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MEPFDLLGALPEPRTTTVLEASAGTGKTFALAGLVTRYVAEGVATLDRMLLITFGRAASQELRERVRSQI VDALRAFDDPAAIGDNEVVRHLVTGDAEECDARRRRLRDALAGFDAATIATTHQFCQLVLRSLGVAGDTD SGVELVESLDDLVAEIVDDLYLAHFGQDRDEPLLTHESALRLAHAVVGNAHTELRPRDPAPGSDAAVRVE FAKAVCAELETRKRKLGILHYDDLLSRLADALEAPDSPARARMQRRWSIVMVDEFQDTDPVQWQVIDRAF RGHATLILIGDPKQAIYAFRGGDIVTYLHAAATAGVQRTLGTNYRSDAPLVEGLQAVMRDAQLGDPRIVV RRVDAHHREHRLQGAPHNEPFRLRVCTRDQFRVRPDRMIPIDVLRNHIPKDMAADIAALLNSGATHCGEK LAPGHIAVIVESHRDGHACFAALADAGIPAVYTGDSDVFSSPAADDWMCLLEAFDQPHRSGLVRAAATTM FFGETAEALALQGDSLTDRIAETLRQWADFARERGVAAVFEAAQLRGMGARVLRWVDGERHMTDLAHLTQ LLHDTAHREQYSLPALRDWLRAQRDDRGGLRGTVERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFN RNVQPRDVVVFHEPATSDGAGDIRCLHIGGESSPDFAAVAQQARLEAAGDDVRLTYVAMTRAQSQVVAWW APSRDELNGGLSRLLRGRAPGDPVVPDRCDPARIDDAEAMARLRAWADEGGPVLEESIIAERVEVELPAP PDTLAVRHFHRRIDPLWRRTSYSGLIRAAEQESGVGSEPEVVELDDEVAELRAPDTEPATPDVDMASPMA GLPMGAKFGTLVHAVLETADPFAVDLAAELEAAVVEHSLWWPVDVPPAELAAALVPLHDTPLGPLAPGVT LRDIGLRDRLREMEFEFPLAGGDRRDDTPDITLADVGRLLRAHLPADDPLAPYAARLTTGALAGQPLKGY LNGSLDAVLRVDGRYLVVDYKTNWLGDPAGELTAADYAPARLAEAMLHSDYPLQALLYCVVLHRFLRWRQ PGYSARRHIAGVLYLFVRGMCGPDTPVLDGHPAGVFSWQPPAALIEELSDLLDAGAVPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5130 | - | - | 100% (1109) | exodeoxyribonuclease V, beta subunit |
| M. gilvum PYR-GCK | Mflv_4665 | - | 5e-17 | 23.75% (1141) | UvrD/REP helicase |
| M. gilvum PYR-GCK | Mflv_4660 | - | 3e-12 | 23.93% (723) | UvrD/REP helicase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0647c | recBa | 0.0 | 62.60% (877) | exonuclease V subunit beta |
| M. tuberculosis H37Rv | Rv0630c | recB | 0.0 | 63.52% (1113) | exonuclease V beta chain |
| M. leprae Br4923 | MLBr_00153 | uvrD | 2e-16 | 23.47% (686) | putative ATP-dependent DNA helicase |
| M. abscessus ATCC 19977 | MAB_0399c | - | 0.0 | 67.51% (1102) | exodeoxyribonuclease V, beta subunit (RecB) |
| M. marinum M | MMAR_0957 | recB | 0.0 | 70.08% (1123) | exodeoxyribonuclease V (beta chain), RecB |
| M. avium 104 | MAV_4543 | recB | 0.0 | 69.22% (1111) | exodeoxyribonuclease V, beta subunit |
| M. smegmatis MC2 155 | MSMEG_1327 | recB | 0.0 | 69.47% (1104) | exodeoxyribonuclease V, beta subunit |
| M. thermoresistible (build 8) | TH_1287 | recB | 0.0 | 68.90% (688) | PROBABLE EXONUCLEASE V (BETA CHAIN) RECB (EXODEOXYRIBONUCLEASE |
| M. ulcerans Agy99 | MUL_0708 | recB | 0.0 | 69.81% (1123) | exodeoxyribonuclease V (beta chain), RecB |
| M. vanbaalenii PYR-1 | Mvan_1209 | - | 0.0 | 82.82% (1106) | exodeoxyribonuclease V, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0647c|M.bovis_AF2122/97 MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEML
Rv0630c|M.tuberculosis_H37Rv MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEML
Mflv_5130|M.gilvum_PYR-GCK MEPFDLLGALPEPRTTTVLEASAGTGKTFALAGLVTRYVAEGVATLDRML
Mvan_1209|M.vanbaalenii_PYR-1 MEPFDLLGPLPAPRTTTVLEASAGTGKTFALAGLVTRYVAEGVATLDQML
