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LIRNAVLIDGTRTDIRVGDTVTEVADDVTAAPGEDEFDAAGGTVLPGLNDHHLHLRAAAAALRSLRVGPD EVRDRAALAGVLAAAVPDQNGWIRAVGYHDSVAGPLTRDLLDAIAPEVPVRIQHRSGVQWTLNTAGLALV GKHDHPDGVLRSADPSWTLPATEPDLEGLGATLSRYGITGVTDATPDLGAGDITELQRRMPQTVRALAPG KRILHDDELDLDALTSWIRHTHSVGVPVALHCVTAAQLVVTLTALRSAGRHPLDRIEHAAVVPDGSVADL ADSGVTVVTQPNFVAERGDQYLVDVPEHEHHELWRVGSLLEAGVPVALSTDAPFGHSDPWAAMRAAVHRR TPSGTVLGPNERITEATALAMFTGNRAGHPGAVVPGAPGDLCILATPPPQALAELDAAAVAATVIAGRVV YER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0443 | - | - | 100% (424) | amidohydrolase 3 |
| M. gilvum PYR-GCK | Mflv_3116 | - | 6e-13 | 29.58% (213) | amidohydrolase 3 |
| M. gilvum PYR-GCK | Mflv_2930 | - | 2e-05 | 23.40% (188) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0567 | - | 4e-14 | 25.98% (512) | hypothetical protein Mb0567 |
| M. tuberculosis H37Rv | Rv0552 | - | 4e-14 | 25.98% (512) | hypothetical protein Rv0552 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2205 | - | 1e-11 | 28.84% (267) | hypothetical protein MAB_2205 |
| M. marinum M | MMAR_0459 | - | 1e-137 | 58.70% (431) | hypothetical protein MMAR_0459 |
| M. avium 104 | MAV_4955 | - | 1e-138 | 60.00% (435) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_0263 | - | 1e-141 | 59.11% (428) | amidohydrolase 3 |
| M. thermoresistible (build 8) | TH_0643 | - | 1e-109 | 63.17% (315) | amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_1109 | - | 1e-128 | 57.07% (417) | hypothetical protein MUL_1109 |
| M. vanbaalenii PYR-1 | Mvan_0224 | - | 1e-166 | 70.02% (427) | amidohydrolase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0567|M.bovis_AF2122/97 -----------------------MADADLVMTGTVLTVDDARPTAEAIAV
Rv0552|M.tuberculosis_H37Rv -----------------------MADADLVMTGTVLTVDDARPTAEAIAV
Mflv_0443|M.gilvum_PYR-GCK ----------------------MLIRNAVLIDGTRTDIRVGDTVTEVA--
Mvan_0224|M.vanbaalenii_PYR-1 ----------------------MLIRRAALLDGTRTDIRVGERITGMA--
MMAR_0459|M.marinum_M ----------------------MLIRRATLLDGSTADIRVCARIQEVG--
MUL_1109|M.ulcerans_Agy99 ---------------------------------------MCARIQEVG--
MAV_4955|M.avium_104 ----------------------MLIQRATLLDGTAADIRVGARIEEVAPA
TH_0643|M.thermoresistible__bu --------------------------------------------------
MSMEG_0263|M.smegmatis_MC2_155 ----------------------MLIQRASLLDGRIADIRVGEAIEDVG--
MAB_2205|M.abscessus_ATCC_1997 MQTRSDALRASGSSRPDALRASGSSRPGALRASGSSQLLINARVYSPSHP
