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M. thermoresistible (build 8) TH_2153 ()

annotation: POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN
coordinates: 4235282 - 4236262
length: 327

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2153-100% (327)POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN
M. thermoresistible (build 8)TH_3952-2e-4032.47% (308) PUTATIVE MscS mechanosensitive ion channel

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3131c-1e-11566.89% (305) transmembrane protein
M. gilvum PYR-GCKMflv_4450-1e-11969.21% (315) MscS mechanosensitive ion channel
M. tuberculosis H37RvRv3104c-1e-11566.89% (305) transmembrane protein
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3477c-5e-9859.66% (290) MscS mechanosensitive ion channel
M. marinum MMMAR_1528-1e-11766.14% (316) transmembrane protein
M. avium 104MAV_4005-2e-9362.24% (286) transporter, small conductance mechanosensitive ion channel
M. smegmatis MC2 155MSMEG_2087-1e-11968.55% (318) transporter, small conductance mechanosensitive ion channel
M. ulcerans Agy99MUL_2411-1e-11765.82% (316) transmembrane protein
M. vanbaalenii PYR-1Mvan_1912-1e-12066.46% (322) MscS mechanosensitive ion channel

CLUSTAL 2.0.9 multiple sequence alignment


Mb3131c|M.bovis_AF2122/97           ---------MTTSGTVLAT---SIAQHWHNFWRGEIGDWILNRGLRIVML
Rv3104c|M.tuberculosis_H37Rv        ---------MTTSGTVLAT---SIAQHWHNFWRGEIGDWILNRGLRIVML
MMAR_1528|M.marinum_M               ---------MTTNTTAFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMV
MUL_2411|M.ulcerans_Agy99           ---------MTTNTTAFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMV
MSMEG_2087|M.smegmatis_MC2_155      ---------MTISSSAATVLAFSVADRWHDFWHGEIGVWILTKGLRIALL
Mvan_1912|M.vanbaalenii_PYR-1       ---------MTSN----RLLAFDLASRWHGFWRGDIGVWILDRGVRIALL
Mflv_4450|M.gilvum_PYR-GCK          MAQPESRRRITLN---TTVLAFDMAGAWRGFWQGDTGVWILGRGVPIALL
TH_2153|M.thermoresistible__bu      ---------MTNS----SYLAFSAADAWHAFWHGQVGAWILTKGLRVMLL
MAV_4005|M.avium_104                ------------------------------------------------MV
MAB_3477c|M.abscessus_ATCC_199      ----------MIRAAEFSAGGLRLAERWNSFWSSQIGRWLLDNGLQIVIA
                                                                                    : 

Mb3131c|M.bovis_AF2122/97           LIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISW
Rv3104c|M.tuberculosis_H37Rv        LIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISW
MMAR_1528|M.marinum_M               LIAAVLAARFVTWVAKRVTQRLDLGFTESDALVRSEVSKHRQAVASVISW
MUL_2411|M.ulcerans_Agy99           LIAAVLAARFVTWVAKRVTQRLDLGFTESDALVRSEVSKHRQAVASVISW
MSMEG_2087|M.smegmatis_MC2_155      LIGGLLAARFISWAAQRVVRRIDAEYQESDQLVRSESAKHRQAVASVISW
Mvan_1912|M.vanbaalenii_PYR-1       LIGGLLAARFINWAAQRITRRIDAEYQESDQLVRSESAKHRQAVASVISW
Mflv_4450|M.gilvum_PYR-GCK          LIGGLLAARFINWSARRITRRIDAQYLESDQLVRTESAKHRQAVASVISW
TH_2153|M.thermoresistible__bu      LIGAVLAARFINWAAMRVTSRLEAQS--GDALVRSEATKHRQAVASVISW
MAV_4005|M.avium_104                LIAAVLAARFVNWVALQVSRQLTTGFVESDALVRSEASKHRQAVASVISW
MAB_3477c|M.abscessus_ATCC_199      ILGAMILVRFINWGAQKITRRLDRSFTQSDALVRSEASKHRQALASVISW
                                    ::..:: .**:.* * ::  ::      .* ***:* :*****:******