MAV_4543|M.avium_104 MERFDLLGALPAARSTTVLEASAGTGKTFALAGLVTRYLADGAATLDQML
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M MRPFDLLGPLPAENSTTVLEASAGTGKTFALAALVTRYVAEGRARLDEML
MUL_0708|M.ulcerans_Agy99 MRPFDLLGPLPAENSTTVLEASAGTGKTFALAALVTRYVAEGRARLDEML
MAB_0399c|M.abscessus_ATCC_199 MKRFDLLGPLPADRSTTVLEASAGTGKTFALAGLVTRYVAEGVATLDQML
MSMEG_1327|M.smegmatis_MC2_155 MKVFDLLGPLPAPNTTTVLEASAGTGKTFALAGLVTRFVAEGVATLDQML
MLBr_00153|M.leprae_Br4923 -------------MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVHEGSPLL
Mb0647c|M.bovis_AF2122/97 LITFNRAASRELRERVRGQIVEALGALQG--------DAPPSGELVEHLL
Rv0630c|M.tuberculosis_H37Rv LITFNRAASRELRERVRGQIVEAVGALQG--------DAPPSGELVEHLL
Mflv_5130|M.gilvum_PYR-GCK LITFGRAASQELRERVRSQIVDALRAFD-------DPAAIGDNEVVRHLV
Mvan_1209|M.vanbaalenii_PYR-1 LITFGRAASQELRERVRAQILDALRAFD-------DPSHAADNEIVAHLL
MAV_4543|M.avium_104 LITFGRAASQELRERVRCQIVDAVAAFA-------DPSRAGDNELVAYLL
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M LITFGRAASQELRERVRCQMVDAVRVFHDSRNGSDDADPAGDNQLLAHLL
MUL_0708|M.ulcerans_Agy99 LITFGRAASQELRERVRCQMVDAVRVFHDSRNGSDDADPAGDNQLLAHLL
MAB_0399c|M.abscessus_ATCC_199 LITFGRAASQELRDRVRGQIVDALRAFA-------DPSTART-DLTQYLI
MSMEG_1327|M.smegmatis_MC2_155 LITFGRAASQELRERVRAQIVAALVALD-------DPSRACN-DLEEYLV
MLBr_00153|M.leprae_Br4923 IVAGAGSGKTTVLARRIAYLIAAR-------------SVGVSQILAITFT
Mb0647c|M.bovis_AF2122/97 RGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADV
Rv0630c|M.tuberculosis_H37Rv RGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADV
Mflv_5130|M.gilvum_PYR-GCK TGDAEECDARRRRLRDALAGFDAATIATTHQFCQLVLRSLGVAGDTDSGV
Mvan_1209|M.vanbaalenii_PYR-1 TGSHGELTERRQRLRDALAGFDAATIATTHQFCQLVLRSLGVAGDTDSGV
MAV_4543|M.avium_104 DGTEDRLAARRQRLRDGLAGFDAATIATTHQFCQLVLRSLGVAGDTAAGV
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M DGTAAERDARQQRLRDALAGFDAATIATTHQFCQLVLKSLGVAGDTDAGV
MUL_0708|M.ulcerans_Agy99 DGTAAERDARQQRLRDALAGFDAATIATTHQFCQLVLKSLGVAGDTDAGV
MAB_0399c|M.abscessus_ATCC_199 S---AEQDTRQRRLRDALAGFDAATIATTHQFCHIVLKSLGVAGDSDSGV
MSMEG_1327|M.smegmatis_MC2_155 K---TDQQARRRRLRDALAGFDAATIATTHQFCQIVLKSLGVAGDSDAGV
MLBr_00153|M.leprae_Br4923 NKAAAEMRERVARLVGDHTG-PSMWVSTFHSTCVRILRNQASLIGGLNSN
Mb0647c|M.bovis_AF2122/97 ELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQ
Rv0630c|M.tuberculosis_H37Rv ELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQ
Mflv_5130|M.gilvum_PYR-GCK ELVESLDDLVAEIVDDLYLAHFGQDRDEPLLTHESALRLAHAVVGNAHTE
Mvan_1209|M.vanbaalenii_PYR-1 ELVESLDDLVTEIVDDLYLAHFGQDHDEPLLTYADALSLAREVVGNAHTE
MAV_4543|M.avium_104 TLLDSLDELVAEIVDDLYLAHFGQDHDDPVLHYREALRLARDVVNNPSAQ
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M TLVEDLDELVTEIVDDLYLVHFGRDRDDPPLTYRDALRIARAVVANPSTQ
MUL_0708|M.ulcerans_Agy99 TLVEDLDELVTEIVDDLYLVHFGRDRDDPPLTYRDALRIARAVVANPSTQ
MAB_0399c|M.abscessus_ATCC_199 TLVENLDELVCEIVNDRYLTHFGKDRDAPPLSYPAALRLAREVVRNPATQ
MSMEG_1327|M.smegmatis_MC2_155 TLVESLDDLVSEIVDDLYLAHFGGQKDDPELSYPEALKLARVVVGNPATQ
MLBr_00153|M.leprae_Br4923 FSIYDVDDSRSLLQMIGQDMGLDIKRYSPRLMANAISNLKNELIDAESAV
