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VYRYRYIVIGVTVALCLLGGVFGISLGKHVTQSGFYDDASQSVKASVLGDQTYGRDRTSHVVATFTTPDG KTVDDAGWRDKVVAELNKFKADHPDQVVGWAGWLAAPDSTNPVIKGMVSEDKKHTFVSIPLKGDDDDTIL NNYKAIAPDMQKLNGGAVQLAGLEPIANALTGTIATDQRRMEVLAVPMVAVVLFLVFGGAVAAGLPAIVG GLSIAGSLGILRLVAVFGPVHYFAQPVVSLIGLGIAIDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGR TVTFSAVLIIASSASLLVLPQGFVHSLTYAIFAAVGLAALLSITFLPACLGILGRHVDALGVRTAFRVPF LRNWKYSRAYLNWLADRLQKTKTREEVEAGFWGKLVNWVMRKPLAFAIPIAVGMILLVIPLGNLSFGGMS EKYLPPNNPVRLAQEHFDKQFPGYRTEQLTVVIQSDNHSKVTDQQVADIRNRISGIGGFTDKTWQERPCP TIAGNPCIPGPNGTTVPKDGSVRVIQNGLANRNDAAKKIAELRAVNPPKGLNLYVGGTPALEQDSIHSLF DKAPLMLVLLLGATLLLMFLAFGSVVLPIKAVLMSALTLGSTMGILTWIFVDGHLSGVLNFTPTPLMVVV IALVVAVGFGLATDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITAAAMVLAVVASSFVFSDLVLM KYLAFGLMAALLLDATVVRMFLVPSVMKLLGDDCWWAPRWARRLQNKIGLGEIDLPDERKRPTLNGRPAR PPVAASLVATAPRPPHDPTHPAAPEPSRPARPAPAEPRPAQEPAASTTRIPARPNQPTEAQTTRFAAPGA PGRQRPAEPRPAPPQRPPTQAAPPSGDQTRAIPVPGNRPDDGDSDADAAEPTTALPKMRAEGSGGSESDA AGDQANARGQGENGDPARQRRRAGGGLSAQDLLRREGRL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_4968 | - | - | 100% (949) | MmpL3 protein |
M. avium 104 | MAV_1287 | - | 3e-91 | 31.31% (776) | mmpL protein |
M. avium 104 | MAV_1659 | - | 1e-84 | 28.64% (789) | mmpl family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0212c | mmpL3 | 0.0 | 69.45% (969) | transmembrane transport protein MmpL3 |
M. gilvum PYR-GCK | Mflv_0456 | - | 0.0 | 50.62% (723) | RND superfamily drug efflux protein |
M. tuberculosis H37Rv | Rv0206c | mmpL3 | 0.0 | 69.66% (969) | transmembrane transport protein MmpL3 |
M. leprae Br4923 | MLBr_02620 | - | 0.0 | 72.00% (968) | hypothetical protein MLBr_02620 |
M. abscessus ATCC 19977 | MAB_4508 | - | 0.0 | 52.55% (1039) | putative membrane protein, MmpL |
M. marinum M | MMAR_0446 | mmpL3 | 0.0 | 73.12% (971) | transmembrane transport protein MmpL3 |
M. smegmatis MC2 155 | MSMEG_0250 | - | 0.0 | 59.73% (1028) | membrane protein, MmpL family protein |
M. thermoresistible (build 8) | TH_4488 | - | 0.0 | 58.57% (963) | PUTATIVE membrane protein, MmpL family protein |
M. ulcerans Agy99 | MUL_1096 | mmpL3 | 0.0 | 72.91% (971) | transmembrane transport protein MmpL3 |
M. vanbaalenii PYR-1 | Mvan_0196 | - | 0.0 | 59.22% (1030) | large membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0456|M.gilvum_PYR-GCK MFAWWGRTVYQYRYIVIGVMVALCLGGGVYGMSLGQHVTQSGFYDEGSQS Mvan_0196|M.vanbaalenii_PYR-1 MFAWWGRTVYQYRYIVIGVMVALCLGGGVYGISLGQHVTQSGFYDDGSQS MSMEG_0250|M.smegmatis_MC2_155 MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQS TH_4488|M.thermoresistible__bu VFAWWGRMVYRYRYIVIGVMVALCLGGGVYGISLGDHVTQSGFYDEGSES Mb0212c|M.bovis_AF2122/97 MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFYDDGSQS Rv0206c|M.tuberculosis_H37Rv MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFYDDGSQS MMAR_0446|M.marinum_M MFAWWGRTVYRYRFIVIGVTVALCLGGGVFGLSLGKHVTQSGFYDEGSQS MUL_1096|M.ulcerans_Agy99 MFAWWGRTVYRYRFIVIGVTVALCLGGGVFGLSLGKHVTQSGFYDEGSQS MLBr_02620|M.leprae_Br4923 MFAWWGRTVYRYRFIVIGITVALCLCGGVFGLSLGKHVTQSGFYDDSSQS MAV_4968|M.avium_104 --------MYRYRYIVIGVTVALCLLGGVFGISLGKHVTQSGFYDDASQS MAB_4508|M.abscessus_ATCC_1997 MFAWWGRMVYRYRFIVVAAFVTVCLGSGLFGITLGDHVTQSGFFADNSES :*::*:**:. *::** .