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LRVSSNLRRFRWAVFAVWLLLLVPSIYLALNQSSHLTGGGFEVEGSQSLYVQRQLEAQFPDQGASPLALV AAPRSDASYDDMTSAVSHLERLAAEVPSVTVVPTPQQPPPRPDRPYVITLQLDFENTGAVDVAKQLREKV GVDGEEPGEMENGKVRLYVIGQGALGAAATLATKHDIAQAEKWNFPIVLVILLAVFGSLAAAAMPLLLGV CTVVVTMGLVFLLSMYTTMSVFVTSTVSMFGIAVAIDYSLFILMRFREELRAGREPEDAADAAMATSGLA VLLSGLTVIASVTGIYLINTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRGVE ATQSKFWSRWTGWVMRRPWVSATAAAAVLLAFAAPAFSMMLGNSMQRQFDPTHEIRGGVNAAAEALGPGA LGPIRVLVTFPVDDGAEAAAPLLESLRQKMGQAPNTVSVSPPVFGSDGRSALLSAVLSVDPEDMGARDTV DWMREQLPPVAGDAARVDVGGPTALIKDFDDRVSQTQPLVFVFVALIAFVMLLVSIRSVFLAFKGVLMTV LSVAAAYGSLVVVFQWGWLADLGFKQISSLDSTIPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDA VAYGVSTSARTITSAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATIVRLVLVPALMAMFDEWNWW LPRWLDRILPSVDFEKPLPKADIGDLVIIPDDISALAPSGSDLRTVVKSAAKLKTLAPQAITVADPLAFS GCLPCGKISGNRVGRDERITAAVTNRAHGKTVAVKLPKHPVTMWRGRLDVALDALAVEQSAGNGEPRIER ISPMETTNVLLPTGDRLQIPTGAETLRLKGFLIMSRNTARDYRDFTELVDSMDVDTAADVLAGMDRYYAG QPARAHWVATQLVRRLAEPLPSDGPDIAAAGADEETEWAKVRQRCLSVAVAMLEETR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0188 | - | - | 100% (968) | MmpL11 |
| M. vanbaalenii PYR-1 | Mvan_1197 | - | 7e-75 | 29.85% (717) | hypothetical protein Mvan_1197 |
| M. vanbaalenii PYR-1 | Mvan_1577 | - | 2e-70 | 28.90% (737) | polyprenyl synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0208c | mmpL11 | 0.0 | 69.33% (978) | transmembrane transport protein MmpL11 |
| M. gilvum PYR-GCK | Mflv_0464 | - | 0.0 | 88.14% (978) | MmpL11 |
| M. tuberculosis H37Rv | Rv0202c | mmpL11 | 0.0 | 69.33% (978) | transmembrane transport protein MmpL11 |
| M. leprae Br4923 | MLBr_02617 | - | 0.0 | 64.60% (1014) | hypothetical protein MLBr_02617 |
| M. abscessus ATCC 19977 | MAB_4529 | - | 0.0 | 54.62% (985) | putative membrane protein, MmpL |
| M. marinum M | MMAR_0442 | mmpL11 | 0.0 | 67.96% (1008) | transmembrane transport protein MmpL11 |
| M. avium 104 | MAV_4973 | - | 0.0 | 68.74% (1011) | MmpL11 protein |
| M. smegmatis MC2 155 | MSMEG_0241 | - | 0.0 | 78.68% (971) | MmpL11 protein |
| M. thermoresistible (build 8) | TH_3087 | - | 0.0 | 75.44% (977) | PUTATIVE MmpL11 |
| M. ulcerans Agy99 | MUL_1092 | mmpL11 | 0.0 | 67.86% (1008) | transmembrane transport protein MmpL11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0188|M.vanbaalenii_PYR-1 MLRVSSNLRRFRWAVFAVWLLLLVPSIYLALNQSSHLTGGGFEVEGSQSL
Mflv_0464|M.gilvum_PYR-GCK MMRVSSNLRRFRWAVFAVWLLLLLPSVYLAMNQAGNLTGGGFEVEGSQSL
MSMEG_0241|M.smegmatis_MC2_155 MMRLSSTLRRFRWAVFATWLLLLVPSIYLALNQSSNLTGGGFEVEGSQSL
TH_3087|M.thermoresistible__bu MMRLSNALRRYRWAVFSGWVLLLLPSIWLALSGTGQLTGGGFEVAGSQSL
Mb0208c|M.bovis_AF2122/97 MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSL
Rv0202c|M.tuberculosis_H37Rv MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSL
MMAR_0442|M.marinum_M MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAGSQSL
MUL_1092|M.ulcerans_Agy99 MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAGSQSL
MAV_4973|M.avium_104 MMRLSRSLRKYRWLVFAGWLLALVPAVYLALTQSGNLTGGGFDVAGSQSL
MLBr_02617|M.leprae_Br4923 -MRLSSYLRRFRWLVFTGWLLALVPAIYLAMTQSGKLTGGGFEVAGSQSL
MAB_4529|M.abscessus_ATCC_1997 MMRTSDYLRRYRWLTVAVWLILIVAAVGLVAGRGEKLTGGGFEVAGSQSL
:* * **: ** ..: *:: ::.:: *. :******:* *****
Mvan_0188|M.vanbaalenii_PYR-1 YVQRQLEAQFPDQGASPLALVAAPRSDASYDDMTSAVSHLERLAAEVP-S
Mflv_0464|M.gilvum_PYR-GCK YVQRQLEAQFPDQGASPLALVAAPRPDASFEDMNNAVAQLESLAAEIP-S
MSMEG_0241|M.smegmatis_MC2_155 HVQRQLEEHFPDQGASPLALVAAPRADASYEDMNAAVVHLEKLAAEVP-S
TH_3087|M.thermoresistible__bu RVQHELEDHFPDEGASPLALVAAPRADATFEDMNAAVAFLEQVAAEVSDD
Mb0208c|M.bovis_AF2122/97 LVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELP-G
Rv0202c|M.tuberculosis_H37Rv LVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELP-G
MMAR_0442|M.marinum_M QVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGEFP-G
MUL_1092|M.ulcerans_Agy99 RVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGEFP-G
MAV_4973|M.avium_104 AVHDQLEDLYHDQGGSSLALVAAPRADASYQDMNDAVAQLRRIAAEVP-G
MLBr_02617|M.leprae_Br4923 LVHDQLQEQYPDQGAVSLALVAAPRSDASYQDMNDAVALLRRIVSEFP-G
MAB_4529|M.abscessus_ATCC_1997 KVHDAMETGFREQGASPLALVAAPRPDATVSDMAAAVDYLKQVAAQIP-Q
*: :: : :.*. .*****:**.**: .*: ** *. :..:..
Mvan_0188|M.vanbaalenii_PYR-1 VTVVPTPQQPPPRPDRPYVITLQLDFENTGAVDVAKQLREKVGVDGEEPG
Mflv_0464|M.gilvum_PYR-GCK ITVVPSPQQPPPQPDRPYVVTLAMDFENTGAVDIAKQLREKVGVDGEDAG
MSMEG_0241|M.smegmatis_MC2_155 VKIVPNPQQPAPQPDRPYVITLQLDFNNTGAVDVAKQLRQKVGIHGEEPG
TH_3087|M.thermoresistible__bu VRIKPNPQQPPPRPDRPYVLTLQLDFDNTGAVDVSNQLREKVGIDGDRPG
Mb0208c|M.bovis_AF2122/97 VTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSG
Rv0202c|M.tuberculosis_H37Rv VTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSG
MMAR_0442|M.marinum_M VSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVGVEGDKPG
MUL_1092|M.ulcerans_Agy99 VSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVGVEGDKPG
MAV_4973|M.avium_104 TTEIPNPTQRPPQPDRPYVLSVRLDSRN--TSDVAKQLRTKVGIKGDQPG
MLBr_02617|M.leprae_Br4923 VSEVPNPTQLPPRPDRPYGVSLRLDDRNSVTSDVAKQLRTKVGIKGDQAG
MAB_4529|M.abscessus_ATCC_1997 VSVEPIPPQLTPQPDRPFVVTLRIGFDNTGATDIAKSLRKKIGVHGGQPG
* * * .*:****: ::: :. * : *:::.** ::*:.* .*
Mvan_0188|M.vanbaalenii_PYR-1 EMENGKVRLYVIGQGALGAAATLATKHDIAQAEKWNFPIVLVILLAVFGS
Mflv_0464|M.gilvum_PYR-GCK ETENGKVRLYVIGQGALGAAATEATKDDIAQAEKWNFPIVLVILLAVFGS
MSMEG_0241|M.smegmatis_MC2_155 ESQNGKVKFYVIGQGALGAAATQATKHDIAAAEKWNMPIVLIVLLAVFGS
TH_3087|M.thermoresistible__bu ETDNGRVRLYVVGQGALGAAASEATKHDIAQAERWNLPIVLIILLAVFGS
Mb0208c|M.bovis_AF2122/97 QTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGS
Rv0202c|M.tuberculosis_H37Rv QTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGS
MMAR_0442|M.marinum_M QTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIVLLAVFGS
MUL_1092|M.ulcerans_Agy99 QTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIVLLAVFGS
MAV_4973|M.avium_104 QTANGRVRLYVIGQGALSAAAAANTKHDIAAAEKWNLPVILIVLLAVFGS
MLBr_02617|M.leprae_Br4923 RTANGKVRLYVIGQGALSAAVAANSKHDIAEAERWNLPIILIVLLAVFGS