Mb0647c|M.bovis_AF2122/97 LRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALE
Rv0630c|M.tuberculosis_H37Rv LRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALE
Mflv_5130|M.gilvum_PYR-GCK LRPRDPAPGSDAAVRVEFAKAVCAELETRKRKLGILHYDDLLSRLADALE
Mvan_1209|M.vanbaalenii_PYR-1 LRPTDPPPGSDPFVRVQFARAVCAELETRKRRLGILHYDDLLSRLAKALE
MAV_4543|M.avium_104 LRPLHPEPGSRAAVSLRFANDVLAELDTRKRRLGVLGYDDLLTRLADALA
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M LRPLDAPPGSRAAICVGFAHHVLEELETRKRRRGILGYDDLLLRLADALA
MUL_0708|M.ulcerans_Agy99 LRPLDAPPGSRAAACVGFAHHVLEGLETRKRRRGILGYDDLLLRLADALA
MAB_0399c|M.abscessus_ATCC_199 LRPLQPEADSYAFAALGFARDVLEQLEIRKRRRGILGFDDLLTRLADALN
MSMEG_1327|M.smegmatis_MC2_155 LRPRDPDPDSPAAVRLKFARDVLAELEIRKRRRGVLGYDDLLTRLADALE
MLBr_00153|M.leprae_Br4923 AN-----LSSDTDDLARTVATVYGEYQRRLRTANALDFDDLIGETVGILQ
Mb0647c|M.bovis_AF2122/97 AADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPK
Rv0630c|M.tuberculosis_H37Rv AADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPK
Mflv_5130|M.gilvum_PYR-GCK APDSPARARMQRRWSIVMVDEFQDTDPVQWQVIDRAFRGHATLILIGDPK
Mvan_1209|M.vanbaalenii_PYR-1 PQDSPARMRMQHRWSIVMVDEFQDTDPVQWQVIDCAFSGHATVILIGDPK
MAV_4543|M.avium_104 TEHSPARLRMHQRWPIVMVDEFQDTDPVQWQVIDRAFSGRSTLILIGDPK
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M SEDSAARARMQQRWPVVMVDEFQDTDAVQWQVIDSAFSGRCTLILIGDPK
MUL_0708|M.ulcerans_Agy99 SEDSAARARMQQRWPVVMVDEFQDTDAVQWQVIDSAFSGRCTLILIGDPK
MAB_0399c|M.abscessus_ATCC_199 ATDSPARVRMHQRWPIVMVDEFQDTDPVQWQVLERAFSGHSTLVLIGDPK
MSMEG_1327|M.smegmatis_MC2_155 PEDSPARVRMQQRWPIVMVDEFQDTDPVQWQVIERAFSGRSTLVLIGDPK
MLBr_00153|M.leprae_Br4923 AFP-QIAEHYRRRFRHVLVDEYQDTNHAQYVLVRELVGHGARNSPDDMPP
Mb0647c|M.bovis_AF2122/97 QAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATL
Rv0630c|M.tuberculosis_H37Rv QAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATL
Mflv_5130|M.gilvum_PYR-GCK QAIYAFRGGDIVTYLHAAATAGVQRTLGTNYRSDAPLVEGLQAVMRDAQL
Mvan_1209|M.vanbaalenii_PYR-1 QAIYAFRGGDIVTYLHAVSTADRQKTLGTNYRSDGPLVDSLQAVMRDAQL
MAV_4543|M.avium_104 QAIYAFRGGDIVTYLRAAETAGQKKTLDTNWRSDSALLQRLQVVLRGAQL
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M QAIYAFRGGDIVTYLHAAQTAGDKRTLATNWRSDSALVDRLQVVLRGAEL
MUL_0708|M.ulcerans_Agy99 QAIYAFRGGDIVTYLHAAQTAGDKRTLATNWRSDSALVDRLQVVLRGAEL
MAB_0399c|M.abscessus_ATCC_199 QAIYAFRGGDIETYLRAAATAGDKQTLGTNWRSDAALVDRLQVVLRGAQL
MSMEG_1327|M.smegmatis_MC2_155 QAIYAFRGGDIATYLRAAATAGDKQTLGTNWRSDRALVDRLQAVLRGAQL
MLBr_00153|M.leprae_Br4923 GELCVVGDADQSIYAFRGSTISNIEDFERDYPDTTTILLEQNYRSTQNIL
Mb0647c|M.bovis_AF2122/97 GHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEA
Rv0630c|M.tuberculosis_H37Rv GHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEA
Mflv_5130|M.gilvum_PYR-GCK GDPRIVVRRVDAHHREHRLQGAPHNEPFRLRVCTRDQFRVRPDRMIPIDV
Mvan_1209|M.vanbaalenii_PYR-1 GDPRIVAHRVEAHHRDHRLAGAPRNAPFRLRVVTRDQFGTRPDRVVAIDQ
MAV_4543|M.avium_104 GDPAIVVNDVAAHHRGHRLSGAPRNDPFRLRVVSRNTLGRRGIANLPIDE