Mb0567|M.bovis_AF2122/97 ADGRVIAVGDRSEVAGLVGA------NTRVIDLGAGCVMPGFVEAHGHPL
Rv0552|M.tuberculosis_H37Rv ADGRVIAVGDRSEVAGLVGA------NTRVIDLGAGCVMPGFVEAHGHPL
Mflv_0443|M.gilvum_PYR-GCK -DDVTAAPGED------------------EFDAAGGTVLPGLNDHHLHLR
Mvan_0224|M.vanbaalenii_PYR-1 -DGLTAEPGET------------------EYDAAGGAVIPGLHDHHIHLR
MMAR_0459|M.marinum_M -QGLVARPGER------------------VLDAAGQTVLPGLHDHHVHLR
MUL_1109|M.ulcerans_Agy99 -QGLVARPGER------------------VLDAAGQTVLPGLHDHHVHLR
MAV_4955|M.avium_104 DDGLAARAGEG------------------VLYAGGGTVLPGLHDHHVHLR
TH_0643|M.thermoresistible__bu --------------------------------------------------
MSMEG_0263|M.smegmatis_MC2_155 -PSLRARRGEA------------------VLDAALGAVIPGLHDHHVHVY
MAB_2205|M.abscessus_ATCC_1997 AATAMAVTGDVISWIGEDDLGRAEFPDAEIVDLEGAFVAPAFVDAHVHVT
Mb0567|M.bovis_AF2122/97 LEAVVLSDRFVDIRPVTMR-DADDVVAAIR--------------------
Rv0552|M.tuberculosis_H37Rv LEAVVLSDRFVDIRPVTMR-DADDVVAAIR--------------------
Mflv_0443|M.gilvum_PYR-GCK -------AAAAALRSLRVGPDEVRDRAALA--------------------
Mvan_0224|M.vanbaalenii_PYR-1 -------AAAAALHSVRVGPDEVHSRAELA--------------------
MMAR_0459|M.marinum_M -------SAASALDSLTLGPPTVDSKEKFR--------------------
MUL_1109|M.ulcerans_Agy99 SHHVHLRSAASAVDSLTLGPPTVDSKEKFR--------------------
MAV_4955|M.avium_104 -------SAASALDSFFVGPPGVSTRAELT--------------------
TH_0643|M.thermoresistible__bu --------------------------------------------------
MSMEG_0263|M.smegmatis_MC2_155 -------SAAAEQNSLRVGPREAHDTGELR--------------------
MAB_2205|M.abscessus_ATCC_1997 ALG--LSLIGLDLSDVTAREQCLDRLAAYAREHPNEVIWGHGWDESRWPD
Mb0567|M.bovis_AF2122/97 ------GEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLV--
Rv0552|M.tuberculosis_H37Rv ------GEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLV--
Mflv_0443|M.gilvum_PYR-GCK ------GVLAAAVPDQNGWIRAVGYHDSVAGPLTRDLLDAIAPEVPVR--
Mvan_0224|M.vanbaalenii_PYR-1 ------ETLAAATVGADGWIRAVGYHDAAAGPLDRHVLDELAPSVPVR--
MMAR_0459|M.marinum_M ------QHLSSAQPGPDGWIRAVGYHESVAGPLDRTVLDALVPHLPVR--
MUL_1109|M.ulcerans_Agy99 ------QHLSSAQPGPDGWIRAVGYHEAVAGPLDRTVLDALVPHLPVR--
MAV_4955|M.avium_104 ------RLLANATPGPDGWIRAVGYHDSVAGALDRTALDAIVRDVPVR--
TH_0643|M.thermoresistible__bu --------------------------------------------VPVR--
MSMEG_0263|M.smegmatis_MC2_155 ------RLLAGAAPGADGWIRAIGYHEQVAGPLDRDRLDALAPAVPVR--
MAB_2205|M.abscessus_ATCC_1997 GRPLTTTELDTAASGRAVYLARIDVHSAAASTALRQQVPGLAEAAGFHPE
.
