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TDEVRVSCVTQHPARRTRVEELPKLLKGCPLFLVVLGSVLALMHFYVWKRTVKDTSQGRARRWLSAALVV LMLMLVAALVVPRTVGVPESRWIAWPGYLWFGVLVYLFLVLLALEPVRLVLRRWTRPAPPPTPTDAETAD PEMAPAVDRRVFLARTAAVTAGAAAVGLTGFGAARALGPPDVLRVPVRLSRLAPAFDGFRIAVVSDIHLG PLLGRAHTERIVRMINEAQPDLVAVVGDLVDGTVEELGAAAEPLQDLVAPEGAFFVTGNHEYFVDDTPAW LRELERFGLDVLSNENTLLTRGGAGLHLAGVNDIAGESRSDPPDFDRALAGAGARGPTVLLAHQPIEVEK AADRGVDLQLSGHTHGGQMWPFHYAVELAQPTLAGLSRVGDTQLYVTRGAGFWGPPLRIGAPPDISVLTL RSGD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4868 | - | - | 100% (425) | metallophosphoesterase |
| M. gilvum PYR-GCK | Mflv_1023 | - | 3e-64 | 47.45% (274) | metallophosphoesterase |
| M. gilvum PYR-GCK | Mflv_1364 | - | 7e-11 | 27.48% (313) | metallophosphoesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3708 | - | 1e-09 | 27.54% (305) | hypothetical protein Mb3708 |
| M. tuberculosis H37Rv | Rv3683 | - | 1e-09 | 27.54% (305) | hypothetical protein Rv3683 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0407c | - | 4e-11 | 27.30% (304) | hypothetical protein MAB_0407c |
| M. marinum M | MMAR_5172 | - | 3e-09 | 26.14% (306) | hypothetical protein MMAR_5172 |
| M. avium 104 | MAV_0445 | - | 4e-11 | 27.85% (298) | secreted protein |
| M. smegmatis MC2 155 | MSMEG_6614 | - | 1e-148 | 66.16% (393) | integral membrane protein |
| M. thermoresistible (build 8) | TH_1617 | - | 1e-140 | 61.32% (393) | integral membrane protein |
| M. ulcerans Agy99 | MUL_4258 | - | 2e-09 | 26.14% (306) | hypothetical protein MUL_4258 |
| M. vanbaalenii PYR-1 | Mvan_5813 | - | 3e-60 | 44.85% (272) | metallophosphoesterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3708|M.bovis_AF2122/97 --------------------------------------------------
Rv3683|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5172|M.marinum_M --------------------------------------------------
MUL_4258|M.ulcerans_Agy99 --------------------------------------------------
MAV_0445|M.avium_104 --------------------------------------------------
MAB_0407c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4868|M.gilvum_PYR-GCK MTDEVRVSCVTQHPARRTRVEELPKLLKGCPLFLVVLGSVLALMHFYVWK
MSMEG_6614|M.smegmatis_MC2_155 -------------------------------MFIVVLIVVLASMHFYVWT
TH_1617|M.thermoresistible__bu -------------------------------MFILVLTAILALIHLYLWK
Mvan_5813|M.vanbaalenii_PYR-1 -------MSDNPAEAVEEAATPPRRSRGRWRRSAVVLAVMLLLFGVPWST
Mb3708|M.bovis_AF2122/97 --------------------------MAAVLP-----------TLIRTGA
Rv3683|M.tuberculosis_H37Rv --------------------------MAAVLP-----------TLIRTGA
MMAR_5172|M.marinum_M -------------------MAYAQPPITKLLPGPLSGRHRAASVLLRGSA
MUL_4258|M.ulcerans_Agy99 -------------------MAYAQPPITKLLPGPLSGRHRAASVLLRGSA
MAV_0445|M.avium_104 -------------------MADAHVSIARRRSGPPRGRRRALPILLRTGA
MAB_0407c|M.abscessus_ATCC_199 --------------------------MSTSLN----------TVIKRAAA
Mflv_4868|M.gilvum_PYR-GCK RTVKDTSQ-GRARRWLSAALVVLMLMLVAALVVPRTVGVPESRWIAWPGY
MSMEG_6614|M.smegmatis_MC2_155 RLAKNTTTPGRSRRVATVLFLIPTALLFAGLIVPRVFDIREAAWLSWPGF
TH_1617|M.thermoresistible__bu RLVKDTTVAGRTRWLLTGVLGALFVVLIAALLLPRMIGVTATRWLAWPGY
Mvan_5813|M.vanbaalenii_PYR-1 LVVGGAAWPTAVAVAGTLVFVAAFAGLPVAMMLG--HGPARRDWAAVLGD
: .