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M GDPAIVVRDVKAHHQGHRLAGAPHNDALRLRVVRRATLGRRGIQNLPIDI
MUL_0708|M.ulcerans_Agy99 GDPAIVVRDVKAHHQGHRLAGAPHNDALRLRVVRRATLGRRGIQNLPIDI
MAB_0399c|M.abscessus_ATCC_199 GGPDIVVHDVQAHHQGHRLAGAPHNDPFRLRVVSRN---RDGIKVIPIAD
MSMEG_1327|M.smegmatis_MC2_155 GGPDIVVHDVQARHQGHRLVGAPRNDPFRLRVVSRK---PGNTRVIPIDQ
MLBr_00153|M.leprae_Br4923 SAANSVIARNFGRRDKRLWTDAGKGELIVG----------------YVSD
Mb0647c|M.bovis_AF2122/97 LRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNAL
Rv0630c|M.tuberculosis_H37Rv LRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNAL
Mflv_5130|M.gilvum_PYR-GCK LRNHIPKDMAADIAALLNSGATHCGEKLAPGHIAVIVESHRDGHACFAAL
Mvan_1209|M.vanbaalenii_PYR-1 LRRHIPQDMAADIAALLASDATFCDRPVQPGDVAVIVESHRDGHACFDAL
MAV_4543|M.avium_104 LRQHIGADLAADIRALLAAGATFDGKPVRAGDIAVIVERHRDAQACFTAL
TH_1287|M.thermoresistible__bu ------------------------------------VETHKDARACYDAL
MMAR_0957|M.marinum_M LRDHIGRDLASDIGALLASGATFAGRALQANDIAVIVEKHKDARACHRAL
MUL_0708|M.ulcerans_Agy99 LRDHIGRDLASDIGALLASGATFAGRALQANDIAVIVEKHKDARACHRAL
MAB_0399c|M.abscessus_ATCC_199 LRRSIGRDLAADIGALLSSGATFDGRPVRARDIAVIVEAHKDARACHTAL
MSMEG_1327|M.smegmatis_MC2_155 LRRHIGRDLAADISALLNSGATWCDQPVQAKDIAVITETHKDARACHAAL
MLBr_00153|M.leprae_Br4923 NEHDEAKFIADEIDALVGGGE------ITYDDVAVLYRANNLSRSLEEVF
. :. .:: .:
Mb0647c|M.bovis_AF2122/97 AEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFG
Rv0630c|M.tuberculosis_H37Rv AEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFG
Mflv_5130|M.gilvum_PYR-GCK ADAGIPAVYTGDSDVFSSPAADDWMCLLEAFDQPHRSGLVRAAATTMFFG
Mvan_1209|M.vanbaalenii_PYR-1 TAAGIPAVYTGDSDVFTSPAADDWMCLLEAFDQPHRSGLVRAAATTMFFG
MAV_4543|M.avium_104 CDAGVPAVYTGNSDVFTSQAAEDWLCLLEAFDQPHRPGVVRAAAATMFFG
TH_1287|M.thermoresistible__bu CQAGIPAVYTGDSDVFGSPAAEDWLCLLEAFDQPHRPGMVRAAAATMFFG
MMAR_0957|M.marinum_M TDAGIHAVYTGDTDVFSSEAADDWLALLEAFDQPHRPGIVRAAAATMFFG
MUL_0708|M.ulcerans_Agy99 TDAGIHAVYTGDTDVFSSEAADDWLALLEAFDQPHRPGIVRAAAATMFFG
MAB_0399c|M.abscessus_ATCC_199 TEAGIPAVYTGDTDVFSSDAAQDWLYLLEAFDQPHRPGLVRAAAATVFFG
MSMEG_1327|M.smegmatis_MC2_155 LAAGIPAVYTGDSDVFTSEAAEDWLYLLEAFDQPHRPGLVRAAAATMFFG
MLBr_00153|M.leprae_Br4923 IPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNPGDAVSMR---------
:*: .*. .: * * : *..:* * . :*
Mb0647c|M.bovis_AF2122/97 ETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVL
Rv0630c|M.tuberculosis_H37Rv ETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVL
Mflv_5130|M.gilvum_PYR-GCK ETAEALALQGDSLTDRIAETLRQWADFARERGVAAVFEAAQLRGMGARVL
Mvan_1209|M.vanbaalenii_PYR-1 ETAESLAAEGDTLTDRVAETLRQWADFARDRGVAAVFEAAQLGGMGERVL
MAV_4543|M.avium_104 ETAETLAAGGDALTDRIAQTLREWAGHARERGVAAIFEAAQLLGMGNRVL
TH_1287|M.thermoresistible__bu ETAESLAAGGDALTDRVADTLREWAAHARERGVAAIFEAAKLSGMGDRVL
MMAR_0957|M.marinum_M KTANDLARGGDALTDRVAETLREWADYARERGVAAIFEAAQLGGMSDRVL
MUL_0708|M.ulcerans_Agy99 KTANDLARGGDALTDRVAETLREWADYARERGVAAIFEAAQLGGMSDRVL
MAB_0399c|M.abscessus_ATCC_199 ETAETLAVGGESLTDEIAGTLRTWAARARERGVAAVFEAAQLAGMGKRVL
MSMEG_1327|M.smegmatis_MC2_155 ETAESLAAGGDALTDRVADTLREWAGHARERGVAAIFEAAQLAGMGKRVL
MLBr_00153|M.leprae_Br4923 ---RILNTPRRGIGDRAEACVSVYAENTG----TSFADALQAVAEGKVPM
. * : *. : :* : ::. :* : . . :
Mb0647c|M.bovis_AF2122/97 SQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAG---P
Rv0630c|M.tuberculosis_H37Rv SQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAG---P
Mflv_5130|M.gilvum_PYR-GCK RWVDGERHMTDLAHLTQLLHDTAHREQYSLPALRDWLRAQRDDRGGLRGT
Mvan_1209|M.vanbaalenii_PYR-1 SWVDGERHMTDLAHLTQVLHGTAHREHFSLPALRDWLRGQRDERS---GA
MAV_4543|M.avium_104 GWQGGARHMTDLAHLTQLLGEVAHCEHHNLPALRDWLRRQRDERSG---A
TH_1287|M.thermoresistible__bu SWADGERHMTDLAHIAQLLQEAAHRDHLGLPALRDWLRARREETSGG--A
MMAR_0957|M.marinum_M SWQEGQRHMTDLAHVTQLLQKVSHRERYTLPALRDWLRGQREDRGG---A
MUL_0708|M.ulcerans_Agy99 SWQEGQRHMTDLAHVTQLLQKVSHRERYTLPALRDWLRGQREDRGG---A
MAB_0399c|M.abscessus_ATCC_199 SWRGGERMMTDLAHLTELLQETAHRNGFGPAALRDWLRTQCSEGGA---E
MSMEG_1327|M.smegmatis_MC2_155 SWQGGERLMTDLAHMTQLLQDTAHREGFGLAALRDWLRTQRSERGG---E
MLBr_00153|M.leprae_Br4923 LN---TRSVKAIAGFVALLDDLRCRVDDDLGELVESVLER----------
* :. :* .. :* * : : :
Mb0647c|M.bovis_AF2122/97 PEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHD
Rv0630c|M.tuberculosis_H37Rv PEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHD
Mflv_5130|M.gilvum_PYR-GCK VERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRNVQPRDVVVFHE
Mvan_1209|M.vanbaalenii_PYR-1 PERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRNIQTRDVVTFHD
MAV_4543|M.avium_104 PERNRRLDSDAAAVQIMTVFVSKGLQYPIVYLPFAFHRNTTDSDVVLFHD
TH_1287|M.thermoresistible__bu TERFRRLDTDAAAVPVMTVFAAKGLQFPVVYLPFAFNRHVRKQELVLYHE
MMAR_0957|M.marinum_M TERNRRIDSDAAAVQIMTVWVSKGLQYPVVYLPFAFNRNIQERELVLFHD
MUL_0708|M.ulcerans_Agy99 TERNRRIDSDAAAVQIMTVWVSKGLQYPVVYLPFAFNRNIQERELVLFHD
MAB_0399c|M.abscessus_ATCC_199 AERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFSFNRYVPEREYVLYHE
MSMEG_1327|M.smegmatis_MC2_155 SERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRYVPEPDLVLFHD
MLBr_00153|M.leprae_Br4923 SGYLRELESSTDPQELARLDNLN------ELVSFAHEFSTEQANAAALAK
*.:::.: . : : : :.*:.. : .
Mb0647c|M.bovis_AF2122/97 D-------GTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRA
Rv0630c|M.tuberculosis_H37Rv D-------GTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRA
Mflv_5130|M.gilvum_PYR-GCK PATSDGAGDIRCLHIGGESSPDFA-AVAQQARLEAAGDDVRLTYVAMTRA
Mvan_1209|M.vanbaalenii_PYR-1 -------GDIRCLHIGGERSPDHA-AAQQQGRREAAGDDVRLTYVAMTRA
MAV_4543|M.avium_104 ED------GTRCLHVGGKDSPDFK-TVERLGRKEDASDDSRLTYVALTRA
TH_1287|M.thermoresistible__bu DD------GTRCLHIGGSDSPDHP-QVAQRGRDEDASDDGRLTYVALTRA
MMAR_0957|M.marinum_M G-------GTRCLHIGGKDSPDFG-TVERLGAKEAANDDSRLTYVAMTRA
MUL_0708|M.ulcerans_Agy99 R-------GTRCLHIGGKDSPDFG-TVERLGAKEAANDDSRLTYVAMTRA
MAB_0399c|M.abscessus_ATCC_199 D-------GLRCLHIGGREDPDYS-MADLAGRTEAARDASRLAYVALTRA
MSMEG_1327|M.smegmatis_MC2_155 D-------GQRCLHVGG-ADP----AVARAGRAEAAGDDSRLTYVALTRA
MLBr_00153|M.leprae_Br4923 S-----------LHTPEDEDVPDTGALAAFLEKVSLMSDTDQIPENNSGV
*: . . : .
