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KVFDLLGPLPAPNTTTVLEASAGTGKTFALAGLVTRFVAEGVATLDQMLLITFGRAASQELRERVRAQIV AALVALDDPSRACNDLEEYLVKTDQQARRRRLRDALAGFDAATIATTHQFCQIVLKSLGVAGDSDAGVTL VESLDDLVSEIVDDLYLAHFGGQKDDPELSYPEALKLARVVVGNPATQLRPRDPDPDSPAAVRLKFARDV LAELEIRKRRRGVLGYDDLLTRLADALEPEDSPARVRMQQRWPIVMVDEFQDTDPVQWQVIERAFSGRST LVLIGDPKQAIYAFRGGDIATYLRAAATAGDKQTLGTNWRSDRALVDRLQAVLRGAQLGGPDIVVHDVQA RHQGHRLVGAPRNDPFRLRVVSRKPGNTRVIPIDQLRRHIGRDLAADISALLNSGATWCDQPVQAKDIAV ITETHKDARACHAALLAAGIPAVYTGDSDVFTSEAAEDWLYLLEAFDQPHRPGLVRAAAATMFFGETAES LAAGGDALTDRVADTLREWAGHARERGVAAIFEAAQLAGMGKRVLSWQGGERLMTDLAHMTQLLQDTAHR EGFGLAALRDWLRTQRSERGGESERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRYVPEPDLVLF HDDGQRCLHVGGADPAVARAGRAEAAGDDSRLTYVALTRAQSQVVAWWAPSYDEPNGGLSRLMRGRAPGE AIVPDKCSPPKISDEDALERLRAWEAAGGPVIEESVIGAVSPVPPEPAPEDLAARKFFRAIDMAWKRTSY SGLLRAAETAGVGVSSEPEVTERDDEFDDIPVVAPAEGADVPSPMAHLPTGAAFGSLVHAVLETADPFAE DLTAELATHIDAHSQHWPVEVETAELAAALVPMHDTPLGPLAPGLTLRQIGLRDRLCELDFEFPMAGGDL RGGRFARLSDVGELLREYLPADDPLAVYAERLSTGILGVQPLRGYLSGSVDAVLRVGEKFVIVDYKTNWL GTGDGTLTAADYGRRRMVEAMLHSDYPLQALLYAVVLHRYLGWRLSGYDPATHLGGVLYLFVRGMCGAGT PVVDGHPAGVFSWEPPADLVVALSKLLDAEAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1327 | recB | - | 100% (1083) | exodeoxyribonuclease V, beta subunit |
| M. smegmatis MC2 155 | MSMEG_1943 | - | 2e-16 | 22.13% (705) | ATP-dependent DNA helicase |
| M. smegmatis MC2 155 | MSMEG_1952 | - | 2e-15 | 22.94% (754) | ATP-dependent DNA helicase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0647c | recBa | 0.0 | 65.70% (860) | exonuclease V subunit beta |
| M. gilvum PYR-GCK | Mflv_5130 | - | 0.0 | 69.47% (1104) | exodeoxyribonuclease V, beta subunit |
| M. tuberculosis H37Rv | Rv0630c | recB | 0.0 | 65.90% (1094) | exonuclease V beta chain |
| M. leprae Br4923 | MLBr_00153 | uvrD | 7e-16 | 22.49% (716) | putative ATP-dependent DNA helicase |
| M. abscessus ATCC 19977 | MAB_0399c | - | 0.0 | 77.36% (1082) | exodeoxyribonuclease V, beta subunit (RecB) |
| M. marinum M | MMAR_0957 | recB | 0.0 | 70.82% (1107) | exodeoxyribonuclease V (beta chain), RecB |
| M. avium 104 | MAV_4543 | recB | 0.0 | 71.78% (1095) | exodeoxyribonuclease V, beta subunit |
| M. thermoresistible (build 8) | TH_1287 | recB | 0.0 | 71.26% (675) | PROBABLE EXONUCLEASE V (BETA CHAIN) RECB (EXODEOXYRIBONUCLEASE |
| M. ulcerans Agy99 | MUL_0708 | recB | 0.0 | 70.55% (1107) | exodeoxyribonuclease V (beta chain), RecB |
| M. vanbaalenii PYR-1 | Mvan_1209 | - | 0.0 | 71.68% (1091) | exodeoxyribonuclease V, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0647c|M.bovis_AF2122/97 MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEML
Rv0630c|M.tuberculosis_H37Rv MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEML
MSMEG_1327|M.smegmatis_MC2_155 MKVFDLLGPLPAPNTTTVLEASAGTGKTFALAGLVTRFVAEGVATLDQML
MAB_0399c|M.abscessus_ATCC_199 MKRFDLLGPLPADRSTTVLEASAGTGKTFALAGLVTRYVAEGVATLDQML
MAV_4543|M.avium_104 MERFDLLGALPAARSTTVLEASAGTGKTFALAGLVTRYLADGAATLDQML
