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MLIRRAALLDGTRTDIRVGERITGMADGLTAEPGETEYDAAGGAVIPGLHDHHIHLRAAAAALHSVRVGP DEVHSRAELAETLAAATVGADGWIRAVGYHDAAAGPLDRHVLDELAPSVPVRIQHRSGAQWILNTAALRR VGLADHPDGRLPSADGSWAATLRSDPGLDELGALLCRYGVTGVTDATPDLAAGDVAALQREMRQRVRCLA PGKRILHDDELDPDELSRWIGDRHAEGFPVAVHCVTAAQLVVTLEALRSSGTHPLDRIEHAAVVPDGSLA DLAGRAVTVVTQPNFVAERGDQYLADVAPAEQPELWRVASLLRAGVPVALSTDAPFGDADPWAAMRAAVF RRTPAGHVLGEAECVPASAALQMFLGDPGRPATPRRVEPGAAADLCILSTPPEATLAELDAAAVAATVIG GEVVYQRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0224 | - | - | 100% (428) | amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_3420 | - | 4e-10 | 24.34% (489) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2078c | - | 1e-09 | 37.14% (105) | hypothetical protein Mb2078c |
| M. gilvum PYR-GCK | Mflv_0443 | - | 1e-166 | 70.02% (427) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv2052c | - | 1e-09 | 37.14% (105) | hypothetical protein Rv2052c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2205 | - | 4e-09 | 26.15% (348) | hypothetical protein MAB_2205 |
| M. marinum M | MMAR_0459 | - | 1e-145 | 61.95% (431) | hypothetical protein MMAR_0459 |
| M. avium 104 | MAV_4955 | - | 1e-145 | 62.67% (434) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_0263 | - | 1e-140 | 59.58% (428) | amidohydrolase 3 |
| M. thermoresistible (build 8) | TH_0643 | - | 1e-109 | 63.17% (315) | amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_1109 | - | 1e-137 | 61.00% (418) | hypothetical protein MUL_1109 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0224|M.vanbaalenii_PYR-1 -------------------------------------MLIRR---AALLD
Mflv_0443|M.gilvum_PYR-GCK -------------------------------------MLIRN---AVLID
MSMEG_0263|M.smegmatis_MC2_155 -------------------------------------MLIQR---ASLLD
TH_0643|M.thermoresistible__bu --------------------------------------------------
MMAR_0459|M.marinum_M -------------------------------------MLIRR---ATLLD
MUL_1109|M.ulcerans_Agy99 --------------------------------------------------
MAV_4955|M.avium_104 -------------------------------------MLIQR---ATLLD
Mb2078c|M.bovis_AF2122/97 ----------------------MSQIP--------VKLLVNGRVYSPTHP