*::*::**.*******: : *:* Mflv_0456|M.gilvum_PYR-GCK VHASLVSDEAYGRDRTSHVVAILTPPDGEKVDNPEWMEKVTGELNDLVAE Mvan_0196|M.vanbaalenii_PYR-1 VHASVVSDEVYGRDRTSHVVAILTPPDGEKVDNPEWMEKVTGELNDVVAE MSMEG_0250|M.smegmatis_MC2_155 VAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKD TH_4488|M.thermoresistible__bu VAASVLADEVYGRDRASHVVAILTPPEGKKVNDPEWMDRTIEELDGLVEA Mb0212c|M.bovis_AF2122/97 VQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQD Rv0206c|M.tuberculosis_H37Rv VQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQD MMAR_0446|M.marinum_M VTASILGDEVYGRDRTGHIVAVFKAPDGKTVNDPAWSKKITDQLNQFVKD MUL_1096|M.ulcerans_Agy99 VTASILGDEVYGRDRTGHIVAVFKAPDGKTVNDPAWSKKITDQLNQFVKD MLBr_02620|M.leprae_Br4923 VKASILGDQVYGRDRSGHIVAIFHAPDGKTVNDPAWAKKITDELNQFQRN MAV_4968|M.avium_104 VKASVLGDQTYGRDRTSHVVATFTTPDGKTVDDAGWRDKVVAELNKFKAD MAB_4508|M.abscessus_ATCC_1997 VKASVMADDALGRDRTTHVVAVIAAPEGKTVDDPAFQKKVIDHFDQLQKD * **::.*:. ****: *:** : .* .:.* : : .: .:: . Mflv_0456|M.gilvum_PYR-GCK NEDRIVSWVGWLRAPDAAAETVQQMKTEDLSKTFVSIPLKGENDDEILKN Mvan_0196|M.vanbaalenii_PYR-1 HEDRIVSWVGWLRAPDSTAETVQQMKTADGSKTFVSIPLKGDDDDEILKN MSMEG_0250|M.smegmatis_MC2_155 HEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKN TH_4488|M.thermoresistible__bu ESDRIVDWVGWLKAPDVDNEVVQRMRSEDYSQTFISIPLKGDDDDEILLN Mb0212c|M.bovis_AF2122/97 HPDQVLGWAGYLRASQAT-----GMATADKKYTFVSIPLKGDDDDTILNN Rv0206c|M.tuberculosis_H37Rv HPDQVLGWAGYLRASQAT-----GMATADKKYTFVSIPLKGDDDDTILNN MMAR_0446|M.marinum_M HPDQVLGWAGYLRAPDSTSPVIKGMATDDKKYTFVSIPLKGDDDDTILNN MUL_1096|M.ulcerans_Agy99 HPDQVLGWAGYLRAPDSTSPVIKGMATDDKKYTFVSIPLKGDDDDTILNN MLBr_02620|M.leprae_Br4923 NSNKVTGWAGYLRASDTTNTVVQGMATPDKKYTFVSIPLKGDDDDTILNN MAV_4968|M.avium_104 HPDQVVGWAGWLAAPDSTNPVIKGMVSEDKKHTFVSIPLKGDDDDTILNN MAB_4508|M.abscessus_ATCC_1997 NPDEVYGWAGWLRAPTTTDPTVKRMVTEDRKHTFVSVSLKGDDDDTILNN . :.: .*.*:* *. * : * **:*:.*:*::** ** * Mflv_0456|M.gilvum_PYR-GCK YQAIEP---------QLSQVNDGGIQLAGLQPLASELTGTIGEDQKRAEV Mvan_0196|M.vanbaalenii_PYR-1 YQAVEP---------DLLKINDGNIKLAGLQPLASELTGTIGEDQKRAEV MSMEG_0250|M.smegmatis_MC2_155 YQVVEP---------ELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEV TH_4488|M.thermoresistible__bu YQAIEP---------DLRSLNDGNIELAGLNPLASELTGTIAVDQRRAEV Mb0212c|M.bovis_AF2122/97 YKAIAP---------DLQRLDGGTVKLAGLQPVAEALTGTIATDQRRMEV Rv0206c|M.tuberculosis_H37Rv YKAIAP---------DLQRLDGGTVKLAGLQPVAEALTGTIATDQRRMEV MMAR_0446|M.marinum_M YKDIAP---------SLQKLDGGTVQLAGLEPVAEGLTGTIATDQRRMEV MUL_1096|M.ulcerans_Agy99 YKDIAP---------SLQKLDGGTVQLAGLEPVAEGLIGTIATDQRRMEV MLBr_02620|M.leprae_Br4923 YKAIAP---------DLQKLDGGTVQLAGLDPIANALTSTIATDQRRMEV MAV_4968|M.avium_104 YKAIAP---------DMQKLNGGAVQLAGLEPIANALTGTIATDQRRMEV MAB_4508|M.abscessus_ATCC_1997 YKALSNPDKDDDPAKNKFLMDGVDIQLAGLQPVASELTGTIGKDQQRMEV *: : . ::. :.