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M MRPFDLLGPLPAENSTTVLEASAGTGKTFALAALVTRYVAEGRARLDEML
MUL_0708|M.ulcerans_Agy99 MRPFDLLGPLPAENSTTVLEASAGTGKTFALAALVTRYVAEGRARLDEML
Mflv_5130|M.gilvum_PYR-GCK MEPFDLLGALPEPRTTTVLEASAGTGKTFALAGLVTRYVAEGVATLDRML
Mvan_1209|M.vanbaalenii_PYR-1 MEPFDLLGPLPAPRTTTVLEASAGTGKTFALAGLVTRYVAEGVATLDQML
MLBr_00153|M.leprae_Br4923 -------------MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVHEGSPLL
Mb0647c|M.bovis_AF2122/97 LITFNRAASRELRERVRGQIVEALGALQG--------DAPPSGELVEHLL
Rv0630c|M.tuberculosis_H37Rv LITFNRAASRELRERVRGQIVEAVGALQG--------DAPPSGELVEHLL
MSMEG_1327|M.smegmatis_MC2_155 LITFGRAASQELRERVRAQIVAALVALD-------DPSRACN-DLEEYLV
MAB_0399c|M.abscessus_ATCC_199 LITFGRAASQELRDRVRGQIVDALRAFA-------DPSTART-DLTQYLI
MAV_4543|M.avium_104 LITFGRAASQELRERVRCQIVDAVAAFA-------DPSRAGDNELVAYLL
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M LITFGRAASQELRERVRCQMVDAVRVFHDSRNGSDDADPAGDNQLLAHLL
MUL_0708|M.ulcerans_Agy99 LITFGRAASQELRERVRCQMVDAVRVFHDSRNGSDDADPAGDNQLLAHLL
Mflv_5130|M.gilvum_PYR-GCK LITFGRAASQELRERVRSQIVDALRAFD-------DPAAIGDNEVVRHLV
Mvan_1209|M.vanbaalenii_PYR-1 LITFGRAASQELRERVRAQILDALRAFD-------DPSHAADNEIVAHLL
MLBr_00153|M.leprae_Br4923 IVAGAGSGKTTVLARRIAYLIAAR-------------SVGVSQILAITFT
Mb0647c|M.bovis_AF2122/97 RGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADV
Rv0630c|M.tuberculosis_H37Rv RGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADV
MSMEG_1327|M.smegmatis_MC2_155 K---TDQQARRRRLRDALAGFDAATIATTHQFCQIVLKSLGVAGDSDAGV
MAB_0399c|M.abscessus_ATCC_199 S---AEQDTRQRRLRDALAGFDAATIATTHQFCHIVLKSLGVAGDSDSGV
MAV_4543|M.avium_104 DGTEDRLAARRQRLRDGLAGFDAATIATTHQFCQLVLRSLGVAGDTAAGV
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M DGTAAERDARQQRLRDALAGFDAATIATTHQFCQLVLKSLGVAGDTDAGV
MUL_0708|M.ulcerans_Agy99 DGTAAERDARQQRLRDALAGFDAATIATTHQFCQLVLKSLGVAGDTDAGV
Mflv_5130|M.gilvum_PYR-GCK TGDAEECDARRRRLRDALAGFDAATIATTHQFCQLVLRSLGVAGDTDSGV
Mvan_1209|M.vanbaalenii_PYR-1 TGSHGELTERRQRLRDALAGFDAATIATTHQFCQLVLRSLGVAGDTDSGV
MLBr_00153|M.leprae_Br4923 NKAAAEMRERVARLVGDHTG-PSMWVSTFHSTCVRILRNQASLIGGLNSN
Mb0647c|M.bovis_AF2122/97 ELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQ
Rv0630c|M.tuberculosis_H37Rv ELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQ
MSMEG_1327|M.smegmatis_MC2_155 TLVESLDDLVSEIVDDLYLAHFGGQKDDPELSYPEALKLARVVVGNPATQ
MAB_0399c|M.abscessus_ATCC_199 TLVENLDELVCEIVNDRYLTHFGKDRDAPPLSYPAALRLAREVVRNPATQ
MAV_4543|M.avium_104 TLLDSLDELVAEIVDDLYLAHFGQDHDDPVLHYREALRLARDVVNNPSAQ
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M TLVEDLDELVTEIVDDLYLVHFGRDRDDPPLTYRDALRIARAVVANPSTQ
MUL_0708|M.ulcerans_Agy99 TLVEDLDELVTEIVDDLYLVHFGRDRDDPPLTYRDALRIARAVVANPSTQ
Mflv_5130|M.gilvum_PYR-GCK ELVESLDDLVAEIVDDLYLAHFGQDRDEPLLTHESALRLAHAVVGNAHTE
Mvan_1209|M.vanbaalenii_PYR-1 ELVESLDDLVTEIVDDLYLAHFGQDHDEPLLTYADALSLAREVVGNAHTE
MLBr_00153|M.leprae_Br4923 FSIYDVDDSRSLLQMIGQDMGLDIKRYSPRLMANAISNLKNELIDAESAV
