For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TERPDTRYPGPTLTTRLEWLLNAGPSDYMLALSVASASLPVIGKHLEPLGALTAAGVWGARHAPDFVGAL AKSLVAPNDVGKKEKQQQERDSTNAITQAALRGLVSQKDLEIEWPAAERTPPVWKMREHRRHVHRTSVRY GPRPTQLLDVWRRDDVPADAPVMIFVPGGAWVHGGRMLQGYALMHHLAEMGWVCLSVEYRVAPHNPWPAH INDVKTAIAWARANVDKFGGNRDFVAIAGTSAGGHLAALAGLTANDPEMQGELPEGSDTSVDAVVGIYGR YDWEDKSTVERVRFMDFLERVVVKRKFDKHPDVFRKASPMARIHSEAPPFLVIHGTGDSVIPVAQAQSFV ERLRNVSRSVVGYVELPGAGHGFDMTDGARTGAAATAIGLFLNHIHRNRSLVGAKEVI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0440 | - | - | 100% (409) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0436 | - | 2e-69 | 47.81% (274) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3735 | - | 1e-17 | 38.79% (116) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0226 | lipC | 1e-160 | 68.49% (403) | esterase LipC |
| M. tuberculosis H37Rv | Rv0220 | lipC | 1e-160 | 68.49% (403) | esterase LipC |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2039 | - | 3e-12 | 34.00% (150) | lipase LipH (carboxylesterase) |
| M. marinum M | MMAR_0463 | lipC | 1e-165 | 68.84% (398) | esterase LipC |
| M. avium 104 | MAV_4953 | - | 1e-156 | 65.41% (399) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_0289 | - | 1e-152 | 68.83% (369) | alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_2755 | - | 1e-160 | 63.12% (423) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_1112 | lipC | 1e-165 | 69.62% (395) | esterase LipC |
| M. vanbaalenii PYR-1 | Mvan_0227 | - | 0.0 | 87.80% (410) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0226|M.bovis_AF2122/97 ---MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPL
Rv0220|M.tuberculosis_H37Rv ---MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPL
MMAR_0463|M.marinum_M MAATGPTTMSMTSMMSRVKWMLRARPADYLLAMSVAGASLPVVGKHLEPL
MUL_1112|M.ulcerans_Agy99 --------------MSRVKWMLRARPADYLLAMSVAGASLPVVGKHLEPL
MAV_4953|M.avium_104 ---------MAPGMTPYLKWLLRARPADYALAVSLAGASLPVVGRHLEPL
Mflv_0440|M.gilvum_PYR-GCK MTERPDTRYPGPTLTTRLEWLLNAGPSDYMLALSVASASLPVIGKHLEPL
Mvan_0227|M.vanbaalenii_PYR-1 MTERPDIRYPGPTLTTRLQWLLNAGPSDFMLAMSVASASLPVIGKHLEPL
MSMEG_0289|M.smegmatis_MC2_155 -----------------------------------------MIGKHFEPL
TH_2755|M.thermoresistible__bu ---MTVRPDGGSSAWLCARRLLRAGPADHLLALSAASGSLPIVGRHLEPL
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0226|M.bovis_AF2122/97 GGVTAIGVWGARHASDFLSATAKDLLTPGINEVR---RRDRASTQEVSVA