MAB_4529|M.abscessus_ATCC_1997 QIAGGRVSLYVIGQGALGAAMTEQIAGDIKKAEKWNIPVILIVLIAAFGS
. .*:* :**:*****.** : ** **:**:*::*::*:*.***
Mvan_0188|M.vanbaalenii_PYR-1 LAAAAMPLLLGVCTVVVTMGLVFLLSMYTTMSVFVTSTVSMFGIAVAIDY
Mflv_0464|M.gilvum_PYR-GCK LAAAAMPLLLGVCTVVVTMGVVFVLSMYTTMSVFVTSTVSMFGIAVAIDY
MSMEG_0241|M.smegmatis_MC2_155 LAAAALPLVLGVCTVVVTMGLVYLLSMFTTMSVFVTSTVSMFGIAVAIDY
TH_3087|M.thermoresistible__bu LAAAAVPLVLGVCTVVVTMGVVYLLSLVTTMSVFVASTVSMLGIALAIDY
Mb0208c|M.bovis_AF2122/97 LAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDY
Rv0202c|M.tuberculosis_H37Rv LAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDY
MMAR_0442|M.marinum_M LTAAAIPLALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFGIALAVDY
MUL_1092|M.ulcerans_Agy99 LTAAAIALALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFGIALAVDY
MAV_4973|M.avium_104 LAAAAIPLALGICTVVVTMGLVYLLSAYTTMSVFVTSTVSMFGIALAVDY
MLBr_02617|M.leprae_Br4923 LAAAAVPLALGVCTVVVTMGLVDLVSMHTIMSVFVTSTVSMFGIALAVDY
MAB_4529|M.abscessus_ATCC_1997 LAAASLPLLLGVCTVALSVAIVLALSNITTISVFALPTVTMIGLAVAVDY
*:**::.* *.:***.:::.:* :* * :***. .**:*:*:*:*:**
Mvan_0188|M.vanbaalenii_PYR-1 SLFILMRFREELRAGREPEDAADAAMATSGLAVLLSGLTVIASVTGIYLI
Mflv_0464|M.gilvum_PYR-GCK SLFILMRFREELRAGREPEDAADAAMATSGLAVVLSGLTVIASVTGIYLI
MSMEG_0241|M.smegmatis_MC2_155 SLFILMRFREELRAGRDQQDAIDAAMATSGLAVALSGLTVIASVTGIYLI
TH_3087|M.thermoresistible__bu SLFILMRFREELRAGRDVDQAADAAMATSGLAVVLSGLTVIASVTGLYLI
Mb0208c|M.bovis_AF2122/97 SLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLI
Rv0202c|M.tuberculosis_H37Rv SLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLI
MMAR_0442|M.marinum_M SLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVVASLSGIYLI
MUL_1092|M.ulcerans_Agy99 SLFILMRFREELRSGRQPQEAADAAMATSGLAVVLSGMTVVASLSGIYLI
MAV_4973|M.avium_104 SLFILMRFREELRSGRQPREAVDAAMATSGLAVVLSGMTVIASLTGIYVI
MLBr_02617|M.leprae_Br4923 SLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVIASLTGIYLI
MAB_4529|M.abscessus_ATCC_1997 SLFILMRYREELNSGKNRQEAIAGAMATSGLTVTFSGLTVIAALAGIYLI
*******:****..*: :* .*******:* :**:**:*:::*:*:*
Mvan_0188|M.vanbaalenii_PYR-1 NTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRG
Mflv_0464|M.gilvum_PYR-GCK NTPVLQSMATGAILAVAIAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRG
MSMEG_0241|M.smegmatis_MC2_155 NTPVLVSMATGAILAVAVAVLTSTTLTPAVLATFGKAAAKRSSYLHWSRR
TH_3087|M.thermoresistible__bu NTPVLRSMATGAVLAVAVAVLAATTLTPAVLATFGRAAARRSSYLHWSRR
Mb0208c|M.bovis_AF2122/97 NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRR
Rv0202c|M.tuberculosis_H37Rv NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRR
MMAR_0442|M.marinum_M NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALLHWSRR
MUL_1092|M.ulcerans_Agy99 NTPALRSMATGAILAVAVAILTSATLTPAVLATFARAAAKRSALLHWSRR
MAV_4973|M.avium_104 NTPALKSMATGAILAVAVAMLTSTTLTPAALATFGRAAAKRSALLHWSRR
MLBr_02617|M.leprae_Br4923 NTAALKSMATGAILAVAIAMLASITLTPAALATFGRAAVKRSVLMHWSQR
MAB_4529|M.abscessus_ATCC_1997 GTPALASMASGAIIVVAIAVLTSTTLMPALLAIFGKAAANQSRFLRVSP-
.*..* ***:**::.**:*:*:: ** ** ** *.: *..:* :: .
