQVHRSRAQF-AKEVI
Rv0220|M.tuberculosis_H37Rv AHAIALFLNQVHRSRAQF-AKEVI
MMAR_0463|M.marinum_M THAISLFLNQIHRTRAQL-SKEVI
MUL_1112|M.ulcerans_Agy99 THAISLFLNQIHRTRAQL-SKEVI
MAV_4953|M.avium_104 AHVCSLFLDQVHRSKTRIGAKEVI
TH_2755|M.thermoresistible__bu ATAVGLFLDHVQRNRSRVRGRAVG
MAB_2814|M.abscessus_ATCC_1997 TEERDLSLAALKQALHG-------
: * * :::