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FAWWGRTVYQYRYIVIGVMVALCLGGGVYGISLGQHVTQSGFYDDGSQSVHASVVSDEVYGRDRTSHVVA ILTPPDGEKVDNPEWMEKVTGELNDVVAEHEDRIVSWVGWLRAPDSTAETVQQMKTADGSKTFVSIPLKG DDDDEILKNYQAVEPDLLKINDGNIKLAGLQPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGGVIAA TLPAIIGGLTIAGALGIMRIFAEFMPVHFFAQPVVTLMGLGIAIDYGLFMVSRFREEIAEGYDTEAAVRR TVMTSGRTVMFSAVILVASSVPLLLFPQGFLKSITYAIIASVMLAAILSVTVLPAAFSILGRNVDALGVR TLLRVPFFRNWKPMRVYLEWLAEKTQKTKTRAEVEKGFWGRLVNVVMKRPIAFAAPILIVMILLVIPLGQ LALGGISEKYLPPDNSVRIAQEDFDRTFPTFRTEPLTLVLERQDGQPVTDQQLAEVRAKAMTFSGFIEDN NDPTKMWQERAAQDSGTKDPSVRVIQNGLVDRNDASQKIEELRSIQPPRGVQISVGGTPALEQDSIHSLF DKLPLMVLVLIVTTTVLMFLAFGSIVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPM IGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALVLAVVAGAFVFSDLVMM KYLAFGLLIALLLDATIIRMFLVPAIMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRENPAP AEALVGAGGPPVAAPPRPLPPHDPTHPAPGGRPPGATTRMTAPPRAGDPSAAGTTRLPSAPPRPPAAPEE EPQTTRLSIAKNAVRNAVSTAAAAAQRATERPASGPPAPPAPSAPPAREDREIESWLGDLRGSRASGTAA ANPPQPLRPSAEPTRAMPDTGAAGNEPTTAIPAQRESERHRESARHDDSDDSAASTRAIPTARQSDADAA TEKLNTRPDDEATRRGGKGLSAQDLLRREGRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0196 | - | - | 100% (1013) | large membrane protein |
| M. vanbaalenii PYR-1 | Mvan_1197 | - | e-102 | 32.85% (755) | hypothetical protein Mvan_1197 |
| M. vanbaalenii PYR-1 | Mvan_4573 | - | 9e-94 | 29.64% (786) | MMPL domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0212c | mmpL3 | 0.0 | 61.93% (1027) | transmembrane transport protein MmpL3 |
| M. gilvum PYR-GCK | Mflv_0456 | - | 0.0 | 79.39% (684) | RND superfamily drug efflux protein |
| M. tuberculosis H37Rv | Rv0206c | mmpL3 | 0.0 | 62.12% (1027) | transmembrane transport protein MmpL3 |
| M. leprae Br4923 | MLBr_02620 | - | 0.0 | 58.46% (1028) | hypothetical protein MLBr_02620 |
| M. abscessus ATCC 19977 | MAB_4508 | - | 0.0 | 54.25% (1071) | putative membrane protein, MmpL |
| M. marinum M | MMAR_0446 | mmpL3 | 0.0 | 59.88% (1032) | transmembrane transport protein MmpL3 |
| M. avium 104 | MAV_4968 | - | 0.0 | 59.22% (1030) | MmpL3 protein |
| M. smegmatis MC2 155 | MSMEG_0250 | - | 0.0 | 74.78% (1035) | membrane protein, MmpL family protein |
| M. thermoresistible (build 8) | TH_4488 | - | 0.0 | 77.41% (810) | PUTATIVE membrane protein, MmpL family protein |
| M. ulcerans Agy99 | MUL_1096 | mmpL3 | 0.0 | 59.69% (1032) | transmembrane transport protein MmpL3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0196|M.vanbaalenii_PYR-1 MFAWWGRTVYQYRYIVIGVMVALCLGGGVYGISLGQHVTQSGFYDDGSQS
Mflv_0456|M.gilvum_PYR-GCK MFAWWGRTVYQYRYIVIGVMVALCLGGGVYGMSLGQHVTQSGFYDEGSQS
MSMEG_0250|M.smegmatis_MC2_155 MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQS
TH_4488|M.thermoresistible__bu VFAWWGRMVYRYRYIVIGVMVALCLGGGVYGISLGDHVTQSGFYDEGSES
MMAR_0446|M.marinum_M MFAWWGRTVYRYRFIVIGVTVALCLGGGVFGLSLGKHVTQSGFYDEGSQS
MUL_1096|M.ulcerans_Agy99 MFAWWGRTVYRYRFIVIGVTVALCLGGGVFGLSLGKHVTQSGFYDEGSQS