Mvan_0188|M.vanbaalenii_PYR-1 VEATQSKFWSRWTGWVMRRPWVSATAAAAVLLAFAAPAFSMMLGNSMQRQ
Mflv_0464|M.gilvum_PYR-GCK VEATQSKFWTRWTGWVMRRPWLSAMAAAAVLLTFAAPAFSMMLGNSMQRQ
MSMEG_0241|M.smegmatis_MC2_155 AEAAQSRFWTRWTGAVMRRPWASAIAAAILLLVLAAPAFNMVLGNSMQRQ
TH_3087|M.thermoresistible__bu PETTQSPFWTRWTGQVMRRPWVSAAAASAVLLVMAAPTVAMELGNSMQRQ
Mb0208c|M.bovis_AF2122/97 PASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ
Rv0202c|M.tuberculosis_H37Rv PASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ
MMAR_0442|M.marinum_M PESTQSRFWTRWVGWVMHRPWITALSASVVLLLMAAPAASMVLGNSLLRQ
MUL_1092|M.ulcerans_Agy99 PESTQSRFWTRWVGWVMHRPWITALSASVVLLLMAAPAASMVLGNSLLRQ
MAV_4973|M.avium_104 PESTQSKFWNRWIGWVMRRPWMSALAASLVLLVMAAPAASMVLGNSLLRQ
MLBr_02617|M.leprae_Br4923 SECTQSLFWTRWVGWVMHRPWISASAASTILIIMATPVTSMMLGNSLLRQ
MAB_4529|M.abscessus_ATCC_1997 LRKHSIPFWRKWTQQVMRRPWLSALGASIFLLALAAPSLQMHVSNSMLRQ
. ** :* **:*** :* .*: .*: :*:* * :.**: **
Mvan_0188|M.vanbaalenii_PYR-1 FDPTHEIRGGVNAAAEALGPGALGPIRVLVTFPVDD--GAEAAA--PLLE
Mflv_0464|M.gilvum_PYR-GCK FDTTHEIRGGVSAAAEALGPGALGPIRVLITFPDGD--AASASAKEPLLA
MSMEG_0241|M.smegmatis_MC2_155 FDPTHEIRGGVNAAADALGPGALGPIRVLVTFPGEG--DASSQAATTTIE
TH_3087|M.thermoresistible__bu FEPTHEIRGGVNAAAEALGPGALGPVRVMVSFP-DG--AASQPANAGTLD
Mb0208c|M.bovis_AF2122/97 FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---GASAPEHSQTIA
Rv0202c|M.tuberculosis_H37Rv FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---GASAPEHSQTIA
MMAR_0442|M.marinum_M FDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG---GASTPAHSQTVG
MUL_1092|M.ulcerans_Agy99 FDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG---GASTPAHSQTVG
MAV_4973|M.avium_104 FDSSHEIRAGVGAAAQALGPGALGPIRVLINFPDG---GAASPEHSHTVG
MLBr_02617|M.leprae_Br4923 FNSSHEIRAGVAAAAQALGPGALGPVQVLITFPDDPNTQASSPKHRQTIG
MAB_4529|M.abscessus_ATCC_1997 FDSSHEIRRGIDAAAVAMGPGALGPVQVLLTFKDSP-----AHAHAQALE
*:.:**** * *** *:*******::*:: * :
Mvan_0188|M.vanbaalenii_PYR-1 SLRQKMGQAPNTVSVSPPVFGSDGRSALLSAVLSVDPEDMGARDTVDWMR
Mflv_0464|M.gilvum_PYR-GCK ELRQTMAGAPNVVSVTPPVFGTDYRIALLSAVLSVDPEDMGARETIDWMR
MSMEG_0241|M.smegmatis_MC2_155 AVRQQMTKAPSVVSVQPPVVSDDNDSALLSAVLSVDPEDMAAREAIDWMR
TH_3087|M.thermoresistible__bu AVRQEISRAPNVVSVSPPVFADDDSSALLSAVLSVDPEDMRARDTIDWLR
Mb0208c|M.bovis_AF2122/97 AIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMR
Rv0202c|M.tuberculosis_H37Rv AIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMR
MMAR_0442|M.marinum_M AVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSVDPEDMGARHTVDWMR
MUL_1092|M.ulcerans_Agy99 AVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSVDPEDMGARHTVDWMR
MAV_4973|M.avium_104 AVRQRMAQAPNIVSVSPPQFAEDNGSALLSAVLSVDPEDMKARETVGWMR
MLBr_02617|M.leprae_Br4923 AIRNRMLQAKNVMSVAPPQFADNNCSALLGAVLSVDPEDLGARETVDWMR
MAB_4529|M.abscessus_ATCC_1997 TAKETIAQAPNIARVSDVSFSTDGHDALISAVLSVDPEANAARDTVSWLR
:. : . . * .. : **:.******** **.:: *:*
Mvan_0188|M.vanbaalenii_PYR-1 EQLPPVA-GDAARVDVGGPTALIKDFDDRVSQTQPLVFVFVALIAFVMLL
Mflv_0464|M.gilvum_PYR-GCK EKLPPVA-GDAASIDVGGPTALIKDFDDKVSATQPLVFAFVALIAFVMLL
MSMEG_0241|M.smegmatis_MC2_155 AELPGVA-GQNATIDVGGPTALIKDFDDRVSATQPLVFVFVALIAFVMLL
TH_3087|M.thermoresistible__bu EHLPAAA-GDGARTDVGGPTALIKDFDDEVATTQPLVFVFVAVIAFVMLL
Mb0208c|M.bovis_AF2122/97 TQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLL
Rv0202c|M.tuberculosis_H37Rv TQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLL
MMAR_0442|M.marinum_M SELPQV--AGGAQVDVGGSTALIKDFDDRVSATEPLVLAFVALIAFVMLL
MUL_1092|M.ulcerans_Agy99 SELPQV--AGGAQFDVGGSTALIKDFDDRVSATEPLVLAFVALIAFVMLL
MAV_4973|M.avium_104 AELPKVSEAGTARVDVGGPTALIKDFDDRVSATEPLVLGFVALIAFVMLL
MLBr_02617|M.leprae_Br4923 TELPKV--PGAAHVNVGGPTALINDFDDRVAKTEPLMLVFVALIAFVMLL
MAB_4529|M.abscessus_ATCC_1997 ANVPDALENSGADINVGGPTALLFDYDTRVEHSLLGVFAFVCVLAFVMLL
.:* . * :***.***: *:* .* : :: **.::**:***
Mvan_0188|M.vanbaalenii_PYR-1 VSIRSVFLAFKGVLMTVLSVAAAYGSLVVVFQWGWLADLGFKQISSLDST
Mflv_0464|M.gilvum_PYR-GCK VSIRSVFLAFKGVLMTVLSVAAAYGSLVVVFQWGWLSSLGFDQLSSLDST
MSMEG_0241|M.smegmatis_MC2_155 VSIRSVVLAFKGVLMTVLSVAAAYGSLVVVFQWGWLEQLGFPRISSLDST
TH_3087|M.thermoresistible__bu IAIRSPVLALKGVLMTVLSVAAAYGSLVAVFQWGWLAPLGFEPISSLDST
Mb0208c|M.bovis_AF2122/97 ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDST
Rv0202c|M.tuberculosis_H37Rv ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDST
MMAR_0442|M.marinum_M ISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGWGERLGFPQLTSIDST
MUL_1092|M.ulcerans_Agy99 ISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGWGERLGFPQLTSIDST
MAV_4973|M.avium_104 VSIHSVFLALKGVLMTLLSVAAAYGSLVMVFQWGWLRDLGFAQISSIDST
MLBr_02617|M.leprae_Br4923 ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWLENLGFTHINSIDST
MAB_4529|M.abscessus_ATCC_1997 ATLRSPVLALKGVVMTVLSVAAAYGSLVIVFQWGWLEFLGFHKAN-IDSS
:::* .**:***:**:*********** ****** *** :**:
Mvan_0188|M.vanbaalenii_PYR-1 IPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTIT
Mflv_0464|M.gilvum_PYR-GCK IPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTIT
MSMEG_0241|M.smegmatis_MC2_155 IPPLVLAMTFGLSMDYEIFLLTRIRERFLQTNSTRDAVAYGVSTSARTIT
TH_3087|M.thermoresistible__bu IPPLVLALTFGLSMDYEIFLLTRIRERFLQTQDTRDAVAYGVSTSARTIT
Mb0208c|M.bovis_AF2122/97 VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTIT
Rv0202c|M.tuberculosis_H37Rv VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTIT
MMAR_0442|M.marinum_M VPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGRTRDAVAYGVSTSARTIT
MUL_1092|M.ulcerans_Agy99 VPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGRTRDAVAYGVSTSARTIT
MAV_4973|M.avium_104 VPPLVLAMTFGLSMDYEIFLLTRIRERFLHSGNTRDAVAYGVSTSARTIT
MLBr_02617|M.leprae_Br4923 VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGHTRDAVAYGVSTSARTIT
MAB_4529|M.abscessus_ATCC_1997 IPPLALALTFGLTMDYEIFLLARVRERYLRTGDCGDAVSYGVRTSARTIT
:***.**:****:********:*:***:*:: ***:*** *******
Mvan_0188|M.vanbaalenii_PYR-1 SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATIVRLVLVPALMAM
Mflv_0464|M.gilvum_PYR-GCK SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATIVRLVLVPALMAM
MSMEG_0241|M.smegmatis_MC2_155 SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM
TH_3087|M.thermoresistible__bu SAALIMIAVFTGFAFAGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM
Mb0208c|M.bovis_AF2122/97 SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM
Rv0202c|M.tuberculosis_H37Rv SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM
MMAR_0442|M.marinum_M SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATIVRLIMVPALMAM
MUL_1092|M.ulcerans_Agy99 SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATIVRLIMVPALMAM
MAV_4973|M.avium_104 SAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAVDATVVRLVMVPALMAM
MLBr_02617|M.leprae_Br4923 SAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAVDVTAVRLVLVPTLMAM
MAB_4529|M.abscessus_ATCC_1997 SAALIMIAVFIGFAFVGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM
********** ****.******::***********.* ***::**:****
Mvan_0188|M.vanbaalenii_PYR-1 FDEWNWWLPRWLDRILPSVDFEKPLPKADIG--DLVIIPDDISALAPSGS
Mflv_0464|M.gilvum_PYR-GCK FDEWNWWLPRWLDRLLPSVDFEKPLPKADIG--DLVIIPDDISALAPSGS
MSMEG_0241|M.smegmatis_MC2_155 FDQWNWWLPRWLDKILPEVDFEKPLPKIEVT--DLVIIPDNIAALGPSGS
TH_3087|M.thermoresistible__bu FDKWNWWLPPWLDRLLPSVDFEKPLPHTDIG--DLVIIPDDISALMPPGS
Mb0208c|M.bovis_AF2122/97 FDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--DVVVIPDDFAAAIPPSA
Rv0202c|M.tuberculosis_H37Rv FDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--DVVVIPDDFAAAIPPSA
MMAR_0442|M.marinum_M FSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--DVVVIPEDIAATIPPGA
MUL_1092|M.ulcerans_Agy99 FSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--DVVVIPEDIAATIPPGA
MAV_4973|M.avium_104 FAQWNWWLPPWLSRVLPSVDFDRPLPEVDLG--DVVVIPDDISALTAPSA
MLBr_02617|M.leprae_Br4923 FAQWNWWLPRWLSRALPAVDFDKPFPPVDLN--EIVVLPADISATKVPCG
MAB_4529|M.abscessus_ATCC_1997 FDKRNWWLPGWLDHVLPTVDFETPCVDELPGPHSESALRLQGSGFEEPRI
* . ***** ** : ** ***: * . : : :. .