****:*:*. * .**. **:* ** Mflv_0456|M.gilvum_PYR-GCK AAIPLVCVVLFFVFGGVIAAALPGIIGGLTIAGALGIMRVFAEFMPVHFF Mvan_0196|M.vanbaalenii_PYR-1 AAIPLVAVVLFFVFGGVIAATLPAIIGGLTIAGALGIMRIFAEFMPVHFF MSMEG_0250|M.smegmatis_MC2_155 AAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFF TH_4488|M.thermoresistible__bu AAIPLVAVLLFFVFGGVVAALLPALIGGLSIAGALGIMRLVAEFGPVHFF Mb0212c|M.bovis_AF2122/97 LALPLVAVVLFFVFGGVIAAGLPVMVGGLCIAGALGIMRFLAIFGPVHYF Rv0206c|M.tuberculosis_H37Rv LALPLVAVVLFFVFGGVIAAGLPVMVGGLCIAGALGIMRFLAIFGPVHYF MMAR_0446|M.marinum_M LALPLVAVVLFLVFGGAVAACLPVMVGGLSIAGALGILRLVAVFGPVHFF MUL_1096|M.ulcerans_Agy99 LALPLVAVVLFLVFGGAVAACLPVMVGGLSIAGALGILRLVAVFGPVHFF MLBr_02620|M.leprae_Br4923 LALPLVAVVLFLVFGGVIAACLPVMVGGLSIAGALGILRFIALFGPVHFF MAV_4968|M.avium_104 LAVPMVAVVLFLVFGGAVAAGLPAIVGGLSIAGSLGILRLVAVFGPVHYF MAB_4508|M.abscessus_ATCC_1997 LSLPVMAVVLFFVFGGVIAAGLPLMVGGLTIAGALGIMRLVTLFAPVHFF ::*::.*:**:*** .:** ** ::*** ***:***:*..: * ***:* Mflv_0456|M.gilvum_PYR-GCK AQPVVTLMGLGIAIDYGLFMVSRFREEIAEGYDTEAAVRRAVMTSGRTVM Mvan_0196|M.vanbaalenii_PYR-1 AQPVVTLMGLGIAIDYGLFMVSRFREEIAEGYDTEAAVRRTVMTSGRTVM MSMEG_0250|M.smegmatis_MC2_155 AQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVV TH_4488|M.thermoresistible__bu AQPVVTLIGLGIAIDYGLFIVSRFREELAEGYDTEQAVRRSVMTSGRTVI Mb0212c|M.bovis_AF2122/97 AQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRRTVITAGRTVT Rv0206c|M.tuberculosis_H37Rv AQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRRTVITAGRTVT MMAR_0446|M.marinum_M AQPVVSLIGLGIAVDYGLFVVSRFREEIAEGYDTETAVRRTVMTAGRTVA MUL_1096|M.ulcerans_Agy99 AQPVVSLIGLGIAVDYGLFVVSRFREEIAEGYDTETAVRRTVMTAGRTVA MLBr_02620|M.leprae_Br4923 AQPVVSLIGLGIAVDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVT MAV_4968|M.avium_104 AQPVVSLIGLGIAIDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVT MAB_4508|M.abscessus_ATCC_1997 AQPVVTLIGLGIAIDYSLFIVSRFREEIAEGYDTETAVRRTVITSGRTVM *****:*:*****:**.**:*******:******* ****:*:*:**** Mflv_0456|M.gilvum_PYR-GCK FSAVILVASSVPLLLFPQGFLKSITYAIIASVMLAAILSVTVLPAALAIL Mvan_0196|M.vanbaalenii_PYR-1 FSAVILVASSVPLLLFPQGFLKSITYAIIASVMLAAILSVTVLPAAFSIL MSMEG_0250|M.smegmatis_MC2_155 FSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAIL TH_4488|M.thermoresistible__bu FSAVIIVASALPLLLFPQGFLKSITYAIIASVMLSSILSITVLAAILGIL Mb0212c|M.bovis_AF2122/97 FSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLGIL Rv0206c|M.tuberculosis_H37Rv FSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLGIL MMAR_0446|M.marinum_M FSAVLIMASGASLLMLPQGFVKSLTYALLAAVGLAALLSITLLPACLGVL MUL_1096|M.ulcerans_Agy99 FSAVLIMASGASLLMLPQGFVKSLTYALLAAVGLAALLSITLLPACLGVL MLBr_02620|M.leprae_Br4923 FSAVLIAASGASLLLLPQGFVKSLTYALIAAVTLAALLSITLLPACLAIL MAV_4968|M.avium_104 FSAVLIIASSASLLVLPQGFVHSLTYAIFAAVGLAALLSITFLPACLGIL MAB_4508|M.abscessus_ATCC_1997 FSATLIAAALMPMLIVPQQFLRSLTYAGIASVLLAAILAVTVLPACLGVL ***.:: *: :*:.** *::*:*** :*:* *:::*::*.*.