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VIDLVVAGGGPAGLATAIHAARAGLETVVIEQRTGPIDKACGEGLMPHAVRQLALLGAQPAGIAFRGISY FDADHAVTALFDSGHGLGVRRKTLHAALLTEADRAGVKLVHAKAGPLTQDADSVSVNGFRARYLAAADGL HSPIRARLGLELPTAGTKRWGLKRHIAVAPWSDMVEVYWSDDPGSGEAYVTPVAPDCVGIALLTSRQGGF DEHMAAFPELRDRIAGFAHEPDRAAGPLRQRVRRRVAGRVLLVGDAAGYVDALTGEGLGLAFAAARLLVD SVAADRPGDYEARWRRATRRYRVMTAGVLRAGTSPLRSVIVPAACRLPPPAGVSRCGEPARRVKRRRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5142 | - | - | 100% (348) | monooxygenase, FAD-binding |
| M. gilvum PYR-GCK | Mflv_5254 | - | 2e-15 | 28.40% (338) | geranylgeranyl reductase |
| M. gilvum PYR-GCK | Mflv_4291 | - | 2e-12 | 25.96% (366) | geranylgeranyl reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1170c | - | 6e-80 | 48.01% (327) | putative oxidoreductase |
| M. tuberculosis H37Rv | Rv1138c | - | 6e-80 | 48.01% (327) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 9e-16 | 29.47% (319) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3929 | - | 3e-18 | 29.67% (337) | oxidoreductase |
| M. marinum M | MMAR_4315 | - | 7e-80 | 47.87% (328) | oxidoreductase |
| M. avium 104 | MAV_1278 | - | 2e-81 | 48.81% (336) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_0811 | - | 1e-112 | 63.03% (330) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1880 | - | 2e-10 | 26.14% (306) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_0979 | - | 2e-79 | 47.56% (328) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1194 | - | 1e-152 | 81.40% (328) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5142|M.gilvum_PYR-GCK -----MIDLVVAGGGPAGLATAIHAARAGLETVVIEQRTGPIDKACGEGL
Mvan_1194|M.vanbaalenii_PYR-1 -----MIDLVVAGGGPAGLATAIHAARAGLDTVVVEQRTGPIDKACGEGL
MSMEG_0811|M.smegmatis_MC2_155 -----MIDLLVAGGGPAGLATAIYAARAGLVTVVVEPRPGPIDKACGEGL
Mb1170c|M.bovis_AF2122/97 -MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPIDKACGEGL
Rv1138c|M.tuberculosis_H37Rv -MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPIDKACGEGL
MMAR_4315|M.marinum_M -MTTYDTDVLVVGGGPGGLATALNARKRGLSVIVADPRESPIDKACGEGL
MUL_0979|M.ulcerans_Agy99 -MTTYDTDVLVVGGGPGGLATALNARKRGLSVIVADPRESPIDKACGEGL
MAV_1278|M.avium_104 --MAYDADLLVVGGGPGGLATALHARRLGLSVIVAEPREAPIDKACGEGL
MLBr_02276|M.leprae_Br4923 MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDGL
MAB_3929|M.abscessus_ATCC_1997 --MQTSADLVVVGAGPAGSAAAAWAARSGREVVLVDSAVFPRDKTCGDGL
TH_1880|M.thermoresistible__bu -----VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAHVRSLGL
*::*.*.** * * * .:: : * :. . **
Mflv_5142|M.gilvum_PYR-GCK MPHAVRQLALLGAQ----PAGIAFRGISYFDADHAVTALFDS----GHGL
Mvan_1194|M.vanbaalenii_PYR-1 MPHAVRQLNLLGAQ----PEGRCFQGVSYFDGSRGVTARFDS----GAGL
MSMEG_0811|M.smegmatis_MC2_155 MPHAVRQLDRLDVH----PDGRAFRGIRYLDGRHTAEARFRD----GNGL
Mb1170c|M.bovis_AF2122/97 MPGGLAELTSLGVD----PVGLPFHGIAYVGEHRRVQARFRT----GPGR
Rv1138c|M.tuberculosis_H37Rv MPGGLAELTSLGVD----PVGLPFHGIAYVGEHRRVQARFRT----GPGR
MMAR_4315|M.marinum_M MPGGLAELKSLDVD----PAGVPFQGIAYVSQQRRAEARFRT----GPGR
MUL_0979|M.ulcerans_Agy99 MPGGLAELKSLDVD----PAGVPFQGIAYVSQQRRAEARFRT----GPGR
MAV_1278|M.avium_104 MPGGLAALTALGVD----PAGMPFQGIAYLSEHRRAQARFRD----GPGR
MLBr_02276|M.leprae_Br4923 TPRAVAELKRLGLDD-WLNTRIRHRGLRMSGFGGEVEVDWPGPSFPSTSS
MAB_3929|M.abscessus_ATCC_1997 TPRAVEQLELLGLRP-WLDEHIRYRGLRLHGFGGNLEVPWPGTSFGGTGS
TH_1880|M.thermoresistible__bu HVRSIEMLDQRGLLDRFLAHGQRHPVGGFFAAIAKPPAELDT--AHGYVL
.: * . . . .