Mb3708|M.bovis_AF2122/97 VALGSAIAGIGYAALVERNAFVLR--------------------------
Rv3683|M.tuberculosis_H37Rv VALGSAIAGIGYAALVERNAFVLR--------------------------
MMAR_5172|M.marinum_M VALGTTVAGIGYASLIERNAFVLR--------------------------
MUL_4258|M.ulcerans_Agy99 VALGTTVAGIGYASLIERNAFVLR--------------------------
MAV_0445|M.avium_104 AALGSTVAGLGYAAIIERNAFVLR--------------------------
MAB_0407c|M.abscessus_ATCC_199 YSAGSAALGIGYASIIERNAFTVR--------------------------
Mflv_4868|M.gilvum_PYR-GCK LWFGVLVYLFLVLLALEPVRLVLRRWTRPAPPPTPTDAETADPEMAPAVD
MSMEG_6614|M.smegmatis_MC2_155 VWLALVFYLVLTLLVLEPVRLVLRRWVKRG------GAQEAAPEST-AVN
TH_1617|M.thermoresistible__bu LWFAVAGYLLLILLVLEPLRVVLRRRPRRE----------PTPEHSPVID
Mvan_5813|M.vanbaalenii_PYR-1 ALLGAAWVLFVWSVLGQLFEVVLLAAGVADP-------------------
. . : ..:
Mb3708|M.bovis_AF2122/97 ------EVTMPVLTPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPD
Rv3683|M.tuberculosis_H37Rv ------EVTMPVLTPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPD
MMAR_5172|M.marinum_M ------EVTMPVLSPGSTPLRVLHLSDLHMLPNQRRKQAWLRELASWEPD
MUL_4258|M.ulcerans_Agy99 ------EVTMPVLSPGSTPLRVLHLSDLHMLPNQRRKQAWLRELASWEPD
MAV_0445|M.avium_104 ------EITMPVLSPGSTPLRVLHISDLHMTPGQRRKQAWLRELAGWEPD
MAB_0407c|M.abscessus_ATCC_199 ------EATMDVLDPGASPLRVLHISDIHMRPGQRLKQAWLRELAQWQPD
Mflv_4868|M.gilvum_PYR-GCK RRVFLARTAAVTAGAAAVGLTGFGAARALGPPDVLRVPVRLSRLAPAFDG
MSMEG_6614|M.smegmatis_MC2_155 RRMFLARGGAVAAGVASVALVGTGASIALGPPKMLQVPVRLGRIDPAFNG
TH_1617|M.thermoresistible__bu RRLFLARGAAALAGVAAAGVVGAGASRALGDPDLLDVTVRLRGLHPAMDG
Mvan_5813|M.vanbaalenii_PYR-1 ---TRSRLVAAVVVTVAVGLLAWGYVEAMRVPRVKNLDVAIRRLGRGLDG
. : : * . : : .