Mb0647c|M.bovis_AF2122/97 LRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALE
Rv0630c|M.tuberculosis_H37Rv LRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALE
MSMEG_1327|M.smegmatis_MC2_155 LRPRDPDPDSPAAVRLKFARDVLAELEIRKRRRGVLGYDDLLTRLADALE
MAB_0399c|M.abscessus_ATCC_199 LRPLQPEADSYAFAALGFARDVLEQLEIRKRRRGILGFDDLLTRLADALN
MAV_4543|M.avium_104 LRPLHPEPGSRAAVSLRFANDVLAELDTRKRRLGVLGYDDLLTRLADALA
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M LRPLDAPPGSRAAICVGFAHHVLEELETRKRRRGILGYDDLLLRLADALA
MUL_0708|M.ulcerans_Agy99 LRPLDAPPGSRAAACVGFAHHVLEGLETRKRRRGILGYDDLLLRLADALA
Mflv_5130|M.gilvum_PYR-GCK LRPRDPAPGSDAAVRVEFAKAVCAELETRKRKLGILHYDDLLSRLADALE
Mvan_1209|M.vanbaalenii_PYR-1 LRPTDPPPGSDPFVRVQFARAVCAELETRKRRLGILHYDDLLSRLAKALE
MLBr_00153|M.leprae_Br4923 AN-----LSSDTDDLARTVATVYGEYQRRLRTANALDFDDLIGETVGILQ
Mb0647c|M.bovis_AF2122/97 AADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPK
Rv0630c|M.tuberculosis_H37Rv AADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPK
MSMEG_1327|M.smegmatis_MC2_155 PEDSPARVRMQQRWPIVMVDEFQDTDPVQWQVIERAFSGRSTLVLIGDPK
MAB_0399c|M.abscessus_ATCC_199 ATDSPARVRMHQRWPIVMVDEFQDTDPVQWQVLERAFSGHSTLVLIGDPK
MAV_4543|M.avium_104 TEHSPARLRMHQRWPIVMVDEFQDTDPVQWQVIDRAFSGRSTLILIGDPK
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M SEDSAARARMQQRWPVVMVDEFQDTDAVQWQVIDSAFSGRCTLILIGDPK
MUL_0708|M.ulcerans_Agy99 SEDSAARARMQQRWPVVMVDEFQDTDAVQWQVIDSAFSGRCTLILIGDPK
Mflv_5130|M.gilvum_PYR-GCK APDSPARARMQRRWSIVMVDEFQDTDPVQWQVIDRAFRGHATLILIGDPK
Mvan_1209|M.vanbaalenii_PYR-1 PQDSPARMRMQHRWSIVMVDEFQDTDPVQWQVIDCAFSGHATVILIGDPK
MLBr_00153|M.leprae_Br4923 AFP-QIAEHYRRRFRHVLVDEYQDTNHAQYVLVRELVGHGARNSPDDMPP
Mb0647c|M.bovis_AF2122/97 QAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATL
Rv0630c|M.tuberculosis_H37Rv QAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATL
MSMEG_1327|M.smegmatis_MC2_155 QAIYAFRGGDIATYLRAAATAGDKQTLGTNWRSDRALVDRLQAVLRGAQL
MAB_0399c|M.abscessus_ATCC_199 QAIYAFRGGDIETYLRAAATAGDKQTLGTNWRSDAALVDRLQVVLRGAQL
MAV_4543|M.avium_104 QAIYAFRGGDIVTYLRAAETAGQKKTLDTNWRSDSALLQRLQVVLRGAQL
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M QAIYAFRGGDIVTYLHAAQTAGDKRTLATNWRSDSALVDRLQVVLRGAEL
MUL_0708|M.ulcerans_Agy99 QAIYAFRGGDIVTYLHAAQTAGDKRTLATNWRSDSALVDRLQVVLRGAEL
Mflv_5130|M.gilvum_PYR-GCK QAIYAFRGGDIVTYLHAAATAGVQRTLGTNYRSDAPLVEGLQAVMRDAQL
Mvan_1209|M.vanbaalenii_PYR-1 QAIYAFRGGDIVTYLHAVSTADRQKTLGTNYRSDGPLVDSLQAVMRDAQL
MLBr_00153|M.leprae_Br4923 GELCVVGDADQSIYAFRGSTISNIEDFERDYPDTTTILLEQNYRSTQNIL
Mb0647c|M.bovis_AF2122/97 GHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEA
Rv0630c|M.tuberculosis_H37Rv GHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEA
MSMEG_1327|M.smegmatis_MC2_155 GGPDIVVHDVQARHQGHRLVGAPRNDPFRLRVVSRK---PGNTRVIPIDQ
MAB_0399c|M.abscessus_ATCC_199 GGPDIVVHDVQAHHQGHRLAGAPHNDPFRLRVVSRN---RDGIKVIPIAD
MAV_4543|M.avium_104 GDPAIVVNDVAAHHRGHRLSGAPRNDPFRLRVVSRNTLGRRGIANLPIDE
TH_1287|M.thermoresistible__bu --------------------------------------------------
