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SQIPVKLLVNGRVYSPTHPEATAMAVRGDVVAWLGSDDVGRDQFPDADVQDLDGRFVAPGFVDSHIHLTA TGLMLSGLDLRPATSRAQCLRMVADYAADHPGQPLWGHGWDESAWPENAAPSTADLDAVLGDCPAYLARI DSHSALVSSGLRRLVPELAAATGYTAQRPLTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAV HECAGPEIGGLDDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLFVDGALGSRTAWLH EPYADAPDCIGTCHLDVDGIEAHVRACTKAEVTAGFHVIGDAAVSAAVAAFERVVADLGVVAVARCGHRL EHVEMVTADQAAKLGAWGVIASVQPNFDELWGGGDGMYARRLGAQRGSELNPLALLASQGVPLALGSDAP VTGFDPWASVRAAVNHRTPGSGVSARAAFAAATRGGWRAGGVRDGRIGTLVPGAPASYAIWDAGDFDVDA PRDAVQRWSTDPRSRVPALPRLGPTDALPRCRQTVHRGAVIYG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2052c | - | - | 100% (534) | hypothetical protein Rv2052c |
| M. tuberculosis H37Rv | Rv0552 | - | 1e-15 | 24.84% (479) | hypothetical protein Rv0552 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2078c | - | 0.0 | 100.00% (534) | hypothetical protein Mb2078c |
| M. gilvum PYR-GCK | Mflv_3116 | - | 0.0 | 70.43% (531) | amidohydrolase 3 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2205 | - | 0.0 | 62.95% (529) | hypothetical protein MAB_2205 |
| M. marinum M | MMAR_3030 | - | 0.0 | 81.84% (534) | hypothetical protein MMAR_3030 |
| M. avium 104 | MAV_2445 | - | 0.0 | 77.92% (530) | amidohydrolase 3 |
| M. smegmatis MC2 155 | MSMEG_3861 | - | 0.0 | 67.93% (527) | amidohydrolase 3 |
| M. thermoresistible (build 8) | TH_0643 | - | 3e-13 | 35.14% (185) | amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_2270 | - | 0.0 | 81.09% (534) | hypothetical protein MUL_2270 |
| M. vanbaalenii PYR-1 | Mvan_3420 | - | 0.0 | 65.79% (535) | amidohydrolase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2052c|M.tuberculosis_H37Rv ------------------------------MSQIPVKLLVNGRVYSPTHP
Mb2078c|M.bovis_AF2122/97 ------------------------------MSQIPVKLLVNGRVYSPTHP
MMAR_3030|M.marinum_M ------------------------------MTRISTKLLVNGRVYSPTHP
MUL_2270|M.ulcerans_Agy99 ------------------------------MTRISTKLLVNGRVYSPTHP
MAV_2445|M.avium_104 --------------------------MDVADRPTPVTLLVNGRVHTPAAP
Mflv_3116|M.gilvum_PYR-GCK ---------------------------------MNTTLLRGGRIHSPAMP
Mvan_3420|M.vanbaalenii_PYR-1 ---------------------------------MTTTLLLNGRVHSPAMP
MSMEG_3861|M.smegmatis_MC2_155 ----------------------------------MTTLLINGRIHSPAQP
MAB_2205|M.abscessus_ATCC_1997 MQTRSDALRASGSSRPDALRASGSSRPGALRASGSSQLLINARVYSPSHP
TH_0643|M.thermoresistible__bu --------------------------------------------------