MLBr_02620|M.leprae_Br4923 MFAWWGRTVYRYRFIVIGITVALCLCGGVFGLSLGKHVTQSGFYDDSSQS
MAV_4968|M.avium_104 --------MYRYRYIVIGVTVALCLLGGVFGISLGKHVTQSGFYDDASQS
Mb0212c|M.bovis_AF2122/97 MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFYDDGSQS
Rv0206c|M.tuberculosis_H37Rv MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFYDDGSQS
MAB_4508|M.abscessus_ATCC_1997 MFAWWGRMVYRYRFIVVAAFVTVCLGSGLFGITLGDHVTQSGFFADNSES
:*::*:**:. *::** .*::*::**.*******: : *:*
Mvan_0196|M.vanbaalenii_PYR-1 VHASVVSDEVYGRDRTSHVVAILTPPDGEKVDNPEWMEKVTGELNDVVAE
Mflv_0456|M.gilvum_PYR-GCK VHASLVSDEAYGRDRTSHVVAILTPPDGEKVDNPEWMEKVTGELNDLVAE
MSMEG_0250|M.smegmatis_MC2_155 VAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKD
TH_4488|M.thermoresistible__bu VAASVLADEVYGRDRASHVVAILTPPEGKKVNDPEWMDRTIEELDGLVEA
MMAR_0446|M.marinum_M VTASILGDEVYGRDRTGHIVAVFKAPDGKTVNDPAWSKKITDQLNQFVKD
MUL_1096|M.ulcerans_Agy99 VTASILGDEVYGRDRTGHIVAVFKAPDGKTVNDPAWSKKITDQLNQFVKD
MLBr_02620|M.leprae_Br4923 VKASILGDQVYGRDRSGHIVAIFHAPDGKTVNDPAWAKKITDELNQFQRN
MAV_4968|M.avium_104 VKASVLGDQTYGRDRTSHVVATFTTPDGKTVDDAGWRDKVVAELNKFKAD
Mb0212c|M.bovis_AF2122/97 VQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQD
Rv0206c|M.tuberculosis_H37Rv VQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQD
MAB_4508|M.abscessus_ATCC_1997 VKASVMADDALGRDRTTHVVAVIAAPEGKTVDDPAFQKKVIDHFDQLQKD
* **::.*:. ****: *:** : .* .:.* : : .: .:: .
Mvan_0196|M.vanbaalenii_PYR-1 HEDRIVSWVGWLRAPDSTAETVQQMKTADGSKTFVSIPLKGDDDDEILKN
Mflv_0456|M.gilvum_PYR-GCK NEDRIVSWVGWLRAPDAAAETVQQMKTEDLSKTFVSIPLKGENDDEILKN
MSMEG_0250|M.smegmatis_MC2_155 HEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKN
TH_4488|M.thermoresistible__bu ESDRIVDWVGWLKAPDVDNEVVQRMRSEDYSQTFISIPLKGDDDDEILLN
MMAR_0446|M.marinum_M HPDQVLGWAGYLRAPDSTSPVIKGMATDDKKYTFVSIPLKGDDDDTILNN
MUL_1096|M.ulcerans_Agy99 HPDQVLGWAGYLRAPDSTSPVIKGMATDDKKYTFVSIPLKGDDDDTILNN
MLBr_02620|M.leprae_Br4923 NSNKVTGWAGYLRASDTTNTVVQGMATPDKKYTFVSIPLKGDDDDTILNN
MAV_4968|M.avium_104 HPDQVVGWAGWLAAPDSTNPVIKGMVSEDKKHTFVSIPLKGDDDDTILNN
Mb0212c|M.bovis_AF2122/97 HPDQVLGWAGYLRASQAT-----GMATADKKYTFVSIPLKGDDDDTILNN
Rv0206c|M.tuberculosis_H37Rv HPDQVLGWAGYLRASQAT-----GMATADKKYTFVSIPLKGDDDDTILNN
MAB_4508|M.abscessus_ATCC_1997 NPDEVYGWAGWLRAPTTTDPTVKRMVTEDRKHTFVSVSLKGDDDDTILNN
. :.: .*.*:* *. * : * **:*:.*:*::** ** *
Mvan_0196|M.vanbaalenii_PYR-1 YQAVEP---------DLLKINDGNIKLAGLQPLASELTGTIGEDQKRAEV
Mflv_0456|M.gilvum_PYR-GCK YQAIEP---------QLSQVNDGGIQLAGLQPLASELTGTIGEDQKRAEV
MSMEG_0250|M.smegmatis_MC2_155 YQVVEP---------ELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEV
TH_4488|M.thermoresistible__bu YQAIEP---------DLRSLNDGNIELAGLNPLASELTGTIAVDQRRAEV
MMAR_0446|M.marinum_M YKDIAP---------SLQKLDGGTVQLAGLEPVAEGLTGTIATDQRRMEV
MUL_1096|M.ulcerans_Agy99 YKDIAP---------SLQKLDGGTVQLAGLEPVAEGLIGTIATDQRRMEV
MLBr_02620|M.leprae_Br4923 YKAIAP---------DLQKLDGGTVQLAGLDPIANALTSTIATDQRRMEV
MAV_4968|M.avium_104 YKAIAP---------DMQKLNGGAVQLAGLEPIANALTGTIATDQRRMEV
Mb0212c|M.bovis_AF2122/97 YKAIAP---------DLQRLDGGTVKLAGLQPVAEALTGTIATDQRRMEV