Mb0567|M.bovis_AF2122/97 ---IIHNSGHKAYFNSHAAWLNGLTRDTADPKGAKYGRDGNGELDGTAEE
Rv0552|M.tuberculosis_H37Rv ---IIHNSGHKAYFNSHAAWLNGLTRDTADPKGAKYGRDGNGELDGTAEE
Mflv_0443|M.gilvum_PYR-GCK ---IQHRSGVQWTLNTAGLALVGKH-DHPDGVLRSADPSWTLPA--TEPD
Mvan_0224|M.vanbaalenii_PYR-1 ---IQHRSGAQWILNTAALRRVGLA-DHPDGRLPSADGSWAATLR-SDPG
MMAR_0459|M.marinum_M ---VQHRSGALWILNSAALNRIGLA-GHVDGRLRSADSDWSDALPRRKTD
MUL_1109|M.ulcerans_Agy99 ---VQHRSGALWILNSAALNRIGLA-GHVDGRLRSADSDWSDALPRRKTD
MAV_4955|M.avium_104 ---IQHRSGALWILNSEALGRIGLA-EHPDGRLRSADRGWSQALAHRETD
TH_0643|M.thermoresistible__bu ---VQHRSGVLWTLNSAGLARIGMP-DHPDGRLRSADPDWSNSLQRRETR
MSMEG_0263|M.smegmatis_MC2_155 ---VQHRSGVLWVLNSAGLAAINRP-DHPDGILRSADPTWAEALPRRDTD
MAB_2205|M.abscessus_ATCC_1997 WPLIGAAHHLLRAHARGAFSAAGRAQARRAALDAAASLGIVSVHECGGPE
: . . .
Mb0567|M.bovis_AF2122/97 IGAILPLLAGVADPSNFGAMLRAECARLNRAGLTTCSEMAFDPGYRPMVE
Rv0552|M.tuberculosis_H37Rv IGAILPLLAGVADPSNFGAMLRAECARLNRAGLTTCSEMAFDPGYRPMVE
Mflv_0443|M.gilvum_PYR-GCK LEGLG--------------------ATLSRYGITGVTDATPD--------
Mvan_0224|M.vanbaalenii_PYR-1 LDELG--------------------ALLCRYGVTGVTDATPD--------
MMAR_0459|M.marinum_M LAALG--------------------DRLTAAGVTGVTDATPD--------
MUL_1109|M.ulcerans_Agy99 LAELG--------------------DRLTAAGVTGVTDATPD--------
MAV_4955|M.avium_104 LAELS--------------------RRITATGVTGVTDATPD--------
TH_0643|M.thermoresistible__bu IADLS--------------------AELTRYGVTGVTDATPG--------
MSMEG_0263|M.smegmatis_MC2_155 IDSYA--------------------ERLARYGITGITDATPD--------
MAB_2205|M.abscessus_ATCC_1997 IGGLEDFR-----------ELLATEHGVQVTGYWGEPARDPD--------
: : * . .
Mb0567|M.bovis_AF2122/97 AVRAELTVRLCTYEISNARMCTDATPGQGDDMLRQVGIKIWVDGSPWVGN
Rv0552|M.tuberculosis_H37Rv AVRAELTVRLCTYEISNARMCTDATPGQGDDMLRQVGIKIWVDGSPWVGN
Mflv_0443|M.gilvum_PYR-GCK --------------LGAGDITELQR-----RMPQTV--RALAPGKRILHD
Mvan_0224|M.vanbaalenii_PYR-1 --------------LAAGDVAALQR-----EMRQRV--RCLAPGKRILHD
MMAR_0459|M.marinum_M --------------LSDEDMAALTVAHQRGEFRPRV--RFLSPGKKILRD
MUL_1109|M.ulcerans_Agy99 --------------LSDEDMAALTVAHQRGEFRPRV--RFLSPGKKILRD
MAV_4955|M.avium_104 --------------LDDDDRAALAAAHARGEFRPRP--SFLSPGKKILHD
TH_0643|M.thermoresistible__bu --------------LDVGDVVRLTGMNRRGNLSQRV--NCLAPGKRILHD
MSMEG_0263|M.smegmatis_MC2_155 --------------LSEPP----------RGLPQHL--HVLAPGKKILHD
MAB_2205|M.abscessus_ATCC_1997 --------------HAGELVAATGAAGLAGDLFVDG---ALGSRTAWLRE
: . : :