* :.:* Mflv_0456|M.gilvum_PYR-GCK GPRVDALGVRWLLKFVNNEVSSDPSNTRTNQFAIASIPAGLLLPPVGIFL Mvan_0196|M.vanbaalenii_PYR-1 GRNVDALGVRTLLRVP--------------------------------FF MSMEG_0250|M.smegmatis_MC2_155 GPRVDALGVTTLLKIP--------------------------------FL TH_4488|M.thermoresistible__bu GPNVDALGVRTLLRVPFLRD------------------------------ Mb0212c|M.bovis_AF2122/97 GKHVDALGVRTLFRVPFLAN------------------------------ Rv0206c|M.tuberculosis_H37Rv GKHVDALGVRTLFRVPFLAN------------------------------ MMAR_0446|M.marinum_M GRHVDALGVRTAFRVPFLRN------------------------------ MUL_1096|M.ulcerans_Agy99 GRHVDALGVRTAFRVPFLRN------------------------------ MLBr_02620|M.leprae_Br4923 AKHVDALGVRTLFRVPLLRN------------------------------ MAV_4968|M.avium_104 GRHVDALGVRTAFRVPFLRN------------------------------ MAB_4508|M.abscessus_ATCC_1997 GRHVDALSIK---------------------------------------- . .****.: Mflv_0456|M.gilvum_PYR-GCK GHRARKQIRQTGEQGLPLTMIGLALGYVGLLGWIAYLAIANRESLGDGLY Mvan_0196|M.vanbaalenii_PYR-1 RN------------------------------------------------ MSMEG_0250|M.smegmatis_MC2_155 AN------------------------------------------------ TH_4488|M.thermoresistible__bu -------------------------------------------------- Mb0212c|M.bovis_AF2122/97 -------------------------------------------------- Rv0206c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0446|M.marinum_M -------------------------------------------------- MUL_1096|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 -------------------------------------------------- MAV_4968|M.avium_104 -------------------------------------------------- MAB_4508|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0456|M.gilvum_PYR-GCK WVLIGVVIFVAVVAGGLALARYVPLARGPIVWWVEWLAEKTQKTKTRAEV Mvan_0196|M.vanbaalenii_PYR-1 --------------------------WKPMRVYLEWLAEKTQKTKTRAEV MSMEG_0250|M.smegmatis_MC2_155 --------------------------WQFSRRIIDWFAEKTQKTKTREEV TH_4488|M.thermoresistible__bu --------------------------WPFSRRIIDWFAEKTQKTKTRAEV Mb0212c|M.bovis_AF2122/97 --------------------------WKISAAYLNWLADRLQRTKTREEV Rv0206c|M.tuberculosis_H37Rv --------------------------WKISAAYLNWLADRLQRTKTREEV MMAR_0446|M.marinum_M --------------------------WKVSRAYLNWLADRLQKTKTREEV MUL_1096|M.ulcerans_Agy99 --------------------------WKVSRAYLNWLADRLQKTKTREEV MLBr_02620|M.leprae_Br4923 --------------------------WRMSHACLNWLADRLQKTKTREEV MAV_4968|M.avium_104 --------------------------WKYSRAYLNWLADRLQKTKTREEV MAB_4508|M.abscessus_ATCC_1997 ---------------------------------------RFSRTKSREEL : .:**:* *: Mflv_0456|M.gilvum_PYR-GCK EKGFWGKLVNVVMKRPIAFAAPILIGMILLILPLGQLALGGISEKYLPPD Mvan_0196|M.vanbaalenii_PYR-1 EKGFWGRLVNVVMKRPIAFAAPILIVMILLVIPLGQLALGGISEKYLPPD MSMEG_0250|M.smegmatis_MC2_155 ERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPD TH_4488|M.thermoresistible__bu ERGFWGKLVNVVMKRPVTFMVPILILMILMIIPIGQLSLGGISEKYLPPN Mb0212c|M.bovis_AF2122/97 EAGIWGKLVNRVMKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPT Rv0206c|M.tuberculosis_H37Rv EAGFWGKLVNRVMKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPT MMAR_0446|M.marinum_M