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TVIHKSPEDWRVTPNLVDYENTCTTFRWDAAPDVCAGMGDGLCNIAYAAVDRHAGGSAGGRTALRFVSES ALTGETSVRDLEYSELASLSSRFTAVLRALGVGKGDRVFTLLGRCPELYVTILGALRNGSVVSPLFSAFG PEPVATRLRLGDAHVLVTTRAMYRKKVADSRSALTSLKHVLLIDEDIDDDIGEEEGATATGFWRWMEATP DGAPIEPTTADDPALLLLRDQVDLDSMDWLNFLVGIHKRLHVDIPEADYRKLRTLADVVGYVGSREAPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4983 | - | - | 100% (280) | acetyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1959 | - | 8e-15 | 34.75% (141) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_1380 | - | 7e-14 | 32.34% (167) | acetyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3691 | acs | 3e-11 | 29.72% (212) | acetyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3667 | acs | 3e-11 | 29.72% (212) | acetyl-CoA synthetase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0425c | - | 4e-11 | 31.21% (141) | Acetyl-CoA synthetase |
| M. marinum M | MMAR_3488 | acs_1 | 4e-70 | 56.83% (227) | acetyl-coenzyme A synthetase Acs_1 |
| M. avium 104 | MAV_0462 | acsA | 9e-13 | 29.25% (212) | acetyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_3986 | - | 3e-16 | 33.85% (130) | acetyl-coenzyme A synthetase |
| M. thermoresistible (build 8) | TH_0966 | acs | 5e-12 | 31.16% (138) | ACETYL-COENZYME A SYNTHETASE ACS (ACETATE--CoA LIGASE) |
| M. ulcerans Agy99 | MUL_4241 | acs | 5e-12 | 29.25% (212) | acetyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1407 | - | 3e-84 | 69.16% (227) | acetyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4983|M.gilvum_PYR-GCK ---------------------------------MTVIHKSPED-----WR
Mvan_1407|M.vanbaalenii_PYR-1 ---------------------------------MTVIHKTAQD-----WR
MMAR_3488|M.marinum_M ---------------------------------MDVIHKTAHD-----SR
MAB_0425c|M.abscessus_ATCC_199 ---------MTETSIEPDS-YPPSPEFVATANATADLYQAAEEDRLGFWE
TH_0966|M.thermoresistible__bu ---------MSETHTEAQSVYPPPAEFAAQSNATADLYREAEADRLAFWA
Mb3691|M.bovis_AF2122/97 ---------MSESTPEVSSSYPPPAHFAEHANARAELYREAEEDRLAFWA
Rv3667|M.tuberculosis_H37Rv ---------MSESTPEVSSSYPPPAHFAEHANARAELYREAEEDRLAFWA
MUL_4241|M.ulcerans_Agy99 MKLNIGDTPVTATSAEEPSSYPPPAEFIEQANARAELYREAEEDRLAFWA
MAV_0462|M.avium_104 ---------MTASNTANPPSYPPPPQFVEQANAGEQLYREAERDRLAFWA
MSMEG_3986|M.smegmatis_MC2_155 ------------------------------------MIPDPES-------
: ..