Mb0567|M.bovis_AF2122/97 IDLTFPYLDTPATRAIGVPPGSRGCANYTREQLAEIVGAYFPRGWQIACH
Rv0552|M.tuberculosis_H37Rv IDLTFPYLDTPATRAIGVPPGSRGCANYTREQLAEIVGAYFPRGWQIACH
Mflv_0443|M.gilvum_PYR-GCK DELDL-------------------------DALTSWIRHTHSVGVPVALH
Mvan_0224|M.vanbaalenii_PYR-1 DELDP-------------------------DELSRWIGDRHAEGFPVAVH
MMAR_0459|M.marinum_M DHLDL-------------------------EALMAWITDSHGAGQPVAIH
MUL_1109|M.ulcerans_Agy99 DHLDL-------------------------ETLMAWITDSHGAGQPVAIH
MAV_4955|M.avium_104 DRLNL-------------------------DALTEWVAGQHDTGQPVAVH
TH_0643|M.thermoresistible__bu DRLDL-------------------------TELTEWIATRHAAGGAVAIH
MSMEG_0263|M.smegmatis_MC2_155 DMLDL-------------------------DGLVTWIGERHARGVPVAVH
MAB_2205|M.abscessus_ATCC_1997 PYHDAPHTCG--------------SRHLDAETVEAHLDSCTRAGITAGFH
: : * . *
Mb0567|M.bovis_AF2122/97 VHGDGGVDTILDVYEEALRRNPRDDHR---LRLEHVGAIRPDQLRRAAEL
Rv0552|M.tuberculosis_H37Rv VHGDGGVDTILDVYEEALRRNPRDDHR---LRLEHVGAIRPDQLRRAAEL
Mflv_0443|M.gilvum_PYR-GCK CVTAAQLVVTLTALRSAG-RHPLD-------RIEHAAVVPDGSVADLADS
Mvan_0224|M.vanbaalenii_PYR-1 CVTAAQLVVTLEALRSSG-THPLD-------RIEHAAVVPDGSLADLAGR
MMAR_0459|M.marinum_M CVTAAQLVVTIAAVRAVG-RHPHD-------RIEHAAVVPDDLVADLAGL
MUL_1109|M.ulcerans_Agy99 CVTAAQLVVTIAAVRAVG-RHPHD-------RIEHAAVVPDDLVADLAGL
MAV_4955|M.avium_104 CVTAAQLVVAIAALRAAG-THPRD-------RIEHAAVVPDDNLADLAEL
TH_0643|M.thermoresistible__bu CVTAAQLVVTLTALRAVG-THPQD-------RIEHAAVVPDDSLEEIAAL
MSMEG_0263|M.smegmatis_MC2_155 CVTSAQLVVTIAAMRVTG-VLPGD-------RIEHAAMVPEDCVRDLCEL
MAB_2205|M.abscessus_ATCC_1997 VIGDAAVTQVIDALGRVAERHGVPAVARCGHRLEHLEMVSAAQAGQLGRL
. : : . *:** :
Mb0567|M.bovis_AF2122/97 GVTCSIFVDQIHYWG--DVIVDDLFGAQRGSRWMPAGSAVAAGMRISLHN
Rv0552|M.tuberculosis_H37Rv GVTCSIFVDQIHYWG--DVIVDDLFGAQRGSRWMPAGSAVAAGMRISLHN
Mflv_0443|M.gilvum_PYR-GCK GVTVVTQPNFVAERG--DQYLVDVPEHEHHELWR-VGSLLEAGVPVALST
Mvan_0224|M.vanbaalenii_PYR-1 AVTVVTQPNFVAERG--DQYLADVAPAEQPELWR-VASLLRAGVPVALST
MMAR_0459|M.marinum_M GLTVVTQPNFVAERG--DQYLDEIPAAEHGQLWR-VASLLNANVPVAFST
MUL_1109|M.ulcerans_Agy99 GLTVVTQPNFVAERG--DQYLDEIPAAEHGQLWR-VASLLNANVPVALST
MAV_4955|M.avium_104 GVTVVTQPNFVAERG--DQYLAEVPADEHDQLWR-LASLRDARVPVALST
TH_0643|M.thermoresistible__bu GLTVVTQPNFIAERG--DQYRTDVPADEHHELWR-LKSLLDAGIPTALST
MSMEG_0263|M.smegmatis_MC2_155 GVTVVTQPNFVTERG--DAYRSDVDAADHHQLWR-VATLLAAGVRVALST
MAB_2205|M.abscessus_ATCC_1997 GVIASVQPAFDALWGGPDGMYADRLGADRGTQLNPLALLASQGVPLAFGS
.: * * : :: : :: .