EAGFWGNLTNRVMRRPLVFAIPIVLGMILLVIPLFNLSLGGMSEKYLPPN MUL_1096|M.ulcerans_Agy99 EAGFWGNLTNRVMRRPLVFAIPIVLGMILLVIPLFNLSLGGMSEKYLPPN MLBr_02620|M.leprae_Br4923 EAGFWGKLVNFVMKRPLVFAIPIVIGMILLVIPLGNLSFGGMSEKYLPPN MAV_4968|M.avium_104 EAGFWGKLVNWVMRKPLAFAIPIAVGMILLVIPLGNLSFGGMSEKYLPPN MAB_4508|M.abscessus_ATCC_1997 ENGFWGRTVVYVMQRPLVFAVPIVIVMLLLIIPLGNLKLGGFSEKYLPPT * *:**. . **::*: * ** : *:*:::*: :* :**:******* Mflv_0456|M.gilvum_PYR-GCK NGVRTAQEDFDRTFPGFRTEPLTLVIERQDGEPVTDQQLAEVRAKAMTVP Mvan_0196|M.vanbaalenii_PYR-1 NSVRIAQEDFDRTFPTFRTEPLTLVLERQDGQPVTDQQLAEVRAKAMTFS MSMEG_0250|M.smegmatis_MC2_155 NAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVS TH_4488|M.thermoresistible__bu NSVRQAQEHFDRDFPTFRTEPLTLVMRSTNGEPITDQQIAEMRAKAMTLS Mb0212c|M.bovis_AF2122/97 NSVRQAQEEFDKLFPGYRTNPLTLVIQTSNHQPVTEAQIADIRSKAMAIG Rv0206c|M.tuberculosis_H37Rv NSVRQAQEEFDKLFPGYRTNPLTLVIQTSNHQPVTDAQIADIRSKAMAIG MMAR_0446|M.marinum_M NAVRQSQEHFDQLFPGYRTNPLTLVIKSTNNQPVTDQQIADIRSKAMSIS MUL_1096|M.ulcerans_Agy99 NAVRQSQEHFDQLFPGYRTNPLTLVIKSTNNQPVTDQQIADIRSKAMSIS MLBr_02620|M.leprae_Br4923 NAVRQSQEHFDQLFPGYRTNPLTLVIQTSNHQPVTDQEIADIRSKAMAIS MAV_4968|M.avium_104 NPVRLAQEHFDKQFPGYRTEQLTVVIQSDNHSKVTDQQVADIRNRISGIG MAB_4508|M.abscessus_ATCC_1997 NSVRQAQENFDSLFPGFRTETITIVTKG-----ATDSQLNQIRADAMKVP * ** :**.** ** :**: :*:* . *: :: ::* . Mflv_0456|M.gilvum_PYR-GCK GFIDP--DNDPSKMWQERAAQDTGT-----KDPSIRVLQNGLVDRNDASQ Mvan_0196|M.vanbaalenii_PYR-1 GFIED--NNDPTKMWQERAAQDSGT-----KDPSVRVIQNGLVDRNDASQ MSMEG_0250|M.smegmatis_MC2_155 GFTDP--DNDPEKMWKERPANDSGS-----KDPSVRVIQNGLENRNDAAK TH_4488|M.thermoresistible__bu GFTVD--DNDPANMWQERSATEEGS-----GDPSVRVLQNGLVERNDAAK Mb0212c|M.bovis_AF2122/97 GFIEP--DNDPANMWQERAYAVGAS-----KDPSVRVLQNGLINPADASK Rv0206c|M.tuberculosis_H37Rv GFIEP--DNDPANMWQERAYAVGAS-----KDPSVRVLQNGLINPADASK MMAR_0446|M.marinum_M GFIDQ--DNDADSMWQERSYAPGGS-----KDPSVRVLQNGLINPGDAPT MUL_1096|M.ulcerans_Agy99 GFIDQ--DNDADSMWQERSYAPGGS-----KDPSVRVLQNGLINPGDAPT MLBr_02620|M.leprae_Br4923 GFIEP--DNNYVNMWQERTVAPGAS-----KDPSVRVLQNGLINPNDASK MAV_4968|M.avium_104 GFTDKTWQERPCPTIAGNPCIPGPNGTTVPKDGSVRVIQNGLANRNDAAK MAB_4508|M.abscessus_ATCC_1997 GFVEP--GGDKTQMWQRRQAVKTDG------DTSVKVIQNALVDRNTAGA ** . * *::*:**.* : * Mflv_0456|M.gilvum_PYR-GCK KIDELRSIQPPRGVDISVGGTPALEQDSIHSLFDKLPLMGLVLIVTTTIL Mvan_0196|M.vanbaalenii_PYR-1 KIEELRSIQPPRGVQISVGGTPALEQDSIHSLFDKLPLMVLVLIVTTTVL MSMEG_0250|M.smegmatis_MC2_155 KIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVL TH_4488|M.thermoresistible__bu KIDELRALTPPHGVEVLVGGTPALEQDSIRSLFHRLPLMVVLLITTTTIL Mb0212c|M.bovis_AF2122/97 KLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVILLTTTIVL Rv0206c|M.tuberculosis_H37Rv KLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVILLTTTIVL MMAR_0446|M.marinum_M KLAELRAITPPKGLEIFVGGTPALEQDSIHSLFENMPAMLVILLTTTTLL MUL_1096|M.ulcerans_Agy99 KLAELRAITPPKGLEIFVGGTPALEQDSIHSLFENMPAMLVILLTTTTLL MLBr_02620|M.leprae_Br4923 KINELRSITPPKGLTVSVGGTPALEQDSIHSLVAQAPLMVIMLITTTMLL MAV_4968|M.avium_104 KIAELRAVNPPKGLNLYVGGTPALEQDSIHSLFDKAPLMLVLLLGATLLL MAB_4508|M.abscessus_ATCC_1997 KVKQLREIPVPKGVTMYVGGTPALEQDSIDTVFDKLPFVIVVLISVTTIL *: :** : *:*: : ******** *** :. . * : ::*: .