Rv0220|M.tuberculosis_H37Rv GGVTAIGVWGARHASDFLSATAKDLLTPGINEVR---RRDRASTQEVSVA
MMAR_0463|M.marinum_M GCVTAMGVWGARHTPEFFAARAKDLFTPGINVTR---QRDRDSTNEVSAA
MUL_1112|M.ulcerans_Agy99 GCVTAMGVWGARHTPEFVAARAKDLFTPGINVTR---QRDRDSTNEVSAA
MAV_4953|M.avium_104 AGLTAMGMWGARHAPEVISAATRDMFAPGGGDAR---RRDRESTQQVSLA
Mflv_0440|M.gilvum_PYR-GCK GALTAAGVWGARHAPDFVGALAKSLVAPNDVGKKEKQQQERDSTNAITQA
Mvan_0227|M.vanbaalenii_PYR-1 GALTAAGIWGTRHAPDFVGALAKSLITPNDAERK---KQERDCTNAVTEA
MSMEG_0289|M.smegmatis_MC2_155 GSMTAMSIWGLRHLPDFVAASAKSRLAPGAAAMR---REEREQTTAAAVA
TH_2755|M.thermoresistible__bu GSAAAMSLWGFRHLPDFVGATVKSWLAPGSAELR---RRQREMTNEVSRQ
MAB_2039|M.abscessus_ATCC_1997 -------------MTSPVDPLLMSVLEASPAVQL-----DRPEDLTLARE
.. . . . . .. :* :
Mb0226|M.bovis_AF2122/97 ALRGIVSPD--------------DLAVEWPAPERTPPVCGALRHRRYVHR
Rv0220|M.tuberculosis_H37Rv ALRGIVSPD--------------DLAVEWPAPERTPPVCGALRHRRYVHR
MMAR_0463|M.marinum_M ALRGIVSTA--------------DLDVEWPAPQRTPPVCEAFRHRRYLHR
MUL_1112|M.ulcerans_Agy99 ALRGIVSTA--------------DLDVEWPAPQRTPPVCEAFRHRRYLHR
MAV_4953|M.avium_104 ALRGLVSAA--------------ELESQWPVAQRTPPIWDGVRRHRHLYR
Mflv_0440|M.gilvum_PYR-GCK ALRGLVSQK--------------DLEIEWPAAERTPPVWKMREHRRHVHR
Mvan_0227|M.vanbaalenii_PYR-1 ALRDVVGPK--------------DLEIEWPAAERTPPVWRMREHRRHVHR
MSMEG_0289|M.smegmatis_MC2_155 ALRNVVPPA--------------ELAAEWPAPQNLPPLWNVLEHRRSVYR
TH_2755|M.thermoresistible__bu ALRGLLPADPAAPGASEVSSGSAGSALDWPAPDRVPPLWRMLQHRRHLYR
MAB_2039|M.abscessus_ATCC_1997 SRRHAAPSD-----------------------AQLPTVGRVKDTSIPVT-
: * . *.: :
Mb0226|M.bovis_AF2122/97 RRVLYGDDPAQLLDVWRRKDMPTKPAPVLIFVPGGAWVHGSRAIQGYAVL
Rv0220|M.tuberculosis_H37Rv RRVLYGDDPAQLLDVWRRKDMPTKPAPVLIFVPGGAWVHGSRAIQGYAVL
MMAR_0463|M.marinum_M GGVHYGNSPAQVLDVWRRDDLPTEPAPVLIFVPGGAWIHGSRAIQGYALL
MUL_1112|M.ulcerans_Agy99 GGVHYGNSPAQVLDVWRRDDLPTEPAPVLIFVPGGAWIHGSRAIQGYALL
MAV_4953|M.avium_104 RAVHYGHHPAQVLDVWRRKDLPAQPAPVLIFVPGGAWVHGKSMGQGSALM
Mflv_0440|M.gilvum_PYR-GCK TSVRYGPRPTQLLDVWRRDDVPAD-APVMIFVPGGAWVHGGRMLQGYALM
Mvan_0227|M.vanbaalenii_PYR-1 TSVRYGPRPTQLLDVWRRDDLPAEPAPVLIFVPGGAWVHGSRMLQGYALM
MSMEG_0289|M.smegmatis_MC2_155 TSVRYGDDPAQLLDVWRPKELPAQPAPVLLFVPGGAWVHGSRVLQGYALM
TH_2755|M.thermoresistible__bu GAVRYGDHTENVLDVWRRKDLPAQPAPVLIFVPGGAWVHGSRMLQGYALL
MAB_2039|M.abscessus_ATCC_1997 -----DAPPIAVRIYWPAGFESAGELPLVLYYHGGGFALGSIDTHDWVAR
. . : * .: *:::: **.: * :. .