Mvan_0188|M.vanbaalenii_PYR-1 DLRTVVKSAAKLKTLAP-QAITVADPLAFSGCLPCGKISGNRV-------
Mflv_0464|M.gilvum_PYR-GCK DLRTVVKSAAKLKTLVP-QAVTVADPLAFSGCLPCNKMTGTRV-------
MSMEG_0241|M.smegmatis_MC2_155 DLRTMVRTAARMKTLAP-QTISVADPLAFSGCT-----------------
TH_3087|M.thermoresistible__bu QLRSVVRSAAKLKSLAP-ETITVADPLAFSGCVRSGEPLGPRIK------
Mb0208c|M.bovis_AF2122/97 DVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGCDGK-------------
Rv0202c|M.tuberculosis_H37Rv DVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGCDGK-------------
MMAR_0442|M.marinum_M DLRMVLKSAAKLKQLAP-DTICVADPLAFTGCERVGKGPERIPELVKDG-
MUL_1092|M.ulcerans_Agy99 DLRMVLKSAAKLKQLAP-DTICVADPLAFTGCEGVGKGPERIPELVKDG-
MAV_4973|M.avium_104 DLRMVLKSAAKLKHLAP-DAICVTDPLAFTGCGRTTAAGADPARGLGPGQ
MLBr_02617|M.leprae_Br4923 DLRMVLKLAAKLKNLAP-DAICVADPLAFTGCGRNNKRSDRVLPGAATQE
MAB_4529|M.abscessus_ATCC_1997 DYHAIAVSAARLKRLADGGTITAPDTQAVLADR-----------------
: : : **::* *. :: ..*. *. .
Mvan_0188|M.vanbaalenii_PYR-1 --------------------------GRDERITAAVTN----RAHGKTVA
Mflv_0464|M.gilvum_PYR-GCK --------------------------GRDERITAAVSN----RAHGKTVA
MSMEG_0241|M.smegmatis_MC2_155 ------------------------------RPTTRLST----QRAGRPKA
TH_3087|M.thermoresistible__bu --------------------------GGDDGTTVPVRTGGGGRRAGTAVA
Mb0208c|M.bovis_AF2122/97 ---------------------------------ALDQVQ-LAYRNGIARA
Rv0202c|M.tuberculosis_H37Rv ---------------------------------ALDQVQ-LAYRNGIARA
MMAR_0442|M.marinum_M ------LNLAGGTDTAGPGGAAEAKNGSNGQSAARKAVG-LAYRSGIARA
MUL_1092|M.ulcerans_Agy99 ------LNLAGGTDTAGPGGGAEAKNGSKGQSAARKAVG-LAYRSGIARA
MAV_4973|M.avium_104 IPHQVALREEKVGVAAGPGEKTGSNGHTNGSAGAKKPAA-RNGRNGIAKA
MLBr_02617|M.leprae_Br4923 SEEDPAMGKASDSTAALTAAQVGPVTRTNGHWTARNLVIGLTHRNSITRV
MAB_4529|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0188|M.vanbaalenii_PYR-1 VKLP---KHPVTMWRGRLDVALDALAVEQ------SAGNGEPRIERISPM
Mflv_0464|M.gilvum_PYR-GCK VKLP---KHPVTMWRGRLDVALEALATER------AQNEGHPTIERISPL
MSMEG_0241|M.smegmatis_MC2_155 HTPG---LHPVTMWRGRLSVAVDALQTEA------DTEQAP--VERRGPV
TH_3087|M.thermoresistible__bu TRPA---VHPVTLWLDRLEVALDALHTAA------DLDGAP--VERRSPM
Mb0208c|M.bovis_AF2122/97 ISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPV
Rv0202c|M.tuberculosis_H37Rv ISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPV
MMAR_0442|M.marinum_M MSWAERPVHPVTVWRGRLSIALDALETNASERRAGPGGGREPSYRRRSPV
MUL_1092|M.ulcerans_Agy99 MSWAERPVHPVTVWRGRLSIALDALETNASERRAGPGSGREPNYRRRSPV
MAV_4973|M.avium_104 IAGADRPVHPVTLWRGRLSVALDALQTDP------DSGADRPRFRRRSPV
MLBr_02617|M.leprae_Br4923 MPWSDRPVHPFTLWRSRFSVAIDALEAHIAVQ---ADAPDQPNYQRCSPV
MAB_4529|M.abscessus_ATCC_1997 -------------WRDNLTVALEALQTSK-NGTDTDIVEMPGPLSRVTPV