Rv0206c|M.tuberculosis_H37Rv YKAIAP---------DLQRLDGGTVKLAGLQPVAEALTGTIATDQRRMEV
MAB_4508|M.abscessus_ATCC_1997 YKALSNPDKDDDPAKNKFLMDGVDIQLAGLQPVASELTGTIGKDQQRMEV
*: : . ::. :.****:*:*. * .**. **:* **
Mvan_0196|M.vanbaalenii_PYR-1 AAIPLVAVVLFFVFGGVIAATLPAIIGGLTIAGALGIMRIFAEFMPVHFF
Mflv_0456|M.gilvum_PYR-GCK AAIPLVCVVLFFVFGGVIAAALPGIIGGLTIAGALGIMRVFAEFMPVHFF
MSMEG_0250|M.smegmatis_MC2_155 AAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFF
TH_4488|M.thermoresistible__bu AAIPLVAVLLFFVFGGVVAALLPALIGGLSIAGALGIMRLVAEFGPVHFF
MMAR_0446|M.marinum_M LALPLVAVVLFLVFGGAVAACLPVMVGGLSIAGALGILRLVAVFGPVHFF
MUL_1096|M.ulcerans_Agy99 LALPLVAVVLFLVFGGAVAACLPVMVGGLSIAGALGILRLVAVFGPVHFF
MLBr_02620|M.leprae_Br4923 LALPLVAVVLFLVFGGVIAACLPVMVGGLSIAGALGILRFIALFGPVHFF
MAV_4968|M.avium_104 LAVPMVAVVLFLVFGGAVAAGLPAIVGGLSIAGSLGILRLVAVFGPVHYF
Mb0212c|M.bovis_AF2122/97 LALPLVAVVLFFVFGGVIAAGLPVMVGGLCIAGALGIMRFLAIFGPVHYF
Rv0206c|M.tuberculosis_H37Rv LALPLVAVVLFFVFGGVIAAGLPVMVGGLCIAGALGIMRFLAIFGPVHYF
MAB_4508|M.abscessus_ATCC_1997 LSLPVMAVVLFFVFGGVIAAGLPLMVGGLTIAGALGIMRLVTLFAPVHFF
::*::.*:**:*** .:** ** ::*** ***:***:*..: * ***:*
Mvan_0196|M.vanbaalenii_PYR-1 AQPVVTLMGLGIAIDYGLFMVSRFREEIAEGYDTEAAVRRTVMTSGRTVM
Mflv_0456|M.gilvum_PYR-GCK AQPVVTLMGLGIAIDYGLFMVSRFREEIAEGYDTEAAVRRAVMTSGRTVM
MSMEG_0250|M.smegmatis_MC2_155 AQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVV
TH_4488|M.thermoresistible__bu AQPVVTLIGLGIAIDYGLFIVSRFREELAEGYDTEQAVRRSVMTSGRTVI
MMAR_0446|M.marinum_M AQPVVSLIGLGIAVDYGLFVVSRFREEIAEGYDTETAVRRTVMTAGRTVA
MUL_1096|M.ulcerans_Agy99 AQPVVSLIGLGIAVDYGLFVVSRFREEIAEGYDTETAVRRTVMTAGRTVA
MLBr_02620|M.leprae_Br4923 AQPVVSLIGLGIAVDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVT
MAV_4968|M.avium_104 AQPVVSLIGLGIAIDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVT
Mb0212c|M.bovis_AF2122/97 AQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRRTVITAGRTVT
Rv0206c|M.tuberculosis_H37Rv AQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRRTVITAGRTVT
MAB_4508|M.abscessus_ATCC_1997 AQPVVTLIGLGIAIDYSLFIVSRFREEIAEGYDTETAVRRTVITSGRTVM
*****:*:*****:**.**:*******:******* ****:*:*:****
Mvan_0196|M.vanbaalenii_PYR-1 FSAVILVASSVPLLLFPQGFLKSITYAIIASVMLAAILSVTVLPAAFSIL
Mflv_0456|M.gilvum_PYR-GCK FSAVILVASSVPLLLFPQGFLKSITYAIIASVMLAAILSVTVLPAALAIL
MSMEG_0250|M.smegmatis_MC2_155 FSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAIL
TH_4488|M.thermoresistible__bu FSAVIIVASALPLLLFPQGFLKSITYAIIASVMLSSILSITVLAAILGIL
MMAR_0446|M.marinum_M FSAVLIMASGASLLMLPQGFVKSLTYALLAAVGLAALLSITLLPACLGVL
MUL_1096|M.ulcerans_Agy99 FSAVLIMASGASLLMLPQGFVKSLTYALLAAVGLAALLSITLLPACLGVL
MLBr_02620|M.leprae_Br4923 FSAVLIAASGASLLLLPQGFVKSLTYALIAAVTLAALLSITLLPACLAIL
MAV_4968|M.avium_104 FSAVLIIASSASLLVLPQGFVHSLTYAIFAAVGLAALLSITFLPACLGIL
Mb0212c|M.bovis_AF2122/97 FSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLGIL
Rv0206c|M.tuberculosis_H37Rv FSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLGIL
MAB_4508|M.abscessus_ATCC_1997 FSATLIAAALMPMLIVPQQFLRSLTYAGIASVLLAAILAVTVLPACLGVL
