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MGVSADTVRTGRPPGGHSRYIGRVGGLAFALGIGAAMLTGTAVASAETSEPSSSSAESSAGPSATERESS KPTVESRSESDADADAESDASEDSDDADAPDESTEGAGDDVDDRASRNTTQPTEVEEPATGTSRAQAEAE EPSFFERIFDNKTPTISHNPADDTVIEGRVIGNLHPEDPDSTQLTYTATRPASGTVTIESDGTFTYTPGA TYTGQDRFRVTVSDARSGFHIHGAAGLLNLFTFGLLGSSGHRSTQDVFIGSQRATVVSGLNSPVDFRFLP DGRILVAEKAGAIRVVEDGVLRTDPLITIAVRTESERGIGGLAVDPDFEDNGRIYVAYIAAETTRNTLSR FVVDGNTASFDAQLVESTLTAAPNHHGGALAFGPDGKLYWGVGDNASGSNAQNLANIHGKILRLNTDGTV PTDNPVLDGERTGIYAYGLRNPFRMTFTPTGELLVADVGAAAFEEVNNVVSGGNYGWPSSEGVCTSNCGG KIDPIYSYPRAGGAAITSVAVRRGKVFIADTVKGWITVLTCTPGYTSCGEATTFDPDAGATVVLAEGPDG ALYQLIYQPGSLVRIELADAAPEQV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5245 | - | - | 100% (585) | glucose/sorbosone dehydrogenases-like protein |
| M. gilvum PYR-GCK | Mflv_0780 | - | 2e-30 | 35.25% (295) | hypothetical protein Mflv_0780 |
| M. gilvum PYR-GCK | Mflv_0864 | - | 2e-19 | 31.60% (269) | hypothetical protein Mflv_0864 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0912 | - | 7e-15 | 29.32% (266) | hypothetical protein Mb0912 |
| M. tuberculosis H37Rv | Rv0888 | - | 7e-15 | 29.32% (266) | hypothetical protein Rv0888 |
| M. leprae Br4923 | MLBr_01022 | rpoT | 4e-05 | 30.43% (115) | RNA polymerase sigma factor |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4644 | - | 5e-11 | 25.38% (264) | hypothetical protein MMAR_4644 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1214 | - | 3e-27 | 31.62% (272) | oxidoreductase |
| M. thermoresistible (build 8) | TH_2267 | - | 2e-32 | 32.56% (301) | oxidoreductase |
| M. ulcerans Agy99 | MUL_3911 | - | 4e-06 | 39.02% (82) | hypothetical protein MUL_3911 |
| M. vanbaalenii PYR-1 | Mvan_1010 | - | 1e-157 | 80.54% (334) | PKD domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5245|M.gilvum_PYR-GCK MGVSADTVRTGRPPGGHSRYIGRVGGLAFALGIGAAMLTGTAVASAETSE
Mvan_1010|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1214|M.smegmatis_MC2_155 --------------------------------------------------
TH_2267|M.thermoresistible__bu --------------------------------------------------
Mb0912|M.bovis_AF2122/97 --------------MDYAKRIGQVGALAVVLGVGAAVTT-HAIGSAAPTD
Rv0888|M.tuberculosis_H37Rv --------------MDYAKRIGQVGALAVVLGVGAAVTT-HAIGSAAPTD
MMAR_4644|M.marinum_M --------------MGYASHAVRVGALVFVLVVGAAVATDQAIGHAAPTD
MUL_3911|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 -----MEQSRRVPPLQWLSAVARPIARVLTLISTPTFDIADTFGYACPNP
Mflv_5245|M.gilvum_PYR-GCK PSSSSAESSAGPSATERESSKPTVESRSESDADADAESDASEDSDDADAP
Mvan_1010|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1214|M.smegmatis_MC2_155 --------------------------------------------------
TH_2267|M.thermoresistible__bu --------------------------------------------------
Mb0912|M.bovis_AF2122/97 PSSSSTDSPVDACSPLGG---SASSLA-----------------------
Rv0888|M.tuberculosis_H37Rv PSSSSTDSPVDACSPLGG---SASSLA-----------------------
MMAR_4644|M.marinum_M SDASNGESWADVPAPPGGENIAASLLPGAAQPGA----------------
MUL_3911|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 PEVSPTEGVYVVATKTSPATGQPVKRTATKTPATPAKRSTTKAANG----
Mflv_5245|M.gilvum_PYR-GCK DESTEGAGDDVDDRASRNTTQPTEVEEPATGTSRAQAEAEEPSFFERIFD
Mvan_1010|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1214|M.smegmatis_MC2_155 --------------------------------------------------
TH_2267|M.thermoresistible__bu --------------------------------------------------
Mb0912|M.bovis_AF2122/97 --------------------------------------------------
Rv0888|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4644|M.marinum_M --------------------------------------------------
MUL_3911|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 --------------------------------------------------
Mflv_5245|M.gilvum_PYR-GCK NKTPTISHNPADDTVIEGRVIGNLHPEDPDSTQLTYTATRPASGTVTIES
Mvan_1010|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1214|M.smegmatis_MC2_155 --------------------------------------------------
TH_2267|M.thermoresistible__bu --------------------------------------------------
Mb0912|M.bovis_AF2122/97 -----------------------------------------AIPGASVPQ
Rv0888|M.tuberculosis_H37Rv -----------------------------------------AIPGASVPQ
MMAR_4644|M.marinum_M ---------------------------VPGAALPGTALPGTALPGAASPG
MUL_3911|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 ----------------SAPTKRATSTASRATKSTTPPKASGASDAAKKAR
Mflv_5245|M.gilvum_PYR-GCK DGTFTYTPGATYTGQDRFRVTVSDARSGFHIHGAAGLLNLFTFGLLGSSG
Mvan_1010|M.vanbaalenii_PYR-1 --------------------------------------------MLGSSG
MSMEG_1214|M.smegmatis_MC2_155 ---------------------------MLAVAASLLLVITCT-QDVESRG
TH_2267|M.thermoresistible__bu --------------VAVGRIRRTTVRAAVALMCLALLAAACDGEAVPAPP
Mb0912|M.bovis_AF2122/97 VGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVPE
Rv0888|M.tuberculosis_H37Rv VGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVPE
MMAR_4644|M.marinum_M MGTPQLDPSNIPDDLLNAVINFLASIRNGVVPILENRTPVATPQQLEIDV
MUL_3911|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 TSVKSVDTKAPSAQDHTTKASAAKDTLNDPEATLNTLDSDATADDLDAEP
Mflv_5245|M.gilvum_PYR-GCK HRSTQDVFIGSQR--ATVVSGLNSPVDFRFLPDGRILVAEKAG-AIRVVE
Mvan_1010|M.vanbaalenii_PYR-1 HRSTQTVFIGYER--ATVVSGLNSPVDFRFLPDGRILVAEKAG-AIRVVE
MSMEG_1214|M.smegmatis_MC2_155 EPAGGPPA---------IATDLDVPWGIAFLPDGSALIAERDSAAIKHLT
TH_2267|M.thermoresistible__bu APPEQPPAQTGESGARDVVTDLGVPWGIAFLPDGSALIAERDSGMIKQLS
Mb0912|M.bovis_AF2122/97 GGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTA
Rv0888|M.tuberculosis_H37Rv GGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTA
MMAR_4644|M.marinum_M NGSTGLVPFSAYDPDGNRMTFKVNPRGTPGGPQHGMVNIDESRAAFVYTP
MUL_3911|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 DLDVEPSEDIDIDIEAADLGLDDLEDDDVVTDIEPGETEDGEATAATKTD
Mflv_5245|M.gilvum_PYR-GCK DGVLRTDPLITIAVRTESERGIGGLAVDPDFEDNGRIYVAYIAAETTRNT
Mvan_1010|M.vanbaalenii_PYR-1 DGVLREDPLITLAVRTESERGIEGLAVDPAFGTNGRIYVAYIDAETTRNT
MSMEG_1214|M.smegmatis_MC2_155 APGVVEQIGAVPGVAPRGEGGLLGLATAGAN-------VYAYLTTGGDNR
TH_2267|M.thermoresistible__bu EPGVVRDVGAVEGVAARGEGGLLGLATAGDT-------VFAYHTTATDNR
Mb0912|M.bovis_AF2122/97 DPGFVGTDTFSVNVSDDTSLHVHGLAGYLGP--------FHGHDDVATVT
Rv0888|M.tuberculosis_H37Rv DPGFVGTDTFSVNVSDDTSLHVHGLAGYLGP--------FHGHDDVATVT
MMAR_4644|M.marinum_M EPNFVGIDTFTVAVSDDTSLHVHGLAGYLGP--------FHGHDDVATVT
MUL_3911|M.ulcerans_Agy99 ---------MAKGSAETSGDELSGKPLPADE-----------PGDEAQSN
MLBr_01022|M.leprae_Br4923 EASTDDDEEIVEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVR
Mflv_5245|M.gilvum_PYR-GCK LSRFVVDGNTASFDAQLVESTLTAAPNHHGGALA--FGPDGKLYWGVGDN
Mvan_1010|M.vanbaalenii_PYR-1 LSRFIVNGNTATFDTDLLVSTLAAAPNHHGGALG--FGPDGALYWGVGDN
MSMEG_1214|M.smegmatis_MC2_155 VVQMRFADGALTNPTPILTGIPAG-SRHDGGRIA--FGPDGKLYVATGEI
TH_2267|M.thermoresistible__bu VVRMDFDGQALGPPAPILTGIPTGGSRHDGGRIA--FGPDGRLYVATGEI
Mb0912|M.bovis_AF2122/97 VFVGNTPTDTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAY
Rv0888|M.tuberculosis_H37Rv VFVGNTPTDTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAY
MMAR_4644|M.marinum_M IFVGNIPTGTISGDFSMLTYNIAGLPFPLSSAMLPRFLYTKEIGKRLNNF
MUL_3911|M.ulcerans_Agy99 PAGADSDSDSDAEPDTEPDSESDGEPDADAPAET---EDASQPEDSRPRR
MLBr_01022|M.leprae_Br4923 AYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGTKLPTAQRR
: . .
Mflv_5245|M.gilvum_PYR-GCK ASGSNAQNLANIHGKILRLNTDGTVPTDNPVLDGERTGIYAYG------L
Mvan_1010|M.vanbaalenii_PYR-1 ATGANAQNLGNIHGKILRLNTDGSVPVDNPVINGARTHIYAYG------L
MSMEG_1214|M.smegmatis_MC2_155 ANPPLAQDRTSLAGKILRVNPDGSVPADNPFPG---SPVWSYG------H
TH_2267|M.thermoresistible__bu GDPPLAQDRSSLAGKILRINPDGSIPADNPDPQ---SPVWSFG------H
Mb0912|M.bovis_AF2122/97 YVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPFSDG------L
Rv0888|M.tuberculosis_H37Rv YVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPFSDG------L
MMAR_4644|M.marinum_M SVSNVQEDFSYHEFLIKKSRMPSQTPPSPPTLLWPIGVPFSDG------L
MUL_3911|M.ulcerans_Agy99 RRPHPKSSWAAVLAWVVLPSLALLLAITAGVLRWQYDTMRYAQ------I
MLBr_01022|M.leprae_Br4923 DMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLI
. : .
Mflv_5245|M.gilvum_PYR-GCK RNPFRMTFTP----TGELLVADVGAAAFEEVN------NVVSGGN----Y
Mvan_1010|M.vanbaalenii_PYR-1 RNPFRLTFTP----TGQLLVADVGAASFEEVN------LVTAGGN----Y
MSMEG_1214|M.smegmatis_MC2_155 RNIQGLAWDA----AGRLWATEYGADRVDELN------LIRPGAN----Y
TH_2267|M.thermoresistible__bu RNVQGLAWDP----GGRLWATEYGADTWDELN------LIEPGGN----Y
Mb0912|M.bovis_AF2122/97 NTLSEFKVQR----LDRQTWYECTSDNCLTLKGFTYSQMRLPGGDTVDVY
Rv0888|M.tuberculosis_H37Rv NTLSEFKVQR----LDRQTWYECTSDNCLTLKGFTYSQMRLPGGDTVDVY
MMAR_4644|M.marinum_M NSLAVFKVKR----LDRQTWFQCDADNCLTPKGFSYSQLQLPGGNTMDLY
MUL_3911|M.ulcerans_Agy99 AGVQALQAAR----EGTVAMLSYKPETVEKDL------------------
MLBr_01022|M.leprae_Br4923 RAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKL
: .
Mflv_5245|M.gilvum_PYR-GCK GWPSSEGVCTSNCGGKIDPIYSYPRAGGAAITSVAVRRGKVFIADTVK--
Mvan_1010|M.vanbaalenii_PYR-1 GWPSSEGLCTSACTGKTDPVFTYPRGSGAAITSVAVYQGKVFIADLVQ--
MSMEG_1214|M.smegmatis_MC2_155 GWPEAEGRGG--IEGMVDPVVEWG-TGEASPSGLAFYGGSLWVAALRG--
TH_2267|M.thermoresistible__bu GWPVAEGRQE--MPGMIDPVLQWR-PAEASPSGLAFWDGALWIANLRG--
Mb0912|M.bovis_AF2122/97 NLHTNTGGGP-TTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQS--
Rv0888|M.tuberculosis_H37Rv NLHTNTGGGP-TTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQS--
MMAR_4644|M.marinum_M NLHANTGGGV-LTNANLRQLANYILQNSAGRAVIVTGDFNALYSEDQA--
MUL_3911|M.ulcerans_Agy99 --TAAQDHLTGTFRDSYTQLTKDVVIPGAKQQRISAVARVPAAATVSA--
MLBr_01022|M.leprae_Br4923 GRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGD
: :
Mflv_5245|M.gilvum_PYR-GCK -------GWITVLTCTPGYTSCGEATTFDPDAGATVVLAEGPDGALYQLI
Mvan_1010|M.vanbaalenii_PYR-1 -------GWIKVLTCTPDYTACGDVQTFDPAAGTTVVLAAGPDGNLYQLT
MSMEG_1214|M.smegmatis_MC2_155 -------ERLFQIPVAGDGTVGTPVPLFVGQYGRLRTVVAAPDGSLWFTT
TH_2267|M.thermoresistible__bu -------QRLLEVPVRADGELGEPVSRFVGEYGRLRTVVAAPDGSLWFTT
Mb0912|M.bovis_AF2122/97 -------ALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKI
Rv0888|M.tuberculosis_H37Rv -------ALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKI
MMAR_4644|M.marinum_M -------GLLDFAGSTGLTDAWVEVEHGPTTPPFAPDCMVGNECELLDKI
MUL_3911|M.ulcerans_Agy99 -------DWGHAVVLVFVDQTTVIGDDPPTDMASTVRVKLDKVGDRWLIS
MLBr_01022|M.leprae_Br4923 EGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRF
Mflv_5245|M.gilvum_PYR-GCK YQPGSLVRIELADAAPEQV-------------------------------
Mvan_1010|M.vanbaalenii_PYR-1 YAPGELIAIKPAGGDADSEV------------------------------
MSMEG_1214|M.smegmatis_MC2_155 SNRDGRGSVRAGDDRILQFRP-----------------------------
TH_2267|M.thermoresistible__bu SNRDGRGVPRSGDDRILRYRR-----------------------------
Mb0912|M.bovis_AF2122/97 FYRSGQGVTLQAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR
Rv0888|M.tuberculosis_H37Rv FYRSGQGVTLQAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR
MMAR_4644|M.marinum_M FYRSGTGVTLQATAYSNEAPNFNNSNGQPLSDHSPPAVAFHYETTNVSYP
MUL_3911|M.ulcerans_Agy99 EFQPI---------------------------------------------
MLBr_01022|M.leprae_Br4923 GLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD-
Mflv_5245|M.gilvum_PYR-GCK -
Mvan_1010|M.vanbaalenii_PYR-1 -
MSMEG_1214|M.smegmatis_MC2_155 -
TH_2267|M.thermoresistible__bu -
Mb0912|M.bovis_AF2122/97 -
Rv0888|M.tuberculosis_H37Rv -
MMAR_4644|M.marinum_M N
MUL_3911|M.ulcerans_Agy99 -
MLBr_01022|M.leprae_Br4923 -