Rv2052c|M.tuberculosis_H37Rv EATAMAVRGDVVAWLGSDDVGRDQFPDADVQDLDGRFVAPGFVDSHIHLT
Mb2078c|M.bovis_AF2122/97 EATAMAVRGDVVAWLGSDDVGRDQFPDADVQDLDGRFVAPGFVDSHIHLT
MMAR_3030|M.marinum_M DATAMAVRGDTVAWLGSDDVGRNQFPDAQVEDLDGGLVAPGFVDSHIHLT
MUL_2270|M.ulcerans_Agy99 DATAMAVRGDTVAWLGSDDVGRNQFPDAQVEDLDGGLVAPGFVDSHIHLT
MAV_2445|M.avium_104 DATAMAVRGGVITWLGGDDVGRSLFPDADVEDLDGGFVTPGFVDSHIHLT
Mflv_3116|M.gilvum_PYR-GCK DATAMAVRGGVVAWVGSDDVGRAQFPDADVADLDGAFVAPAFVDSHVHTT
Mvan_3420|M.vanbaalenii_PYR-1 DATAMAVRDGIVAWVGADDIGRKQFPDAAVTDLDGAFVAPAFVDTHVHTT
MSMEG_3861|M.smegmatis_MC2_155 DATAMAIRDGVVAWLGSDDVGRALHPDAHIVDLDGGFVAPAFVDSHVHIT
MAB_2205|M.abscessus_ATCC_1997 AATAMAVTGDVISWIGEDDLGRAEFPDAEIVDLEGAFVAPAFVDAHVHVT
TH_0643|M.thermoresistible__bu VPVRVQHRSGVLWTLNSAGLARIGMP------------------------
.. : .. : :. .:.* *
Rv2052c|M.tuberculosis_H37Rv ATGLMLSGLDLRPATSRAQCLRMVADYAADHPGQPLWGHGWDESAWPENA
Mb2078c|M.bovis_AF2122/97 ATGLMLSGLDLRPATSRAQCLRMVADYAADHPGQPLWGHGWDESAWPENA
MMAR_3030|M.marinum_M ATGLTISGLDLRPASSLAECLQLAADHAAAHPGQPLWGHGWDESAWPQHI
MUL_2270|M.ulcerans_Agy99 ATGLTISGLDLRPASSLGGCLQLAADHAAAHPGQPLWGHGWDESAWPQHI
MAV_2445|M.avium_104 ATGLTLCGLDLRPARSRAHCLQLIADHAAAHPGRPVWGHGWDETSWPERT
Mflv_3116|M.gilvum_PYR-GCK ATGLTLTGLDLRAATSRRHCLAMLAEFAADHPDGVLWGHGWDESGWPDQT
Mvan_3420|M.vanbaalenii_PYR-1 ATGLALTGLDLRPATSLRHCLDLLVDFAGTNADGVIWGHGWDETRWPERR
MSMEG_3861|M.smegmatis_MC2_155 ATGLNLVGLDLHAATSLQHCLQLVADHARRHPDGLVWGHGWDESGWPERT
MAB_2205|M.abscessus_ATCC_1997 ALGLSLIGLDLSDVTAREQCLDRLAAYAREHPNEVIWGHGWDESRWPDGR
TH_0643|M.thermoresistible__bu -----------------------------DHPDGRLRSADPDWSNSLQRR
:.. : . . * : :
Rv2052c|M.tuberculosis_H37Rv APSTADLDAVLGDCPAYLARIDSHSALVSSGLRRLVPELAAATGYTAQRP
Mb2078c|M.bovis_AF2122/97 APSTADLDAVLGDCPAYLARIDSHSALVSSGLRRLVPELAAATGYTAQRP
MMAR_3030|M.marinum_M APSTAQLDAVLGERPAYLARVDVHSALASSGLRRLVPHLSEAAGFTEQGP
MUL_2270|M.ulcerans_Agy99 APSTAQLDAVLGERPTYLARVDVHSALASSGLRRLVPHLSEAAGFTEQGP
MAV_2445|M.avium_104 PPSTAELDAVLGDRPAYLTRVDVHSALASTGLRRRVAQLPSATGFSPDRP
Mflv_3116|M.gilvum_PYR-GCK PPDTADIDAAVGSRPAYLARVDVHSAAASTSLRR-------AAGVTDTEP
Mvan_3420|M.vanbaalenii_PYR-1 APSTAEVDAAVGGRAAYLARVDVHSAVASTLLRR-------TAGVDDAAP
MSMEG_3861|M.smegmatis_MC2_155 PPGTDDLDAVLGDRPAYLARVDVHSAAATTALRRAVPDLAGASGFSPQGP
MAB_2205|M.abscessus_ATCC_1997 PLTTTELDTAASGRAVYLARIDVHSAAASTALRQQVPGLAEAAGFHPEWP
TH_0643|M.thermoresistible__bu ETRIADLSAELTR-------------------------------------
::.:
