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MSLDAFAEVFEPADIHVAQRLTELGRDSDPTVALAVALAVRAVRSGSVCVDLRTVAAQVGVPELPWPDPD GWLSTVGASPLAEHKVVRLDGDLLYLDRYWREEEQVRDDVVALLSSPPRTAVPGLERLFPAGWEEQRAAA EAALTRSLTVLTGGPGTGKTTTVARLLAAFAEQAELAGGPPPRMALAAPTGKAAARLQDAVQAEVDRLSA VDRARLAGLRATTMHRLLGSRPDTSSRFRHHRGNRLPHDVIVVDETSMVSLTMMARLLEAVRPDTRLLFV GDPDQLASVDAGAVLADLVDGLGEAGVVELTTSHRFGERIGALALAIRSGDADATVEVLRAGGDAIGWLD TDDAADALRGPLVDRAADLREAALLGDGETALRILDGHRLLCAHRRGPFGVAHWNRQIERWLAERTGQSI WSQPYAGRPLLVTANDYGLGVYNGDTGVVVAAPEGLRAHIGTPASSRELAVGRLGEVETMFAMTIHKSQG SQADEVTVLMPPQDSRLLTRELFYTAVTRAKERVQVVGTEASVRAAVGRRAVRASGLARRLSTAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5131 | - | - | 100% (555) | exodeoxyribonuclease V, alpha subunit |
| M. gilvum PYR-GCK | Mflv_2792 | - | 2e-07 | 26.22% (389) | exonuclease V subunit alpha |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0645c | recD | 0.0 | 66.12% (552) | exonuclease V alpha chain |
| M. tuberculosis H37Rv | Rv0629c | recD | 0.0 | 66.30% (552) | exonuclease V alpha chain |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0398c | - | 0.0 | 70.24% (551) | exodeoxyribonuclease V, alpha subunit (RecD) |
| M. marinum M | MMAR_0956 | recD | 0.0 | 66.01% (559) | exodeoxyribonuclease V (alpha chain), RecD |
| M. avium 104 | MAV_4544 | recD | 0.0 | 69.15% (551) | exodeoxyribonuclease V, alpha subunit |
| M. smegmatis MC2 155 | MSMEG_1325 | recD | 0.0 | 71.25% (553) | exodeoxyribonuclease V, alpha subunit |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0707 | recD | 0.0 | 66.01% (559) | exodeoxyribonuclease V (alpha chain), RecD |
| M. vanbaalenii PYR-1 | Mvan_1208 | - | 0.0 | 79.93% (553) | exodeoxyribonuclease V, alpha subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0645c|M.bovis_AF2122/97 -----MKLTDVDFAVEASGMVRAFNQAGVLDVSDVHVAQRLCALAGESDE
Rv0629c|M.tuberculosis_H37Rv -----MKLTDVDFAVEASGMVRAFNQAGVLDVSDVHVAQRLCALAGESDE
MAV_4544|M.avium_104 ------MLPER---VFDAGPLRPFADAGIFEAADIHVAQRLTALTGESDD
MMAR_0956|M.marinum_M MTIDVVDPADWRQAASASGPLRTFNEAGVIDAADVHVAQRLAAMSGESDP
MUL_0707|M.ulcerans_Agy99 MTIEVVDPADWRQAASASGPLRTFNEARVIDAADVHVAQRLAAMSGESDP
MAB_0398c|M.abscessus_ATCC_199 -----------------MSLVEAF--GEILEPADVHVAQRLTALASETDE
MSMEG_1325|M.smegmatis_MC2_155 -----------------MSLLEAF--AEILEPADVHVAQRLTVLADEPDA