Mflv_4983|M.gilvum_PYR-GCK VTPNLVDYENTCTTFRWDAAPDVCAGMGDGLCNIAYAAVDRHAGGSAGGR
Mvan_1407|M.vanbaalenii_PYR-1 VTPNLVDYEKTCATFDWAAAPNLCAEMGPGLCNIAYAAVDRHAHGPTASR
MMAR_3488|M.marinum_M VAPNLSDYQRARAQFRWTDVPALCEGMGDDKCNIAFAAVDRHCAGPIATR
MAB_0425c|M.abscessus_ATCC_199 QQAGRLHWDEPFGQVLDWSDAPFAKWFVGGKLNVAYNCVDRHVEAGNGDR
TH_0966|M.thermoresistible__bu RQAERLTWAKPFEQVLDWSEAPFAKWFVGGRLNVAYNCVDRHVEAGNGDR
Mb3691|M.bovis_AF2122/97 KQANRLSWTTPFTEVLDWSEAPFAKWFVGGELNVAYNCVDRHVEAGHGDR
Rv3667|M.tuberculosis_H37Rv KQANRLSWTTPFTEVLDWSGAPFAKWFVGGELNVAYNCVDRHVEAGHGDR
MUL_4241|M.ulcerans_Agy99 KQADRLSWATPFGEVLDWSDAPFANWFVGGKLNVAYNCVDRHVEAGNGDR
MAV_0462|M.avium_104 EQANRLSWATPFTEVLDWSRAPFAEWFADGTLNVAYNCVDRHVQAGHGDR
MSMEG_3986|M.smegmatis_MC2_155 ---RVYELLRQYDEPTACAATLICDRHPDD--DVAFTVVEPDLSAAD---
. .. . ::*: *: . .
Mflv_4983|M.gilvum_PYR-GCK TALRFVSESALTGETSVRDLEYSELASLSSRFTAVLRALGVGKGDRVFTL
Mvan_1407|M.vanbaalenii_PYR-1 TALRFVSESDGDTGLSVRGLSYGELGLLARKFTDVLRSLDVHKGDRVFTL
MMAR_3488|M.marinum_M TALRFVTDQSREDQPPTQDVSYAELGRLVRKFTAVLRGLGVNKGDRVFTI
MAB_0425c|M.abscessus_ATCC_199 VAIHWEGEP-GDTRT----ITYAELLAQVSQAANYLTELGLVSGDRVAIY
TH_0966|M.thermoresistible__bu VAIYWEGEPVGDSRT----LTYAQLKDEVSKAANALTRLGLRTGDRVAIY
Mb3691|M.bovis_AF2122/97 VAIHWEGEPVGDRRT----LTYSDLLAEVSKAANALTDLGLVAGDRVAIY
Rv3667|M.tuberculosis_H37Rv VAIHWEGEPVGDRRT----LTYSDLLAEVSKAANALTDLGLVAGDRVAIY
MUL_4241|M.ulcerans_Agy99 VAIHWVGEPIEDSRT----LTYADLQAEVSKAANALTGLGLVAGDRVAIY
MAV_0462|M.avium_104 VAIHWEGESPGDQRS----LTYSELYTQVCKAANALTDLGLVAGDRVAIY
MSMEG_3986|M.smegmatis_MC2_155 -------------------LTYGQLREQSTKFAAALSELGIGPGDHVATL
: *.:* : : * *.: **:*
Mflv_4983|M.gilvum_PYR-GCK LGRCPELYVTILGALRNGSVVSPLFSAFGPEPVATRLRLGDAHVLVTTRA
Mvan_1407|M.vanbaalenii_PYR-1 LGRCPELYVAILGALRNGSVVSPLFSAFGPEPVATRLSIGEADVLITTKA
MMAR_3488|M.marinum_M MGRIPELYITMLGALRNGSVVSPLFSAFGPEPIATRVEIGQADVLVTTAA
MAB_0425c|M.abscessus_ATCC_199 MPMLPEAIVAMLACARLGLMHSVVFAGFSAAALRARIDDAQAKLVITSDG
TH_0966|M.thermoresistible__bu MPMIPEAIISMLACARLGVLHSVVFAGFSSSALTARIQDAEAKLLITADG