Mb3708|M.bovis_AF2122/97 LVVNTGDNLAHP---------KAVPAVVQTLSDLLSRPGVFVFGSNDYFG
Rv3683|M.tuberculosis_H37Rv LVVNTGDNLAHP---------KAVPAVVQTLSDLLSRPGVFVFGSNDYFG
MMAR_5172|M.marinum_M LVVNTGDNLAHP---------KAVPAVVQTLGDLLSRPGVFVFGSNDYFG
MUL_4258|M.ulcerans_Agy99 LVVNTGDNLAHP---------KAVPAVVQTLGDLLSRPGVFVFGSNDYFG
MAV_0445|M.avium_104 LVVNTGDNLAHP---------KAVPAVIQALGDLLSRPGVFVFGSNDYFG
MAB_0407c|M.abscessus_ATCC_199 LVINTGDNLAHP---------KAVSSVVQSLGDLLSIPGLFVFGSNDYFG
Mflv_4868|M.gilvum_PYR-GCK FRIAVVSDIHLGPLLGRAHTERIVRMINEAQPDLVAVVGDLVDGTVEELG
MSMEG_6614|M.smegmatis_MC2_155 FRIAVVSDIHLGPMLGRSHTERIVRMINETEPDLVAIVGDLVDGTVSELG
TH_1617|M.thermoresistible__bu FRVAMLSDLHLGPLLGRSFTERIVRLVNDTEPDLIVIVGDLVDGEVHELA
Mvan_5813|M.vanbaalenii_PYR-1 LRVAVITDTHYGPIDRARWSAGVVERVNELDADVVCHVGDIADGTADIRE
: : : * : : *:: * :. *
Mb3708|M.bovis_AF2122/97 PRLKNPMNYLTSP-DHRVRGAALPWQDLRAAFTER----GWLDLTHTRRE
Rv3683|M.tuberculosis_H37Rv PRLKNPMNYLTSP-DHRVRGAALPWQDLRAAFTER----GWLDLTHTRRE
MMAR_5172|M.marinum_M PRLKNPANYLINP-GHRVRGEPLPWQDLRAAFTER----GWLDLTHTRRE
MUL_4258|M.ulcerans_Agy99 PRLKNPANYLINP-GHRVRGEPLPWQDLRAAFTER----GWLDLTHTRRE
MAV_0445|M.avium_104 PHLKNPLNYVTNP-SHRVRGEPLPWQDLRAAFTER----GWLDLTHTRRE
MAB_0407c|M.abscessus_ATCC_199 PRLKNPAKYLYKS-HERKHGEPLPWQDLRAAFTER----GWHDMTHTRRE
Mflv_4868|M.gilvum_PYR-GCK AAAEPLQDLVAPEGAFFVTGNHEYFVDDTPAWLRELERFGLDVLSNENTL
MSMEG_6614|M.smegmatis_MC2_155 AAVEPLQDLAAREGSFFVTGNHEYFTDETGEWLRELERLGVAPLRNENTP
TH_1617|M.thermoresistible__bu AATEPLHALRAAHGTFFATGNHEYYLTDTDAWIEQLDRLGVGTLRNAHTV
Mvan_5813|M.vanbaalenii_PYR-1 AQASPLARVRARSARVYVTGNHEYFS-EAQGWLDYMERIGWDVLHNRHVV
. . * : : * : : .