Mflv_5131|M.gilvum_PYR-GCK ------------------MSLDAF--AEVFEPADIHVAQRLTELGRDSDP
Mvan_1208|M.vanbaalenii_PYR-1 ------------------MTVEAF--SELFEPADLHVAQRLTTLGKEGDD
: .* . ::: :*:****** : : *
Mb0645c|M.bovis_AF2122/97 RVALAVAVAVRALRAGSVCVDLLSIARVAGHDDLPWPDPADWLAAVRASP
Rv0629c|M.tuberculosis_H37Rv RVALAVAVAVRALRAGSVCVDLLSIARVAGHDDLPWPDPADWLAAVRASP
MAV_4544|M.avium_104 RVALAVALLVRALRGGSVCVDLRAVPAQVGAADLPWPAAGDWLAAVRASP
MMAR_0956|M.marinum_M VVLLAIAFVVRALRGGSVCVDLSTIEAQVGIADLPWPAAGEWLAAVRASP
MUL_0707|M.ulcerans_Agy99 VVLLAIAFVVRALRGGSVCVDLSTIEAQVGIADLPWPAAGEWLAAVRASP
MAB_0398c|M.abscessus_ATCC_199 SVELAIALAVRALRGGSVCVDLRAVAAQVDMPSLPWPAADDWLAAVRASP
MSMEG_1325|M.smegmatis_MC2_155 SVELAVALAVRALRGGSVCVDLRSVAGQVELPDLPWPDPDAWLAALAASP
Mflv_5131|M.gilvum_PYR-GCK TVALAVALAVRAVRSGSVCVDLRTVAAQVGVPELPWPDPDGWLSTVGASP
Mvan_1208|M.vanbaalenii_PYR-1 SVALAVALAVRALRGGSVCVDLRAIATQVGMPELPWPEPDRWLAAVGASP
* **:*. ***:*.******* :: . .**** . **::: ***
Mb0645c|M.bovis_AF2122/97 LLADPPVLHLYDDRLLYLDRYWREEEQVCADLLALLT-SRRPAGVPDLR-
Rv0629c|M.tuberculosis_H37Rv LLADPPVLHLYDDRLLYLDRYWREEEQVCADLLALLT-SRRPAGVPDLR-
MAV_4544|M.avium_104 LLGPPPVLRFFGD-LLYFDRYWLEEEQVCTDLLALSA-PAGDVESSCYE-
MMAR_0956|M.marinum_M LVGSPAVLRLHEDNLVYLDRYWREEQQVADDILALLA-ARASASGPAIEV
MUL_0707|M.ulcerans_Agy99 LVGSPAVLRLHEDNLVYLDRYWREEQQVADDILALLA-ARASASGPAIEV
MAB_0398c|M.abscessus_ATCC_199 LAGEPPVLRLFGD-LLYLDRYWREEQQVCTDVQALMAAAQPRTEVPTYE-
MSMEG_1325|M.smegmatis_MC2_155 LLGQPPVLRLFGD-LLYLDRYWLEEQQVCDDVLALVS-ARPGGAVPDVS-
Mflv_5131|M.gilvum_PYR-GCK LAEHK-VVRLDGD-LLYLDRYWREEEQVRDDVVALLS-SPPRTAVPGLE-
Mvan_1208|M.vanbaalenii_PYR-1 LADER-VLRMHGD-LLYLDRYWREEQQVCDDVLALLA-SPLPATAPSIE-
* *::: * *:*:**** **:** *: ** : . .
Mb0645c|M.bovis_AF2122/97 -RLFPTGFDEQRRAAEIALSQGVTVLTGGPGTGKTTTVARLLALVAEQAE
Rv0629c|M.tuberculosis_H37Rv -RLFPTGFDEQRRAAEIALSQGVTVLTGGPGTGKTTTVARLLALVAEQAE
MAV_4544|M.avium_104 -RLFPPGYEEQRAAARIAVSQALTVLTGGPGTGKTTTVARLLALLVEQAE
MMAR_0956|M.marinum_M NRLFPPGYEEQRAAAKIALAQGLTVLTGGPGTGKTTTVARLLALFAEQAQ
MUL_0707|M.ulcerans_Agy99 NRLFPPGYEEQRAAAKIALAQGLTVLTGGPGTGKTTTVARLLALFAEQAQ
MAB_0398c|M.abscessus_ATCC_199 -RLFPQGFEEQRAAADIALSQGLTVLTGGPGTGKTTTVARLLALLADQAS
MSMEG_1325|M.smegmatis_MC2_155 -RLFGAGFEEQRAAAKVALSQGLTVLTGGPGTGKTTTVARLLALLAEQAA
Mflv_5131|M.gilvum_PYR-GCK -RLFPAGWEEQRAAAEAALTRSLTVLTGGPGTGKTTTVARLLAAFAEQAE