MMAR_0957|M.marinum_M GDPAIVVRDVKAHHQGHRLAGAPHNDALRLRVVRRATLGRRGIQNLPIDI
MUL_0708|M.ulcerans_Agy99 GDPAIVVRDVKAHHQGHRLAGAPHNDALRLRVVRRATLGRRGIQNLPIDI
Mflv_5130|M.gilvum_PYR-GCK GDPRIVVRRVDAHHREHRLQGAPHNEPFRLRVCTRDQFRVRPDRMIPIDV
Mvan_1209|M.vanbaalenii_PYR-1 GDPRIVAHRVEAHHRDHRLAGAPRNAPFRLRVVTRDQFGTRPDRVVAIDQ
MLBr_00153|M.leprae_Br4923 SAANSVIARNFGRRDKRLWTDAGKGELIVG----------------YVSD
Mb0647c|M.bovis_AF2122/97 LRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNAL
Rv0630c|M.tuberculosis_H37Rv LRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNAL
MSMEG_1327|M.smegmatis_MC2_155 LRRHIGRDLAADISALLNSGATWCDQPVQAKDIAVITETHKDARACHAAL
MAB_0399c|M.abscessus_ATCC_199 LRRSIGRDLAADIGALLSSGATFDGRPVRARDIAVIVEAHKDARACHTAL
MAV_4543|M.avium_104 LRQHIGADLAADIRALLAAGATFDGKPVRAGDIAVIVERHRDAQACFTAL
TH_1287|M.thermoresistible__bu ------------------------------------VETHKDARACYDAL
MMAR_0957|M.marinum_M LRDHIGRDLASDIGALLASGATFAGRALQANDIAVIVEKHKDARACHRAL
MUL_0708|M.ulcerans_Agy99 LRDHIGRDLASDIGALLASGATFAGRALQANDIAVIVEKHKDARACHRAL
Mflv_5130|M.gilvum_PYR-GCK LRNHIPKDMAADIAALLNSGATHCGEKLAPGHIAVIVESHRDGHACFAAL
Mvan_1209|M.vanbaalenii_PYR-1 LRRHIPQDMAADIAALLASDATFCDRPVQPGDVAVIVESHRDGHACFDAL
MLBr_00153|M.leprae_Br4923 NEHDEAKFIADEIDALVGGGE------ITYDDVAVLYRANNLSRSLEEVF
. :. .:: .:
Mb0647c|M.bovis_AF2122/97 AEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFG
Rv0630c|M.tuberculosis_H37Rv AEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFG
MSMEG_1327|M.smegmatis_MC2_155 LAAGIPAVYTGDSDVFTSEAAEDWLYLLEAFDQPHRPGLVRAAAATMFFG
MAB_0399c|M.abscessus_ATCC_199 TEAGIPAVYTGDTDVFSSDAAQDWLYLLEAFDQPHRPGLVRAAAATVFFG
MAV_4543|M.avium_104 CDAGVPAVYTGNSDVFTSQAAEDWLCLLEAFDQPHRPGVVRAAAATMFFG
TH_1287|M.thermoresistible__bu CQAGIPAVYTGDSDVFGSPAAEDWLCLLEAFDQPHRPGMVRAAAATMFFG
MMAR_0957|M.marinum_M TDAGIHAVYTGDTDVFSSEAADDWLALLEAFDQPHRPGIVRAAAATMFFG
MUL_0708|M.ulcerans_Agy99 TDAGIHAVYTGDTDVFSSEAADDWLALLEAFDQPHRPGIVRAAAATMFFG
Mflv_5130|M.gilvum_PYR-GCK ADAGIPAVYTGDSDVFSSPAADDWMCLLEAFDQPHRSGLVRAAATTMFFG
Mvan_1209|M.vanbaalenii_PYR-1 TAAGIPAVYTGDSDVFTSPAADDWMCLLEAFDQPHRSGLVRAAATTMFFG
MLBr_00153|M.leprae_Br4923 IPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNPGDAVSMR---------
:*: .*. .: * * : *..:* * . :*
Mb0647c|M.bovis_AF2122/97 ETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVL
Rv0630c|M.tuberculosis_H37Rv ETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVL
MSMEG_1327|M.smegmatis_MC2_155 ETAESLAAGGDALTDRVADTLREWAGHARERGVAAIFEAAQLAGMGKRVL
MAB_0399c|M.abscessus_ATCC_199 ETAETLAVGGESLTDEIAGTLRTWAARARERGVAAVFEAAQLAGMGKRVL
MAV_4543|M.avium_104 ETAETLAAGGDALTDRIAQTLREWAGHARERGVAAIFEAAQLLGMGNRVL
TH_1287|M.thermoresistible__bu ETAESLAAGGDALTDRVADTLREWAAHARERGVAAIFEAAKLSGMGDRVL
MMAR_0957|M.marinum_M KTANDLARGGDALTDRVAETLREWADYARERGVAAIFEAAQLGGMSDRVL
MUL_0708|M.ulcerans_Agy99 KTANDLARGGDALTDRVAETLREWADYARERGVAAIFEAAQLGGMSDRVL
Mflv_5130|M.gilvum_PYR-GCK ETAEALALQGDSLTDRIAETLRQWADFARERGVAAVFEAAQLRGMGARVL
