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AQPESRRRITLNTTVLAFDMAGAWRGFWQGDTGVWILGRGVPIALLLIGGLLAARFINWSARRITRRIDA QYLESDQLVRTESAKHRQAVASVISWVSVALLFVMVAVQITDILAIPIGSLVAPAAVIGAALGFGAQKLV QDLLAGFFIITERQYGFGDLVELNMVGAPQAAQGTVEEVTLRVTKLRTSEGEVFTVPNGNIVQSLNMSKD WARAVVDIPVPTTVDLNRVNEVLHRVGETAMQDDELRALLLDTPQLMGVESIEVDTVNLRMVARTLPGKQ FEVGRRLRILIIAALAGAGISTQEHTPVVSNISADGDTASSEADARSRAEQKS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4450 | - | - | 100% (334) | MscS mechanosensitive ion channel |
| M. gilvum PYR-GCK | Mflv_2744 | - | 2e-35 | 33.33% (240) | MscS mechanosensitive ion channel |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3131c | - | 1e-113 | 68.03% (294) | transmembrane protein |
| M. tuberculosis H37Rv | Rv3104c | - | 1e-113 | 68.03% (294) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3477c | - | 1e-101 | 57.51% (313) | MscS mechanosensitive ion channel |
| M. marinum M | MMAR_1528 | - | 1e-114 | 63.30% (327) | transmembrane protein |
| M. avium 104 | MAV_4005 | - | 1e-92 | 60.90% (289) | transporter, small conductance mechanosensitive ion channel |
| M. smegmatis MC2 155 | MSMEG_2087 | - | 1e-120 | 70.19% (312) | transporter, small conductance mechanosensitive ion channel |
| M. thermoresistible (build 8) | TH_2153 | - | 1e-119 | 69.21% (315) | POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_2411 | - | 1e-114 | 63.00% (327) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_1912 | - | 1e-127 | 77.47% (293) | MscS mechanosensitive ion channel |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3131c|M.bovis_AF2122/97 ---------MTTSGTVLAT---SIAQHWHNFWRGEIGDWILNRGLRIVML
Rv3104c|M.tuberculosis_H37Rv ---------MTTSGTVLAT---SIAQHWHNFWRGEIGDWILNRGLRIVML
MMAR_1528|M.marinum_M ---------MTTNTTAFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMV
MUL_2411|M.ulcerans_Agy99 ---------MTTNTTAFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMV
MSMEG_2087|M.smegmatis_MC2_155 ---------MTISSSAATVLAFSVADRWHDFWHGEIGVWILTKGLRIALL
Mvan_1912|M.vanbaalenii_PYR-1 ---------MTSN----RLLAFDLASRWHGFWRGDIGVWILDRGVRIALL
Mflv_4450|M.gilvum_PYR-GCK MAQPESRRRITLN---TTVLAFDMAGAWRGFWQGDTGVWILGRGVPIALL
TH_2153|M.thermoresistible__bu ---------MTNS----SYLAFSAADAWHAFWHGQVGAWILTKGLRVMLL
MAV_4005|M.avium_104 ------------------------------------------------MV
MAB_3477c|M.abscessus_ATCC_199 ----------MIRAAEFSAGGLRLAERWNSFWSSQIGRWLLDNGLQIVIA
:
Mb3131c|M.bovis_AF2122/97 LIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISW
Rv3104c|M.tuberculosis_H37Rv LIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISW
MMAR_1528|M.marinum_M LIAAVLAARFVTWVAKRVTQRLDLGFTESDALVRSEVSKHRQAVASVISW
MUL_2411|M.ulcerans_Agy99 LIAAVLAARFVTWVAKRVTQRLDLGFTESDALVRSEVSKHRQAVASVISW
MSMEG_2087|M.smegmatis_MC2_155 LIGGLLAARFISWAAQRVVRRIDAEYQESDQLVRSESAKHRQAVASVISW
Mvan_1912|M.vanbaalenii_PYR-1 LIGGLLAARFINWAAQRITRRIDAEYQESDQLVRSESAKHRQAVASVISW
Mflv_4450|M.gilvum_PYR-GCK LIGGLLAARFINWSARRITRRIDAQYLESDQLVRTESAKHRQAVASVISW
TH_2153|M.thermoresistible__bu LIGAVLAARFINWAAMRVTSRLEAQS--GDALVRSEATKHRQAVASVISW
MAV_4005|M.avium_104 LIAAVLAARFVNWVALQVSRQLTTGFVESDALVRSEASKHRQAVASVISW
MAB_3477c|M.abscessus_ATCC_199 ILGAMILVRFINWGAQKITRRLDRSFTQSDALVRSEASKHRQALASVISW
::..:: .**:.* * :: :: .* ***:* :*****:******
Mb3131c|M.bovis_AF2122/97 VSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAG
Rv3104c|M.tuberculosis_H37Rv VSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAG
MMAR_1528|M.marinum_M VSIVLIYVIVLYEIVDILPFPVGSLVGPAAVLGAALGFGAQRLVQDLLAG
MUL_2411|M.ulcerans_Agy99 VSIVVIYVIVLYEIVDILPFPVGSLVGPAAVLGAALGFGAQRLVQDLLAG
MSMEG_2087|M.smegmatis_MC2_155 VSVALLFVIVLVEVTDVLAVPVASLVAPAAVLGAALGFGAQRIVQDLLAG
Mvan_1912|M.vanbaalenii_PYR-1 VSVALLFVMVAVQITDILAIPIGSLVAPAAVIGAALGFGAQRLVQDLLSG
Mflv_4450|M.gilvum_PYR-GCK VSVALLFVMVAVQITDILAIPIGSLVAPAAVIGAALGFGAQKLVQDLLAG
TH_2153|M.thermoresistible__bu VSIVLLFVVVAVQITNELDIPVSSLVAPAAVLGAALGFGAQKLVQDLLAG
MAV_4005|M.avium_104 VSVVIIGIWVMLQIASILQFSVGGLVAPATVVGAALGFGAQQLVKDLLSG
MAB_3477c|M.abscessus_ATCC_199 IIVVLVVVLTTVHVVGVLGISVGGLAGPAAVLGGALGFGAQRVVQDLLSG
: :.:: : . .: . * ..:..*..**:*:*.*******::*:***:*
Mb3131c|M.bovis_AF2122/97 FFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTV
Rv3104c|M.tuberculosis_H37Rv FFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTV
MMAR_1528|M.marinum_M FFIIVEKQYGFGDLVELSMVGSPENAAGTVEEVTLRVTKLRSSDGEVYTV
MUL_2411|M.ulcerans_Agy99 FFIIVEKQYGFGDLVELSMVGSPENAAGTVEEVTLRVTKLRSSDGEVYTV
MSMEG_2087|M.smegmatis_MC2_155 FFIITEKQYGFGDLVRLTIG-ASNEAEGTVEDVTLRVTKLRSTEGEMYTV
Mvan_1912|M.vanbaalenii_PYR-1 FFIITEKQYGFGDLVALTVSGIAAPAEGTVEDVTLRVTKLRSAEGEMFTI
Mflv_4450|M.gilvum_PYR-GCK FFIITERQYGFGDLVELNMVGAPQAAQGTVEEVTLRVTKLRTSEGEVFTV
TH_2153|M.thermoresistible__bu FFIITERQYGFGDLVQLSMLGAPEEAVGTVEEVTLRVTKLRTADGEVYTV
MAV_4005|M.avium_104 FFILAERQYGFGDLVTLTVV-AATEASGTVENVTLRVTRLRSPDGEVLTI
MAB_3477c|M.abscessus_ATCC_199 FFLITEKQYGFGDLVELYVQGQTTESRGTVEEVTLRVTKLRSGDGEVITI
**::.*:******** * : . : ****:******:**: :**: *:
Mb3131c|M.bovis_AF2122/97 PNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLL
Rv3104c|M.tuberculosis_H37Rv PNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLL
MMAR_1528|M.marinum_M PNGNIVKSINLSKDWARAVIDIPVPTGADLNRVNEVLHRECQHAREDAIL