Mvan_1208|M.vanbaalenii_PYR-1 -RLFPAGWEEQREAAKVALRQSLTVLTGGPGTGKTTTVARLLASIAEQAE
*** *::*** ** *: :.:******************** ..:**
Mb0645c|M.bovis_AF2122/97 LAGEPRPRIALAAPTGKAAARLAEAVRREMAKLDATDRARLGDLHAVTLH
Rv0629c|M.tuberculosis_H37Rv LAGEPRPRIALAAPTGKAAARLAEAVRREMAKLDATDRARLGDLHAVTLH
MAV_4544|M.avium_104 RAGEPRPRIALAAPTGKAAARLAEAVAAEIEHLDPADRARLAGLTGTTLH
MMAR_0956|M.marinum_M LAGKARLRIALAAPTGKAAARLHEAVQSQIDKLDAIDQQRVRGLQATTLH
MUL_0707|M.ulcerans_Agy99 LAGKARLRIALAAPTGKAAARLHEAVQSQIDKLDAIDQQRVRGLQATTLH
MAB_0398c|M.abscessus_ATCC_199 SASAAPLRIALAAPTGKAAARLQEAVQLEVNQLDAVDRSRLAGLQATTLH
MSMEG_1325|M.smegmatis_MC2_155 LAGKPSPRIALAAPTGKAAARLQEAVQLEIDQLDLIERRRLTGLHATTLH
Mflv_5131|M.gilvum_PYR-GCK LAGGPPPRMALAAPTGKAAARLQDAVQAEVDRLSAVDRARLAGLRATTMH
Mvan_1208|M.vanbaalenii_PYR-1 SAGGAPPRMALAAPTGKAAARLQDAVHAEVGKLPAVDQGRLAGLRATTLH
*. . *:************* :** :: :* :: *: .* ..*:*
Mb0645c|M.bovis_AF2122/97 RLLGAKP--GARFRQDRQNRLPHNVIVVDETSMVSLTLMARLAEAVRPGA
Rv0629c|M.tuberculosis_H37Rv RLLGAKP--GARFRQDRQNRLPHNVIVVDETSMVSLTLMARLAEAVRPGA
MAV_4544|M.avium_104 RLLGPRPDTSVRFKHNRGNRLPHDIIVVDETSMVSLTMMARLAEAVRPDT
MMAR_0956|M.marinum_M RLLGSRPDTSSRFRHHRGNRLPHDVIVIDETSMVSLTMMARLLEAVRPQT
MUL_0707|M.ulcerans_Agy99 RLLGSRPDTSSRFRHHRGNRLPHDVIVIDETSMVSLTMMARLLEAVRPQT
MAB_0398c|M.abscessus_ATCC_199 RLLGSRPDTSSRFKHDRGNRLPHDVIVVDETSMVSLTMMARLLEAVRPQA
MSMEG_1325|M.smegmatis_MC2_155 RLLGPRPDTSSRFRHHRANRLPHDVIVVDETSMVSLTMMARLLEAVRPQT
Mflv_5131|M.gilvum_PYR-GCK RLLGSRPDTSSRFRHHRGNRLPHDVIVVDETSMVSLTMMARLLEAVRPDT
Mvan_1208|M.vanbaalenii_PYR-1 RLLGSRPDTSSRFRHHRDNRLPHDVIVVDETSMVSLTMMARLLEAVRPDT
****.:* . **::.* *****::**:*********:**** ***** :
Mb0645c|M.bovis_AF2122/97 RLILVGDADQLASVEAGAVLADLVDGFSVRDDALVAQLRTSHRFGKVIGT
Rv0629c|M.tuberculosis_H37Rv RLILVGDADQLASVEAGAVLADLVDGFSVRDDALVAQLRTSHRFGKVIGT
MAV_4544|M.avium_104 RLILVGDPDQLASVEAGAVLADLVDGLAGRAGVRVAALATPHRFGSAIGA
MMAR_0956|M.marinum_M RLLLVGDPDQLASVEAGAVLADLVDGLGARHDTHVAALRRLHRFGESIGQ
MUL_0707|M.ulcerans_Agy99 RLLLVGDPDQLASVEAGAVLADLVDGLGARHDTHVAALRRLHRFGESIGQ
MAB_0398c|M.abscessus_ATCC_199 RLLLVGDPDQLASVEAGAVLADLVEGLESER---VAALRTSHRFGAAIGA
MSMEG_1325|M.smegmatis_MC2_155 RLVLVGDPDQLASVEAGAVLADLVEGLGSRG---VAELKTSHRFGESIGA
Mflv_5131|M.gilvum_PYR-GCK RLLFVGDPDQLASVDAGAVLADLVDGLGEAG---VVELTTSHRFGERIGA
Mvan_1208|M.vanbaalenii_PYR-1 RLLFVGDPDQLASVDAGAVLADLVEGLGDAG---VVELKTPHRFGETIGS