Mb0226|M.bovis_AF2122/97 SRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWARANVDKFGGDRNF
Rv0220|M.tuberculosis_H37Rv SRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWARANVDKFGGDRNF
MMAR_0463|M.marinum_M SRLAEQGWVCLSIDYRVAPHHRWPRHIHDVKAAIAWARANVDKFGGDRNF
MUL_1112|M.ulcerans_Agy99 SRLAEQGWVCLSIDYRVAPHHRWPRHIHDVKAAIAWARANVDKFGGDRNF
MAV_4953|M.avium_104 SRLAEQGWVCLAIDYRVAPHHRWPRHIVDVKTAIAWARANVDKFGGDRNF
Mflv_0440|M.gilvum_PYR-GCK HHLAEMGWVCLSVEYRVAPHNPWPAHINDVKTAIAWARANVDKFGGNRDF
Mvan_0227|M.vanbaalenii_PYR-1 SHLAERGWVCLSIDYRVAPHNPWPAHVADVKTAIAWARANVDKFGGDRNF
MSMEG_0289|M.smegmatis_MC2_155 SHLAQQGWVCLSVDYRVSPHHRWPRHIHDVKAAIAWARANVDKFGGDRHF
TH_2755|M.thermoresistible__bu SHLAEQGWVCLSIDYRVAPQHPWPAHLTDVKTAIAWARANVDKFGGDRDF
MAB_2039|M.abscessus_ATCC_1997 SICAHIEAVVVSVDYRLAPENPYPAAVDDAFAALSWAAEHAPELGADPAR
* * ::::**::*.: :* : *. :*::** :. ::*.:
Mb0226|M.bovis_AF2122/97 IAVAGCSAGGHLSALAG-LTANDPQYQAELPEGSDTSVDAVVGIYGRYDW
Rv0220|M.tuberculosis_H37Rv IAVAGCSAGGHLSALAG-LTANDPQYQAELPEGSDTSVDAVVGIYGRYDW
MMAR_0463|M.marinum_M IAVAGCSAGGHLSALAG-LTANDPDYQSELPEGSDTSVDAAVGIYGRYDW
MUL_1112|M.ulcerans_Agy99 IAVAGCSAGGHLSALAG-LTANDPDYQSELPEGSDTSVDAAVGIYGRYDW
MAV_4953|M.avium_104 VAIAGCSAGGHLSALAG-LTPDDPQYRGMLPEGADTSVDAVVGIYGRYDW
Mflv_0440|M.gilvum_PYR-GCK VAIAGTSAGGHLAALAG-LTANDPEMQGELPEGSDTSVDAVVGIYGRYDW
Mvan_0227|M.vanbaalenii_PYR-1 VAISGASAGGHLAALAG-LTANDPEMQDELPEGSDTSVDAVVGIYGRYDW
MSMEG_0289|M.smegmatis_MC2_155 IAIAGCSAGGHLAALAG-LTPNHPELQGDLPDGADTSVDAVVGIYGRYDW
TH_2755|M.thermoresistible__bu VAVAGCSAGGHLAALAG-LTENDPDMQTELPEGSDTSVDAVVGVYGRYDW
MAB_2039|M.abscessus_ATCC_1997 IAVAGDSAGGNLATVAAQLAEIRGGPHLKFQLLWYPGTTSDLSLPSVVEN
:*::* ****:*:::*. *: : : ... : :.: . :
Mb0226|M.bovis_AF2122/97 EDRSTPERARFVDFLERVVVQRTIDRHPEVFR-DASPIQRVTRNAPPFLV
Rv0220|M.tuberculosis_H37Rv EDRSTPERARFVDFLERVVVQRTIDRHPEVFR-DASPIQRVTRNAPPFLV
MMAR_0463|M.marinum_M EDRSTAERARFVDFLERVVVKRSIKRHPQVFR-DASPVARVHTNAPPFLV
MUL_1112|M.ulcerans_Agy99 EDRSTAERARFVDFLERVVVKRSIKRHPQVFR-DASPVARVHTNAPPFLV