MUL_2411|M.ulcerans_Agy99 PNGNIVKSINLSKDWARAVIDIPVPTGADLNRVNEVLHRECQHAREDAIL
MSMEG_2087|M.smegmatis_MC2_155 PNGQIVKSLNLSKDWARAVVDIPVSVSVDLNVVNDVLNEVAERATEDAEL
Mvan_1912|M.vanbaalenii_PYR-1 PNGQIVKTVNLSKDWARAVIDIPVPTSADLNLVNDVLHDVAQKAIDDSQL
Mflv_4450|M.gilvum_PYR-GCK PNGNIVQSLNMSKDWARAVVDIPVPTTVDLNRVNEVLHRVGETAMQDDEL
TH_2153|M.thermoresistible__bu PNGNIVRSLNMSKDWARAVVDIPVPVTADLNRVNEVLHEVGDASMDDPVL
MAV_4005|M.avium_104 PNGQIVKVVNLSKDWARAVVDIPVSTSADLNRVNEVLHQECDRAMDNPVL
MAB_3477c|M.abscessus_ATCC_199 PNGLIVKAVNLSKDWARAVVDIPVPTSVDLARVNDVLYDVCQQALVDRDL
*** **: :*:********:****.. .** **:** : : : *
Mb3131c|M.bovis_AF2122/97 GELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALT
Rv3104c|M.tuberculosis_H37Rv GELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALT
MMAR_1528|M.marinum_M GDLLLDEPTVMGVEKLEMDTVTLRLVARTLPGKQFAAGRQLRVLVIRALT
MUL_2411|M.ulcerans_Agy99 GDLLLDEPTVMGVEKLEMDTVTLRLVARTLPGKQFAAGRQLRVLVIRALT
MSMEG_2087|M.smegmatis_MC2_155 SKLVLDKPQLMGVESIGVDTVNLRMVARTLPGKQFEVGRRLRVRVVRALR
Mvan_1912|M.vanbaalenii_PYR-1 HDLLLDPPQLMGVESIELDTVNLRMVARTLPGKQFEVGRRLRVLVIRELR
Mflv_4450|M.gilvum_PYR-GCK RALLLDTPQLMGVESIEVDTVNLRMVARTLPGKQFEVGRRLRILIIAALA
TH_2153|M.thermoresistible__bu KDLLLDQPSLMGVESIGLDNVNLRMVARTLPGKQYDAGRRLRVLVVRALG
MAV_4005|M.avium_104 GQLLLDSPTVMGVESIEVDTVTLRLVARTLPGKQFEVGRQLRVLVIRALA
MAB_3477c|M.abscessus_ATCC_199 SQLLLDAPSLMGVESIEVDRVNVRMVARTLPGKQFEVGRRLRAKVIAALA
*:** * :**** : :* *.:*:*********: .**:** :: *
Mb3131c|M.bovis_AF2122/97 RAGIVTAADARAAV------------AESP---EQ---------------
Rv3104c|M.tuberculosis_H37Rv RAGIVTAADARAAV------------AESP---EQ---------------
MMAR_1528|M.marinum_M GAGIITPADAQAAVGVMAHPATVSGAADAPAGAEQQR-------------
MUL_2411|M.ulcerans_Agy99 GAGIITPADAQAAVGVMAHPATVSGAADAPAGAEQQR-------------
MSMEG_2087|M.smegmatis_MC2_155 RAGVVTSSDASVAAAGDIIHPAAAAEVQIAP---QEPKK-----------
Mvan_1912|M.vanbaalenii_PYR-1 RSGIVAPGEAPPPTVGAIVHPATAGGAEEET---QGPESRR---------
Mflv_4450|M.gilvum_PYR-GCK GAGISTQEHTPVVSNISADGDTASSEADARS---RAEQKS----------
TH_2153|M.thermoresistible__bu RAGVVTPTEAMPTVGGLPQTAATGGRAPEEPPPDQAPERER---------
MAV_4005|M.avium_104 RAGIVTAADARVGLVEDASVPAAQAAEQQSDDDVQGAVQKR---------
MAB_3477c|M.abscessus_ATCC_199 KAGVALVGDSRPTVRTMSSSGSGELKREGKREDAKRDEVKREEEGVDTKP
:*: .: :
Mb3131c|M.bovis_AF2122/97 ----------
Rv3104c|M.tuberculosis_H37Rv ----------
MMAR_1528|M.marinum_M ----------
MUL_2411|M.ulcerans_Agy99 ----------
MSMEG_2087|M.smegmatis_MC2_155 ----------
Mvan_1912|M.vanbaalenii_PYR-1 ----------
Mflv_4450|M.gilvum_PYR-GCK ----------
TH_2153|M.thermoresistible__bu ----------
MAV_4005|M.avium_104 ----------
MAB_3477c|M.abscessus_ATCC_199 QPIVQAEELT