* :* Mflv_0456|M.gilvum_PYR-GCK MFLAFGSIVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLM Mvan_0196|M.vanbaalenii_PYR-1 MFLAFGSIVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLM MSMEG_0250|M.smegmatis_MC2_155 MFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLM TH_4488|M.thermoresistible__bu MFLAFGSLVLPIKAALMSALTLGSTMGVLTFMFVEGHGSGLLNFTPQPLM Mb0212c|M.bovis_AF2122/97 MFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLT Rv0206c|M.tuberculosis_H37Rv MFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLT MMAR_0446|M.marinum_M MFLAFGSVVLPIKAAVMSALTLGSTMGILTWIFVDGHGSGVLNFTATPLT MUL_1096|M.ulcerans_Agy99 MFLAFGSVVLPIKAAVMSALTLGSTMGILTWIFVDGHGSGVLNFTATPLT MLBr_02620|M.leprae_Br4923 MFLAFGSFVLPIKAAVMSALTLGSTMGILTWIFVDGHLSKWLNFTPTPLM MAV_4968|M.avium_104 MFLAFGSVVLPIKAVLMSALTLGSTMGILTWIFVDGHLSGVLNFTPTPLM MAB_4508|M.abscessus_ATCC_1997 MFLAFGSLVLPIKAAVMSALGLGSTMGILTWIFVDGHFSKWLNFTPTPLT *******.******.:**** ******:**::**:** * :*:*. ** Mflv_0456|M.gilvum_PYR-GCK APMIGLIIAVIWGLSTDYEVFLVSRMVEARERGLSTAEAIRIGTATTGRL Mvan_0196|M.vanbaalenii_PYR-1 APMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRL MSMEG_0250|M.smegmatis_MC2_155 APMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRL TH_4488|M.thermoresistible__bu APMIGLIIAVIYGLSTDYEVFLVARMVEARERGMSTAEAIRIGTATTGRL Mb0212c|M.bovis_AF2122/97 APVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRI Rv0206c|M.tuberculosis_H37Rv APVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRI MMAR_0446|M.marinum_M APVIALVVAVGYGLATDYEVFLVSRMVEARENGMSTQEAIRIGTATTGRL MUL_1096|M.ulcerans_Agy99 APVIALVVAVGYGLATDYEVFLISRMVEARENGMSTQEAIRIGTATTGRL MLBr_02620|M.leprae_Br4923 VVIIALVVAVGYGLATDYEVFLVSRMVEARAESMSTQEAVRIGTASTGRL MAV_4968|M.avium_104 VVVIALVVAVGFGLATDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRL MAB_4508|M.abscessus_ATCC_1997 APVIVLIIVVIYGLSSDYEVFLMSRMIEARHQGLSTTEAVRVGTANTGRI . :* *::.: :**::******::**:*** ..:** **:*:*** ***: Mflv_0456|M.gilvum_PYR-GCK ITGAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAIM Mvan_0196|M.vanbaalenii_PYR-1 ITGAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAIM MSMEG_0250|M.smegmatis_MC2_155 ITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVM TH_4488|M.thermoresistible__bu ITAAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIVRMFLVPSVM Mb0212c|M.bovis_AF2122/97 ITAAALIVAVVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM Rv0206c|M.tuberculosis_H37Rv ITAAALIVAVVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM MMAR_0446|M.marinum_M ITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM MUL_1096|M.ulcerans_Agy99 ITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM MLBr_02620|M.leprae_Br4923 ITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM MAV_4968|M.avium_104 ITAAAMVLAVVASSFVFSDLVLMKYLAFGLMAALLLDATVVRMFLVPSVM MAB_4508|M.abscessus_ATCC_1997 ITAAALILIVVAGGFAFSDLVMMKYLAFGLIAALILDATVVRMLLIPAVM **.