For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RPFDLLGPLPAENSTTVLEASAGTGKTFALAALVTRYVAEGRARLDEMLLITFGRAASQELRERVRCQMV DAVRVFHDSRNGSDDADPAGDNQLLAHLLDGTAAERDARQQRLRDALAGFDAATIATTHQFCQLVLKSLG VAGDTDAGVTLVEDLDELVTEIVDDLYLVHFGRDRDDPPLTYRDALRIARAVVANPSTQLRPLDAPPGSR AAACVGFAHHVLEGLETRKRRRGILGYDDLLLRLADALASEDSAARARMQQRWPVVMVDEFQDTDAVQWQ VIDSAFSGRCTLILIGDPKQAIYAFRGGDIVTYLHAAQTAGDKRTLATNWRSDSALVDRLQVVLRGAELG DPAIVVRDVKAHHQGHRLAGAPHNDALRLRVVRRATLGRRGIQNLPIDILRDHIGRDLASDIGALLASGA TFAGRALQANDIAVIVEKHKDARACHRALTDAGIHAVYTGDTDVFSSEAADDWLALLEAFDQPHRPGIVR AAAATMFFGKTANDLARGGDALTDRVAETLREWADYARERGVAAIFEAAQLGGMSDRVLSWQEGQRHMTD LAHVTQLLQKVSHRERYTLPALRDWLRGQREDRGGATERNRRIDSDAAAVQIMTVWVSKGLQYPVVYLPF AFNRNIQERELVLFHDRGTRCLHIGGKDSPDFGTVERLGAKEAANDDSRLTYVAMTRAQSQVVAWWSPAY DEPNGGLSRLLRGRRPGDSVVPDRATPAKITDEDAWDRFQQWQAAGGPTVEESVIAAAPAIAGQPAPSEL ATRRFDRDIDIRWRRTSYSGLIRMAEATGVSSEPEVTERDDEVAEVPLTEVVMSGPEQPSPMADLPSGAK FGSLVHAVLETSDPFAIDLAAELESQIRVQSAWWPVQVPAAQLAAALVPMHDTPLGPLAGGLTLRQIGLP DRLREMDFEFPLAGGDEADAGGHAPDLRLADVGALLRAHLDASDPLAPYDDRLSGDALGGQTLRGYLSGS VDVVLRIPDGPGQRYLVVDYKTNWLGDPDRPLTAADYHRPRLIEAMLHSDYPLQALLYTVVLHRFLRWRQ PGYDPARHLGGVLYLFVRGMCGPDTPMLDGHPAGVFSWSPPAALVTALSDLLDAGRAVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0708 | recB | - | 100% (1110) | exodeoxyribonuclease V (beta chain), RecB |
| M. ulcerans Agy99 | MUL_2512 | uvrD2 | 3e-09 | 23.79% (269) | ATP-dependent DNA helicase II UvrD2 |
| M. ulcerans Agy99 | MUL_2521 | - | 5e-05 | 26.32% (171) | ATP-dependent DNA helicase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0647c | recBa | 0.0 | 63.98% (869) | exonuclease V subunit beta |
| M. gilvum PYR-GCK | Mflv_5130 | - | 0.0 | 69.81% (1123) | exodeoxyribonuclease V, beta subunit |
| M. tuberculosis H37Rv | Rv0630c | recB | 0.0 | 65.29% (1112) | exonuclease V beta chain |
| M. leprae Br4923 | MLBr_00637 | uvrD2 | 4e-12 | 21.67% (466) | putative ATP-dependent DNA helicase |
| M. abscessus ATCC 19977 | MAB_0399c | - | 0.0 | 70.11% (1104) | exodeoxyribonuclease V, beta subunit (RecB) |
| M. marinum M | MMAR_0957 | recB | 0.0 | 99.28% (1110) | exodeoxyribonuclease V (beta chain), RecB |
| M. avium 104 | MAV_4543 | recB | 0.0 | 73.24% (1106) | exodeoxyribonuclease V, beta subunit |
| M. smegmatis MC2 155 | MSMEG_1327 | recB | 0.0 | 70.55% (1107) | exodeoxyribonuclease V, beta subunit |
| M. thermoresistible (build 8) | TH_1287 | recB | 0.0 | 70.67% (682) | PROBABLE EXONUCLEASE V (BETA CHAIN) RECB (EXODEOXYRIBONUCLEASE |
| M. vanbaalenii PYR-1 | Mvan_1209 | - | 0.0 | 70.57% (1111) | exodeoxyribonuclease V, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0647c|M.bovis_AF2122/97 MDRFELLG-------------PLPREGTTTVLEASAGTGKTFALAGLVTR
Rv0630c|M.tuberculosis_H37Rv MDRFELLG-------------PLPREGTTTVLEASAGTGKTFALAGLVTR
MUL_0708|M.ulcerans_Agy99 MRPFDLLG-------------PLPAENSTTVLEASAGTGKTFALAALVTR
MMAR_0957|M.marinum_M MRPFDLLG-------------PLPAENSTTVLEASAGTGKTFALAALVTR
Mflv_5130|M.gilvum_PYR-GCK MEPFDLLG-------------ALPEPRTTTVLEASAGTGKTFALAGLVTR