Rv2052c|M.tuberculosis_H37Rv LTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAVHECA-GPEI
Mb2078c|M.bovis_AF2122/97 LTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAVHECA-GPEI
MMAR_3030|M.marinum_M LTGEAHHLVRARARDLLTQPQLAEARTAALGSLAAAGIVAVHECG-GPEI
MUL_2270|M.ulcerans_Agy99 LTGEAHHLVRARARDLLTQPQLAEARTAALGSLAAAGIVAVHECG-GPEI
MAV_2445|M.avium_104 LVGHAHHAVRAAARNLLTAEQLAEARAAALHAAAAAGIVAVHECA-GPEI
Mflv_3116|M.gilvum_PYR-GCK LIADAHHRVRRAAREQLTATQRAQARQAALDAAAAAGIVAVHECA-GPEI
Mvan_3420|M.vanbaalenii_PYR-1 LTADAHHKVRRAARAGLTAAQRARARQAALDAAAGLGIAAVHECA-GPEI
MSMEG_3861|M.smegmatis_MC2_155 LSADAHHLIRAAARAQLTARQKHQARVAALDHAAAHGIVAVHECA-GPEI
MAB_2205|M.abscessus_ATCC_1997 LIGAAHHLLRAHARGAFSAAGRAQARRAALDAAASLGIVSVHECG-GPEI
TH_0643|M.thermoresistible__bu -----------------------------------YGVTGVTDATPGLDV
*:..* :. * ::
Rv2052c|M.tuberculosis_H37Rv GGLDDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLFV
Mb2078c|M.bovis_AF2122/97 GGLDDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLFV
MMAR_3030|M.marinum_M GGLDDWLQLSALPHGVEVIGYWGEAVTTAAQARTLVAETGARGLAGDLFV
MUL_2270|M.ulcerans_Agy99 GGLDDWLQLSALPHGVEVIGYWGEAVTTAAQARTLMAETGARGLAGDLFV
MAV_2445|M.avium_104 GGMDDWLQLRALDHGVEVIGYWGEPVSTATDARALIEATGARGLAGDLFI
Mflv_3116|M.gilvum_PYR-GCK GGLDDWLELRTHDHGVEIVGYWGEHVGTAAAARELIEATGARGLAGDLFV
Mvan_3420|M.vanbaalenii_PYR-1 AGLDDWQELRAHPHGVEVVGYWGEHVATAARARELMETTQARGLAGDLFV
MSMEG_3861|M.smegmatis_MC2_155 GGLDDWLELRALDHGVDVIGLWGEAARDVDHAKALIAETGAYGLAGDLFV
MAB_2205|M.abscessus_ATCC_1997 GGLEDFRELLATEHGVQVTGYWGEPARDPDHAGELVAATGAAGLAGDLFV
TH_0643|M.thermoresistible__bu G---DVVRLTGMNR----RGNLSQRVNCLAPGKRILHDD-----------
. * .* : * .: . . ::
Rv2052c|M.tuberculosis_H37Rv DGALGSRTAWLHEPYADA----PDCIGTCHLDVDGIEAHVRACTKAEVTA
Mb2078c|M.bovis_AF2122/97 DGALGSRTAWLHEPYADA----PDCIGTCHLDVDGIEAHVRACTKAEVTA
MMAR_3030|M.marinum_M DGALGSRTAWLHEPYADQ----PGCVGTCHLDGPAVEAHARACTEAEVTA
MUL_2270|M.ulcerans_Agy99 DGALGSRTAWLHEPYADQ----PGCVGTCHLDGPAVEAHARACTEAEVTA
MAV_2445|M.avium_104 DGALGSRTAWLREPYADA----PDRTGTCYLDPDAVEAHLLACTEAEITA
Mflv_3116|M.gilvum_PYR-GCK DGALGSRTAWLRDPYADIGADCPAPTGNAYLDVDAITAHLNACTEAGVTA
Mvan_3420|M.vanbaalenii_PYR-1 DGALGSRTAWLREPYTDAPEGCPAPTGNSYLGVDEIAAHLGACTEAGVTA
MSMEG_3861|M.smegmatis_MC2_155 DGALGSRTAWLSAPYSDATHTC----GNRYLDQDTVIAHLRACTQAGIPA
MAB_2205|M.abscessus_ATCC_1997 DGALGSRTAWLREPYHDA----PHTCGSRHLDAETVEAHLDSCTRAGITA
TH_0643|M.thermoresistible__bu -----------------------------RLDLTELTEWIATRHAAGGAV
*. : : * ..