Mb3708|M.bovis_AF2122/97 FEVAGLHIAAAGVDDPHIDRD----RYDTIAGPASPAANLRLGLTHSPEP
Rv3683|M.tuberculosis_H37Rv FEVAGLHIAAAGVDDPHIDRD----RYDTIAGPASPAANLRLGLTHSPEP
MMAR_5172|M.marinum_M FEVAGLHIAAAGVDDPHINRD----RYDAIAGPASPAANLRLGLTHSPEP
MUL_4258|M.ulcerans_Agy99 FEVAGLHIAAAGVDDPHINRD----RYDAIAGPASPAANLRLGLTHSPEP
MAV_0445|M.avium_104 FEVAGLHVAAAGVDDPHIDRD----RYDTIAGPASPAANLRLGLTHSPEP
MAB_0407c|M.abscessus_ATCC_199 IEVGGVRIAAAGVDDPHLHRD----RYDTIAGMPNPLATLRLGLTHSPEP
Mflv_4868|M.gilvum_PYR-GCK LTRGGAGLHLAGVNDIAGESR---SDPPDFDRALAGAGARGPTVLLAHQP
MSMEG_6614|M.smegmatis_MC2_155 IRRGRASFALAGVNDVAGERS---SDPPDLDRALAGVAPSQATVLLAHQP
TH_1617|M.thermoresistible__bu IRRGPAAFTLAGVTDVAGARR---GDPPDFDRALSGTDPALPTVLLAHQP
Mvan_5813|M.vanbaalenii_PYR-1 VERGGDRMVVAGIDDATASGSGVSGHGADLDSALIGADRSLPVLLLAHQP
. . . **: * : : : :*
Mb3708|M.bovis_AF2122/97 RVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWG
Rv3683|M.tuberculosis_H37Rv RVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWG
MMAR_5172|M.marinum_M RVLDRFAADGYQLVMAGHTHGGQLCLPFYGALVTNCGLDRTRAKGASQWG
MUL_4258|M.ulcerans_Agy99 RVLDRFAADGYQLVMAGHTHGGQLCLPFYGALVTNCGLDRTRAKGASQWG
MAV_0445|M.avium_104 RVLDRFAADGYQLVMAGHTHGGQVCLPFYGALVTNCGLDRSRAKGPSRWG
MAB_0407c|M.abscessus_ATCC_199 RVLDRFAEDGYQLVMAGHTHGGQLCLPLYGAIVTNCELDRSRVKGPSQWG
Mflv_4868|M.gilvum_PYR-GCK IEVEKAADRGVDLQLSGHTHGGQMWP-----FHYAVELAQPTLAGLSRVG
MSMEG_6614|M.smegmatis_MC2_155 VQVTEAAERGVDLQLSGHTHGGQLWP-----FHYVVSAVQPSLAGLSTVG
TH_1617|M.thermoresistible__bu DLITEAAARGVDLQLSGHTHGGQVWP-----FHLAVRAVQPTLAGLAAVG
Mvan_5813|M.vanbaalenii_PYR-1 KQVVHAVRGGVDLQISGHTHGGQIWP-----FNFLVRLEQPVVHGLSTHG
: . . * :* ::*******: : :. * : *
Mb3708|M.bovis_AF2122/97 ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSSSNLGRSQ
Rv3683|M.tuberculosis_H37Rv ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSSSNLGRSQ
MMAR_5172|M.marinum_M ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIAAPMGGRDSSSNLDRSQ
MUL_4258|M.ulcerans_Agy99 ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIAAPMGGRDSSSNLDRSQ
MAV_0445|M.avium_104 AHMQLHVSAGMGTSPYAPVRFCCRPEATLLTLIATPMGDRDAVSDLSRSQ
MAB_0407c|M.abscessus_ATCC_199 SHMQLHVSAGIGTSPFAPMRFFCRPEATLLTLVPARTSGHGADAESGDRS
Mflv_4868|M.gilvum_PYR-GCK D-TQLYVTRGAGFWG-PPLRIGAPPDISVLTLRSGD--------------
MSMEG_6614|M.smegmatis_MC2_155 D-TQLYVTRGAGFWG-PPVRIGAPPDISVLTLRADQ--------------
TH_1617|M.thermoresistible__bu D-TQLYVSRGAGFWG-PPARVGAPPDISVLTLRAAG--------------
Mvan_5813|M.vanbaalenii_PYR-1 DRTQLYTSRGTGFWG-PPFRVFAPSEITVLTLRRCSSDDDQAARHEPR--
:*:.: * * .* *. . .: ::***
Mb3708|M.bovis_AF2122/97 PTVSVR
Rv3683|M.tuberculosis_H37Rv PTVSVR
MMAR_5172|M.marinum_M PTMSIR
MUL_4258|M.ulcerans_Agy99 PTMSIR
MAV_0445|M.avium_104 PTASVR
MAB_0407c|M.abscessus_ATCC_199 PSATVQ
Mflv_4868|M.gilvum_PYR-GCK ------
MSMEG_6614|M.smegmatis_MC2_155 ------
TH_1617|M.thermoresistible__bu ------
Mvan_5813|M.vanbaalenii_PYR-1 ------