**::: ***..*.*****:********: **:****::**:*:*::* Mflv_0456|M.gilvum_PYR-GCK KLLGDDCWWAPRWMKRIQEKLGLGETELPDERKRPAVREEREAPAEALVG Mvan_0196|M.vanbaalenii_PYR-1 KLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVREN-PAPAEALVG MSMEG_0250|M.smegmatis_MC2_155 KLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRES-ETDQRALVG TH_4488|M.thermoresistible__bu KLLGDDCWWAPLWMKRIQDKLGLGETELPDERKRPAFAEP--GDEQALVG Mb0212c|M.bovis_AF2122/97 KLLGDDCWWAPRWARRLQTRIGLGEIHLPDERKRPVSNGR---PARPPVT Rv0206c|M.tuberculosis_H37Rv KLLGDDCWWAPRWARRLQTRIGLGEIHLPDERKRPVSNGR---PARPPVT MMAR_0446|M.marinum_M KLLGDDCWWAPRWMRRLQTRIGLGEIQLPDERKRPANNG----SARPPVK MUL_1096|M.ulcerans_Agy99 KLLGDDCWWAPRWMRRLQTRIGLGEIQLPDERKRPANNG----SARPPVK MLBr_02620|M.leprae_Br4923 KLLGDDCWWAPRWARLLQNRIGLGEIHLPDERRRPTVSGR---PVRPPVT MAV_4968|M.avium_104 KLLGDDCWWAPRWARRLQNKIGLGEIDLPDERKRPTLNGR---PARPPVA MAB_4508|M.abscessus_ATCC_1997 KLLGDDCWWAPAWMKRIQVKLGLGEVTLPDERKRPTGREQAIAAASSPVG *********** * : :* ::**** *****:**. . * Mflv_0456|M.gilvum_PYR-GCK AGGPPVMAPPRALPPHDPTHPAPGRPAPVRPPAVTTRMGTPTYP-DPAAA Mvan_0196|M.vanbaalenii_PYR-1 AGGPPVAAPPRPLPPHDPTHPAPGG----RPPGATTRMTAPPRAGDPSAA MSMEG_0250|M.smegmatis_MC2_155 VGAPP--PPPR---PHDPTHPAPEP----------VRPMPPMRSNAPSAA TH_4488|M.thermoresistible__bu AGAXX---XPG---VQPPQHVHPDLD---------VLPLSPAHLTPGADR Mb0212c|M.bovis_AF2122/97 AGLVAARAAGDPRPPHDPTHPLAESP-------------RPARSSPASSP Rv0206c|M.tuberculosis_H37Rv AGLVAARAAGDPRPPHDPTHPLAESP-------------RPARSSPASSP MMAR_0446|M.marinum_M AA-LAAATA---RAPHDPTHPSAPEAA------------RPSRSGGPART MUL_1096|M.ulcerans_Agy99 AA-LAAATA---RAPHDPTHPSAPEAA------------RPSRSGGPART MLBr_02620|M.leprae_Br4923 AASLAAPAS---RVPRGPTHPATLEPS------------QRARSGLASRP MAV_4968|M.avium_104 AS-LVATAP---RPPHDPTHPAAPEPS------------RPAR---PAPA MAB_4508|M.abscessus_ATCC_1997 SNARTTKLPIASERTRLPSTPTPRQHDP----------SAPARPTPPPPA : * . . Mflv_0456|M.gilvum_PYR-GCK GTTRIPTAP--PRPPVTPPPPAQDEPQTTRLSIAKNAVRNAVSGAAAAAQ Mvan_0196|M.vanbaalenii_PYR-1 GTTRLPSAP--PRPPAAP----EEEPQTTRLSIAKNAVRNAVSTAAAAAQ MSMEG_0250|M.smegmatis_MC2_155 GTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGA TH_4488|M.thermoresistible__bu EVVQIAVLD------------------PDQIGFVQREIQVEVDQVVQRLR Mb0212c|M.bovis_AF2122/97 ELTPALEAT----AAPAAPSGASTTRMQIGSS--TEPPTTRLAAAGRSVQ Rv0206c|M.tuberculosis_H37Rv ELTPALEAT----AAPAAPSGASTTRMQIGSS--TEPPTTRLAAAGRSVQ MMAR_0446|M.marinum_M ELG----------SAQSGPSSAGTKEIQTRASQPSDPPTTRLTAPGAPPA MUL_1096|M.ulcerans_Agy99 ELG----------SAQSGPSSAGTKEIQTRASQPSDPPTTRLTAPGAPPA MLBr_02620|M.leprae_Br4923 QIK----------RPQELPSGASTARIQMRPSQSVEATTTRLSVPGNAPT MAV_4968|M.avium_104 EPR----------PAQEP--AASTTRIPARPNQPTEAQTTRFAAPGAPGR MAB_4508|M.abscessus_ATCC_1997 PPTAPVNLAG---NDSGDASATTRMAVPGKNVAPTDAPTTRVPGGNPAGP . Mflv_0456|M.gilvum_PYR-GCK RAMPSSSPTPPSPTP------------PSPTPPPSGSPARDEREI--ESW Mvan_0196|M.vanbaalenii_PYR-1 RATERPASGPPAP------------------PAPSAPPAREDREI--ESW MSMEG_0250|M.smegmatis_MC2_155 