Mvan_1209|M.vanbaalenii_PYR-1 MEPFDLLG-------------PLPAPRTTTVLEASAGTGKTFALAGLVTR
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 MERFDLLG-------------ALPAARSTTVLEASAGTGKTFALAGLVTR
MAB_0399c|M.abscessus_ATCC_199 MKRFDLLG-------------PLPADRSTTVLEASAGTGKTFALAGLVTR
MSMEG_1327|M.smegmatis_MC2_155 MKVFDLLG-------------PLPAPNTTTVLEASAGTGKTFALAGLVTR
MLBr_00637|M.leprae_Br4923 MDPMVMVVNPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAH
Mb0647c|M.bovis_AF2122/97 YLAETAATLDEMLLITFNRAASRELRERVRGQIVEALGALQGD-------
Rv0630c|M.tuberculosis_H37Rv YLAETAATLDEMLLITFNRAASRELRERVRGQIVEAVGALQGD-------
MUL_0708|M.ulcerans_Agy99 YVAEGRARLDEMLLITFGRAASQELRERVRCQMVDAVRVFHDSRNGSDDA
MMAR_0957|M.marinum_M YVAEGRARLDEMLLITFGRAASQELRERVRCQMVDAVRVFHDSRNGSDDA
Mflv_5130|M.gilvum_PYR-GCK YVAEGVATLDRMLLITFGRAASQELRERVRSQIVDALRAFDDP-------
Mvan_1209|M.vanbaalenii_PYR-1 YVAEGVATLDQMLLITFGRAASQELRERVRAQILDALRAFDDP-------
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 YLADGAATLDQMLLITFGRAASQELRERVRCQIVDAVAAFADP-------
MAB_0399c|M.abscessus_ATCC_199 YVAEGVATLDQMLLITFGRAASQELRDRVRGQIVDALRAFADP-------
MSMEG_1327|M.smegmatis_MC2_155 FVAEGVATLDQMLLITFGRAASQELRERVRAQIVAALVALDDP-------
MLBr_00637|M.leprae_Br4923 LVGAGHVATGQVLAVTFTQRAAAEMRSRLR--------------------
Mb0647c|M.bovis_AF2122/97 -APPSGELVEHLLRGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVL
Rv0630c|M.tuberculosis_H37Rv -APPSGELVEHLLRGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVL
MUL_0708|M.ulcerans_Agy99 DPAGDNQLLAHLLDGTAAERDARQQRLRDALAGFDAATIATTHQFCQLVL
MMAR_0957|M.marinum_M DPAGDNQLLAHLLDGTAAERDARQQRLRDALAGFDAATIATTHQFCQLVL
Mflv_5130|M.gilvum_PYR-GCK AAIGDNEVVRHLVTGDAEECDARRRRLRDALAGFDAATIATTHQFCQLVL
Mvan_1209|M.vanbaalenii_PYR-1 SHAADNEIVAHLLTGSHGELTERRQRLRDALAGFDAATIATTHQFCQLVL
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 SRAGDNELVAYLLDGTEDRLAARRQRLRDGLAGFDAATIATTHQFCQLVL
MAB_0399c|M.abscessus_ATCC_199 -STARTDLTQYLIS---AEQDTRQRRLRDALAGFDAATIATTHQFCHIVL
MSMEG_1327|M.smegmatis_MC2_155 -SRACNDLEEYLVK---TDQQARRRRLRDALAGFDAATIATTHQFCQIVL
MLBr_00637|M.leprae_Br4923 ----------------------ALGAAVQAVSDFGVVRVLTFHAAAHRQL
Mb0647c|M.bovis_AF2122/97 KSLGVAGDNAADVELKESLTDLVTEIVDDRYLANFGRQETDPE--LTYAE
Rv0630c|M.tuberculosis_H37Rv KSLGVAGDNAADVELKESLTDLVTEIVDDRYLANFGRQETDPE--LTYAE
MUL_0708|M.ulcerans_Agy99 KSLGVAGDTDAGVTLVEDLDELVTEIVDDLYLVHFGRDRDDPP--LTYRD
MMAR_0957|M.marinum_M KSLGVAGDTDAGVTLVEDLDELVTEIVDDLYLVHFGRDRDDPP--LTYRD
Mflv_5130|M.gilvum_PYR-GCK RSLGVAGDTDSGVELVESLDDLVAEIVDDLYLAHFGQDRDEPL--LTHES
Mvan_1209|M.vanbaalenii_PYR-1 RSLGVAGDTDSGVELVESLDDLVTEIVDDLYLAHFGQDHDEPL--LTYAD
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 RSLGVAGDTAAGVTLLDSLDELVAEIVDDLYLAHFGQDHDDPV--LHYRE
MAB_0399c|M.abscessus_ATCC_199 KSLGVAGDSDSGVTLVENLDELVCEIVNDRYLTHFGKDRDAPP--LSYPA
MSMEG_1327|M.smegmatis_MC2_155 KSLGVAGDSDAGVTLVESLDDLVSEIVDDLYLAHFGGQKDDPE--LSYPE
MLBr_00637|M.leprae_Br4923 RYFWPRVIGDTGWQLLDSKFATVARAASSVRLHAGTDDVCDLAGEIEWAK
Mb0647c|M.bovis_AF2122/97 ALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRA
Rv0630c|M.tuberculosis_H37Rv ALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRA
MUL_0708|M.ulcerans_Agy99 ALRIARAVVANPSTQLRPLDAPPGSRAAACVGFAHHVLEGLETRKRRRGI
MMAR_0957|M.marinum_M ALRIARAVVANPSTQLRPLDAPPGSRAAICVGFAHHVLEELETRKRRRGI
Mflv_5130|M.gilvum_PYR-GCK ALRLAHAVVGNAHTELRPRDPAPGSDAAVRVEFAKAVCAELETRKRKLGI
Mvan_1209|M.vanbaalenii_PYR-1 ALSLAREVVGNAHTELRPTDPPPGSDPFVRVQFARAVCAELETRKRRLGI
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 ALRLARDVVNNPSAQLRPLHPEPGSRAAVSLRFANDVLAELDTRKRRLGV
MAB_0399c|M.abscessus_ATCC_199 ALRLAREVVRNPATQLRPLQPEADSYAFAALGFARDVLEQLEIRKRRRGI
MSMEG_1327|M.smegmatis_MC2_155 ALKLARVVVGNPATQLRPRDPDPDSPAAVRLKFARDVLAELEIRKRRRGV
MLBr_00637|M.leprae_Br4923 ASLIGPEEYVAAVAAIG-RDTPLDAAQIASVYAAYEALKARGNGVPGVTL
Mb0647c|M.bovis_AF2122/97 QGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLER
Rv0630c|M.tuberculosis_H37Rv QGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLER
MUL_0708|M.ulcerans_Agy99 LGYDDLLLRLADALASEDSAARARMQQRWPVVMVDEFQDTDAVQWQVIDS
MMAR_0957|M.marinum_M LGYDDLLLRLADALASEDSAARARMQQRWPVVMVDEFQDTDAVQWQVIDS
Mflv_5130|M.gilvum_PYR-GCK LHYDDLLSRLADALEAPDSPARARMQRRWSIVMVDEFQDTDPVQWQVIDR
Mvan_1209|M.vanbaalenii_PYR-1 LHYDDLLSRLAKALEPQDSPARMRMQHRWSIVMVDEFQDTDPVQWQVIDC
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 LGYDDLLTRLADALATEHSPARLRMHQRWPIVMVDEFQDTDPVQWQVIDR
MAB_0399c|M.abscessus_ATCC_199 LGFDDLLTRLADALNATDSPARVRMHQRWPIVMVDEFQDTDPVQWQVLER
MSMEG_1327|M.smegmatis_MC2_155 LGYDDLLTRLADALEPEDSPARVRMQQRWPIVMVDEFQDTDPVQWQVIER
MLBr_00637|M.leprae_Br4923 LDFDDLLLHTAAAIEN-DAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLSA
Mb0647c|M.bovis_AF2122/97 AFSRHSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDR
Rv0630c|M.tuberculosis_H37Rv AFSRHSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDR
MUL_0708|M.ulcerans_Agy99 AFSGRCTLILIGDPKQAIYAFRGGDIVTYLHAAQTAGDKRTLATNWRSDS
MMAR_0957|M.marinum_M AFSGRCTLILIGDPKQAIYAFRGGDIVTYLHAAQTAGDKRTLATNWRSDS
Mflv_5130|M.gilvum_PYR-GCK AFRGHATLILIGDPKQAIYAFRGGDIVTYLHAAATAGVQRTLGTNYRSDA
Mvan_1209|M.vanbaalenii_PYR-1 AFSGHATVILIGDPKQAIYAFRGGDIVTYLHAVSTADRQKTLGTNYRSDG
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 AFSGRSTLILIGDPKQAIYAFRGGDIVTYLRAAETAGQKKTLDTNWRSDS
MAB_0399c|M.abscessus_ATCC_199 AFSGHSTLVLIGDPKQAIYAFRGGDIETYLRAAATAGDKQTLGTNWRSDA
MSMEG_1327|M.smegmatis_MC2_155 AFSGRSTLVLIGDPKQAIYAFRGGDIATYLRAAATAGDKQTLGTNWRSDR
MLBr_00637|M.leprae_Br4923 WLGDRDDLTVVGDANQTIYSFTGASPCFLLDFPRRFPDATVVR-------
Mb0647c|M.bovis_AF2122/97 ALVESLQTVLRDATLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKR
Rv0630c|M.tuberculosis_H37Rv ALVESLQTVLRDATLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKR
MUL_0708|M.ulcerans_Agy99 ALVDRLQVVLRGAELGDPAIVVRDVKAHHQGHRLAGAPHNDALRLRVVRR
MMAR_0957|M.marinum_M ALVDRLQVVLRGAELGDPAIVVRDVKAHHQGHRLAGAPHNDALRLRVVRR
Mflv_5130|M.gilvum_PYR-GCK PLVEGLQAVMRDAQLGDPRIVVRRVDAHHREHRLQGAPHNEPFRLRVCTR
Mvan_1209|M.vanbaalenii_PYR-1 PLVDSLQAVMRDAQLGDPRIVAHRVEAHHRDHRLAGAPRNAPFRLRVVTR
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 ALLQRLQVVLRGAQLGDPAIVVNDVAAHHRGHRLSGAPRNDPFRLRVVSR