Mb3131c|M.bovis_AF2122/97           VSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAG
Rv3104c|M.tuberculosis_H37Rv        VSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAG
MMAR_1528|M.marinum_M               VSIVLIYVIVLYEIVDILPFPVGSLVGPAAVLGAALGFGAQRLVQDLLAG
MUL_2411|M.ulcerans_Agy99           VSIVVIYVIVLYEIVDILPFPVGSLVGPAAVLGAALGFGAQRLVQDLLAG
MSMEG_2087|M.smegmatis_MC2_155      VSVALLFVIVLVEVTDVLAVPVASLVAPAAVLGAALGFGAQRIVQDLLAG
Mvan_1912|M.vanbaalenii_PYR-1       VSVALLFVMVAVQITDILAIPIGSLVAPAAVIGAALGFGAQRLVQDLLSG
Mflv_4450|M.gilvum_PYR-GCK          VSVALLFVMVAVQITDILAIPIGSLVAPAAVIGAALGFGAQKLVQDLLAG
TH_2153|M.thermoresistible__bu      VSIVLLFVVVAVQITNELDIPVSSLVAPAAVLGAALGFGAQKLVQDLLAG
MAV_4005|M.avium_104                VSVVIIGIWVMLQIASILQFSVGGLVAPATVVGAALGFGAQQLVKDLLSG
MAB_3477c|M.abscessus_ATCC_199      IIVVLVVVLTTVHVVGVLGISVGGLAGPAAVLGGALGFGAQRVVQDLLSG
                                    : :.:: : .  .: . * ..:..*..**:*:*.*******::*:***:*

Mb3131c|M.bovis_AF2122/97           FFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTV
Rv3104c|M.tuberculosis_H37Rv        FFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTV
MMAR_1528|M.marinum_M               FFIIVEKQYGFGDLVELSMVGSPENAAGTVEEVTLRVTKLRSSDGEVYTV
MUL_2411|M.ulcerans_Agy99           FFIIVEKQYGFGDLVELSMVGSPENAAGTVEEVTLRVTKLRSSDGEVYTV
MSMEG_2087|M.smegmatis_MC2_155      FFIITEKQYGFGDLVRLTIG-ASNEAEGTVEDVTLRVTKLRSTEGEMYTV
Mvan_1912|M.vanbaalenii_PYR-1       FFIITEKQYGFGDLVALTVSGIAAPAEGTVEDVTLRVTKLRSAEGEMFTI
Mflv_4450|M.gilvum_PYR-GCK          FFIITERQYGFGDLVELNMVGAPQAAQGTVEEVTLRVTKLRTSEGEVFTV
TH_2153|M.thermoresistible__bu      FFIITERQYGFGDLVQLSMLGAPEEAVGTVEEVTLRVTKLRTADGEVYTV
MAV_4005|M.avium_104                FFILAERQYGFGDLVTLTVV-AATEASGTVENVTLRVTRLRSPDGEVLTI
MAB_3477c|M.abscessus_ATCC_199      FFLITEKQYGFGDLVELYVQGQTTESRGTVEEVTLRVTKLRSGDGEVITI
                                    **::.*:******** * :   .  : ****:******:**: :**: *:

Mb3131c|M.bovis_AF2122/97           PNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLL
Rv3104c|M.tuberculosis_H37Rv        PNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLL
MMAR_1528|M.marinum_M               PNGNIVKSINLSKDWARAVIDIPVPTGADLNRVNEVLHRECQHAREDAIL
MUL_2411|M.ulcerans_Agy99           PNGNIVKSINLSKDWARAVIDIPVPTGADLNRVNEVLHRECQHAREDAIL
MSMEG_2087|M.smegmatis_MC2_155      PNGQIVKSLNLSKDWARAVVDIPVSVSVDLNVVNDVLNEVAERATEDAEL
Mvan_1912|M.vanbaalenii_PYR-1       PNGQIVKTVNLSKDWARAVIDIPVPTSADLNLVNDVLHDVAQKAIDDSQL
Mflv_4450|M.gilvum_PYR-GCK          PNGNIVQSLNMSKDWARAVVDIPVPTTVDLNRVNEVLHRVGETAMQDDEL
TH_2153|M.thermoresistible__bu      PNGNIVRSLNMSKDWARAVVDIPVPVTADLNRVNEVLHEVGDASMDDPVL
MAV_4005|M.avium_104                PNGQIVKVVNLSKDWARAVVDIPVSTSADLNRVNEVLHQECDRAMDNPVL
MAB_3477c|M.abscessus_ATCC_199      PNGLIVKAVNLSKDWARAVVDIPVPTSVDLARVNDVLYDVCQQALVDRDL
                                    *** **: :*:********:****.. .**  **:**    : :  :  *

