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MLTSVGQWIMTTGLHIAMVVVFALVVTRAIRWAAERVSRRIADGDDREPTVRSETVKHRQAVAAATSSVA IGVLYVLVALDIANQLGLPIASLVAPAAVLGAALGFGAQRLVQDLLSGFFVISEKQYGFGDLVELTVSAG GTATGTVEAVTLRVTKLRTSEGEVYTVPNGMIAKSRNLSKDWASAVVDVPVPSTADINRVNDVLREVAVT AGNDEDLARLLLDEPQLMGVESIEVDTVNVRMVARTLPGKQFEVGRRLRALVVAALRREGIALAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0128 | - | - | 100% (275) | MscS mechanosensitive ion channel |
| M. vanbaalenii PYR-1 | Mvan_1912 | - | 1e-93 | 64.68% (269) | MscS mechanosensitive ion channel |
| M. vanbaalenii PYR-1 | Mvan_3795 | - | 6e-40 | 35.76% (288) | MscS mechanosensitive ion channel |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3131c | - | 7e-88 | 61.17% (273) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4450 | - | 5e-92 | 64.31% (269) | MscS mechanosensitive ion channel |
| M. tuberculosis H37Rv | Rv3104c | - | 7e-88 | 61.17% (273) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3477c | - | 2e-85 | 58.24% (273) | MscS mechanosensitive ion channel |
| M. marinum M | MMAR_1528 | - | 8e-86 | 60.44% (273) | transmembrane protein |
| M. avium 104 | MAV_4005 | - | 7e-79 | 58.69% (259) | transporter, small conductance mechanosensitive ion channel |
| M. smegmatis MC2 155 | MSMEG_2087 | - | 2e-95 | 64.34% (272) | transporter, small conductance mechanosensitive ion channel |
| M. thermoresistible (build 8) | TH_2153 | - | 2e-89 | 62.31% (268) | POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_2411 | - | 2e-86 | 60.81% (273) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3131c|M.bovis_AF2122/97 MTTSGT------VLAT---SIAQHWHNFWRGEIGDWILNRGLRIVMLLIA
Rv3104c|M.tuberculosis_H37Rv MTTSGT------VLAT---SIAQHWHNFWRGEIGDWILNRGLRIVMLLIA
MMAR_1528|M.marinum_M MTTNTT------AFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMVLIA
MUL_2411|M.ulcerans_Agy99 MTTNTT------AFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMVLIA
MAV_4005|M.avium_104 ---------------------------------------------MVLIA
MSMEG_2087|M.smegmatis_MC2_155 MTISSS------AATVLAFSVADRWHDFWHGEIGVWILTKGLRIALLLIG
TH_2153|M.thermoresistible__bu MTNSS----------YLAFSAADAWHAFWHGQVGAWILTKGLRVMLLLIG
Mflv_4450|M.gilvum_PYR-GCK MAQPESRRRITLNTTVLAFDMAGAWRGFWQGDTGVWILGRGVPIALLLIG
Mvan_0128|M.vanbaalenii_PYR-1 ----------------------------MLTSVGQWIMTTGLHIAMVVVF
MAB_3477c|M.abscessus_ATCC_199 MIRAAE-------FSAGGLRLAERWNSFWSSQIGRWLLDNGLQIVIAILG
: ::
Mb3131c|M.bovis_AF2122/97 AVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSI
Rv3104c|M.tuberculosis_H37Rv AVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSI
MMAR_1528|M.marinum_M AVLAARFVTWVAKRVTQRLDLGFTESDALVRSEVSKHRQAVASVISWVSI
MUL_2411|M.ulcerans_Agy99 AVLAARFVTWVAKRVTQRLDLGFTESDALVRSEVSKHRQAVASVISWVSI
MAV_4005|M.avium_104 AVLAARFVNWVALQVSRQLTTGFVESDALVRSEASKHRQAVASVISWVSV
MSMEG_2087|M.smegmatis_MC2_155 GLLAARFISWAAQRVVRRIDAEYQESDQLVRSESAKHRQAVASVISWVSV
TH_2153|M.thermoresistible__bu AVLAARFINWAAMRVTSRLEAQS--GDALVRSEATKHRQAVASVISWVSI
Mflv_4450|M.gilvum_PYR-GCK GLLAARFINWSARRITRRIDAQYLESDQLVRTESAKHRQAVASVISWVSV
Mvan_0128|M.vanbaalenii_PYR-1 ALVVTRAIRWAAERVSRRIADGD-DREPTVRSETVKHRQAVAAATSSVAI
MAB_3477c|M.abscessus_ATCC_199 AMILVRFINWGAQKITRRLDRSFTQSDALVRSEASKHRQALASVISWIIV
.:: .* : * * :: :: : **:* *****:*:. * : :
Mb3131c|M.bovis_AF2122/97 VLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFI
Rv3104c|M.tuberculosis_H37Rv VLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFI
MMAR_1528|M.marinum_M VLIYVIVLYEIVDILPFPVGSLVGPAAVLGAALGFGAQRLVQDLLAGFFI
MUL_2411|M.ulcerans_Agy99 VVIYVIVLYEIVDILPFPVGSLVGPAAVLGAALGFGAQRLVQDLLAGFFI
MAV_4005|M.avium_104 VIIGIWVMLQIASILQFSVGGLVAPATVVGAALGFGAQQLVKDLLSGFFI
MSMEG_2087|M.smegmatis_MC2_155 ALLFVIVLVEVTDVLAVPVASLVAPAAVLGAALGFGAQRIVQDLLAGFFI
TH_2153|M.thermoresistible__bu VLLFVVVAVQITNELDIPVSSLVAPAAVLGAALGFGAQKLVQDLLAGFFI
Mflv_4450|M.gilvum_PYR-GCK ALLFVMVAVQITDILAIPIGSLVAPAAVIGAALGFGAQKLVQDLLAGFFI
Mvan_0128|M.vanbaalenii_PYR-1 GVLYVLVALDIANQLGLPIASLVAPAAVLGAALGFGAQRLVQDLLSGFFV
MAB_3477c|M.abscessus_ATCC_199 VLVVVLTTVHVVGVLGISVGGLAGPAAVLGGALGFGAQRVVQDLLSGFFL
:: : . .: . * ..:..*..**:*:*.*******::*:***:***:
Mb3131c|M.bovis_AF2122/97 IVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNG
Rv3104c|M.tuberculosis_H37Rv IVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNG
MMAR_1528|M.marinum_M IVEKQYGFGDLVELSMVGSPENAAGTVEEVTLRVTKLRSSDGEVYTVPNG
MUL_2411|M.ulcerans_Agy99 IVEKQYGFGDLVELSMVGSPENAAGTVEEVTLRVTKLRSSDGEVYTVPNG
MAV_4005|M.avium_104 LAERQYGFGDLVTLTVVAATE-ASGTVENVTLRVTRLRSPDGEVLTIPNG
MSMEG_2087|M.smegmatis_MC2_155 ITEKQYGFGDLVRLT-IGASNEAEGTVEDVTLRVTKLRSTEGEMYTVPNG
TH_2153|M.thermoresistible__bu ITERQYGFGDLVQLSMLGAPEEAVGTVEEVTLRVTKLRTADGEVYTVPNG
Mflv_4450|M.gilvum_PYR-GCK ITERQYGFGDLVELNMVGAPQAAQGTVEEVTLRVTKLRTSEGEVFTVPNG
Mvan_0128|M.vanbaalenii_PYR-1 ISEKQYGFGDLVELT-VSAGGTATGTVEAVTLRVTKLRTSEGEVYTVPNG
MAB_3477c|M.abscessus_ATCC_199 ITEKQYGFGDLVELYVQGQTTESRGTVEEVTLRVTKLRSGDGEVITIPNG
: *:******** * . : **** ******:**: :**: *:***
Mb3131c|M.bovis_AF2122/97 NIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLLGEL
Rv3104c|M.tuberculosis_H37Rv NIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLLGEL
MMAR_1528|M.marinum_M NIVKSINLSKDWARAVIDIPVPTGADLNRVNEVLHRECQHAREDAILGDL