**::***.******:*********:*: *. * **** **
Mb0645c|M.bovis_AF2122/97 LAEAIRAGDGDAVLGLLRSGEERIEFVDDEDPAPRLRAVLVPHALRLREA
Rv0629c|M.tuberculosis_H37Rv LAEAIRAGDGDAVLGLLRSGEERIEFVDDEDPAPRLRAVLVPHALRLREA
MAV_4544|M.avium_104 LAAAIRAGDADRVVELLAAGGEHIEWVDSERPADRLREVLVSHALRLRSA
MMAR_0956|M.marinum_M LAAAIRGGDADRVVEILRAGDDHIEWINAADPTPQLRNVLLPHALELRRA
MUL_0707|M.ulcerans_Agy99 LAAAIRGGDADRVVEILRAGDDHIEWINAADPTPQLRNVLLPHALELRRA
MAB_0398c|M.abscessus_ATCC_199 LAAAVRDGDADRALEVLASGDPHVEWS-TDS--EGLRDVLVPQALALRAA
MSMEG_1325|M.smegmatis_MC2_155 LASAIRTGDADAALAVLAAGGEHIEWV-HEDPVEQLREVVVPHAMRLRQA
Mflv_5131|M.gilvum_PYR-GCK LALAIRSGDADATVEVLRAGGDAIGWLDTDDAADALRGPLVDRAADLREA
Mvan_1208|M.vanbaalenii_PYR-1 LAEAIRAGDADTAVQLLRAGGDAVAWLDTDDPSDALRATLVARADELRRA
** *:* **.* .: :* :* : : ** :: :* ** *
Mb0645c|M.bovis_AF2122/97 ALLGASDVALATLDEHRLLCAHRDGPTGVLHWNRRVQAWLAEETGQPPWT
Rv0629c|M.tuberculosis_H37Rv ALLGASDVALATLDEHRLLCAHRDGPTGVLHWNRRVQAWLAEETGQPPWT
MAV_4544|M.avium_104 ALLGAAQAALATLDEHRLLCAHRDGPHGAVRWNTLVHNWIAEETGQPAWS
MMAR_0956|M.marinum_M GALGDTAAALATLDEQRLLCAHRRGPYGIAHWNHQVQRWLTEATGEPIWS
MUL_0707|M.ulcerans_Agy99 GALGDTAAALATLDEQRLLCAHRRGPYGIAHWNHQVQRWLTEATGEPIWS
MAB_0398c|M.abscessus_ATCC_199 SLSGDATAALAVLDEHRMLCAHRHGPFGVTHWNRQVERWITEETGEPHWA
MSMEG_1325|M.smegmatis_MC2_155 AILGDQREALATLDEHRLLCAHRRGPAGVDHWNRQVQRWLGEETGEPLWG
Mflv_5131|M.gilvum_PYR-GCK ALLGDGETALRILDGHRLLCAHRRGPFGVAHWNRQIERWLAERTGQSIWS
Mvan_1208|M.vanbaalenii_PYR-1 ALLGDARAALGVLDGHRLLCAHRRGPFGVTHWNRQVERWLADKTGQPMWS
. * ** ** :*:***** ** * :** :. *: : **:. *
Mb0645c|M.bovis_AF2122/97 PWYAGRPLLVTANDYGLRVYNGDTGVVLAG-------PTGLRAVISGASG
Rv0629c|M.tuberculosis_H37Rv PWYAGRPLLVTANDYGLRVYNGDTGVVLAG-------PTGLRAVISGASG
MAV_4544|M.avium_104 QWYAGRPLLVTANDYGLRLYNGDTGVTVAG-------ADGLRAVIAGAAG
MMAR_0956|M.marinum_M SWYAGRPVLVTANDYGLGVYNGDTGVAVLDGTNRAAAPGALRVLIAGAQE
MUL_0707|M.ulcerans_Agy99 SWYAGRPVLVTANDYGLGVYNGDTGVAVLDGTNRAAAPGALRVVIAGAQE
MAB_0398c|M.abscessus_ATCC_199 PWYAGRPILVTANDYGLRLYNGDTGVTVAG-------PDGLRAVIG-AAS
MSMEG_1325|M.smegmatis_MC2_155 SWYVGRPILVTANDYGLKLYNGDTGVVVAT-------PDGMRAVIGDAGT
Mflv_5131|M.gilvum_PYR-GCK QPYAGRPLLVTANDYGLGVYNGDTGVVVAA-------PEGLRAHIGTPAS
Mvan_1208|M.vanbaalenii_PYR-1 QWYPGRPLLVTANDYGLGVYNGDTGVVVAA-------PDGLRAHVG----
* ***:********* :*******.: . .:*. :.