***.:: *: :*:.** *::*:*** :*:* *:::*::*.*.* :.:*
Mvan_0196|M.vanbaalenii_PYR-1 GRNVDALGVRTLLRVP--------------------------------FF
Mflv_0456|M.gilvum_PYR-GCK GPRVDALGVRWLLKFVNNEVSSDPSNTRTNQFAIASIPAGLLLPPVGIFL
MSMEG_0250|M.smegmatis_MC2_155 GPRVDALGVTTLLKIP--------------------------------FL
TH_4488|M.thermoresistible__bu GPNVDALGVRTLLRVPFLRD------------------------------
MMAR_0446|M.marinum_M GRHVDALGVRTAFRVPFLRN------------------------------
MUL_1096|M.ulcerans_Agy99 GRHVDALGVRTAFRVPFLRN------------------------------
MLBr_02620|M.leprae_Br4923 AKHVDALGVRTLFRVPLLRN------------------------------
MAV_4968|M.avium_104 GRHVDALGVRTAFRVPFLRN------------------------------
Mb0212c|M.bovis_AF2122/97 GKHVDALGVRTLFRVPFLAN------------------------------
Rv0206c|M.tuberculosis_H37Rv GKHVDALGVRTLFRVPFLAN------------------------------
MAB_4508|M.abscessus_ATCC_1997 GRHVDALSIK----------------------------------------
. .****.:
Mvan_0196|M.vanbaalenii_PYR-1 RN------------------------------------------------
Mflv_0456|M.gilvum_PYR-GCK GHRARKQIRQTGEQGLPLTMIGLALGYVGLLGWIAYLAIANRESLGDGLY
MSMEG_0250|M.smegmatis_MC2_155 AN------------------------------------------------
TH_4488|M.thermoresistible__bu --------------------------------------------------
MMAR_0446|M.marinum_M --------------------------------------------------
MUL_1096|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02620|M.leprae_Br4923 --------------------------------------------------
MAV_4968|M.avium_104 --------------------------------------------------
Mb0212c|M.bovis_AF2122/97 --------------------------------------------------
Rv0206c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4508|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0196|M.vanbaalenii_PYR-1 --------------------------WKPMRVYLEWLAEKTQKTKTRAEV
Mflv_0456|M.gilvum_PYR-GCK WVLIGVVIFVAVVAGGLALARYVPLARGPIVWWVEWLAEKTQKTKTRAEV
MSMEG_0250|M.smegmatis_MC2_155 --------------------------WQFSRRIIDWFAEKTQKTKTREEV
TH_4488|M.thermoresistible__bu --------------------------WPFSRRIIDWFAEKTQKTKTRAEV
MMAR_0446|M.marinum_M --------------------------WKVSRAYLNWLADRLQKTKTREEV
MUL_1096|M.ulcerans_Agy99 --------------------------WKVSRAYLNWLADRLQKTKTREEV
MLBr_02620|M.leprae_Br4923 --------------------------WRMSHACLNWLADRLQKTKTREEV
MAV_4968|M.avium_104 --------------------------WKYSRAYLNWLADRLQKTKTREEV
Mb0212c|M.bovis_AF2122/97 --------------------------WKISAAYLNWLADRLQRTKTREEV
Rv0206c|M.tuberculosis_H37Rv --------------------------WKISAAYLNWLADRLQRTKTREEV
MAB_4508|M.abscessus_ATCC_1997 ---------------------------------------RFSRTKSREEL
: .:**:* *:
Mvan_0196|M.vanbaalenii_PYR-1 EKGFWGRLVNVVMKRPIAFAAPILIVMILLVIPLGQLALGGISEKYLPPD
Mflv_0456|M.gilvum_PYR-GCK EKGFWGKLVNVVMKRPIAFAAPILIGMILLILPLGQLALGGISEKYLPPD
MSMEG_0250|M.smegmatis_MC2_155 ERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPD
TH_4488|M.thermoresistible__bu ERGFWGKLVNVVMKRPVTFMVPILILMILMIIPIGQLSLGGISEKYLPPN
MMAR_0446|M.marinum_M EAGFWGNLTNRVMRRPLVFAIPIVLGMILLVIPLFNLSLGGMSEKYLPPN