MAV_4953|M.avium_104 EDRSTPERVRFVDFLERVVVRKSIARHPEVFR-DASPIARVHRNAPPFLV
Mflv_0440|M.gilvum_PYR-GCK EDKSTVERVRFMDFLERVVVKRKFDKHPDVFR-KASPMARIHSEAPPFLV
Mvan_0227|M.vanbaalenii_PYR-1 EDKSTVERVRFMDFLERVVVRRKFDRHPELFR-KASPMARVHPEAPPFLV
MSMEG_0289|M.smegmatis_MC2_155 EDRSTVERERFVDFLERVVVKRSIERHPEIFR-LASPIAQVHADAPPFLV
TH_2755|M.thermoresistible__bu VDRSTAERVRFLDFLERVVVRKRLDRHPEVFH-RASPMHRVHGDAPPFLL
MAB_2039|M.abscessus_ATCC_1997 ADGPVLSRDIMRIFGQAYLGELSETADPTALPFTVAPVNGKLDGLPPAYI
* .. .* : * : : . .* : .:*: ** :
Mb0226|M.bovis_AF2122/97 IHGSRDCVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTG
Rv0220|M.tuberculosis_H37Rv IHGSRDCVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTG
MMAR_0463|M.marinum_M IHGSRDGVIPVAQARSFVERLRAVSRSLVAYVELPGAGHGFDLLDGARTG
MUL_1112|M.ulcerans_Agy99 IHGSRDGVIPVAQARSFVERLRAVSRSLVAYVELPGAGHGFDLLDGARTG
MAV_4953|M.avium_104 IHGSKDSVIPVEQARSFVERLRAVSHSTVGYLELPGAGHGYDLIDGERAG
Mflv_0440|M.gilvum_PYR-GCK IHGTGDSVIPVAQAQSFVERLRNVSRSVVGYVELPGAGHGFDMTDGARTG
Mvan_0227|M.vanbaalenii_PYR-1 VHGTGDSVIPVAQAQSFVERLRGVSRSVVGYVELPGAGHGFDMTDGARTG
MSMEG_0289|M.smegmatis_MC2_155 VHGSADTVIPVAQARSFVDRLGAASRAPVSYLELPGAGHGFDMTDGARTG
TH_2755|M.thermoresistible__bu VHGSADTVIPVRQARDFADRLRSVSRSAVSYLELPGAGHGFDLLDGARTG
MAB_2039|M.abscessus_ATCC_1997 ATAQHDPLR--DDGKIYATRLADAG-VPVQLRNADTLVHGY--LDFARIV
. * : :.: :. ** .. * : **: * *
Mb0226|M.bovis_AF2122/97 PTAHAIALFLNQVHRSRAQF-AKEVI--
Rv0220|M.tuberculosis_H37Rv PTAHAIALFLNQVHRSRAQF-AKEVI--
MMAR_0463|M.marinum_M SATHAISLFLNQIHRTRAQL-SKEVI--
MUL_1112|M.ulcerans_Agy99 SATHAISLFLNQIHRTRAQL-SKEVI--
MAV_4953|M.avium_104 AAAHVCSLFLDQVHRSKTRIGAKEVI--
Mflv_0440|M.gilvum_PYR-GCK AAATAIGLFLNHIHRNRSLVGAKEVI--
Mvan_0227|M.vanbaalenii_PYR-1 AASTAIGLFLNHIHRNRTLIGAKEVI--
MSMEG_0289|M.smegmatis_MC2_155 AMATAIGLFLKEIHRNRTRNTAKAVI--
TH_2755|M.thermoresistible__bu SAATAVGLFLDHVQRNRSRVRGRAVG--
MAB_2039|M.abscessus_ATCC_1997 PAANEEFRLSLDACKTALQASPRPKAGP
. : : . :. :