* .: :*::** . * *:
Mvan_0188|M.vanbaalenii_PYR-1 ETTNVLLPTGDRLQIPTGAETLRLKGFLIMSRNTARDYRDFTELVDSMDV
Mflv_0464|M.gilvum_PYR-GCK ETTNVLLPTGDRLQIPTGAETLRLKSYLILERNSTRDFSEFSELVDSMDT
MSMEG_0241|M.smegmatis_MC2_155 ETTNVQLPTGDRLQIPTGAETLRLAGYLIMCRNTTKDFEDFARLVDLMDS
TH_3087|M.thermoresistible__bu ETTTVQLPTGDRLQIPTGAETVRLMGYLIMCRNSARDYAEFADLVECMDA
Mb0208c|M.bovis_AF2122/97 ETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAP
Rv0202c|M.tuberculosis_H37Rv ETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAP
MMAR_0442|M.marinum_M ETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNSSRDYAELADMVEAMEP
MUL_1092|M.ulcerans_Agy99 ETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNSSRDYAELADMVEAMEP
MAV_4973|M.avium_104 ETTNVQLPTGDRLLVPTGAEALRLKGYLLMCRNSRRDYADFADMVDALEP
MLBr_02617|M.leprae_Br4923 ETAHVQLPTGDRLLIPTGAETLRLVSYLIMCRNSIRDYAELADMVDAIEP
MAB_4529|M.abscessus_ATCC_1997 EITQVKLPTGQKCVVPTDAEALRMQGLLLMRRNAERDYTEFARLASAMEP
* : * ****:: :**.**::*: . *:: **: :*: ::: :.. :
Mvan_0188|M.vanbaalenii_PYR-1 DTAADVLAGMDRYYAGQPAR--------AHWVATQLVRRLAEPLPSDGPD
Mflv_0464|M.gilvum_PYR-GCK STAAEVLASMDRYYSGQSARDQQAGARTRHWVATQLVRRLAEPAPADGPD
MSMEG_0241|M.smegmatis_MC2_155 HTAALVLASMDRYYCGRDPS--------NRWVATQLVRRLADPQPSDEHD
TH_3087|M.thermoresistible__bu ETAAAVLARMDRYYCGQYPR--------QHWVATQLVRRLADPHPSDVDD
Mb0208c|M.bovis_AF2122/97 ETAAAVLAGMDRYYSCQAPG--------RQWMATQLVGRLADPQPSD-LG
Rv0202c|M.tuberculosis_H37Rv ETAAAVLAGMDRYYSCQAPG--------RQWMATQLVGRLADPQPSD-LG
MMAR_0442|M.marinum_M ETAAVVLAGMDRYYCCQPPR--------RQWIATQLVRRLADPHPSD-VD
MUL_1092|M.ulcerans_Agy99 ETAAVVLAGMDRYYCCQPPR--------RQWIATQLVRRLADPHPSD-VD
MAV_4973|M.avium_104 ETAAVVLAGMDRYYCCESSR--------RQWIATQLVRRLADPDPCDYPD
MLBr_02617|M.leprae_Br4923 ETAAVVLTELDRYYSCQLPM--------RQWMATQLVRRLSDPHPVDLTE
MAB_4529|M.abscessus_ATCC_1997 RMAAKVLAGIDQHYCVQSNQ---------RWVSSQLVRRLADPKPGD---
** **: :*::*. . :*:::*** **::* * *
Mvan_0188|M.vanbaalenii_PYR-1 IAAAGADEETEWAKVRQRCLSVAVAMLEETR
Mflv_0464|M.gilvum_PYR-GCK IAAAGADGEAEWATVRQRCLSVAVAMLEETR
MSMEG_0241|M.smegmatis_MC2_155 VRMSGPDAAEDWEKVRQRCLSVAVAMLEEAK
TH_3087|M.thermoresistible__bu DGETESSAVADWDEVRKRCLSVAVAMLEEAR
Mb0208c|M.bovis_AF2122/97 DQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
Rv0202c|M.tuberculosis_H37Rv DQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
MMAR_0442|M.marinum_M VEWPQPDDKADWEEVRQRCLAVAVAMLEEAR
MUL_1092|M.ulcerans_Agy99 VEWPQPDDKADWEEVRQRCLAVAVAMLEEAR
MAV_4973|M.avium_104 DQGPDADAPADWEQIRQRCLAVAVAMLEEAR
MLBr_02617|M.leprae_Br4923 DQWSDPDNKAEWQDVRQRCLSVAVAMLEEAR
MAB_4529|M.abscessus_ATCC_1997 -------GAMECPTVRRQCLSVAVAMLEDAR
. :*::**:*******:::