Mvan_1209|M.vanbaalenii_PYR-1 ETAESLAAEGDTLTDRVAETLRQWADFARDRGVAAVFEAAQLGGMGERVL
MLBr_00153|M.leprae_Br4923 ---RILNTPRRGIGDRAEACVSVYAENTG----TSFADALQAVAEGKVPM
. * : *. : :* : ::. :* : . . :
Mb0647c|M.bovis_AF2122/97 SQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAG---P
Rv0630c|M.tuberculosis_H37Rv SQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAG---P
MSMEG_1327|M.smegmatis_MC2_155 SWQGGERLMTDLAHMTQLLQDTAHREGFGLAALRDWLRTQRSERGG---E
MAB_0399c|M.abscessus_ATCC_199 SWRGGERMMTDLAHLTELLQETAHRNGFGPAALRDWLRTQCSEGGA---E
MAV_4543|M.avium_104 GWQGGARHMTDLAHLTQLLGEVAHCEHHNLPALRDWLRRQRDERSG---A
TH_1287|M.thermoresistible__bu SWADGERHMTDLAHIAQLLQEAAHRDHLGLPALRDWLRARREETSGG--A
MMAR_0957|M.marinum_M SWQEGQRHMTDLAHVTQLLQKVSHRERYTLPALRDWLRGQREDRGG---A
MUL_0708|M.ulcerans_Agy99 SWQEGQRHMTDLAHVTQLLQKVSHRERYTLPALRDWLRGQREDRGG---A
Mflv_5130|M.gilvum_PYR-GCK RWVDGERHMTDLAHLTQLLHDTAHREQYSLPALRDWLRAQRDDRGGLRGT
Mvan_1209|M.vanbaalenii_PYR-1 SWVDGERHMTDLAHLTQVLHGTAHREHFSLPALRDWLRGQRDERS---GA
MLBr_00153|M.leprae_Br4923 LN---TRSVKAIAGFVALLDDLRCRVDDDLGELVESVLER----------
* :. :* .. :* * : : :
Mb0647c|M.bovis_AF2122/97 PEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHD
Rv0630c|M.tuberculosis_H37Rv PEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHD
MSMEG_1327|M.smegmatis_MC2_155 SERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRYVPEPDLVLFHD
MAB_0399c|M.abscessus_ATCC_199 AERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFSFNRYVPEREYVLYHE
MAV_4543|M.avium_104 PERNRRLDSDAAAVQIMTVFVSKGLQYPIVYLPFAFHRNTTDSDVVLFHD
TH_1287|M.thermoresistible__bu TERFRRLDTDAAAVPVMTVFAAKGLQFPVVYLPFAFNRHVRKQELVLYHE
MMAR_0957|M.marinum_M TERNRRIDSDAAAVQIMTVWVSKGLQYPVVYLPFAFNRNIQERELVLFHD
MUL_0708|M.ulcerans_Agy99 TERNRRIDSDAAAVQIMTVWVSKGLQYPVVYLPFAFNRNIQERELVLFHD
Mflv_5130|M.gilvum_PYR-GCK VERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRNVQPRDVVVFHE
Mvan_1209|M.vanbaalenii_PYR-1 PERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRNIQTRDVVTFHD
MLBr_00153|M.leprae_Br4923 SGYLRELESSTDPQELARLDNLN------ELVSFAHEFSTEQANAAALAK
*.:::.: . : : : :.*:.. : .
Mb0647c|M.bovis_AF2122/97 D-------GTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRA
Rv0630c|M.tuberculosis_H37Rv D-------GTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRA
MSMEG_1327|M.smegmatis_MC2_155 D-------GQRCLHVGG-ADP----AVARAGRAEAAGDDSRLTYVALTRA
MAB_0399c|M.abscessus_ATCC_199 D-------GLRCLHIGGREDPDYS-MADLAGRTEAARDASRLAYVALTRA
MAV_4543|M.avium_104 ED------GTRCLHVGGKDSPDFK-TVERLGRKEDASDDSRLTYVALTRA
TH_1287|M.thermoresistible__bu DD------GTRCLHIGGSDSPDHP-QVAQRGRDEDASDDGRLTYVALTRA
MMAR_0957|M.marinum_M G-------GTRCLHIGGKDSPDFG-TVERLGAKEAANDDSRLTYVAMTRA
MUL_0708|M.ulcerans_Agy99 R-------GTRCLHIGGKDSPDFG-TVERLGAKEAANDDSRLTYVAMTRA
Mflv_5130|M.gilvum_PYR-GCK PATSDGAGDIRCLHIGGESSPDFA-AVAQQARLEAAGDDVRLTYVAMTRA
Mvan_1209|M.vanbaalenii_PYR-1 -------GDIRCLHIGGERSPDHA-AAQQQGRREAAGDDVRLTYVAMTRA
MLBr_00153|M.leprae_Br4923 S-----------LHTPEDEDVPDTGALAAFLEKVSLMSDTDQIPENNSGV
*: . . : .