Rv2052c|M.tuberculosis_H37Rv ----------------------MSQIP--------VKLLVNGRVYSPTHP
MAB_2205|M.abscessus_ATCC_1997 MQTRSDALRASGSSRPDALRASGSSRPGALRASGSSQLLINARVYSPSHP
Mvan_0224|M.vanbaalenii_PYR-1 GTRTDIRVGERITGMA---DGLTAEPGETEYDAAGGAVIPGLHDHHIHLR
Mflv_0443|M.gilvum_PYR-GCK GTRTDIRVGDTVTEVA---DDVTAAPGEDEFDAAGGTVLPGLNDHHLHLR
MSMEG_0263|M.smegmatis_MC2_155 GRIADIRVGEAIEDVG---PSLRARRGEAVLDAALGAVIPGLHDHHVHVY
TH_0643|M.thermoresistible__bu --------------------------------------------------
MMAR_0459|M.marinum_M GSTADIRVCARIQEVG---QGLVARPGERVLDAAGQTVLPGLHDHHVHLR
MUL_1109|M.ulcerans_Agy99 -------MCARIQEVG---QGLVARPGERVLDAAGQTVLPGLHDHHVHLR
MAV_4955|M.avium_104 GTAADIRVGARIEEVAPADDGLAARAGEGVLYAGGGTVLPGLHDHHVHLR
Mb2078c|M.bovis_AF2122/97 EATAMAVRGDVVAWLGSDDVGRDQFPDADVQDLDGRFVAPGFVDSHIHLT
Rv2052c|M.tuberculosis_H37Rv EATAMAVRGDVVAWLGSDDVGRDQFPDADVQDLDGRFVAPGFVDSHIHLT
MAB_2205|M.abscessus_ATCC_1997 AATAMAVTGDVISWIGEDDLGRAEFPDAEIVDLEGAFVAPAFVDAHVHVT
Mvan_0224|M.vanbaalenii_PYR-1 -------AAAAALHSVRVGPDEVHSRAELAETLAAATVGADGWIRAVGYH
Mflv_0443|M.gilvum_PYR-GCK -------AAAAALRSLRVGPDEVRDRAALAGVLAAAVPDQNGWIRAVGYH
MSMEG_0263|M.smegmatis_MC2_155 -------SAAAEQNSLRVGPREAHDTGELRRLLAGAAPGADGWIRAIGYH
TH_0643|M.thermoresistible__bu --------------------------------------------------
MMAR_0459|M.marinum_M -------SAASALDSLTLGPPTVDSKEKFRQHLSSAQPGPDGWIRAVGYH
MUL_1109|M.ulcerans_Agy99 SHHVHLRSAASAVDSLTLGPPTVDSKEKFRQHLSSAQPGPDGWIRAVGYH
MAV_4955|M.avium_104 -------SAASALDSFFVGPPGVSTRAELTRLLANATPGPDGWIRAVGYH
Mb2078c|M.bovis_AF2122/97 ATG--LMLSGLDLRPATSRAQCLRMVADYAADHPGQPLWGHGWDESAWPE
Rv2052c|M.tuberculosis_H37Rv ATG--LMLSGLDLRPATSRAQCLRMVADYAADHPGQPLWGHGWDESAWPE
MAB_2205|M.abscessus_ATCC_1997 ALG--LSLIGLDLSDVTAREQCLDRLAAYAREHPNEVIWGHGWDESRWPD
Mvan_0224|M.vanbaalenii_PYR-1 DAAAGPLDRHVLDELAPSVPVRIQHRSGAQWILNTAALRRVGLAD-----
Mflv_0443|M.gilvum_PYR-GCK DSVAGPLTRDLLDAIAPEVPVRIQHRSGVQWTLNTAGLALVGKHD-----
MSMEG_0263|M.smegmatis_MC2_155 EQVAGPLDRDRLDALAPAVPVRVQHRSGVLWVLNSAGLAAINRPD-----
TH_0643|M.thermoresistible__bu ------------------VPVRVQHRSGVLWTLNSAGLARIGMPD-----
MMAR_0459|M.marinum_M ESVAGPLDRTVLDALVPHLPVRVQHRSGALWILNSAALNRIGLAG-----
MUL_1109|M.ulcerans_Agy99 EAVAGPLDRTVLDALVPHLPVRVQHRSGALWILNSAALNRIGLAG-----