Mb0647c|M.bovis_AF2122/97 QSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTP-RVTDEQAWAV
Rv0630c|M.tuberculosis_H37Rv QSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTP-RVTDEQAWAV
Mflv_5130|M.gilvum_PYR-GCK QSQVVAWWAPSRDELNGGLSRLLRGRAPGDPVVPDRCDPARIDDAEAMAR
Mvan_1209|M.vanbaalenii_PYR-1 QSQVVAWWAPSNDEPNGGLSRLLRGRAPGDPVVPDRCDPPRIDDPDAMAQ
MAV_4543|M.avium_104 QAQVVAWWSPAYHEPNGGLSRLLRGRRPGEPVVPDRCEPAKISDEDALAR
TH_1287|M.thermoresistible__bu QAQVVAWWAPSWDEPNGGLSRLLRGRRPGERSVPHRCPDDRITDDQAWER
MMAR_0957|M.marinum_M QSQVVAWWSPAYDEPNGGLSRLLRGRRPGDSVVPDRATPAKITDEDAWDR
MUL_0708|M.ulcerans_Agy99 QSQVVAWWSPAYDEPNGGLSRLLRGRRPGDSVVPDRATPAKITDEDAWDR
MAB_0399c|M.abscessus_ATCC_199 QSQVVAWWAPSFDEPNGGLSRLLRGRAPGNPSVPDKCSPAKISDADVLKR
MSMEG_1327|M.smegmatis_MC2_155 QSQVVAWWAPSYDEPNGGLSRLMRGRAPGEAIVPDKCSPPKISDEDALER
MLBr_00153|M.leprae_Br4923 VTLMTLHAAKGLEFPVVFVTGWEDGMLPHMRTLGD---PTELSEERRLAY
: :. : . :: * * : . .: :
Mb0647c|M.bovis_AF2122/97 FAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSY
Rv0630c|M.tuberculosis_H37Rv FAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSY
Mflv_5130|M.gilvum_PYR-GCK LRAWADEGGPVLEESIIAERVEVELPAPPDTLAVRHFHRRIDPLWRRTSY
Mvan_1209|M.vanbaalenii_PYR-1 LRAWSDAGGPVLEESVIAASVTVELPSPAEDLDVRHFHRRIDTSWRRTSY
MAV_4543|M.avium_104 LREWEAAGGPVIEEAVPAPAPPLPGVPVPARLENRHFHRGIDTGWRRTSY
TH_1287|M.thermoresistible__bu LREWEAAGGPVLEESLPRPVTALPPEPTPTELGARHFHRSIDTDWRRTSY
MMAR_0957|M.marinum_M FQQWQAAGGPTVEESVIAAAPAIAGRPAPSELATRRFDRGIDIRWRRTSY
MUL_0708|M.ulcerans_Agy99 FQQWQAAGGPTVEESVIAAAPAIAGQPAPSELATRRFDRDIDIRWRRTSY
MAB_0399c|M.abscessus_ATCC_199 LRAWEAQGGPVVEDALVTGFVPAATSSPSDNLAVRVFDRPIDTAWRRTSY
MSMEG_1327|M.smegmatis_MC2_155 LRAWEAAGGPVIEESVIGAVSPVPPEPAPEDLAARKFFRAIDMAWKRTSY
MLBr_00153|M.leprae_Br4923 VGITRARQRLYLSRAITRSSWGQPILNPESRFLREIPPELID--WRRSIL
. :. :: : . . ** *:*:
Mb0647c|M.bovis_AF2122/97 SDLVRGSEAVT---------VTSEPAAGGRADEVEIAVFAAPGSGA---D
Rv0630c|M.tuberculosis_H37Rv SDLVRGSEAVT---------VTSEPAAGGRADEVEIAVVAAPGSGA---D
Mflv_5130|M.gilvum_PYR-GCK SGLIRAAEQE--------SGVGSEPEVVELDDEVAELRAPDTEPATPDVD
Mvan_1209|M.vanbaalenii_PYR-1 SGLIRAAESEQ-------TGVGSEPEVVELDDEAGEVPVPGAGGGGD--Q
MAV_4543|M.avium_104 SGLIRQAQPSG---------VGSEPEAAGLDDEVGDILLAPATSVG---D
TH_1287|M.thermoresistible__bu SGLLRASQSDGGVAASGSPGVTSEPEVAELDDEVGEIPLTPATDGA---E
MMAR_0957|M.marinum_M SGLIRMAEATG---------VSSEPEVTERDDEVAEVPLTEVVMSGP--E
MUL_0708|M.ulcerans_Agy99 SGLIRMAEATG---------VSSEPEVTERDDEVAEVPLTEVVMSGP--E
MAB_0399c|M.abscessus_ATCC_199 SGLLRAAEES---------GVSSEPEIAELDDEVDEIPLRSMPAGA---D
MSMEG_1327|M.smegmatis_MC2_155 SGLLRAAETAG-------VGVSSEPEVTERDDEFDDIPVVAPAEGA---D
MLBr_00153|M.leprae_Br4923 TDSYSTPASGAS--------RFGRVRPSSIRSGASKRALLVLAPGDRVTH
:. . .. . .