Mb3691|M.bovis_AF2122/97 LPLIPEAVIAMLACARLGIMHSVVFGGFTAAALQARIVDAQAKLLITADG
Rv3667|M.tuberculosis_H37Rv LPLIPEAVIAMLACARLGIMHSVVFGGFTAAALQARIVDAQAKLLITADG
MUL_4241|M.ulcerans_Agy99 LPLIPEAVIAMLACARLGIMHSVVFGGFTANTLHARIVDAQAKLLITSDG
MAV_0462|M.avium_104 LPLIPEAVIAMLACARLGVMHSVVFAGFTAKALQARIADAAAKLLITSDG
MSMEG_3986|M.smegmatis_MC2_155 MGKSAELVVALLGIWRRGAIHVPLFTAFAPPAITHRLRASDARLVICDAD
: .* :::*. * * : :* .* . .: *: . * :::
Mflv_4983|M.gilvum_PYR-GCK MYRKKVADSRSALT-------------------SLKHVLLIDEDIDDDIG
Mvan_1407|M.vanbaalenii_PYR-1 QYRKKIAGIRDQLP-------------------SLRHVFVIDDHDDD---
MMAR_3488|M.marinum_M IYRRKIAKIRERLT-------------------SVRHILVVDAQSSGD--
MAB_0425c|M.abscessus_ATCC_199 QWRRGTAAPLKSQVDEALGAAGPATSDLGGEPSSVEHVLVVRRTEIPVEW
TH_0966|M.thermoresistible__bu QYRRGNAVPLKTNADEAVQNQ-----------PTVEHVLVVRRTGLDVPW
Mb3691|M.bovis_AF2122/97 QFRRGKPSPLKAAADEALAAI---------PDCSVEHVLVVRRTGIEMAW
Rv3667|M.tuberculosis_H37Rv QFRRGKPSPLKAAADEALAAI---------PDCSVEHVLVVRRTGIEMAW
MUL_4241|M.ulcerans_Agy99 QFRRGHPAPLKDAADEAVSQ----------PDSPVEHVLVVRRTGIDVSW
MAV_0462|M.avium_104 QFRRGKPAPLKDAADEAVAD----------PDSPVEHVVVVRRTGIDVSW
MSMEG_3986|M.smegmatis_MC2_155 QLHKITHDDSAPSP-------------------APWRVVVAGPSTTDDVL
:: . ::.:
Mflv_4983|M.gilvum_PYR-GCK EEEGATATGFWRWMEATPDGAPIEPTTADDPALLLLR-------------
Mvan_1407|M.vanbaalenii_PYR-1 --SGAQTMGFWPRMDAAGDDAPIEPTTADDPALLHFTSGTTGTPKGALHV
MMAR_3488|M.marinum_M --QLPGTLSLWELMAAADDNAPAEPTTADDPALLHFTSGTTGTPKGAIHV
MAB_0425c|M.abscessus_ATCC_199 T--EGRDLWWHETVDKADTTHTAEPFDSEHPLFLLYTSGTTGKPKGIVHT
TH_0966|M.thermoresistible__bu T--EGRDVWWHDAVDNASTEHTPDAFDSEHPLFLLYTSGTTGKPKGIVHT
Mb3691|M.bovis_AF2122/97 S--EGRDLWWHHVVGSASPAHTPEPFDSEHPLFLLYTSGTTGKPKGIMHT
Rv3667|M.tuberculosis_H37Rv S--EGRDLWWHHVVGSASPAHTPEPFDSEHPLFLLYTSGTTGKPKGIMHT
MUL_4241|M.ulcerans_Agy99 N--DERDLWWHDVVDSASPQHTPEPFDAEQPLFLLYTSGTTGKPKGIVHT
MAV_0462|M.avium_104 T--DGRDLWWHDVVDAAAPEHTPEPFPAEQPLFLLYTSGTTGKPKGIVHT
MSMEG_3986|M.smegmatis_MC2_155 E-----LAGLIRRHDGVSTAEMTAVTGGSGTLVELFTSGTTGSPKGVAVP
. .. . .