MAB_0399c|M.abscessus_ATCC_199 ALVDRLQVVLRGAQLGGPDIVVHDVQAHHQGHRLAGAPHNDPFRLRVVSR
MSMEG_1327|M.smegmatis_MC2_155 ALVDRLQAVLRGAQLGGPDIVVHDVQARHQGHRLVGAPRNDPFRLRVVSR
MLBr_00637|M.leprae_Br4923 -LERDYRSTPQVVSLANQVIAAAHGRVADSKFQLSGQREPGPAAS-----
Mb0647c|M.bovis_AF2122/97 HTLGYDGTAHVPIEALRRHIPDDLAADVAALLASGATFAGRPVVAADIAV
Rv0630c|M.tuberculosis_H37Rv HTLGYDGTAHVPIEALRRHIPDDLAADVAALLASGATFAGRPVVAADIAV
MUL_0708|M.ulcerans_Agy99 ATLGRRGIQNLPIDILRDHIGRDLASDIGALLASGATFAGRALQANDIAV
MMAR_0957|M.marinum_M ATLGRRGIQNLPIDILRDHIGRDLASDIGALLASGATFAGRALQANDIAV
Mflv_5130|M.gilvum_PYR-GCK DQFRVRPDRMIPIDVLRNHIPKDMAADIAALLNSGATHCGEKLAPGHIAV
Mvan_1209|M.vanbaalenii_PYR-1 DQFGTRPDRVVAIDQLRRHIPQDMAADIAALLASDATFCDRPVQPGDVAV
TH_1287|M.thermoresistible__bu --------------------------------------------------
MAV_4543|M.avium_104 NTLGRRGIANLPIDELRQHIGADLAADIRALLAAGATFDGKPVRAGDIAV
MAB_0399c|M.abscessus_ATCC_199 N---RDGIKVIPIADLRRSIGRDLAADIGALLSSGATFDGRPVRARDIAV
MSMEG_1327|M.smegmatis_MC2_155 K---PGNTRVIPIDQLRRHIGRDLAADISALLNSGATWCDQPVQAKDIAV
MLBr_00637|M.leprae_Br4923 -----------------FHEYSDEPAEAAAVAASIARLIEFGTSPSEIAV
Mb0647c|M.bovis_AF2122/97 IVEHHKDARACRNALAEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQ
Rv0630c|M.tuberculosis_H37Rv IVEHHKDARACRNALAEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQ
MUL_0708|M.ulcerans_Agy99 IVEKHKDARACHRALTDAGIHAVYTGDTDVFSSEAADDWLALLEAFDQPH
MMAR_0957|M.marinum_M IVEKHKDARACHRALTDAGIHAVYTGDTDVFSSEAADDWLALLEAFDQPH
Mflv_5130|M.gilvum_PYR-GCK IVESHRDGHACFAALADAGIPAVYTGDSDVFSSPAADDWMCLLEAFDQPH
Mvan_1209|M.vanbaalenii_PYR-1 IVESHRDGHACFDALTAAGIPAVYTGDSDVFTSPAADDWMCLLEAFDQPH
TH_1287|M.thermoresistible__bu -VETHKDARACYDALCQAGIPAVYTGDSDVFGSPAAEDWLCLLEAFDQPH
MAV_4543|M.avium_104 IVERHRDAQACFTALCDAGVPAVYTGNSDVFTSQAAEDWLCLLEAFDQPH
MAB_0399c|M.abscessus_ATCC_199 IVEAHKDARACHTALTEAGIPAVYTGDTDVFSSDAAQDWLYLLEAFDQPH
MSMEG_1327|M.smegmatis_MC2_155 ITETHKDARACHAALLAAGIPAVYTGDSDVFTSEAAEDWLYLLEAFDQPH
MLBr_00637|M.leprae_Br4923 LYRVNAQSEAYEEALTEVGIAYQVRGGEGFFNRQEIKQALLALQRSAE--
. : :..* ** .*: *. ..* .: : *:
Mb0647c|M.bovis_AF2122/97 RSGLVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWADHARHRGVAA
Rv0630c|M.tuberculosis_H37Rv RSGLVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWADHARHRGVAA
MUL_0708|M.ulcerans_Agy99 RPGIVRAAAATMFFGKTANDLARGGDALTDRVAETLREWADYARERGVAA
MMAR_0957|M.marinum_M RPGIVRAAAATMFFGKTANDLARGGDALTDRVAETLREWADYARERGVAA
Mflv_5130|M.gilvum_PYR-GCK RSGLVRAAATTMFFGETAEALALQGDSLTDRIAETLRQWADFARERGVAA
Mvan_1209|M.vanbaalenii_PYR-1 RSGLVRAAATTMFFGETAESLAAEGDTLTDRVAETLRQWADFARDRGVAA
TH_1287|M.thermoresistible__bu RPGMVRAAAATMFFGETAESLAAGGDALTDRVADTLREWAAHARERGVAA
MAV_4543|M.avium_104 RPGVVRAAAATMFFGETAETLAAGGDALTDRIAQTLREWAGHARERGVAA
MAB_0399c|M.abscessus_ATCC_199 RPGLVRAAAATVFFGETAETLAVGGESLTDEIAGTLRTWAARARERGVAA
MSMEG_1327|M.smegmatis_MC2_155 RPGLVRAAAATMFFGETAESLAAGGDALTDRVADTLREWAGHARERGVAA
MLBr_00637|M.leprae_Br4923 -----------------RSSQTEPNSPLSDVVRGVLEPLGLTAEKP----
. : ...*:* : .*. . *..