MUL_2411|M.ulcerans_Agy99 NIVKSINLSKDWARAVIDIPVPTGADLNRVNEVLHRECQHAREDAILGDL
MAV_4005|M.avium_104 QIVKVVNLSKDWARAVVDIPVSTSADLNRVNEVLHQECDRAMDNPVLGQL
MSMEG_2087|M.smegmatis_MC2_155 QIVKSLNLSKDWARAVVDIPVSVSVDLNVVNDVLNEVAERATEDAELSKL
TH_2153|M.thermoresistible__bu NIVRSLNMSKDWARAVVDIPVPVTADLNRVNEVLHEVGDASMDDPVLKDL
Mflv_4450|M.gilvum_PYR-GCK NIVQSLNMSKDWARAVVDIPVPTTVDLNRVNEVLHRVGETAMQDDELRAL
Mvan_0128|M.vanbaalenii_PYR-1 MIAKSRNLSKDWASAVVDVPVPSTADINRVNDVLREVAVTAGNDEDLARL
MAB_3477c|M.abscessus_ATCC_199 LIVKAVNLSKDWARAVVDIPVPTSVDLARVNDVLYDVCQQALVDRDLSQL
*.: *:***** **:*:**. .*: **:** : : * *
Mb3131c|M.bovis_AF2122/97 LLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAG
Rv3104c|M.tuberculosis_H37Rv LLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAG
MMAR_1528|M.marinum_M LLDEPTVMGVEKLEMDTVTLRLVARTLPGKQFAAGRQLRVLVIRALTGAG
MUL_2411|M.ulcerans_Agy99 LLDEPTVMGVEKLEMDTVTLRLVARTLPGKQFAAGRQLRVLVIRALTGAG
MAV_4005|M.avium_104 LLDSPTVMGVESIEVDTVTLRLVARTLPGKQFEVGRQLRVLVIRALARAG
MSMEG_2087|M.smegmatis_MC2_155 VLDKPQLMGVESIGVDTVNLRMVARTLPGKQFEVGRRLRVRVVRALRRAG
TH_2153|M.thermoresistible__bu LLDQPSLMGVESIGLDNVNLRMVARTLPGKQYDAGRRLRVLVVRALGRAG
Mflv_4450|M.gilvum_PYR-GCK LLDTPQLMGVESIEVDTVNLRMVARTLPGKQFEVGRRLRILIIAALAGAG
Mvan_0128|M.vanbaalenii_PYR-1 LLDEPQLMGVESIEVDTVNVRMVARTLPGKQFEVGRRLRALVVAALRREG
MAB_3477c|M.abscessus_ATCC_199 LLDAPSLMGVESIEVDRVNVRMVARTLPGKQFEVGRRLRAKVIAALAKAG
:** * :**** : :* *.:*:*********: .**:** :: ** *
Mb3131c|M.bovis_AF2122/97 IVTAADARAAV----------------AESP---EQ--------------
Rv3104c|M.tuberculosis_H37Rv IVTAADARAAV----------------AESP---EQ--------------
MMAR_1528|M.marinum_M IITPADAQAAVGVMAHPATVSGA----ADAPAGAEQQR------------
MUL_2411|M.ulcerans_Agy99 IITPADAQAAVGVMAHPATVSGA----ADAPAGAEQQR------------
MAV_4005|M.avium_104 IVTAADARVGLVEDASVPAAQAAEQQSDDDVQGAVQKR------------
MSMEG_2087|M.smegmatis_MC2_155 VVTSSDASVAAAGDIIHPAAAAEVQ--IAP---QEPKK------------
TH_2153|M.thermoresistible__bu VVTPTEAMPTVGGLPQTAATGGRAP--EEPPPDQAPERER----------
Mflv_4450|M.gilvum_PYR-GCK ISTQEHTPVVSNISADGDTASSEAD--ARS---RAEQKS-----------
Mvan_0128|M.vanbaalenii_PYR-1 IALAA---------------------------------------------
MAB_3477c|M.abscessus_ATCC_199 VALVGDSRPTVRTMSSSGSGELKREGKREDAKRDEVKREEEGVDTKPQPI
:
Mb3131c|M.bovis_AF2122/97 -------
Rv3104c|M.tuberculosis_H37Rv -------
MMAR_1528|M.marinum_M -------
MUL_2411|M.ulcerans_Agy99 -------
MAV_4005|M.avium_104 -------
MSMEG_2087|M.smegmatis_MC2_155 -------
TH_2153|M.thermoresistible__bu -------
Mflv_4450|M.gilvum_PYR-GCK -------
Mvan_0128|M.vanbaalenii_PYR-1 -------
MAB_3477c|M.abscessus_ATCC_199 VQAEELT