Rv2052c|M.tuberculosis_H37Rv GFHVIGDAAVSAAVAAFERVVADLGVVAVARCGHRLEHVEMVTADQAAKL
Mb2078c|M.bovis_AF2122/97 GFHVIGDAAVSAAVAAFERVVADLGVVAVARCGHRLEHVEMVTADQAAKL
MMAR_3030|M.marinum_M GFHVIGDAAVATVVDAFERVVADLGVVAVARCGHRLEHAEMVTAEQAAKL
MUL_2270|M.ulcerans_Agy99 GFHVIGDAAVATVVDAFERVVADLGVVAVARCGHRLEHAEMVTAEQAAKL
MAV_2445|M.avium_104 GFHVIGDAAVAAAVDAFEKVAARLGPVAVARCGHRLEHVEMIDAEQAAKL
Mflv_3116|M.gilvum_PYR-GCK GFHVIGDAATAAVVAALQITVDRFGVAAVARCGHRLEHLEMVTDDQAALL
Mvan_3420|M.vanbaalenii_PYR-1 GFHVIGDAAVAAVTSALQTVVERFGVAAVARCGHRLEHVEMVTPEQAEML
MSMEG_3861|M.smegmatis_MC2_155 GFHVIGDAAVSAVVDALADVVERHGAPTVARCGHRLEHLEMVTAAQAAQL
MAB_2205|M.abscessus_ATCC_1997 GFHVIGDAAVTQVIDALGRVAERHGVPAVARCGHRLEHLEMVSAAQAGQL
TH_0643|M.thermoresistible__bu AIHCVTAAQLVVTLTALRAVGTHP--------QDRIEHAAVVPDDSLEEI
.:* : * . *: . .*:** :: . :
Rv2052c|M.tuberculosis_H37Rv GAWGVIASVQPNFDELWGGGDGMYARRLGAQRGSELNPLALLASQGVPLA
Mb2078c|M.bovis_AF2122/97 GAWGVIASVQPNFDELWGGGDGMYARRLGAQRGSELNPLALLASQGVPLA
MMAR_3030|M.marinum_M GAWGIIASVQPNFDALWGGAEGMYARRLGPKRARLLNPLALLASQGVPLA
MUL_2270|M.ulcerans_Agy99 GAWGIIASVQPNFDARWGGAEGMYARRLGPKRARLLNPLALLASQGVPLA
MAV_2445|M.avium_104 GRWGVIASVQPNFDALWGGADGMYAQRLGAERGSQLNPFALLASQGVPLA
Mflv_3116|M.gilvum_PYR-GCK GSWGVVASMQPAFDALWGGPDGMYARRLGVTRAAGLNPFALLASQGVPLA
Mvan_3420|M.vanbaalenii_PYR-1 GGWGVIASMQPNFDALWGGETGMYAQRLGVERASQLNRFALLASRGVPLA
MSMEG_3861|M.smegmatis_MC2_155 GAWGVTASMQPMFDASWGGDHGMYAQRLGPQRVHQLNPFALLASEGVPLA
MAB_2205|M.abscessus_ATCC_1997 GRLGVIASVQPAFDALWGGPDGMYADRLGADRGTQLNPLALLASQGVPLA
TH_0643|M.thermoresistible__bu AALGLTVVTQPNFIAERGDQ---YRTDVPADEHHELWRLKSLLDAGIPTA
. *: . ** * *. * : . * : * . *:* *
Rv2052c|M.tuberculosis_H37Rv LGSDAPVTGFDPWASVRAAVNHRTPGSGVSARAAFAAATRGGWRAGGVRD
Mb2078c|M.bovis_AF2122/97 LGSDAPVTGFDPWASVRAAVNHRTPGSGVSARAAFAAATRGGWRAGGVRD
MMAR_3030|M.marinum_M FGSDAPVTGFDPWASVRAAVNHHTAGSAVSARAAFAAATRGGWRAAGVRD