Mb3131c|M.bovis_AF2122/97           GELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALT
Rv3104c|M.tuberculosis_H37Rv        GELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALT
MMAR_1528|M.marinum_M               GDLLLDEPTVMGVEKLEMDTVTLRLVARTLPGKQFAAGRQLRVLVIRALT
MUL_2411|M.ulcerans_Agy99           GDLLLDEPTVMGVEKLEMDTVTLRLVARTLPGKQFAAGRQLRVLVIRALT
MSMEG_2087|M.smegmatis_MC2_155      SKLVLDKPQLMGVESIGVDTVNLRMVARTLPGKQFEVGRRLRVRVVRALR
Mvan_1912|M.vanbaalenii_PYR-1       HDLLLDPPQLMGVESIELDTVNLRMVARTLPGKQFEVGRRLRVLVIRELR
Mflv_4450|M.gilvum_PYR-GCK          RALLLDTPQLMGVESIEVDTVNLRMVARTLPGKQFEVGRRLRILIIAALA
TH_2153|M.thermoresistible__bu      KDLLLDQPSLMGVESIGLDNVNLRMVARTLPGKQYDAGRRLRVLVVRALG
MAV_4005|M.avium_104                GQLLLDSPTVMGVESIEVDTVTLRLVARTLPGKQFEVGRQLRVLVIRALA
MAB_3477c|M.abscessus_ATCC_199      SQLLLDAPSLMGVESIEVDRVNVRMVARTLPGKQFEVGRRLRAKVIAALA
                                      *:** * :**** : :* *.:*:*********: .**:**  ::  * 

Mb3131c|M.bovis_AF2122/97           RAGIVTAADARAAV------------AESP---EQ---------------
Rv3104c|M.tuberculosis_H37Rv        RAGIVTAADARAAV------------AESP---EQ---------------
MMAR_1528|M.marinum_M               GAGIITPADAQAAVGVMAHPATVSGAADAPAGAEQQR-------------
MUL_2411|M.ulcerans_Agy99           GAGIITPADAQAAVGVMAHPATVSGAADAPAGAEQQR-------------
MSMEG_2087|M.smegmatis_MC2_155      RAGVVTSSDASVAAAGDIIHPAAAAEVQIAP---QEPKK-----------
Mvan_1912|M.vanbaalenii_PYR-1       RSGIVAPGEAPPPTVGAIVHPATAGGAEEET---QGPESRR---------
Mflv_4450|M.gilvum_PYR-GCK          GAGISTQEHTPVVSNISADGDTASSEADARS---RAEQKS----------
TH_2153|M.thermoresistible__bu      RAGVVTPTEAMPTVGGLPQTAATGGRAPEEPPPDQAPERER---------
MAV_4005|M.avium_104                RAGIVTAADARVGLVEDASVPAAQAAEQQSDDDVQGAVQKR---------
MAB_3477c|M.abscessus_ATCC_199      KAGVALVGDSRPTVRTMSSSGSGELKREGKREDAKRDEVKREEEGVDTKP
                                     :*:    .:                        :               

Mb3131c|M.bovis_AF2122/97           ----------
Rv3104c|M.tuberculosis_H37Rv        ----------
MMAR_1528|M.marinum_M               ----------
MUL_2411|M.ulcerans_Agy99           ----------
MSMEG_2087|M.smegmatis_MC2_155      ----------
Mvan_1912|M.vanbaalenii_PYR-1       ----------
Mflv_4450|M.gilvum_PYR-GCK          ----------
TH_2153|M.thermoresistible__bu      ----------
MAV_4005|M.avium_104                ----------
MAB_3477c|M.abscessus_ATCC_199      QPIVQAEELT