Mflv_5142|M.gilvum_PYR-GCK GVRRKTLHAALLTEADRAGVKLVH-AKAGPLTQDADSVSVNG--------
Mvan_1194|M.vanbaalenii_PYR-1 GVRRTTLHAALLQAARAAGVTLVH-DKIGTLTQDAESVSVNG--------
MSMEG_0811|M.smegmatis_MC2_155 GVRRTVLHAALADAAAAAGVRVVA-GQVDTIIQTATTVCAAG--------
Mb1170c|M.bovis_AF2122/97 GVRRTTLHAALAARAKEQDTEWIR-SRVATIQQDAHGVTAAG--------
Rv1138c|M.tuberculosis_H37Rv GVRRTTLHAALAARAKEQDTEWIR-SRVATIQQDAHGVTAAG--------
MMAR_4315|M.marinum_M GVRRTTLHATLAARAKEQDAEWIR-TRVTDVVQDAHGVTAAG--------
MUL_0979|M.ulcerans_Agy99 GVRRTTVHATLAARAKEQDAEWIR-TRVTDVVQDAHGVTAAG--------
MAV_1278|M.avium_104 GVRRTTLHAALAARAKEQDTEWIR-ARVSSVAQDAHGVSAAG--------
MLBr_02276|M.leprae_Br4923 AVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRRAASVTLADG---
MAB_3929|M.abscessus_ATCC_1997 AVRRTELDDKIRQVAVDSGAKMAESTKAVDVERDSAGRITSVRVLDDNGP
TH_1880|M.thermoresistible__bu GIRQPVTDRLLAEWAAERGAVIRRGCAVVGLDQDAAGITVELADG-----
.: : . : * .. : : : .
Mflv_5142|M.gilvum_PYR-GCK --FRARYLAAADGLHSPIRARLGLELPTAGTKRWGLKRHIAVAP-----W
Mvan_1194|M.vanbaalenii_PYR-1 --FRARYLAAADGLHSPIRARLGLELPPGRARRWGLKRHVAVAP-----W
MSMEG_0811|M.smegmatis_MC2_155 --FRARYLAAADGLHSPIRRSLGLAHDESPRRRWGIRRHIQIAP-----W
Mb1170c|M.bovis_AF2122/97 --VRAKWLVAADGLHSAVRRAVGIKATAGTPRRYGVRWHYRLPV-----W
Rv1138c|M.tuberculosis_H37Rv --VRAKWLVAADGLHSAVRRAVGIKATAGTPRRYGVRWHYRLPV-----W
MMAR_4315|M.marinum_M --VRAKWLVAADGLHSAVRRAVGITATAGTPRRYGVRRHYRVPA-----W
MUL_0979|M.ulcerans_Agy99 --VRAKWLVAADGLHSAVRRAVGITATAGTPRRYGVRRHYRVPA-----W
MAV_1278|M.avium_104 --VRARWLVAADGLHSTVRRAVGIAATAGTPRRYGVRWHYRVPA-----W
MLBr_02276|M.leprae_Br4923 TEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPRSDDLWL
MAB_3929|M.abscessus_ATCC_1997 GEIACKAVIVADGVRSTLGKILGREWHKDTVYAVAGRAYIESARGDEEWM
TH_1880|M.thermoresistible__bu SVQRARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSLSAD-----
.: : .** :*.: * .