MUL_2270|M.ulcerans_Agy99 FGSDAPVTGFDPWASVRAAVNHHTAGSAVSARAAFAAATRGGWRAAGVRD
MAV_2445|M.avium_104 LGSDAPVTGLDPWTSVRAAAHHRTPGSAISVRAAFAAATRGGWRAAGVRD
Mflv_3116|M.gilvum_PYR-GCK FGSDSPVTDMNPWHAVRAATAHRTPGSAISARAAFAAATRGAWRAGGVRD
Mvan_3420|M.vanbaalenii_PYR-1 FGSDTPVTDMNPWATIRAATTHHTPGSAISARAAFAAVTRGAWRAGGTRD
MSMEG_3861|M.smegmatis_MC2_155 FGSDTPVTSMNPWEAVRAAVLHHSPTAAISPRAAFAAATRGGWRAGGVRD
MAB_2205|M.abscessus_ATCC_1997 FGSDAPVTPMNPWVTVRAAAHHRTPSSSVSVRAAFGAATRGGWRAQGVHD
TH_0643|M.thermoresistible__bu LSTDAPFGDADPWAAMRAAVHRTTGSGAVLGADERIDAGTALRMFFGTAD
:.:*:*. :** ::***. : : ..: . . *. *
Rv2052c|M.tuberculosis_H37Rv GRIG--TLVPGAPASYAIWDAGDFDVDAPRDAVQRWSTDPRSRVPALPRL
Mb2078c|M.bovis_AF2122/97 GRIG--TLVPGAPASYAIWDAGDFDVDAPRDAVQRWSTDPRSRVPALPRL
MMAR_3030|M.marinum_M GKTG--TLVPGAPASYAVWDAGALTVSAPRDAVQRWSTDPRSRVPALPRL
MUL_2270|M.ulcerans_Agy99 GKTG--TLVPGAPASYAVWDAGALTVSAPRDAVQRWSTDPRSRVPALPRL
MAV_2445|M.avium_104 GMTG--TLVPGAPASYAVWDAGDLEVSAPRDTVARWSTDPRSRVPALPRL
Mflv_3116|M.gilvum_PYR-GCK GVTG--TLVPGAPASYAVWEADDFEVSAPTDAVQRWSTDPRSRVPVLPVL
Mvan_3420|M.vanbaalenii_PYR-1 GVTG--TLVPGAPATYAIWEADEFEVSAPADAVQRWSTDPRSRVPVLPRL
MSMEG_3861|M.smegmatis_MC2_155 GVSG--TLTPGAPASYAIWDVEELEVSAPANAVQRWSTDPRSRVPALPRL
MAB_2205|M.abscessus_ATCC_1997 GVTG--TLTPGALASYAIWETGDLTINTSQPGVQRWSTDPRSRVPALPDL
TH_0643|M.thermoresistible__bu RPTRPRTVEPGQPADLCVLS-------APPDRVLRELSAELVSATIVG--
*: ** * .: . :. * * : .. :
Rv2052c|M.tuberculosis_H37Rv GPTD-ALPRCRQTVHRGAVIYG
Mb2078c|M.bovis_AF2122/97 GPTD-ALPRCRQTVHRGAVIYG
MMAR_3030|M.marinum_M DPAD-PLPRCRQTVHRGAVIYG
MUL_2270|M.ulcerans_Agy99 DPAD-PLPRCRQTVHRGAVIYG
MAV_2445|M.avium_104 GPTD-ALPRCRRTVHRGAVIHG
Mflv_3116|M.gilvum_PYR-GCK TD---GLPRCRQTVHRGAVLHG
Mvan_3420|M.vanbaalenii_PYR-1 DG---ELPRCRQTVHRGLVLHG
MSMEG_3861|M.smegmatis_MC2_155 ADDA-ALPRCRQTVHRGVVLHG
MAB_2205|M.abscessus_ATCC_1997 SDGAAALPTCLRTVHRGKVIHG
TH_0643|M.thermoresistible__bu -----GKPVYQKPV--------
* :.*