Mb0567|M.bovis_AF2122/97 DPPVTPEEPLRNISVAATRVAPSGRVLAPEER-LTVEQAIRAQTIDAAWQ
Rv0552|M.tuberculosis_H37Rv DPPVTPEEPLRNISVAATRVAPSGRVLAPEER-LTVEQAIRAQTIDAAWQ
Mflv_0443|M.gilvum_PYR-GCK DAPFGHSDPWAAMRAAVHRRTPSGTVLGPNER-ITEATALAMFTGN--RA
Mvan_0224|M.vanbaalenii_PYR-1 DAPFGDADPWAAMRAAVFRRTPAGHVLGEAEC-VPASAALQMFLGDPGRP
MMAR_0459|M.marinum_M DLPFGSGDPWAAMRAAVHRRTPRGVVLGVDEC-VTARAALTMFLGRPDQP
MUL_1109|M.ulcerans_Agy99 DLPFGSGDPWAPMRAAVHRRTPRGVVLGVDEC-VTARAALTMFLGRPDQP
MAV_4955|M.avium_104 DMPFGHGDPWTAMRAAVHRTTPSGVVLGAREC-VSARTALTMFLGRADQP
TH_0643|M.thermoresistible__bu DAPFGDADPWAAMRAAVHRTTGSGAVLGADER-IDAGTALRMFFGTADRP
MSMEG_0263|M.smegmatis_MC2_155 DAPFGDADPWAVMRAAVHRRTPHGFVLNPAER-IPPRTALELFFGTAQDP
MAB_2205|M.abscessus_ATCC_1997 DAPVTPMNPWVTVRAAAHHRTPSSSVSVRAAFGAATRGGWRAQGVHDGVT
* *. :* : .*. : : . * .
Mb0567|M.bovis_AF2122/97 LFAED-AIGSLQVGKYADMVVLSADP------------RTVPPEQIADLA
Rv0552|M.tuberculosis_H37Rv LFAED-AIGSLQVGKYADMVVLSADP------------RTVPPEQIADLA
Mflv_0443|M.gilvum_PYR-GCK GHPG-----AVVPGAPGDLCILATPP------------PQALAELDAAAV
Mvan_0224|M.vanbaalenii_PYR-1 ATPR-----RVEPGAAADLCILSTPP------------EATLAELDAAAV
MMAR_0459|M.marinum_M GRVR-----AVAAGQPGDLCVLAQTP------------AMVLTELDASLV
MUL_1109|M.ulcerans_Agy99 GRVR-----AVAAGQPGDLCVLAQTP------------AVVLTELDASLV
MAV_4955|M.avium_104 DRVR-----SVQPGEPGDLCVLNEPP------------HTALAELDAGMV
TH_0643|M.thermoresistible__bu TRPR-----TVEPGQPADLCVLSAPP------------DRVLRELSAELV
MSMEG_0263|M.smegmatis_MC2_155 AHPR-----RVDVGQPGDLCVLAAPP------------RQVVETLDADLV
MAB_2205|M.abscessus_ATCC_1997 GTLTPGALASYAIWETGDLTINTSQPGVQRWSTDPRSRVPALPDLSDGAA
.*: : * . .
Mb0567|M.bovis_AF2122/97 VR----ATFLAGRQVYRR--
Rv0552|M.tuberculosis_H37Rv VR----ATFLAGRQVYRR--
Mflv_0443|M.gilvum_PYR-GCK A-----ATVIAGRVVYER--
Mvan_0224|M.vanbaalenii_PYR-1 A-----ATVIGGEVVYQRG-
MMAR_0459|M.marinum_M S-----ATIIGGEVAYAA--
MUL_1109|M.ulcerans_Agy99 S-----ATIIGGEVAYAA--
MAV_4955|M.avium_104 A-----ATIIGGELVYFAM-
TH_0643|M.thermoresistible__bu S-----ATIVGGKPVYQKPV
MSMEG_0263|M.smegmatis_MC2_155 A-----ATIIGGSVVFSR--
MAB_2205|M.abscessus_ATCC_1997 ALPTCLRTVHRGKVIHG---
*. * .