GSAAAPTERAPRPGG------------P---AQPPAPPQREEREI--ESW TH_4488|M.thermoresistible__bu WSRSVPVGALGDRPG------------PG--QQPRADAHQEFGQQ--RLL Mb0212c|M.bovis_AF2122/97 SPASTPPPT------------------------PTPPSAPSAGQT--RAM Rv0206c|M.tuberculosis_H37Rv SPASTPPPT------------------------PTPPSAPSAGQT--RAM MMAR_0446|M.marinum_M RGSSNPAPPAQTRPT------------TPAPPAPAPPPAPSAGQT--RAM MUL_1096|M.ulcerans_Agy99 RGSSNPAPPAQTRPT------------TPAPPAPAPPPAPSAGQT--RAM MLBr_02620|M.leprae_Br4923 TAAVSSSQGVQAVP-------------LAATRHPLPTPSPASGQT--RAM MAV_4968|M.avium_104 QRPAEPRPAPPQRP-------------------PTQAAPPSGDQT--RAI MAB_4508|M.abscessus_ATCC_1997 DAPTTRSSVAGTHRPDRRNADREIESWLGELRGPKQPGAAAGTEAGDATT * : Mflv_0456|M.gilvum_PYR-GCK LGDLRGGGTTGPAGA--PQPMRPSAEPTRAMPDSGED------------- Mvan_0196|M.vanbaalenii_PYR-1 LGDLRGSRASGTAAANPPQPLRPSAEPTRAMPDTGAAGNEPTTAIPAQRE MSMEG_0250|M.smegmatis_MC2_155 LGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADR-GNENA TH_4488|M.thermoresistible__bu VGEVAVDRRSAHAGRG-----TDVLQPHSEIAPLG--------------- Mb0212c|M.bovis_AF2122/97 PLAANRSTD--AAGDP--------AEPTAALPIIR--------------- Rv0206c|M.tuberculosis_H37Rv PLAANRSTD--AAGDP--------AEPTAALPIIR--------------- MMAR_0446|M.marinum_M QIPTNRSSD--TGGDP--------ADPTAALPIQR--------------- MUL_1096|M.ulcerans_Agy99 QIPTNRSSD--TGGDP--------ADPTAALPIQR--------------- MLBr_02620|M.leprae_Br4923 PVPANRSSD--NASET--------AEPTTALPIMR--------------- MAV_4968|M.avium_104 PVPGNRPDDGDSDADA--------AEPTTALPKMR--------------- MAB_4508|M.abscessus_ATCC_1997 AIPVSKPQSTPRPAQPNRASGTPGEDATTAMPIAKPEVQRQGPP------ :. :. Mflv_0456|M.gilvum_PYR-GCK ------AASDDEPDD--TATRAIPAQRKPDAEAATEKLNTR---PDPDAP Mvan_0196|M.vanbaalenii_PYR-1 SERHRESARHDDSDDSAASTRAIPTARQSDADAATEKLNTR---PDDEAT MSMEG_0250|M.smegmatis_MC2_155 PTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPET TH_4488|M.thermoresistible__bu ------HQPFGGGEDLAATVRLGPAAPGGRRPG------------GGCVA Mb0212c|M.bovis_AF2122/97 ------SDGD---DSEAATEQLNARG----TSDKT------------RQR Rv0206c|M.tuberculosis_H37Rv ------SDGD---DSEAATEQLNARG----TSDKT------------RQR MMAR_0446|M.marinum_M ------PEGT---DTEAATEQLNARGGQPDGGENP------------RPR MUL_1096|M.ulcerans_Agy99 ------PEGT---DTEAATEQLNARGGQPDGGENP------------RPR MLBr_02620|M.leprae_Br4923 ------PQDN---DSEVATEKLNALG----QGDNS------------RQH MAV_4968|M.avium_104 ------AEGSGGSESDAAGDQANARG-QGENGDPA------------RQR MAB_4508|M.abscessus_ATCC_1997 RAQRPQPEQQQPAKPSTDATEALPAPGQNRTPQQQE---------VDEAT . Mflv_0456|M.gilvum_PYR-GCK RRGGS---GVSAQDLLRREGRL- Mvan_0196|M.vanbaalenii_PYR-1 RRGGK---GLSAQDLLRREGRL- MSMEG_0250|M.smegmatis_MC2_155 KRRGG---GMSAQDLLRREGRL- TH_4488|M.thermoresistible__bu RHQRP---PSVMLDIPVNDD--- Mb0212c|M.bovis_AF2122/97 RRGGG---ALSAQDLLRREGRL- Rv0206c|M.tuberculosis_H37Rv RRGGG---ALSAQDLLRREGRL- MMAR_0446|M.marinum_M RRGAGGAGGLSAQDLLRREGRL- MUL_1096|M.ulcerans_Agy99 RRGAGGAGGLSAQDLLRREGRL- MLBr_02620|M.leprae_Br4923 RRATG--GGISAQDLLRREGRL- MAV_4968|M.avium_104 RRAGG---GLSAQDLLRREGRL- MAB_4508|M.abscessus_ATCC_1997 RRSRG--GSVSAQDLLRREGRRI :: *: .:.