Mb0647c|M.bovis_AF2122/97 VFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRD
Rv0630c|M.tuberculosis_H37Rv VFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRD
MUL_0708|M.ulcerans_Agy99 IFEAAQLGGMSDRVLSWQEGQRHMTDLAHVTQLLQKVSHRERYTLPALRD
MMAR_0957|M.marinum_M IFEAAQLGGMSDRVLSWQEGQRHMTDLAHVTQLLQKVSHRERYTLPALRD
Mflv_5130|M.gilvum_PYR-GCK VFEAAQLRGMGARVLRWVDGERHMTDLAHLTQLLHDTAHREQYSLPALRD
Mvan_1209|M.vanbaalenii_PYR-1 VFEAAQLGGMGERVLSWVDGERHMTDLAHLTQVLHGTAHREHFSLPALRD
TH_1287|M.thermoresistible__bu IFEAAKLSGMGDRVLSWADGERHMTDLAHIAQLLQEAAHRDHLGLPALRD
MAV_4543|M.avium_104 IFEAAQLLGMGNRVLGWQGGARHMTDLAHLTQLLGEVAHCEHHNLPALRD
MAB_0399c|M.abscessus_ATCC_199 VFEAAQLAGMGKRVLSWRGGERMMTDLAHLTELLQETAHRNGFGPAALRD
MSMEG_1327|M.smegmatis_MC2_155 IFEAAQLAGMGKRVLSWQGGERLMTDLAHMTQLLQDTAHREGFGLAALRD
MLBr_00637|M.leprae_Br4923 ---------VGSRARDRWEALTALAELAD-----DEVAQHPRLDLPGLLA
:. *. . :::**. .:: ..*
Mb0647c|M.bovis_AF2122/97 WLRRQAKAGA---GPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFA
Rv0630c|M.tuberculosis_H37Rv WLRRQAKAGA---GPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFA
MUL_0708|M.ulcerans_Agy99 WLRGQREDRG---GATERNRRIDSDAAAVQIMTVWVSKGLQYPVVYLPFA
MMAR_0957|M.marinum_M WLRGQREDRG---GATERNRRIDSDAAAVQIMTVWVSKGLQYPVVYLPFA
Mflv_5130|M.gilvum_PYR-GCK WLRAQRDDRGGLRGTVERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFA
Mvan_1209|M.vanbaalenii_PYR-1 WLRGQRDERS---GAPERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFA
TH_1287|M.thermoresistible__bu WLRARREETSG--GATERFRRLDTDAAAVPVMTVFAAKGLQFPVVYLPFA
MAV_4543|M.avium_104 WLRRQRDERS---GAPERNRRLDSDAAAVQIMTVFVSKGLQYPIVYLPFA
MAB_0399c|M.abscessus_ATCC_199 WLRTQCSEGG---AEAERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFS
MSMEG_1327|M.smegmatis_MC2_155 WLRTQRSERG---GESERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFA
MLBr_00637|M.leprae_Br4923 ELRLRADARHP------------PVVQGVTLASLHAVKGLEWDAVFLVGL
** : . . . .* : :: . ***:: *:*
Mb0647c|M.bovis_AF2122/97 FNRNVRSDDILLYHD-------DGTRCLYIGGKDGGAQRRTVEGLNRVEA
Rv0630c|M.tuberculosis_H37Rv FNRNVRSDDILLYHD-------DGTRCLYIGGKDGGAQRRTVEGLNRVEA
MUL_0708|M.ulcerans_Agy99 FNRNIQERELVLFHD-------RGTRCLHIGGKDSPDFG-TVERLGAKEA
MMAR_0957|M.marinum_M FNRNIQERELVLFHD-------GGTRCLHIGGKDSPDFG-TVERLGAKEA
Mflv_5130|M.gilvum_PYR-GCK FNRNVQPRDVVVFHEPATSDGAGDIRCLHIGGESSPDFA-AVAQQARLEA
Mvan_1209|M.vanbaalenii_PYR-1 FNRNIQTRDVVTFHD-------GDIRCLHIGGERSPDHA-AAQQQGRREA
TH_1287|M.thermoresistible__bu FNRHVRKQELVLYHE------DDGTRCLHIGGSDSPDHP-QVAQRGRDED
MAV_4543|M.avium_104 FHRNTTDSDVVLFHD------EDGTRCLHVGGKDSPDFK-TVERLGRKED
MAB_0399c|M.abscessus_ATCC_199 FNRYVPEREYVLYHE-------DGLRCLHIGGREDPDYS-MADLAGRTEA
MSMEG_1327|M.smegmatis_MC2_155 FNRYVPEPDLVLFHD-------DGQRCLHVGG-ADP----AVARAGRAEA