MAV_4955|M.avium_104 DSVAGALDRTALDAIVRDVPVRIQHRSGALWILNSEALGRIGLAE-----
Mb2078c|M.bovis_AF2122/97 NAAPSTADLDAVLGDCPAYLARIDSHSALVSSGLRRLVPELAAATGYTAQ
Rv2052c|M.tuberculosis_H37Rv NAAPSTADLDAVLGDCPAYLARIDSHSALVSSGLRRLVPELAAATGYTAQ
MAB_2205|M.abscessus_ATCC_1997 GRPLTTTELDTAASGRAVYLARIDVHSAAASTALRQQVPGLAEAAGFHPE
.*:: :*. : :
Mvan_0224|M.vanbaalenii_PYR-1 -----HPDGRLPSADGSWAATLR-SDPGLDELGALLCR------------
Mflv_0443|M.gilvum_PYR-GCK -----HPDGVLRSADPSWTLPA--TEPDLEGLGATLSR------------
MSMEG_0263|M.smegmatis_MC2_155 -----HPDGILRSADPTWAEALPRRDTDIDSYAERLAR------------
TH_0643|M.thermoresistible__bu -----HPDGRLRSADPDWSNSLQRRETRIADLSAELTR------------
MMAR_0459|M.marinum_M -----HVDGRLRSADSDWSDALPRRKTDLAALGDRLTA------------
MUL_1109|M.ulcerans_Agy99 -----HVDGRLRSADSDWSDALPRRKTDLAELGDRLTA------------
MAV_4955|M.avium_104 -----HPDGRLRSADRGWSQALAHRETDLAELSRRITA------------
Mb2078c|M.bovis_AF2122/97 RPLTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAVHECAGPE
Rv2052c|M.tuberculosis_H37Rv RPLTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAVHECAGPE
MAB_2205|M.abscessus_ATCC_1997 WPLIGAAHHLLRAHARGAFSAAGRAQARRAALDAAASLGIVSVHECGGPE
. : ..
Mvan_0224|M.vanbaalenii_PYR-1 -------------------YGVTGVTDATPDLAAGDVA-----ALQREMR
Mflv_0443|M.gilvum_PYR-GCK -------------------YGITGVTDATPDLGAGDIT-----ELQRRMP
MSMEG_0263|M.smegmatis_MC2_155 -------------------YGITGITDATPDLSE----------PPRGLP
TH_0643|M.thermoresistible__bu -------------------YGVTGVTDATPGLDVGDVVRLTGMNRRGNLS
MMAR_0459|M.marinum_M -------------------AGVTGVTDATPDLSDEDMAALTVAHQRGEFR
MUL_1109|M.ulcerans_Agy99 -------------------AGVTGVTDATPDLSDEDMAALTVAHQRGEFR
MAV_4955|M.avium_104 -------------------TGVTGVTDATPDLDDDDRAALAAAHARGEFR
Mb2078c|M.bovis_AF2122/97 IGGLDDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLF
Rv2052c|M.tuberculosis_H37Rv IGGLDDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLF
MAB_2205|M.abscessus_ATCC_1997 IGGLEDFRELLATEHGVQVTGYWGEPARDPDHAGELVAATGAAGLAGDLF
* * . * :
Mvan_0224|M.vanbaalenii_PYR-1 QR----------VRCLAPGKRILHDDELDPDELSRWIGDRHAEGFPVAVH
Mflv_0443|M.gilvum_PYR-GCK QT----------VRALAPGKRILHDDELDLDALTSWIRHTHSVGVPVALH