Mb0647c|M.bovis_AF2122/97 QSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTP-RVTDEQAWAV
Rv0630c|M.tuberculosis_H37Rv QSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTP-RVTDEQAWAV
MSMEG_1327|M.smegmatis_MC2_155 QSQVVAWWAPSYDEPNGGLSRLMRGRAPGEAIVPDKCSPPKISDEDALER
MAB_0399c|M.abscessus_ATCC_199 QSQVVAWWAPSFDEPNGGLSRLLRGRAPGNPSVPDKCSPAKISDADVLKR
MAV_4543|M.avium_104 QAQVVAWWSPAYHEPNGGLSRLLRGRRPGEPVVPDRCEPAKISDEDALAR
TH_1287|M.thermoresistible__bu QAQVVAWWAPSWDEPNGGLSRLLRGRRPGERSVPHRCPDDRITDDQAWER
MMAR_0957|M.marinum_M QSQVVAWWSPAYDEPNGGLSRLLRGRRPGDSVVPDRATPAKITDEDAWDR
MUL_0708|M.ulcerans_Agy99 QSQVVAWWSPAYDEPNGGLSRLLRGRRPGDSVVPDRATPAKITDEDAWDR
Mflv_5130|M.gilvum_PYR-GCK QSQVVAWWAPSRDELNGGLSRLLRGRAPGDPVVPDRCDPARIDDAEAMAR
Mvan_1209|M.vanbaalenii_PYR-1 QSQVVAWWAPSNDEPNGGLSRLLRGRAPGDPVVPDRCDPPRIDDPDAMAQ
MLBr_00153|M.leprae_Br4923 VTLMTLHAAKGLEFPVVFVTGWEDGMLPHMRTLGD---PTELSEERRLAY
: :. : . :: * * : . .: :
Mb0647c|M.bovis_AF2122/97 FAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSY
Rv0630c|M.tuberculosis_H37Rv FAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSY
MSMEG_1327|M.smegmatis_MC2_155 LRAWEAAGGPVIEESVIGAVSPVPPEPAPEDLAARKFFRAIDMAWKRTSY
MAB_0399c|M.abscessus_ATCC_199 LRAWEAQGGPVVEDALVTGFVPAATSSPSDNLAVRVFDRPIDTAWRRTSY
MAV_4543|M.avium_104 LREWEAAGGPVIEEAVPAPAPPLPGVPVPARLENRHFHRGIDTGWRRTSY
TH_1287|M.thermoresistible__bu LREWEAAGGPVLEESLPRPVTALPPEPTPTELGARHFHRSIDTDWRRTSY
MMAR_0957|M.marinum_M FQQWQAAGGPTVEESVIAAAPAIAGRPAPSELATRRFDRGIDIRWRRTSY
MUL_0708|M.ulcerans_Agy99 FQQWQAAGGPTVEESVIAAAPAIAGQPAPSELATRRFDRDIDIRWRRTSY
Mflv_5130|M.gilvum_PYR-GCK LRAWADEGGPVLEESIIAERVEVELPAPPDTLAVRHFHRRIDPLWRRTSY
Mvan_1209|M.vanbaalenii_PYR-1 LRAWSDAGGPVLEESVIAASVTVELPSPAEDLDVRHFHRRIDTSWRRTSY
MLBr_00153|M.leprae_Br4923 VGITRARQRLYLSRAITRSSWGQPILNPESRFLREIPPELID--WRRSIL
. :. :: : . . ** *:*:
Mb0647c|M.bovis_AF2122/97 SDLVRGSEAVT---------VTSEPAAGGRADEVEIAVFAAPGSGA---D
Rv0630c|M.tuberculosis_H37Rv SDLVRGSEAVT---------VTSEPAAGGRADEVEIAVVAAPGSGA---D
MSMEG_1327|M.smegmatis_MC2_155 SGLLRAAETAG-------VGVSSEPEVTERDDEFDDIPVVAPAEGA---D
MAB_0399c|M.abscessus_ATCC_199 SGLLRAAEES---------GVSSEPEIAELDDEVDEIPLRSMPAGA---D
MAV_4543|M.avium_104 SGLIRQAQPSG---------VGSEPEAAGLDDEVGDILLAPATSVG---D
TH_1287|M.thermoresistible__bu SGLLRASQSDGGVAASGSPGVTSEPEVAELDDEVGEIPLTPATDGA---E
MMAR_0957|M.marinum_M SGLIRMAEATG---------VSSEPEVTERDDEVAEVPLTEVVMSGP--E
MUL_0708|M.ulcerans_Agy99 SGLIRMAEATG---------VSSEPEVTERDDEVAEVPLTEVVMSGP--E
Mflv_5130|M.gilvum_PYR-GCK SGLIRAAEQE--------SGVGSEPEVVELDDEVAELRAPDTEPATPDVD
Mvan_1209|M.vanbaalenii_PYR-1 SGLIRAAESEQ-------TGVGSEPEVVELDDEAGEVPVPGAGGGGD--Q
MLBr_00153|M.leprae_Br4923 TDSYSTPASGAS--------RFGRVRPSSIRSGASKRALLVLAPGDRVTH
:. . .. . .
Mb0647c|M.bovis_AF2122/97 LTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVP---------
Rv0630c|M.tuberculosis_H37Rv LTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVRRHAPWWTVD
MSMEG_1327|M.smegmatis_MC2_155 VPSPMAHLPTGAAFGSLVHAVLETADPFAEDLTAELATHIDAHSQHWPVE
MAB_0399c|M.abscessus_ATCC_199 VPSPMAQLPAGAAFGSLVHAVLETTDPLAPDLVAELQTQIIRHRERWPVE
MAV_4543|M.avium_104 VASPMADLPAGATFGTLVHAVLQTADPFAPDLAAELTARIREHSVWWPVA
TH_1287|M.thermoresistible__bu VPSPMAGLPTGAKLGTLVHAVLETADPFAPDLAAELADRVREHAVWWPVD
MMAR_0957|M.marinum_M QPSPMADLPSGAKFGSLVHAVLETSDPFAIDLAAELESQIRVQSAWWPVQ
MUL_0708|M.ulcerans_Agy99 QPSPMADLPSGAKFGSLVHAVLETSDPFAIDLAAELESQIRVQSAWWPVQ
Mflv_5130|M.gilvum_PYR-GCK MASPMAGLPMGAKFGTLVHAVLETADPFAVDLAAELEAAVVEHSLWWPVD
Mvan_1209|M.vanbaalenii_PYR-1 MPSPMADLPMGAKFGTLVHAVLETADPFATDLAAELESHVRRHSLWWPVD
MLBr_00153|M.leprae_Br4923 DKYGLGRVEEVSGVGESAISLIDFGSSGRIKLMHNHAPVTKL--------
:. : : .* . :::: .. .* :
Mb0647c|M.bovis_AF2122/97 --------------------------------------------------
Rv0630c|M.tuberculosis_H37Rv VDHAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDFEMPLA
MSMEG_1327|M.smegmatis_MC2_155 VE----TAELAAALVPMHDTPLGPLAPGLTLRQIGLRDRLCELDFEFPMA
MAB_0399c|M.abscessus_ATCC_199 IP----AAELAAALEPMHDTPLGPLLPGVTLRQIGLRDRLCELDFEFPLA
MAV_4543|M.avium_104 AT----PEDMAAAMVPMHDTPLGPLAGGLTLRRIGLSDRLCELDFELPLA
TH_1287|M.thermoresistible__bu VP----AEELAAALVPVHDTPLGPLAPGLTLRQIGLRDRMREMEFEFPLA
MMAR_0957|M.marinum_M VP----AAQLAAALVPMHDTPLGPLAGGLTLRQIGLPDRLREMDFEFPLA
MUL_0708|M.ulcerans_Agy99 VP----AAQLAAALVPMHDTPLGPLAGGLTLRQIGLPDRLREMDFEFPLA
Mflv_5130|M.gilvum_PYR-GCK VP----PAELAAALVPLHDTPLGPLAPGVTLRDIGLRDRLREMEFEFPLA
Mvan_1209|M.vanbaalenii_PYR-1 VP----AADLAAALVPLHDTPLGPLAPGVTLRDIGLRDRLREMEFEFPLA
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 -GTRRG-------------------------------------GPWTSTT
Rv0630c|M.tuberculosis_H37Rv GGDLRGR---SPDVSLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPL
MSMEG_1327|M.smegmatis_MC2_155 GGDLRGG----RFARLSDVGELLREYLPADDPLAVYAERLSTGILGVQPL
MAB_0399c|M.abscessus_ATCC_199 GGDAAAD----SFARLADVGMLLREHLAADDPLGVYASRLTGPGLGGQSL
MAV_4543|M.avium_104 GGDRRSA---PPEVRLADLAPLLRAHLPADDVLACYADRLTDRSLGAESL
TH_1287|M.thermoresistible__bu GGDARDA---APDIRLADVGDLLGAHLPEDDPLACYAERLTGTGLGRQPL
MMAR_0957|M.marinum_M GGDEADAGGHAPDLRLADVGALLRAHLDASDPLAPYADRLSGDALGGQSL
MUL_0708|M.ulcerans_Agy99 GGDEADAGGHAPDLRLADVGALLRAHLDASDPLAPYDDRLSGDALGGQTL
Mflv_5130|M.gilvum_PYR-GCK GGDRRDD---TPDITLADVGRLLRAHLPADDPLAPYAARLTTGALAGQPL
Mvan_1209|M.vanbaalenii_PYR-1 GGDRRVE---VPDISLADVGRLLAAHLPADDPLAPYAERLTGGTLAAQSL
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 RSWLP---------------------------------------------
Rv0630c|M.tuberculosis_H37Rv RGYLAGSIDVVLRLP---GQRYLVVDYKTNHLGD-----TAADYGFERLT
MSMEG_1327|M.smegmatis_MC2_155 RGYLSGSVDAVLRVG----EKFVIVDYKTNWLGTGDGTLTAADYGRRRMV
MAB_0399c|M.abscessus_ATCC_199 RGYLSGSVDAVLRVG----SRYVVVDYKTNWLGTGDAPLTAADYSRPRMV
MAV_4543|M.avium_104 RGYLTGSIDAVLRIPDGAGHRYLVVDYKTNRLGDAQHPLTAADYDRPRMV
TH_1287|M.thermoresistible__bu RGYLTGSVDAVLRIPAGDDHRYLVVDYKTNWLGPVDRPLTAADYTRPRLV
MMAR_0957|M.marinum_M RGYLSGSVDAVLRIPDGPGQRYLVVDYKTNWLGDPDRPLTAADYHRPRLI
MUL_0708|M.ulcerans_Agy99 RGYLSGSVDVVLRIPDGPGQRYLVVDYKTNWLGDPDRPLTAADYHRPRLI
Mflv_5130|M.gilvum_PYR-GCK KGYLNGSLDAVLRVD----GRYLVVDYKTNWLGDPAGELTAADYAPARLA
Mvan_1209|M.vanbaalenii_PYR-1 KGYLNGSVDAVLRVG----DRYLVVDYKTNWLGDPARPLTAADYGKARLT
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 -----------------------NWPER------------------CCRC
Rv0630c|M.tuberculosis_H37Rv EAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARHLGGVLYLFVRGMCGA
MSMEG_1327|M.smegmatis_MC2_155 EAMLHSDYPLQALLYAVVLHRYLGWRLSGYDPATHLGGVLYLFVRGMCGA
MAB_0399c|M.abscessus_ATCC_199 EAMLHSDYPLQALLYSVVLHRFLSWRLPGYRPEEHLGGAVYLFVRGMCGA
MAV_4543|M.avium_104 EAMLHSDYPLQALLYSAVLHRFLRWRLAGYDPDRHLGGILYLFVRGMCGP
TH_1287|M.thermoresistible__bu EAMLHSDYPLQALLYSVVLHRFLRWRLPAYTPEEHLGGVLYLFLRGMCGP
MMAR_0957|M.marinum_M EAMLHSDYPLQALLYTVVLHRFLRWRQPGYDPARHLGGVLYLFVRGMCGP
MUL_0708|M.ulcerans_Agy99 EAMLHSDYPLQALLYTVVLHRFLRWRQPGYDPARHLGGVLYLFVRGMCGP
Mflv_5130|M.gilvum_PYR-GCK EAMLHSDYPLQALLYCVVLHRFLRWRQPGYSARRHIAGVLYLFVRGMCGP
Mvan_1209|M.vanbaalenii_PYR-1 EVMLHSDYPLQALLYCVVLHRFLRWRAPGYRAESHIAGVLYLFVRGMCGA
MLBr_00153|M.leprae_Br4923 --------------------------------------------------
Mb0647c|M.bovis_AF2122/97 TTRR----------WDPPPPH---------------
Rv0630c|M.tuberculosis_H37Rv ATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQS
MSMEG_1327|M.smegmatis_MC2_155 GTPVVDGHPAGVFSWEPPADLVVALSKLLDAEAP--
MAB_0399c|M.abscessus_ATCC_199 TTPVVEGHPAGVFSWQPPSALVVALSELLS------
MAV_4543|M.avium_104 DTPVRDGHPSGVFDWRPPSSLIAALSDLLDAQGVAV
TH_1287|M.thermoresistible__bu DTPVVDGHPAGVFSWQPPAGLVVALSDLLDAGRTAE
MMAR_0957|M.marinum_M DTPMLDGHPAGVFSWSPPAALVTALSDLLDAGRAVA
MUL_0708|M.ulcerans_Agy99 DTPMLDGHPAGVFSWSPPAALVTALSDLLDAGRAVA
Mflv_5130|M.gilvum_PYR-GCK DTPVLDGHPAGVFSWQPPAALIEELSDLLDAGAVPA
Mvan_1209|M.vanbaalenii_PYR-1 DTPVVDGHPAGVFSWQPPAALIEALSDLLDAGVAA-
MLBr_00153|M.leprae_Br4923 ------------------------------------