MLBr_00637|M.leprae_Br4923 ADGTLPIS-----------------RALAHGAE--------------SEP
. *.* *. *
Mb0647c|M.bovis_AF2122/97 AHDNLRLTYVALTRAQSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPD
Rv0630c|M.tuberculosis_H37Rv AHDNLRLTYVALTRAQSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPD
MUL_0708|M.ulcerans_Agy99 ANDDSRLTYVAMTRAQSQVVAWWSPAYDEPNGGLSRLLRGRRPGDSVVPD
MMAR_0957|M.marinum_M ANDDSRLTYVAMTRAQSQVVAWWSPAYDEPNGGLSRLLRGRRPGDSVVPD
Mflv_5130|M.gilvum_PYR-GCK AGDDVRLTYVAMTRAQSQVVAWWAPSRDELNGGLSRLLRGRAPGDPVVPD
Mvan_1209|M.vanbaalenii_PYR-1 AGDDVRLTYVAMTRAQSQVVAWWAPSNDEPNGGLSRLLRGRAPGDPVVPD
TH_1287|M.thermoresistible__bu ASDDGRLTYVALTRAQAQVVAWWAPSWDEPNGGLSRLLRGRRPGERSVPH
MAV_4543|M.avium_104 ASDDSRLTYVALTRAQAQVVAWWSPAYHEPNGGLSRLLRGRRPGEPVVPD
MAB_0399c|M.abscessus_ATCC_199 ARDASRLAYVALTRAQSQVVAWWAPSFDEPNGGLSRLLRGRAPGNPSVPD
MSMEG_1327|M.smegmatis_MC2_155 AGDDSRLTYVALTRAQSQVVAWWAPSYDEPNGGLSRLMRGRAPGEAIVPD
MLBr_00637|M.leprae_Br4923 VEEERRLLYVGITRARVYLALSWALS-RTPGGRQSRKPSRFLNDIAPQMG
. : ** **.:***: :. *: : .* ** .
Mb0647c|M.bovis_AF2122/97 RCTP-RVTDEQAWAVFAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVR
Rv0630c|M.tuberculosis_H37Rv RCTP-RVTDEQAWAVFAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVR
MUL_0708|M.ulcerans_Agy99 RATPAKITDEDAWDRFQQWQAAGGPTVEESVIAAAPAIAGQPAPSELATR
MMAR_0957|M.marinum_M RATPAKITDEDAWDRFQQWQAAGGPTVEESVIAAAPAIAGRPAPSELATR
Mflv_5130|M.gilvum_PYR-GCK RCDPARIDDAEAMARLRAWADEGGPVLEESIIAERVEVELPAPPDTLAVR
Mvan_1209|M.vanbaalenii_PYR-1 RCDPPRIDDPDAMAQLRAWSDAGGPVLEESVIAASVTVELPSPAEDLDVR
TH_1287|M.thermoresistible__bu RCPDDRITDDQAWERLREWEAAGGPVLEESLPRPVTALPPEPTPTELGAR
MAV_4543|M.avium_104 RCEPAKISDEDALARLREWEAAGGPVIEEAVPAPAPPLPGVPVPARLENR
MAB_0399c|M.abscessus_ATCC_199 KCSPAKISDADVLKRLRAWEAQGGPVVEDALVTGFVPAATSSPSDNLAVR
MSMEG_1327|M.smegmatis_MC2_155 KCSPPKISDEDALERLRAWEAAGGPVIEESVIGAVSPVPPEPAPEDLAAR
MLBr_00637|M.leprae_Br4923 QNPASSRSRRNRTATLRCRICKNDLTTPAAVMLQRCQICAADVDEELLLQ
: : : .. :: : :
Mb0647c|M.bovis_AF2122/97 HFHRRIDTTWRRTSYSDLVRGSEAVT---------VTSEPAAGGRADEVE
Rv0630c|M.tuberculosis_H37Rv HFHRRIDTTWRRTSYSDLVRGSEAVT---------VTSEPAAGGRADEVE
MUL_0708|M.ulcerans_Agy99 RFDRDIDIRWRRTSYSGLIRMAEAT---------GVSSEPEVTERDDEVA
MMAR_0957|M.marinum_M RFDRGIDIRWRRTSYSGLIRMAEAT---------GVSSEPEVTERDDEVA
Mflv_5130|M.gilvum_PYR-GCK HFHRRIDPLWRRTSYSGLIRAAEQE--------SGVGSEPEVVELDDEVA
Mvan_1209|M.vanbaalenii_PYR-1 HFHRRIDTSWRRTSYSGLIRAAESEQ-------TGVGSEPEVVELDDEAG
TH_1287|M.thermoresistible__bu HFHRSIDTDWRRTSYSGLLRASQSDGGVAASGSPGVTSEPEVAELDDEVG
MAV_4543|M.avium_104 HFHRGIDTGWRRTSYSGLIRQAQPS---------GVGSEPEAAGLDDEVG
MAB_0399c|M.abscessus_ATCC_199 VFDRPIDTAWRRTSYSGLLRAAEES---------GVSSEPEIAELDDEVD
MSMEG_1327|M.smegmatis_MC2_155 KFFRAIDMAWKRTSYSGLLRAAETAG-------VGVSSEPEVTERDDEFD