Mb0647c|M.bovis_AF2122/97 LTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVP---------
Rv0630c|M.tuberculosis_H37Rv LTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVRRHAPWWTVD
Mflv_5130|M.gilvum_PYR-GCK MASPMAGLPMGAKFGTLVHAVLETADPFAVDLAAELEAAVVEHSLWWPVD
Mvan_1209|M.vanbaalenii_PYR-1 MPSPMADLPMGAKFGTLVHAVLETADPFATDLAAELESHVRRHSLWWPVD
MAV_4543|M.avium_104 VASPMADLPAGATFGTLVHAVLQTADPFAPDLAAELTARIREHSVWWPVA
TH_1287|M.thermoresistible__bu VPSPMAGLPTGAKLGTLVHAVLETADPFAPDLAAELADRVREHAVWWPVD
MMAR_0957|M.marinum_M QPSPMADLPSGAKFGSLVHAVLETSDPFAIDLAAELESQIRVQSAWWPVQ
MUL_0708|M.ulcerans_Agy99 QPSPMADLPSGAKFGSLVHAVLETSDPFAIDLAAELESQIRVQSAWWPVQ
MAB_0399c|M.abscessus_ATCC_199 VPSPMAQLPAGAAFGSLVHAVLETTDPLAPDLVAELQTQIIRHRERWPVE
MSMEG_1327|M.smegmatis_MC2_155 VPSPMAHLPTGAAFGSLVHAVLETADPFAEDLTAELATHIDAHSQHWPVE
MLBr_00153|M.leprae_Br4923 DKYGLGRVEEVSGVGESAISLIDFGSSGRIKLMHNHAPVTKL--------
:. : : .* . :::: .. .* :
Mb0647c|M.bovis_AF2122/97 --------------------------------------------------
Rv0630c|M.tuberculosis_H37Rv VDHAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDFEMPLA
Mflv_5130|M.gilvum_PYR-GCK VP----PAELAAALVPLHDTPLGPLAPGVTLRDIGLRDRLREMEFEFPLA
Mvan_1209|M.vanbaalenii_PYR-1 VP----AADLAAALVPLHDTPLGPLAPGVTLRDIGLRDRLREMEFEFPLA
MAV_4543|M.avium_104 AT----PEDMAAAMVPMHDTPLGPLAGGLTLRRIGLSDRLCELDFELPLA
TH_1287|M.thermoresistible__bu VP----AEELAAALVPVHDTPLGPLAPGLTLRQIGLRDRMREMEFEFPLA
MMAR_0957|M.marinum_M VP----AAQLAAALVPMHDTPLGPLAGGLTLRQIGLPDRLREMDFEFPLA
MUL_0708|M.ulcerans_Agy99 VP----AAQLAAALVPMHDTPLGPLAGGLTLRQIGLPDRLREMDFEFPLA
MAB_0399c|M.abscessus_ATCC_199 IP----AAELAAALEPMHDTPLGPLLPGVTLRQIGLRDRLCELDFEFPLA
MSMEG_1327|M.smegmatis_MC2_155 VE----TAELAAALVPMHDTPLGPLAPGLTLRQIGLRDRLCELDFEFPMA
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 -GTRRG-------------------------------------GPWTSTT
Rv0630c|M.tuberculosis_H37Rv GGDLRGR---SPDVSLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPL
Mflv_5130|M.gilvum_PYR-GCK GGDRRDD---TPDITLADVGRLLRAHLPADDPLAPYAARLTTGALAGQPL
Mvan_1209|M.vanbaalenii_PYR-1 GGDRRVE---VPDISLADVGRLLAAHLPADDPLAPYAERLTGGTLAAQSL
MAV_4543|M.avium_104 GGDRRSA---PPEVRLADLAPLLRAHLPADDVLACYADRLTDRSLGAESL
TH_1287|M.thermoresistible__bu GGDARDA---APDIRLADVGDLLGAHLPEDDPLACYAERLTGTGLGRQPL
MMAR_0957|M.marinum_M GGDEADAGGHAPDLRLADVGALLRAHLDASDPLAPYADRLSGDALGGQSL
MUL_0708|M.ulcerans_Agy99 GGDEADAGGHAPDLRLADVGALLRAHLDASDPLAPYDDRLSGDALGGQTL
MAB_0399c|M.abscessus_ATCC_199 GGDAAAD----SFARLADVGMLLREHLAADDPLGVYASRLTGPGLGGQSL