MSMEG_0263|M.smegmatis_MC2_155 QH----------LHVLAPGKKILHDDMLDLDGLVTWIGERHARGVPVAVH
TH_0643|M.thermoresistible__bu QR----------VNCLAPGKRILHDDRLDLTELTEWIATRHAAGGAVAIH
MMAR_0459|M.marinum_M PR----------VRFLSPGKKILRDDHLDLEALMAWITDSHGAGQPVAIH
MUL_1109|M.ulcerans_Agy99 PR----------VRFLSPGKKILRDDHLDLETLMAWITDSHGAGQPVAIH
MAV_4955|M.avium_104 PR----------PSFLSPGKKILHDDRLNLDALTEWVAGQHDTGQPVAVH
Mb2078c|M.bovis_AF2122/97 VDGALGSRTAWLHEPYADAPDCIGTCHLDVDGIEAHVRACTKAEVTAGFH
Rv2052c|M.tuberculosis_H37Rv VDGALGSRTAWLHEPYADAPDCIGTCHLDVDGIEAHVRACTKAEVTAGFH
MAB_2205|M.abscessus_ATCC_1997 VDGALGSRTAWLREPYHDAPHTCGSRHLDAETVEAHLDSCTRAGITAGFH
. *: : : ....*
Mvan_0224|M.vanbaalenii_PYR-1 CVTAAQLVVTLEALRSSGTHP--------LDRIEHAAVVPDGSLADLAGR
Mflv_0443|M.gilvum_PYR-GCK CVTAAQLVVTLTALRSAGRHP--------LDRIEHAAVVPDGSVADLADS
MSMEG_0263|M.smegmatis_MC2_155 CVTSAQLVVTIAAMRVTGVLP--------GDRIEHAAMVPEDCVRDLCEL
TH_0643|M.thermoresistible__bu CVTAAQLVVTLTALRAVGTHP--------QDRIEHAAVVPDDSLEEIAAL
MMAR_0459|M.marinum_M CVTAAQLVVTIAAVRAVGRHP--------HDRIEHAAVVPDDLVADLAGL
MUL_1109|M.ulcerans_Agy99 CVTAAQLVVTIAAVRAVGRHP--------HDRIEHAAVVPDDLVADLAGL
MAV_4955|M.avium_104 CVTAAQLVVAIAALRAAGTHP--------RDRIEHAAVVPDDNLADLAEL
Mb2078c|M.bovis_AF2122/97 VIGDAAVSAAVAAFERVVADLGVVAVARCGHRLEHVEMVTADQAAKLGAW
Rv2052c|M.tuberculosis_H37Rv VIGDAAVSAAVAAFERVVADLGVVAVARCGHRLEHVEMVTADQAAKLGAW
MAB_2205|M.abscessus_ATCC_1997 VIGDAAVTQVIDALGRVAERHGVPAVARCGHRLEHLEMVSAAQAGQLGRL
: * : .: *. .*:** :*. .:
Mvan_0224|M.vanbaalenii_PYR-1 AVTVVTQPNFVAERGD---QYLADVAPAEQPELWRVASLLRAGVPVALST
Mflv_0443|M.gilvum_PYR-GCK GVTVVTQPNFVAERGD---QYLVDVPEHEHHELWRVGSLLEAGVPVALST
MSMEG_0263|M.smegmatis_MC2_155 GVTVVTQPNFVTERGD---AYRSDVDAADHHQLWRVATLLAAGVRVALST
TH_0643|M.thermoresistible__bu GLTVVTQPNFIAERGD---QYRTDVPADEHHELWRLKSLLDAGIPTALST
MMAR_0459|M.marinum_M GLTVVTQPNFVAERGD---QYLDEIPAAEHGQLWRVASLLNANVPVAFST
MUL_1109|M.ulcerans_Agy99 GLTVVTQPNFVAERGD---QYLDEIPAAEHGQLWRVASLLNANVPVALST
MAV_4955|M.avium_104 GVTVVTQPNFVAERGD---QYLAEVPADEHDQLWRLASLRDARVPVALST
Mb2078c|M.bovis_AF2122/97 GVIASVQPNFDELWGGGDGMYARRLGAQRGSELNPLALLASQGVPLALGS
Rv2052c|M.tuberculosis_H37Rv GVIASVQPNFDELWGGGDGMYARRLGAQRGSELNPLALLASQGVPLALGS
MAB_2205|M.abscessus_ATCC_1997 GVIASVQPAFDALWGGPDGMYADRLGADRGTQLNPLALLASQGVPLAFGS
.: . .** * *. * : :* : * : *:.:
Mvan_0224|M.vanbaalenii_PYR-1 DAPFGDADPWAAMRAAVFRRTPAGHVLGEAECVPASAALQMFLGDPGRPA
Mflv_0443|M.gilvum_PYR-GCK DAPFGHSDPWAAMRAAVHRRTPSGTVLGPNERITEATALAMFTGN--RAG
MSMEG_0263|M.smegmatis_MC2_155 DAPFGDADPWAVMRAAVHRRTPHGFVLNPAERIPPRTALELFFGTAQDPA
TH_0643|M.thermoresistible__bu DAPFGDADPWAAMRAAVHRTTGSGAVLGADERIDAGTALRMFFGTADRPT
MMAR_0459|M.marinum_M DLPFGSGDPWAAMRAAVHRRTPRGVVLGVDECVTARAALTMFLGRPDQPG
MUL_1109|M.ulcerans_Agy99 DLPFGSGDPWAPMRAAVHRRTPRGVVLGVDECVTARAALTMFLGRPDQPG
MAV_4955|M.avium_104 DMPFGHGDPWTAMRAAVHRTTPSGVVLGARECVSARTALTMFLGRADQPD
Mb2078c|M.bovis_AF2122/97 DAPVTGFDPWASVRAAVNHRTPGSGVS--ARAAFAAATRGGWRAGGVRDG
Rv2052c|M.tuberculosis_H37Rv DAPVTGFDPWASVRAAVNHRTPGSGVS--ARAAFAAATRGGWRAGGVRDG
MAB_2205|M.abscessus_ATCC_1997 DAPVTPMNPWVTVRAAAHHRTPSSSVS--VRAAFGAATRGGWRAQGVHDG
* *. :**. :***. : * . * . :: : .
Mvan_0224|M.vanbaalenii_PYR-1 TPRRVEPGAAADLCILST-----------------PPEATLAELD-----
Mflv_0443|M.gilvum_PYR-GCK HPGAVVPGAPGDLCILAT-----------------PPPQALAELD-----
MSMEG_0263|M.smegmatis_MC2_155 HPRRVDVGQPGDLCVLAA-----------------PPRQVVETLD-----
TH_0643|M.thermoresistible__bu RPRTVEPGQPADLCVLSA-----------------PPDRVLRELS-----
MMAR_0459|M.marinum_M RVRAVAAGQPGDLCVLAQ-----------------TPAMVLTELD-----
MUL_1109|M.ulcerans_Agy99 RVRAVAAGQPGDLCVLAQ-----------------TPAVVLTELD-----
MAV_4955|M.avium_104 RVRSVQPGEPGDLCVLNE-----------------PPHTALAELD-----
Mb2078c|M.bovis_AF2122/97 RIGTLVPGAPASYAIWDAGDFDVDAPRDAVQRWSTDPRSRVPALPRLGP-
Rv2052c|M.tuberculosis_H37Rv RIGTLVPGAPASYAIWDAGDFDVDAPRDAVQRWSTDPRSRVPALPRLGP-
MAB_2205|M.abscessus_ATCC_1997 VTGTLTPGALASYAIWETGDLTINTSQPGVQRWSTDPRSRVPALPDLSDG
: * .. .: * : *
Mvan_0224|M.vanbaalenii_PYR-1 ---AAAVAATVIGGEVVYQRG-
Mflv_0443|M.gilvum_PYR-GCK ---AAAVAATVIAGRVVYER--
MSMEG_0263|M.smegmatis_MC2_155 ---ADLVAATIIGGSVVFSR--
TH_0643|M.thermoresistible__bu ---AELVSATIVGGKPVYQKPV
MMAR_0459|M.marinum_M ---ASLVSATIIGGEVAYAA--
MUL_1109|M.ulcerans_Agy99 ---ASLVSATIIGGEVAYAA--
MAV_4955|M.avium_104 ---AGMVAATIIGGELVYFAM-
Mb2078c|M.bovis_AF2122/97 TDALPRCRQTVHRGAVIYG---
Rv2052c|M.tuberculosis_H37Rv TDALPRCRQTVHRGAVIYG---
MAB_2205|M.abscessus_ATCC_1997 AAALPTCLRTVHRGKVIHG---
*: * .