MLBr_00637|M.leprae_Br4923 LKAWRLSTAKEQNVPAYVVLT--------------------------DNT
:. .:. : :: :
Mb0647c|M.bovis_AF2122/97 IAVFAAPGSGAD---LTSPLAALPSGASFGSLVHAVLETADPAAPDLAAE
Rv0630c|M.tuberculosis_H37Rv IAVVAAPGSGAD---LTSPLAALPSGASFGSLVHAVLETADPAAPDLAAE
MUL_0708|M.ulcerans_Agy99 EVPLTEVVMSGP--EQPSPMADLPSGAKFGSLVHAVLETSDPFAIDLAAE
MMAR_0957|M.marinum_M EVPLTEVVMSGP--EQPSPMADLPSGAKFGSLVHAVLETSDPFAIDLAAE
Mflv_5130|M.gilvum_PYR-GCK ELRAPDTEPATPDVDMASPMAGLPMGAKFGTLVHAVLETADPFAVDLAAE
Mvan_1209|M.vanbaalenii_PYR-1 EVPVPGAGGGGD--QMPSPMADLPMGAKFGTLVHAVLETADPFATDLAAE
TH_1287|M.thermoresistible__bu EIPLT---PATDGAEVPSPMAGLPTGAKLGTLVHAVLETADPFAPDLAAE
MAV_4543|M.avium_104 DILLAPATSVGD---VASPMADLPAGATFGTLVHAVLQTADPFAPDLAAE
MAB_0399c|M.abscessus_ATCC_199 EIPLRSMPAGAD---VPSPMAQLPAGAAFGSLVHAVLETTDPLAPDLVAE
MSMEG_1327|M.smegmatis_MC2_155 DIPVVAPAEGAD---VPSPMAHLPTGAAFGSLVHAVLETADPFAEDLTAE
MLBr_00637|M.leprae_Br4923 LIAIAELLPADEAALIAVPGMSVRKIEQYGSDVLQLVRCRAVAVRTQT--
. * : *: * ::. . .
Mb0647c|M.bovis_AF2122/97 LEAQVP--------------------------------------------
Rv0630c|M.tuberculosis_H37Rv LEAQVRRHAPWWTVDVDHAQLAPELARALLPMHDTPLGPAAAALTLRQIG
MUL_0708|M.ulcerans_Agy99 LESQIRVQSAWWPVQVP----AAQLAAALVPMHDTPLGPLAGGLTLRQIG
MMAR_0957|M.marinum_M LESQIRVQSAWWPVQVP----AAQLAAALVPMHDTPLGPLAGGLTLRQIG
Mflv_5130|M.gilvum_PYR-GCK LEAAVVEHSLWWPVDVP----PAELAAALVPLHDTPLGPLAPGVTLRDIG
Mvan_1209|M.vanbaalenii_PYR-1 LESHVRRHSLWWPVDVP----AADLAAALVPLHDTPLGPLAPGVTLRDIG
TH_1287|M.thermoresistible__bu LADRVREHAVWWPVDVP----AEELAAALVPVHDTPLGPLAPGLTLRQIG
MAV_4543|M.avium_104 LTARIREHSVWWPVAAT----PEDMAAAMVPMHDTPLGPLAGGLTLRRIG
MAB_0399c|M.abscessus_ATCC_199 LQTQIIRHRERWPVEIP----AAELAAALEPMHDTPLGPLLPGVTLRQIG
MSMEG_1327|M.smegmatis_MC2_155 LATHIDAHSQHWPVEVE----TAELAAALVPMHDTPLGPLAPGLTLRQIG
MLBr_00637|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 ----------------GTRRG-----------------------------
Rv0630c|M.tuberculosis_H37Rv VRDRLRELDFEMPLAGGDLRGR---SPDVSLADVGELLASHLPGDDPLSP
MUL_0708|M.ulcerans_Agy99 LPDRLREMDFEFPLAGGDEADAGGHAPDLRLADVGALLRAHLDASDPLAP
MMAR_0957|M.marinum_M LPDRLREMDFEFPLAGGDEADAGGHAPDLRLADVGALLRAHLDASDPLAP
Mflv_5130|M.gilvum_PYR-GCK LRDRLREMEFEFPLAGGDRRDD---TPDITLADVGRLLRAHLPADDPLAP
Mvan_1209|M.vanbaalenii_PYR-1 LRDRLREMEFEFPLAGGDRRVE---VPDISLADVGRLLAAHLPADDPLAP
TH_1287|M.thermoresistible__bu LRDRMREMEFEFPLAGGDARDA---APDIRLADVGDLLGAHLPEDDPLAC
MAV_4543|M.avium_104 LSDRLCELDFELPLAGGDRRSA---PPEVRLADLAPLLRAHLPADDVLAC
MAB_0399c|M.abscessus_ATCC_199 LRDRLCELDFEFPLAGGDAAAD----SFARLADVGMLLREHLAADDPLGV
MSMEG_1327|M.smegmatis_MC2_155 LRDRLCELDFEFPMAGGDLRGG----RFARLSDVGELLREYLPADDPLAV
MLBr_00637|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 --------GPWTSTTRSWLP------------------------------