MSMEG_1327|M.smegmatis_MC2_155 GGDLRGG----RFARLSDVGELLREYLPADDPLAVYAERLSTGILGVQPL
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 RSWLP---------------------------------------------
Rv0630c|M.tuberculosis_H37Rv RGYLAGSIDVVLRLP---GQRYLVVDYKTNHLGD-----TAADYGFERLT
Mflv_5130|M.gilvum_PYR-GCK KGYLNGSLDAVLRVD----GRYLVVDYKTNWLGDPAGELTAADYAPARLA
Mvan_1209|M.vanbaalenii_PYR-1 KGYLNGSVDAVLRVG----DRYLVVDYKTNWLGDPARPLTAADYGKARLT
MAV_4543|M.avium_104 RGYLTGSIDAVLRIPDGAGHRYLVVDYKTNRLGDAQHPLTAADYDRPRMV
TH_1287|M.thermoresistible__bu RGYLTGSVDAVLRIPAGDDHRYLVVDYKTNWLGPVDRPLTAADYTRPRLV
MMAR_0957|M.marinum_M RGYLSGSVDAVLRIPDGPGQRYLVVDYKTNWLGDPDRPLTAADYHRPRLI
MUL_0708|M.ulcerans_Agy99 RGYLSGSVDVVLRIPDGPGQRYLVVDYKTNWLGDPDRPLTAADYHRPRLI
MAB_0399c|M.abscessus_ATCC_199 RGYLSGSVDAVLRVG----SRYVVVDYKTNWLGTGDAPLTAADYSRPRMV
MSMEG_1327|M.smegmatis_MC2_155 RGYLSGSVDAVLRVG----EKFVIVDYKTNWLGTGDGTLTAADYGRRRMV
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 -----------------------NWPER------------------CCRC
Rv0630c|M.tuberculosis_H37Rv EAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARHLGGVLYLFVRGMCGA
Mflv_5130|M.gilvum_PYR-GCK EAMLHSDYPLQALLYCVVLHRFLRWRQPGYSARRHIAGVLYLFVRGMCGP
Mvan_1209|M.vanbaalenii_PYR-1 EVMLHSDYPLQALLYCVVLHRFLRWRAPGYRAESHIAGVLYLFVRGMCGA
MAV_4543|M.avium_104 EAMLHSDYPLQALLYSAVLHRFLRWRLAGYDPDRHLGGILYLFVRGMCGP
TH_1287|M.thermoresistible__bu EAMLHSDYPLQALLYSVVLHRFLRWRLPAYTPEEHLGGVLYLFLRGMCGP
MMAR_0957|M.marinum_M EAMLHSDYPLQALLYTVVLHRFLRWRQPGYDPARHLGGVLYLFVRGMCGP
MUL_0708|M.ulcerans_Agy99 EAMLHSDYPLQALLYTVVLHRFLRWRQPGYDPARHLGGVLYLFVRGMCGP
MAB_0399c|M.abscessus_ATCC_199 EAMLHSDYPLQALLYSVVLHRFLSWRLPGYRPEEHLGGAVYLFVRGMCGA
MSMEG_1327|M.smegmatis_MC2_155 EAMLHSDYPLQALLYAVVLHRYLGWRLSGYDPATHLGGVLYLFVRGMCGA
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 TTRR----------WDPPPPH---------------
Rv0630c|M.tuberculosis_H37Rv ATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQS
Mflv_5130|M.gilvum_PYR-GCK DTPVLDGHPAGVFSWQPPAALIEELSDLLDAGAVPA
Mvan_1209|M.vanbaalenii_PYR-1 DTPVVDGHPAGVFSWQPPAALIEALSDLLDAGVAA-
MAV_4543|M.avium_104 DTPVRDGHPSGVFDWRPPSSLIAALSDLLDAQGVAV
TH_1287|M.thermoresistible__bu DTPVVDGHPAGVFSWQPPAGLVVALSDLLDAGRTAE
MMAR_0957|M.marinum_M DTPMLDGHPAGVFSWSPPAALVTALSDLLDAGRAVA
MUL_0708|M.ulcerans_Agy99 DTPMLDGHPAGVFSWSPPAALVTALSDLLDAGRAVA
MAB_0399c|M.abscessus_ATCC_199 TTPVVEGHPAGVFSWQPPSALVVALSELLS------
MSMEG_1327|M.smegmatis_MC2_155 GTPVVDGHPAGVFSWEPPADLVVALSKLLDAEAP--
MLBr_00153|M.leprae_Br4923 ------------------------------------