Mflv_4983|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1407|M.vanbaalenii_PYR-1 HG--AVTMHYVTGRYALDLHEDDVYWCTADPGWVTGMSYGVIAPLLHGVT
MMAR_3488|M.marinum_M HG--AVTMHYVTGLYALDLHPDDIYWCTADPGWVTGTSYGIISPLLHGVT
MAB_0425c|M.abscessus_ATCC_199 SGGFLTQTSYTHFNIFDLKPETDVYWCTADIGWVTGHTYIVYGPLSNGAT
TH_0966|M.thermoresistible__bu TGGFLTQTAYSHHYVFDIKPETDVFWCTADIGWVTGHSYIVFGPLANGAS
Mb3691|M.bovis_AF2122/97 SGGYLTQCCYTMRTIFDVKPDSDVFWCTADIGWVTGHTYGVYGPLCNGVT
Rv3667|M.tuberculosis_H37Rv SGGYLTQCCYTMRTIFDVKPDSDVFWCTADIGWVTGHTYGVYGPLCNGVT
MUL_4241|M.ulcerans_Agy99 SGGYLTQCCYTVHTIFDVKPETDVFWCTADIGWVTGHTYGVYGPLANGIT
MAV_0462|M.avium_104 SGGYLTQAAYTHYYVFDIKADTDVFWCTADIGWVTGHTYGVYGPLANGVT
MSMEG_3986|M.smegmatis_MC2_155 LR--ALASFHAYQEFGLDVRREDVFWNAADPGWAYGLYYAILSPLATGTR
Mflv_4983|M.gilvum_PYR-GCK ---DQVDLDSMD---WLNFLVG----------------------------
Mvan_1407|M.vanbaalenii_PYR-1 SIVDEGDFDAER---WYRILESQGVTVWYTAPTAIRMLIKAGAELAAGYR
MMAR_3488|M.marinum_M SIVDQAEFDAER---WYRILQDQNVSVWYTAPTGIRMLIKAGAELAAQYC
MAB_0425c|M.abscessus_ATCC_199 QVVYEGTPTSPNEHRHFEIIEKYGVTIYYIAPTLVRTFMKWGREIPFAHD
TH_0966|M.thermoresistible__bu QVVYEGTPNSPDEHRHFQIIEKYGVTIYYTAPTLIRTFMKWGREIPDAHD
Mb3691|M.bovis_AF2122/97 EVLYEGTPDTPDRHRHFQIIEKYGVTIYYTAPTLIRMFMKWGREIPDSHD
Rv3667|M.tuberculosis_H37Rv EVLYEGTPDTPDRHRHFQIIEKYGVTIYYTAPTLIRMFMKWGREIPDSHD
MUL_4241|M.ulcerans_Agy99 EVLYEGTPNTPDEHRHFQIIEEYGVTIYYTAPTLIRTFMKWGRAIPDAHD
MAV_0462|M.avium_104 EVLYEGTPDTPTQHRHFEIIEKYGVTIYYTAPTLIRTFMKWGREIPDAHD
MSMEG_3986|M.smegmatis_MC2_155 SILLHAGFSPPL---VWRVMERFGVTNFTAAPTVYRSLLTDPTSVPPTVR
. . ..:
Mflv_4983|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1407|M.vanbaalenii_PYR-1 FPRLRFVASVGEPLNAEAVWWGKRVLG---LPIHDNWWQTETGGIMIANT
MMAR_3488|M.marinum_M FPHLRFIASVGEPLDPEAVWWGKRVLG---LPIHDNWWQTETGGIMIANT
MAB_0425c|M.abscessus_ATCC_199 LSSLRLLGSVGEPINPEAWRWYREVIGGNRTPIVDTWWQTETGSAMISPL
TH_0966|M.thermoresistible__bu LSSLRLLGSVGEPINPEAWRWYRKVIGGDRTPVVDTWWQTETGAIMISPL
Mb3691|M.bovis_AF2122/97 LSSLRLLGSVGEPINPEAWRWYRDVIGGGRTPLVDTWWQTETGSAMISPL
Rv3667|M.tuberculosis_H37Rv LSSLRLLGSVGEPINPEAWRWYRDVIGGGRTPLVDTWWQTETGSAMISPL
MUL_4241|M.ulcerans_Agy99 LSSLRLLGSVGEPINPEAWRWYRDVVGAGHTPIVDTWWQTETGSAMISPL
MAV_0462|M.avium_104 LSSLRLLGSVGEPINPEAWRWYRSVIGADRLPIVDTWWQTETGATMISPL
MSMEG_3986|M.smegmatis_MC2_155 ---LRRASSAGEPLTPDVISWSRANLG---VLVRDHYGQTEHGMFIANAW
Mflv_4983|M.gilvum_PYR-GCK ------------------------IHKR------LHVDIP----------
Mvan_1407|M.vanbaalenii_PYR-1 P---AFDIKPGSMGRPLPGVHATIVHRRDDGA-VEVIDTPGVEGELALKP
MMAR_3488|M.marinum_M P---AFDIKPGSMGRPLPGVDAHILRHNDDGT-TSVIDDPDEEGELALEP
MAB_0425c|M.abscessus_ATCC_199 PG--VTETKPGSAMRAVPGISAKIVDDEGNQLEPAS-GDEPVTGYLVLDK
TH_0966|M.thermoresistible__bu PG--VTAAKPGAAMAPLPGISAQIVDDDGDRIPNSPEGGEPITGYLVLDQ
Mb3691|M.bovis_AF2122/97 PG--IAAAKPGSAMTPLPGISAKIVDDHGDPLPPHTEGAQHVTGYLVLDQ
Rv3667|M.tuberculosis_H37Rv PG--IAAAKPGSAMTPLPGISAKIVDDHGDPLPPHTEGAQHVTGYLVLDQ
MUL_4241|M.ulcerans_Agy99 PG--IAAAKPGSAMTPLPGISAKVVDDHGDPLAPETDEGTHVTGYLVLDQ
MAV_0462|M.avium_104 PG--VAAAKPGSAMRPLPGISARIVDDHGDQLVPGIHHGEHVTGYLVLDQ
MSMEG_3986|M.smegmatis_MC2_155 ADGLRDEVHEGSMGAVLPGWRCNVLDLNTVTAAPSRRMGRVAIDAHNSPL
:
Mflv_4983|M.gilvum_PYR-GCK ------------EADYRK--------------------------------
Mvan_1407|M.vanbaalenii_PYR-1 GWPSMFRGYLHQEERYRKTFA-----DGLYLTGDMAKRDDDGYFWFVGRA
MMAR_3488|M.marinum_M GWPSMFRGYLHAEDRYRKCFS-----DGLYLTGDLAKKDADGYFWFVGRK
MAB_0425c|M.abscessus_ATCC_199 PWPSMLRGIWGDPERFKETYWSRYAEQGWYFAGDGARYDSDGAIWVLGRI
TH_0966|M.thermoresistible__bu PWPAMLRGIWNDPERYRETYWQRFESKGWYFAGDGARYDADGDIWVLGRI
Mb3691|M.bovis_AF2122/97 PWPSMLRGIWGDPARYWHSYWSKFSDKGYYFAGDGARIDPDGAIWVLGRI
Rv3667|M.tuberculosis_H37Rv PWPSMLRGIWGDPARYWHSYWSKFSDKGYYFAGDGARIDPDGAIWVLGRI
MUL_4241|M.ulcerans_Agy99 PWPSMLRGIWGDPARFHYAYWSKFEDKGYYFAGDGARLDSDGAIWVLGRI
MAV_0462|M.avium_104 PWPSMLRGIWGDPDRYVETYWSRFAEQGWYFAGDSAYYDRDGAIWVVGRI
MSMEG_3986|M.smegmatis_MC2_155 MWFNGYTNAPDKTAERFTPDG------HWYLTGDIGHVDDEGKFHFCGRD
Mflv_4983|M.gilvum_PYR-GCK ---LRTLADVVG--------------------------------------
Mvan_1407|M.vanbaalenii_PYR-1 DDVIKSAGHLIGPFEVENALTDHPAVAEAAVIGVPDPTVGEVVKAFVTLK