Mb0645c|M.bovis_AF2122/97 PLDVATGRLGDVETMHAMTIHKSQGSQVDEVTVLMPQEDSRLLTRELLYT
Rv0629c|M.tuberculosis_H37Rv PLDVATGRLGDVETMHAMTIHKSQGSQVDEVTVLMPQEDSRLLTRELLYT
MAV_4544|M.avium_104 PLDFATSRLGEVETMHAMTIHKSQGSQADEVTVLIPPEDSRLLTRELFYT
MMAR_0956|M.marinum_M PLKFATSRLSDVETMHAMTIHKSQGSQADDVTVLLPPADSRLLTRELFYT
MUL_0707|M.ulcerans_Agy99 PLKFATSRLSDVETMHAMTIHKSQGSQADDVTVLLPPADSRLLTRELFYT
MAB_0398c|M.abscessus_ATCC_199 ---FATSRLVEVETMHAMTIHKSQGSQANEVTVLLPSEDSRLLTRELFYT
MSMEG_1325|M.smegmatis_MC2_155 ---FATGRLTDVETMHAMTIHKSQGSQADEVTVLLPSEDSRLLTRELFYT
Mflv_5131|M.gilvum_PYR-GCK SRELAVGRLGEVETMFAMTIHKSQGSQADEVTVLMPPQDSRLLTRELFYT
Mvan_1208|M.vanbaalenii_PYR-1 SLQFAPGRLGEVETMFAMTIHKSQGSQADEVTVLLPPQDSRLLTRELFYT
.* .** :****.***********.::****:* *********:**
Mb0645c|M.bovis_AF2122/97 AVARAKRKVRVVGSEASVRAAIARRAVRASGLRMRLQSTGCG
Rv0629c|M.tuberculosis_H37Rv AVTRAKRKVRVVGSEASVRAAIARRAVRASGLRMRLQSTGCG
MAV_4544|M.avium_104 AVTRAKSRVRVVGPEASVRAAIERRAIRATGLRQRLRVVG--
MMAR_0956|M.marinum_M AVTRAARKVRIVGPECDVRAAIARRAIRATGLRSRLQP----
MUL_0707|M.ulcerans_Agy99 AVTRAARKVRIVGPECDVRAAIARRAIRATGLRSRLQP----
MAB_0398c|M.abscessus_ATCC_199 AVTRAKQRVRVVGSEAEVRAAIQRQAVRASGLGRRLRHSPN-
MSMEG_1325|M.smegmatis_MC2_155 AVTRAKTRVRVVGAEAEVRAAIERQAVRATGLRKRLRPAGV-
Mflv_5131|M.gilvum_PYR-GCK AVTRAKERVQVVGTEASVRAAVGRRAVRASGLARRLSTAR--
Mvan_1208|M.vanbaalenii_PYR-1 AVTRAKKHVRVVGTEASVRTAIGRRATRASGLAQRLRTRP--
**:** :*::**.*..**:*: *:* **:** **