Mflv_5142|M.gilvum_PYR-GCK SDMVEVYWSDDPGS-GEAYVTPVAPD--CVGIALLTSRQG----GFDEHM
Mvan_1194|M.vanbaalenii_PYR-1 SDFVEVYWSPRPDA-GEAYVTPVADD--CVGIAILTSRQG----NFETHL
MSMEG_0811|M.smegmatis_MC2_155 SDCVEVYWAPDARVNAEAYVTPVADD--CVGVAVLTSTRG----SFAEHL
Mb1170c|M.bovis_AF2122/97 SDFVEVHWSR----WGEAYVTPVEPD--LVGVAILSRQR--------PEL
Rv1138c|M.tuberculosis_H37Rv SDFVEVHWSR----WGEAYVTPVEPD--LVGVAILSRQR--------PEL
MMAR_4315|M.marinum_M SEFVEVHWSP----WGEAYVTPVEPD--LVGVAILSRQR--------PEI
MUL_0979|M.ulcerans_Agy99 SEFVEVHWSP----WGEAYVTPVEPD--LVGVAILSRQR--------PEI
MAV_1278|M.avium_104 SEFVEVHWSR----WGEAYVTPVEPD--LVGVAILSRAR--------PDL
MLBr_02276|M.leprae_Br4923 TSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKRPADLALRSLI
MAB_3929|M.abscessus_ATCC_1997 TSHLELRSPEGDVLPGYGWIFPLGGGQINIGVGALATSKRPADAALRPLI
TH_1880|M.thermoresistible__bu PATVAAVVAEVRKTQLRFGAMPLGDGVYRVIVPAEGVAGDRAEPTLDEFR
. : . *: . : :
Mflv_5142|M.gilvum_PYR-GCK AAFPELRDR---IAGFAHEPDRAAGPLRQRVRRRVAGRVLLVGDAAGYVD
Mvan_1194|M.vanbaalenii_PYR-1 DAFPALRAR---LEGLSHEPDRAAGPLRQRVQRRVAGRVLLVGDAAGYVD
MSMEG_0811|M.smegmatis_MC2_155 AQFPGLAAR---LDGLPHGRDRAAGPLLQKVRGRVAGRVLLVGDAAGYID
Mb1170c|M.bovis_AF2122/97 AWFPSLAHH---LQDASRGHARGCGPLRQVVSRRVAGRVLLVGDAAGYED
Rv1138c|M.tuberculosis_H37Rv AWFPSLAHH---LQDASRGHARGCGPLRQVVSRRVAGRVLLVGDAAGYED
MMAR_4315|M.marinum_M DWFPWLAQQ---LRGASPGAARGCGPLRQVVSRRVAGRVLLVGDAAGYED
MUL_0979|M.ulcerans_Agy99 DWFPWLAQQ---LRGASPGAARGCGPLRQVVSRRVAGRVLLVGDAAGYED
MAV_1278|M.avium_104 GWFPGLAER---LRAADRGRPRGCGPLRQVVSRRVAGRVLLVGDAAGYED
MLBr_02276|M.leprae_Br4923 SYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPNWMLIGDAAACVN
MAB_3929|M.abscessus_ATCC_1997 EYYTELRREDFGLTGRLQSIASALLPMGGAVSGVAGPNWMLIGDAAACVN
TH_1880|M.thermoresistible__bu RRLKAFAGT--DFGAHTPRWLSRFGDATRLAERYRAGRVFLAGDAAHVHP
: : . . . :* ****
Mflv_5142|M.gilvum_PYR-GCK ALTGEGLGLAFAAARLLVDSVAADR---------PGDYEARWRRATRRYR
Mvan_1194|M.vanbaalenii_PYR-1 ALTGEGLGLSFAAARLLVDSVLADR---------PQDYEARWRGATRRYR
MSMEG_0811|M.smegmatis_MC2_155 ALTGEGMGLAFGGAELLVDCVRHNR---------PEEYDRRWLAMTRRYR
Mb1170c|M.bovis_AF2122/97 ALTGEGISLAVKQAAAAVSAIVDDT---------PASYEAAWHRITRDYR
Rv1138c|M.tuberculosis_H37Rv ALTGEGISLAVKQAAAAVSAIVDDT---------PASYEAAWHRITRDYR
MMAR_4315|M.marinum_M ALTGEGISLAVKQAAAAVRAIADND---------PASYEAAWHRVTRSYR
MUL_0979|M.ulcerans_Agy99 ALTGEGITLAVKQAAAAVRAIADND---------PASYEAAWHRVTRSYR
MAV_1278|M.avium_104 ALTGEGISLAVKQAAAAVRAIVDER---------PASYEAAWHRITRDYR
MLBr_02276|M.leprae_Br4923 PLNGEGIDYGLETGRLAAELLDLRDL----SYVWPSLLQQHYGRGFSVAR
MAB_3929|M.abscessus_ATCC_1997 PLNGEGIDYGLETGHLAAEVLDAGDY----SQLWPQLLRDRYGRSFSIAR
TH_1880|M.thermoresistible__bu PAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTYHAERHPVAADVLN
. *:*: .. . : .