MUL_1096|M.ulcerans_Agy99 EAGFWGNLTNRVMRRPLVFAIPIVLGMILLVIPLFNLSLGGMSEKYLPPN
MLBr_02620|M.leprae_Br4923 EAGFWGKLVNFVMKRPLVFAIPIVIGMILLVIPLGNLSFGGMSEKYLPPN
MAV_4968|M.avium_104 EAGFWGKLVNWVMRKPLAFAIPIAVGMILLVIPLGNLSFGGMSEKYLPPN
Mb0212c|M.bovis_AF2122/97 EAGIWGKLVNRVMKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPT
Rv0206c|M.tuberculosis_H37Rv EAGFWGKLVNRVMKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPT
MAB_4508|M.abscessus_ATCC_1997 ENGFWGRTVVYVMQRPLVFAVPIVIVMLLLIIPLGNLKLGGFSEKYLPPT
* *:**. . **::*: * ** : *:*:::*: :* :**:*******
Mvan_0196|M.vanbaalenii_PYR-1 NSVRIAQEDFDRTFPTFRTEPLTLVLERQDGQPVTDQQLAEVRAKAMTFS
Mflv_0456|M.gilvum_PYR-GCK NGVRTAQEDFDRTFPGFRTEPLTLVIERQDGEPVTDQQLAEVRAKAMTVP
MSMEG_0250|M.smegmatis_MC2_155 NAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVS
TH_4488|M.thermoresistible__bu NSVRQAQEHFDRDFPTFRTEPLTLVMRSTNGEPITDQQIAEMRAKAMTLS
MMAR_0446|M.marinum_M NAVRQSQEHFDQLFPGYRTNPLTLVIKSTNNQPVTDQQIADIRSKAMSIS
MUL_1096|M.ulcerans_Agy99 NAVRQSQEHFDQLFPGYRTNPLTLVIKSTNNQPVTDQQIADIRSKAMSIS
MLBr_02620|M.leprae_Br4923 NAVRQSQEHFDQLFPGYRTNPLTLVIQTSNHQPVTDQEIADIRSKAMAIS
MAV_4968|M.avium_104 NPVRLAQEHFDKQFPGYRTEQLTVVIQSDNHSKVTDQQVADIRNRISGIG
Mb0212c|M.bovis_AF2122/97 NSVRQAQEEFDKLFPGYRTNPLTLVIQTSNHQPVTEAQIADIRSKAMAIG
Rv0206c|M.tuberculosis_H37Rv NSVRQAQEEFDKLFPGYRTNPLTLVIQTSNHQPVTDAQIADIRSKAMAIG
MAB_4508|M.abscessus_ATCC_1997 NSVRQAQENFDSLFPGFRTETITIVTKG-----ATDSQLNQIRADAMKVP
* ** :**.** ** :**: :*:* . *: :: ::* .
Mvan_0196|M.vanbaalenii_PYR-1 GFIED--NNDPTKMWQERAAQDSGT-----KDPSVRVIQNGLVDRNDASQ
Mflv_0456|M.gilvum_PYR-GCK GFIDP--DNDPSKMWQERAAQDTGT-----KDPSIRVLQNGLVDRNDASQ
MSMEG_0250|M.smegmatis_MC2_155 GFTDP--DNDPEKMWKERPANDSGS-----KDPSVRVIQNGLENRNDAAK
TH_4488|M.thermoresistible__bu GFTVD--DNDPANMWQERSATEEGS-----GDPSVRVLQNGLVERNDAAK
MMAR_0446|M.marinum_M GFIDQ--DNDADSMWQERSYAPGGS-----KDPSVRVLQNGLINPGDAPT
MUL_1096|M.ulcerans_Agy99 GFIDQ--DNDADSMWQERSYAPGGS-----KDPSVRVLQNGLINPGDAPT
MLBr_02620|M.leprae_Br4923 GFIEP--DNNYVNMWQERTVAPGAS-----KDPSVRVLQNGLINPNDASK
MAV_4968|M.avium_104 GFTDKTWQERPCPTIAGNPCIPGPNGTTVPKDGSVRVIQNGLANRNDAAK
Mb0212c|M.bovis_AF2122/97 GFIEP--DNDPANMWQERAYAVGAS-----KDPSVRVLQNGLINPADASK
Rv0206c|M.tuberculosis_H37Rv GFIEP--DNDPANMWQERAYAVGAS-----KDPSVRVLQNGLINPADASK
MAB_4508|M.abscessus_ATCC_1997 GFVEP--GGDKTQMWQRRQAVKTDG------DTSVKVIQNALVDRNTAGA
** . * *::*:**.* : *
Mvan_0196|M.vanbaalenii_PYR-1 KIEELRSIQPPRGVQISVGGTPALEQDSIHSLFDKLPLMVLVLIVTTTVL
Mflv_0456|M.gilvum_PYR-GCK KIDELRSIQPPRGVDISVGGTPALEQDSIHSLFDKLPLMGLVLIVTTTIL
MSMEG_0250|M.smegmatis_MC2_155 KIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVL
TH_4488|M.thermoresistible__bu KIDELRALTPPHGVEVLVGGTPALEQDSIRSLFHRLPLMVVLLITTTTIL
MMAR_0446|M.marinum_M KLAELRAITPPKGLEIFVGGTPALEQDSIHSLFENMPAMLVILLTTTTLL
MUL_1096|M.ulcerans_Agy99 KLAELRAITPPKGLEIFVGGTPALEQDSIHSLFENMPAMLVILLTTTTLL
MLBr_02620|M.leprae_Br4923 KINELRSITPPKGLTVSVGGTPALEQDSIHSLVAQAPLMVIMLITTTMLL
MAV_4968|M.avium_104 KIAELRAVNPPKGLNLYVGGTPALEQDSIHSLFDKAPLMLVLLLGATLLL
Mb0212c|M.bovis_AF2122/97 KLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVILLTTTIVL
Rv0206c|M.tuberculosis_H37Rv KLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVILLTTTIVL
MAB_4508|M.abscessus_ATCC_1997 KVKQLREIPVPKGVTMYVGGTPALEQDSIDTVFDKLPFVIVVLISVTTIL
*: :** : *:*: : ******** *** :. . * : ::*: .* :*
Mvan_0196|M.vanbaalenii_PYR-1 MFLAFGSIVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLM
Mflv_0456|M.gilvum_PYR-GCK MFLAFGSIVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLM
MSMEG_0250|M.smegmatis_MC2_155 MFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLM
TH_4488|M.thermoresistible__bu MFLAFGSLVLPIKAALMSALTLGSTMGVLTFMFVEGHGSGLLNFTPQPLM
MMAR_0446|M.marinum_M MFLAFGSVVLPIKAAVMSALTLGSTMGILTWIFVDGHGSGVLNFTATPLT
MUL_1096|M.ulcerans_Agy99 MFLAFGSVVLPIKAAVMSALTLGSTMGILTWIFVDGHGSGVLNFTATPLT
MLBr_02620|M.leprae_Br4923 MFLAFGSFVLPIKAAVMSALTLGSTMGILTWIFVDGHLSKWLNFTPTPLM
MAV_4968|M.avium_104 MFLAFGSVVLPIKAVLMSALTLGSTMGILTWIFVDGHLSGVLNFTPTPLM
Mb0212c|M.bovis_AF2122/97 MFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLT
Rv0206c|M.tuberculosis_H37Rv MFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLT
MAB_4508|M.abscessus_ATCC_1997 MFLAFGSLVLPIKAAVMSALGLGSTMGILTWIFVDGHFSKWLNFTPTPLT
*******.******.:**** ******:**::**:** * :*:*. **
Mvan_0196|M.vanbaalenii_PYR-1 APMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRL
Mflv_0456|M.gilvum_PYR-GCK APMIGLIIAVIWGLSTDYEVFLVSRMVEARERGLSTAEAIRIGTATTGRL
MSMEG_0250|M.smegmatis_MC2_155 APMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRL
TH_4488|M.thermoresistible__bu APMIGLIIAVIYGLSTDYEVFLVARMVEARERGMSTAEAIRIGTATTGRL
MMAR_0446|M.marinum_M APVIALVVAVGYGLATDYEVFLVSRMVEARENGMSTQEAIRIGTATTGRL
MUL_1096|M.ulcerans_Agy99 APVIALVVAVGYGLATDYEVFLISRMVEARENGMSTQEAIRIGTATTGRL
MLBr_02620|M.leprae_Br4923 VVIIALVVAVGYGLATDYEVFLVSRMVEARAESMSTQEAVRIGTASTGRL
MAV_4968|M.avium_104 VVVIALVVAVGFGLATDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRL
Mb0212c|M.bovis_AF2122/97 APVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRI
Rv0206c|M.tuberculosis_H37Rv APVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRI
MAB_4508|M.abscessus_ATCC_1997 APVIVLIIVVIYGLSSDYEVFLMSRMIEARHQGLSTTEAVRVGTANTGRI
. :* *::.: :**::******::**:*** ..:** **:*:*** ***:
Mvan_0196|M.vanbaalenii_PYR-1 ITGAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAIM
Mflv_0456|M.gilvum_PYR-GCK ITGAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAIM
MSMEG_0250|M.smegmatis_MC2_155 ITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVM
TH_4488|M.thermoresistible__bu ITAAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIVRMFLVPSVM
MMAR_0446|M.marinum_M ITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM
MUL_1096|M.ulcerans_Agy99 ITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM
MLBr_02620|M.leprae_Br4923 ITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM
MAV_4968|M.avium_104 ITAAAMVLAVVASSFVFSDLVLMKYLAFGLMAALLLDATVVRMFLVPSVM
Mb0212c|M.bovis_AF2122/97 ITAAALIVAVVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM
Rv0206c|M.tuberculosis_H37Rv ITAAALIVAVVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM
MAB_4508|M.abscessus_ATCC_1997 ITAAALILIVVAGGFAFSDLVMMKYLAFGLIAALILDATVVRMLLIPAVM
**.**::: ***..*.*****:********: **:****::**:*:*::*
Mvan_0196|M.vanbaalenii_PYR-1 KLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVREN-PAPAEALVG
Mflv_0456|M.gilvum_PYR-GCK KLLGDDCWWAPRWMKRIQEKLGLGETELPDERKRPAVREEREAPAEALVG
MSMEG_0250|M.smegmatis_MC2_155 KLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRES-ETDQRALVG
TH_4488|M.thermoresistible__bu KLLGDDCWWAPLWMKRIQDKLGLGETELPDERKRPAFAEP--GDEQALVG
MMAR_0446|M.marinum_M KLLGDDCWWAPRWMRRLQTRIGLGEIQLPDERKRPANNG----SARPPVK
MUL_1096|M.ulcerans_Agy99 KLLGDDCWWAPRWMRRLQTRIGLGEIQLPDERKRPANNG----SARPPVK
MLBr_02620|M.leprae_Br4923 KLLGDDCWWAPRWARLLQNRIGLGEIHLPDERRRPTVSGR---PVRPPVT
MAV_4968|M.avium_104 KLLGDDCWWAPRWARRLQNKIGLGEIDLPDERKRPTLNGR---PARPPVA
Mb0212c|M.bovis_AF2122/97 KLLGDDCWWAPRWARRLQTRIGLGEIHLPDERKRPVSNGR---PARPPVT
Rv0206c|M.tuberculosis_H37Rv KLLGDDCWWAPRWARRLQTRIGLGEIHLPDERKRPVSNGR---PARPPVT
MAB_4508|M.abscessus_ATCC_1997 KLLGDDCWWAPAWMKRIQVKLGLGEVTLPDERKRPTGREQAIAAASSPVG
*********** * : :* ::**** *****:**. . *
Mvan_0196|M.vanbaalenii_PYR-1 AGGPPVAAPPRPLPPHDPTHPAPGG----RPPGATTRMTAPPRAGDPSAA
Mflv_0456|M.gilvum_PYR-GCK AGGPPVMAPPRALPPHDPTHPAPGRPAPVRPPAVTTRMGTPTYP-DPAAA
MSMEG_0250|M.smegmatis_MC2_155 VGAPP--PPPR---PHDPTHPAPEP----------VRPMPPMRSNAPSAA
TH_4488|M.thermoresistible__bu AGAXX---XPG---VQPPQHVHPDLD---------VLPLSPAHLTPGADR
MMAR_0446|M.marinum_M AA-LAAATA---RAPHDPTHPSAPEAA------------RPSRSGGPART
MUL_1096|M.ulcerans_Agy99 AA-LAAATA---RAPHDPTHPSAPEAA------------RPSRSGGPART
MLBr_02620|M.leprae_Br4923 AASLAAPAS---RVPRGPTHPATLEPS------------QRARSGLASRP
MAV_4968|M.avium_104 AS-LVATAP---RPPHDPTHPAAPEPS------------RPAR---PAPA
Mb0212c|M.bovis_AF2122/97 AGLVAARAAGDPRPPHDPTHPLAESP-------------RPARSSPASSP
Rv0206c|M.tuberculosis_H37Rv AGLVAARAAGDPRPPHDPTHPLAESP-------------RPARSSPASSP
MAB_4508|M.abscessus_ATCC_1997 SNARTTKLPIASERTRLPSTPTPRQHDP----------SAPARPTPPPPA
: * . .
Mvan_0196|M.vanbaalenii_PYR-1 GTTRLPSAP--PRPPAAP----EEEPQTTRLSIAKNAVRNAVSTAAAAAQ
Mflv_0456|M.gilvum_PYR-GCK GTTRIPTAP--PRPPVTPPPPAQDEPQTTRLSIAKNAVRNAVSGAAAAAQ
MSMEG_0250|M.smegmatis_MC2_155 GTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGA
TH_4488|M.thermoresistible__bu EVVQIAVLD------------------PDQIGFVQREIQVEVDQVVQRLR
MMAR_0446|M.marinum_M ELG----------SAQSGPSSAGTKEIQTRASQPSDPPTTRLTAPGAPPA
MUL_1096|M.ulcerans_Agy99 ELG----------SAQSGPSSAGTKEIQTRASQPSDPPTTRLTAPGAPPA
MLBr_02620|M.leprae_Br4923 QIK----------RPQELPSGASTARIQMRPSQSVEATTTRLSVPGNAPT
MAV_4968|M.avium_104 EPR----------PAQEP--AASTTRIPARPNQPTEAQTTRFAAPGAPGR
Mb0212c|M.bovis_AF2122/97 ELTPALEAT----AAPAAPSGASTTRMQIGSS--TEPPTTRLAAAGRSVQ
Rv0206c|M.tuberculosis_H37Rv ELTPALEAT----AAPAAPSGASTTRMQIGSS--TEPPTTRLAAAGRSVQ
MAB_4508|M.abscessus_ATCC_1997 PPTAPVNLAG---NDSGDASATTRMAVPGKNVAPTDAPTTRVPGGNPAGP
.