Rv0630c|M.tuberculosis_H37Rv YADRLGSAGLGDQPLRGYLAGSIDVVLRLPG---QRYLVVDYKTNHLGD-
MUL_0708|M.ulcerans_Agy99 YDDRLSGDALGGQTLRGYLSGSVDVVLRIPDGPGQRYLVVDYKTNWLGDP
MMAR_0957|M.marinum_M YADRLSGDALGGQSLRGYLSGSVDAVLRIPDGPGQRYLVVDYKTNWLGDP
Mflv_5130|M.gilvum_PYR-GCK YAARLTTGALAGQPLKGYLNGSLDAVLRVDG----RYLVVDYKTNWLGDP
Mvan_1209|M.vanbaalenii_PYR-1 YAERLTGGTLAAQSLKGYLNGSVDAVLRVGD----RYLVVDYKTNWLGDP
TH_1287|M.thermoresistible__bu YAERLTGTGLGRQPLRGYLTGSVDAVLRIPAGDDHRYLVVDYKTNWLGPV
MAV_4543|M.avium_104 YADRLTDRSLGAESLRGYLTGSIDAVLRIPDGAGHRYLVVDYKTNRLGDA
MAB_0399c|M.abscessus_ATCC_199 YASRLTGPGLGGQSLRGYLSGSVDAVLRVGS----RYVVVDYKTNWLGTG
MSMEG_1327|M.smegmatis_MC2_155 YAERLSTGILGVQPLRGYLSGSVDAVLRVGE----KFVIVDYKTNWLGTG
MLBr_00637|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 --------------------------------------NWPER-------
Rv0630c|M.tuberculosis_H37Rv ----TAADYGFERLTEAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARH
MUL_0708|M.ulcerans_Agy99 DRPLTAADYHRPRLIEAMLHSDYPLQALLYTVVLHRFLRWRQPGYDPARH
MMAR_0957|M.marinum_M DRPLTAADYHRPRLIEAMLHSDYPLQALLYTVVLHRFLRWRQPGYDPARH
Mflv_5130|M.gilvum_PYR-GCK AGELTAADYAPARLAEAMLHSDYPLQALLYCVVLHRFLRWRQPGYSARRH
Mvan_1209|M.vanbaalenii_PYR-1 ARPLTAADYGKARLTEVMLHSDYPLQALLYCVVLHRFLRWRAPGYRAESH
TH_1287|M.thermoresistible__bu DRPLTAADYTRPRLVEAMLHSDYPLQALLYSVVLHRFLRWRLPAYTPEEH
MAV_4543|M.avium_104 QHPLTAADYDRPRMVEAMLHSDYPLQALLYSAVLHRFLRWRLAGYDPDRH
MAB_0399c|M.abscessus_ATCC_199 DAPLTAADYSRPRMVEAMLHSDYPLQALLYSVVLHRFLSWRLPGYRPEEH
MSMEG_1327|M.smegmatis_MC2_155 DGTLTAADYGRRRMVEAMLHSDYPLQALLYAVVLHRYLGWRLSGYDPATH
MLBr_00637|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 -----------CCRCTTRR----------WDPPPPH--------------
Rv0630c|M.tuberculosis_H37Rv LGGVLYLFVRGMCGAATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQ
MUL_0708|M.ulcerans_Agy99 LGGVLYLFVRGMCGPDTPMLDGHPAGVFSWSPPAALVTALSDLLDAGRAV
MMAR_0957|M.marinum_M LGGVLYLFVRGMCGPDTPMLDGHPAGVFSWSPPAALVTALSDLLDAGRAV
Mflv_5130|M.gilvum_PYR-GCK IAGVLYLFVRGMCGPDTPVLDGHPAGVFSWQPPAALIEELSDLLDAGAVP
Mvan_1209|M.vanbaalenii_PYR-1 IAGVLYLFVRGMCGADTPVVDGHPAGVFSWQPPAALIEALSDLLDAGVAA
TH_1287|M.thermoresistible__bu LGGVLYLFLRGMCGPDTPVVDGHPAGVFSWQPPAGLVVALSDLLDAGRTA
MAV_4543|M.avium_104 LGGILYLFVRGMCGPDTPVRDGHPSGVFDWRPPSSLIAALSDLLDAQGVA
MAB_0399c|M.abscessus_ATCC_199 LGGAVYLFVRGMCGATTPVVEGHPAGVFSWQPPSALVVALSELLS-----
MSMEG_1327|M.smegmatis_MC2_155 LGGVLYLFVRGMCGAGTPVVDGHPAGVFSWEPPADLVVALSKLLDAEAP-
MLBr_00637|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 -
Rv0630c|M.tuberculosis_H37Rv S
MUL_0708|M.ulcerans_Agy99 A
MMAR_0957|M.marinum_M A
Mflv_5130|M.gilvum_PYR-GCK A
Mvan_1209|M.vanbaalenii_PYR-1 -
TH_1287|M.thermoresistible__bu E
MAV_4543|M.avium_104 V
MAB_0399c|M.abscessus_ATCC_199 -
MSMEG_1327|M.smegmatis_MC2_155 -
MLBr_00637|M.leprae_Br4923 -