MMAR_3488|M.marinum_M DDVIKSAGHLIGPFEVESALTDHPAVAEAAVIGKPDPTVGAIIKAFVVLK
MAB_0425c|M.abscessus_ATCC_199 DDVMNISGHRISTAEVESALVGHDGVAEAAVVGASDETTGQAIVAFVILK
TH_0966|M.thermoresistible__bu DDVMNVSGHRISTAEVESALVGHSGVAEAAVVGASDPQTGQAICAFVILE
Mb3691|M.bovis_AF2122/97 DDVMNVSGHRISTAEVESALVAHSGVAEAAVVGVTDETTTQAICAFVVLR
Rv3667|M.tuberculosis_H37Rv DDVMNVSGHRISTAEVESALVAHSGVAEAAVVGVTDETTTQAICAFVVLR
MUL_4241|M.ulcerans_Agy99 DDVMNVSGHRISTAEVESALVGHPGVAEAAVVGVVDDTTTQAICAFVVLR
MAV_0462|M.avium_104 DDVMNVSGHRLSTAEVESALVGHHGVAEAAVVGATDATTGQAICAFVVLC
MSMEG_3986|M.smegmatis_MC2_155 DDVIIMAGYRIGPFDVESVLVMHPSVIEAAVVARPDHLRGEVLEAFVVLR
: . :.
Mflv_4983|M.gilvum_PYR-GCK --------------------YVGSREAPS---------------------
Mvan_1407|M.vanbaalenii_PYR-1 DGYQPD-DALQRDLMAHARKRLGAAVAPKTIAFADSLPHTRSGKIMRRLL
MMAR_3488|M.marinum_M DGFTAD-DDLRLELLGHARKHLGAAVAPKEIEFADALPHTSSGKIMRRLL
MAB_0425c|M.abscessus_ATCC_199 ASHTVEGDELVSHLKAQVSKEISPIAKPREIHVVPELPKTRSGKIMRRLL
TH_0966|M.thermoresistible__bu A-DAKDNDNMVEELRAQVAREISPIAKPREIHVVPELPKTRSGKIMRRLL
Mb3691|M.bovis_AF2122/97 ANYAPH-DRTAEELRTEVARVISPIARPRDVHVVPELPKTRSGKIMRRLL
Rv3667|M.tuberculosis_H37Rv ANYAPH-DRTAEELRTEVARVISPIARPRDVHVVPELPKTRSGKIMRRLL
MUL_4241|M.ulcerans_Agy99 GNYEQH-DGTSEELRAEVAEAISPIARPREVHVVPELPKTRSGKIMRRLL
MAV_0462|M.avium_104 ADYQVH-DGIVDELRAEVAREISPIAKPREVHVVPELPKTRSGKIMRRLL
MSMEG_3986|M.smegmatis_MC2_155 EGTEGS-EDLEKELQTLVKKKYAAHAYPRTVHFVTELPKTSSGKVQRHLL
.. *
Mflv_4983|M.gilvum_PYR-GCK ---------------------------------
Mvan_1407|M.vanbaalenii_PYR-1 KARELGLPEGDTSTIETTGSASATAVTR-----
MMAR_3488|M.marinum_M KARELGLPEGDTSTVVGFPEPKPQGVPL-----
MAB_0425c|M.abscessus_ATCC_199 RDVAEGRELGDTSTLVDPSVFEAIR-ASK----
TH_0966|M.thermoresistible__bu RDVAEGRELGDTSTLVDPNVFEAIR-ATKGGPS
Mb3691|M.bovis_AF2122/97 RDVAENRELGDTSTLLDPTVFDAIR-AAK----
Rv3667|M.tuberculosis_H37Rv RDVAENRELGDTSTLLDPTVFDAIR-AAK----
MUL_4241|M.ulcerans_Agy99 RDIAEKRELGDTSTLLDPTVFDAIRNAAK----
MAV_0462|M.avium_104 RDIAENRELGDTSTLLDPGVFDAIR-AAK----
MSMEG_3986|M.smegmatis_MC2_155 RRGML----------------------------