Mvan_0196|M.vanbaalenii_PYR-1 RATERPASGPPAP------------------PAPSAPPAREDREI--ESW
Mflv_0456|M.gilvum_PYR-GCK RAMPSSSPTPPSPTP------------PSPTPPPSGSPARDEREI--ESW
MSMEG_0250|M.smegmatis_MC2_155 GSAAAPTERAPRPGG------------P---AQPPAPPQREEREI--ESW
TH_4488|M.thermoresistible__bu WSRSVPVGALGDRPG------------PG--QQPRADAHQEFGQQ--RLL
MMAR_0446|M.marinum_M RGSSNPAPPAQTRPT------------TPAPPAPAPPPAPSAGQT--RAM
MUL_1096|M.ulcerans_Agy99 RGSSNPAPPAQTRPT------------TPAPPAPAPPPAPSAGQT--RAM
MLBr_02620|M.leprae_Br4923 TAAVSSSQGVQAVP-------------LAATRHPLPTPSPASGQT--RAM
MAV_4968|M.avium_104 QRPAEPRPAPPQRP-------------------PTQAAPPSGDQT--RAI
Mb0212c|M.bovis_AF2122/97 SPASTPPPT------------------------PTPPSAPSAGQT--RAM
Rv0206c|M.tuberculosis_H37Rv SPASTPPPT------------------------PTPPSAPSAGQT--RAM
MAB_4508|M.abscessus_ATCC_1997 DAPTTRSSVAGTHRPDRRNADREIESWLGELRGPKQPGAAAGTEAGDATT
* :
Mvan_0196|M.vanbaalenii_PYR-1 LGDLRGSRASGTAAANPPQPLRPSAEPTRAMPDTGAAGNEPTTAIPAQRE
Mflv_0456|M.gilvum_PYR-GCK LGDLRGGGTTGPAGA--PQPMRPSAEPTRAMPDSGED-------------
MSMEG_0250|M.smegmatis_MC2_155 LGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADR-GNENA
TH_4488|M.thermoresistible__bu VGEVAVDRRSAHAGRG-----TDVLQPHSEIAPLG---------------
MMAR_0446|M.marinum_M QIPTNRSSD--TGGDP--------ADPTAALPIQR---------------
MUL_1096|M.ulcerans_Agy99 QIPTNRSSD--TGGDP--------ADPTAALPIQR---------------
MLBr_02620|M.leprae_Br4923 PVPANRSSD--NASET--------AEPTTALPIMR---------------
MAV_4968|M.avium_104 PVPGNRPDDGDSDADA--------AEPTTALPKMR---------------
Mb0212c|M.bovis_AF2122/97 PLAANRSTD--AAGDP--------AEPTAALPIIR---------------
Rv0206c|M.tuberculosis_H37Rv PLAANRSTD--AAGDP--------AEPTAALPIIR---------------
MAB_4508|M.abscessus_ATCC_1997 AIPVSKPQSTPRPAQPNRASGTPGEDATTAMPIAKPEVQRQGPP------
:. :.
Mvan_0196|M.vanbaalenii_PYR-1 SERHRESARHDDSDDSAASTRAIPTARQSDADAATEKLNTR---PDDEAT
Mflv_0456|M.gilvum_PYR-GCK ------AASDDEPDD--TATRAIPAQRKPDAEAATEKLNTR---PDPDAP
MSMEG_0250|M.smegmatis_MC2_155 PTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPET
TH_4488|M.thermoresistible__bu ------HQPFGGGEDLAATVRLGPAAPGGRRPG------------GGCVA
MMAR_0446|M.marinum_M ------PEGT---DTEAATEQLNARGGQPDGGENP------------RPR
MUL_1096|M.ulcerans_Agy99 ------PEGT---DTEAATEQLNARGGQPDGGENP------------RPR
MLBr_02620|M.leprae_Br4923 ------PQDN---DSEVATEKLNALG----QGDNS------------RQH
MAV_4968|M.avium_104 ------AEGSGGSESDAAGDQANARG-QGENGDPA------------RQR
Mb0212c|M.bovis_AF2122/97 ------SDGD---DSEAATEQLNARG----TSDKT------------RQR
Rv0206c|M.tuberculosis_H37Rv ------SDGD---DSEAATEQLNARG----TSDKT------------RQR
MAB_4508|M.abscessus_ATCC_1997 RAQRPQPEQQQPAKPSTDATEALPAPGQNRTPQQQE---------VDEAT
.
Mvan_0196|M.vanbaalenii_PYR-1 RRGGK---GLSAQDLLRREGRL-
Mflv_0456|M.gilvum_PYR-GCK RRGGS---GVSAQDLLRREGRL-
MSMEG_0250|M.smegmatis_MC2_155 KRRGG---GMSAQDLLRREGRL-
TH_4488|M.thermoresistible__bu RHQRP---PSVMLDIPVNDD---
MMAR_0446|M.marinum_M RRGAGGAGGLSAQDLLRREGRL-
MUL_1096|M.ulcerans_Agy99 RRGAGGAGGLSAQDLLRREGRL-
MLBr_02620|M.leprae_Br4923 RRATG--GGISAQDLLRREGRL-
MAV_4968|M.avium_104 RRAGG---GLSAQDLLRREGRL-
Mb0212c|M.bovis_AF2122/97 RRGGG---ALSAQDLLRREGRL-
Rv0206c|M.tuberculosis_H37Rv RRGGG---ALSAQDLLRREGRL-
MAB_4508|M.abscessus_ATCC_1997 RRSRG--GSVSAQDLLRREGRRI
:: *: .:.