Mflv_5142|M.gilvum_PYR-GCK VMTAGVLR-AGTSPLRSVIVPAACRLPPPAGVSRCGEPAR----------
Mvan_1194|M.vanbaalenii_PYR-1 LMTAGMLR-AGTSPLRSLIVPASSTFP--------GVFSR----------
MSMEG_0811|M.smegmatis_MC2_155 WLTAALLRGSGIRPVRACITPVAAALP--------GVFAR----------
Mb1170c|M.bovis_AF2122/97 LVTRGLVLASTPRAARRAIVPLCALLP--------TAF----RY------
Rv1138c|M.tuberculosis_H37Rv LVTRGLVLASTPRAARRAIVPLCALLP--------TAF----RY------
MMAR_4315|M.marinum_M WLTRGLVLASAPRPARRAIVPACALLP--------PVF----RY------
MUL_0979|M.ulcerans_Agy99 WLTRGLVLASAPRPARRAIVPACALLP--------PVFPVWGKYPGKLTA
MAV_1278|M.avium_104 LLTRALVLASTPRAVRRAIVPAGALLP--------GAFR-----------
MLBr_02276|M.leprae_Br4923 RLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVTDD----------
MAB_3929|M.abscessus_ATCC_1997 RLAALLTLPRFLPVMGPVGMHSAVLMRIAVRLMGNLVTDD----------
TH_1880|M.thermoresistible__bu NTRAQMELMSPEPGPRAVRWLLAELMDFEEVNRYLTEKITAIGVRYHTMG
: :
Mflv_5142|M.gilvum_PYR-GCK ---------------------------------------------RVKRR
Mvan_1194|M.vanbaalenii_PYR-1 ---------------------------------------------MVNLL
MSMEG_0811|M.smegmatis_MC2_155 ---------------------------------------------AVNAL
Mb1170c|M.bovis_AF2122/97 ---------------------------------------------GVNIL
Rv1138c|M.tuberculosis_H37Rv ---------------------------------------------GVNIL
MMAR_4315|M.marinum_M ---------------------------------------------GVNIL
MUL_0979|M.ulcerans_Agy99 QSGGHQADAAHPGHRLIPAPPKPSLPARIQIGPIPSAAHCQPSAPGVPLL
MAV_1278|M.avium_104 --------------------------------------------AGVNIL
MLBr_02276|M.leprae_Br4923 ---------------------------------------------DADWV
MAB_3929|M.abscessus_ATCC_1997 ---------------------------------------------DQDMI
TH_1880|M.thermoresistible__bu DGHGLLGRRMRDIPLTGGRLYARMHAGRGVLLDRTGTLSVSGWADRVDHI
Mflv_5142|M.gilvum_PYR-GCK RP-------------------------------------------
Mvan_1194|M.vanbaalenii_PYR-1 AD-------------------------------------------
MSMEG_0811|M.smegmatis_MC2_155 GE-------------------------------------------
Mb1170c|M.bovis_AF2122/97 AY-------------------------------------------
Rv1138c|M.tuberculosis_H37Rv AY-------------------------------------------
MMAR_4315|M.marinum_M AS-------------------------------------------
MUL_0979|M.ulcerans_Agy99 PSAPAAPLPNWPYPPAPPEAAPPPAPPGPPG--------------
MAV_1278|M.avium_104 AR-------------------------------------------
MLBr_02276|M.leprae_Br4923 ARVWRSGGWASWLVDRRPPFS------------------------
MAB_3929|M.abscessus_ATCC_1997 ARAWRVAGGGSRRLDSRPPFS------------------------
TH_1880|M.thermoresistible__bu VDPGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLSRWFGAPA