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FIVVLIVVLASMHFYVWTRLAKNTTTPGRSRRVATVLFLIPTALLFAGLIVPRVFDIREAAWLSWPGFVW LALVFYLVLTLLVLEPVRLVLRRWVKRGGAQEAAPESTAVNRRMFLARGGAVAAGVASVALVGTGASIAL GPPKMLQVPVRLGRIDPAFNGFRIAVVSDIHLGPMLGRSHTERIVRMINETEPDLVAIVGDLVDGTVSEL GAAVEPLQDLAAREGSFFVTGNHEYFTDETGEWLRELERLGVAPLRNENTPIRRGRASFALAGVNDVAGE RSSDPPDLDRALAGVAPSQATVLLAHQPVQVTEAAERGVDLQLSGHTHGGQLWPFHYVVSAVQPSLAGLS TVGDTQLYVTRGAGFWGPPVRIGAPPDISVLTLRADQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6614 | - | - | 100% (388) | integral membrane protein |
| M. smegmatis MC2 155 | MSMEG_6202 | - | 3e-11 | 27.24% (312) | secreted protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3708 | - | 3e-12 | 29.24% (301) | hypothetical protein Mb3708 |
| M. gilvum PYR-GCK | Mflv_4868 | - | 1e-148 | 66.16% (393) | metallophosphoesterase |
| M. tuberculosis H37Rv | Rv3683 | - | 3e-12 | 29.24% (301) | hypothetical protein Rv3683 |
| M. leprae Br4923 | MLBr_02309 | - | 1e-08 | 26.69% (296) | hypothetical protein MLBr_02309 |
| M. abscessus ATCC 19977 | MAB_0407c | - | 4e-11 | 26.89% (305) | hypothetical protein MAB_0407c |
| M. marinum M | MMAR_5172 | - | 8e-13 | 29.24% (301) | hypothetical protein MMAR_5172 |
| M. avium 104 | MAV_0445 | - | 8e-13 | 27.08% (325) | secreted protein |
| M. thermoresistible (build 8) | TH_1617 | - | 1e-136 | 61.14% (386) | integral membrane protein |
| M. ulcerans Agy99 | MUL_4258 | - | 5e-13 | 29.24% (301) | hypothetical protein MUL_4258 |
| M. vanbaalenii PYR-1 | Mvan_5813 | - | 1e-57 | 44.32% (273) | metallophosphoesterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3708|M.bovis_AF2122/97 --------------------------------------------------
Rv3683|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5172|M.marinum_M --------------------------------------------------
MUL_4258|M.ulcerans_Agy99 --------------------------------------------------
MAV_0445|M.avium_104 --------------------------------------------------
MLBr_02309|M.leprae_Br4923 --------------------------------------------------
MAB_0407c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6614|M.smegmatis_MC2_155 -------------------------------MFIVVLIVVLASMHFYVWT
Mflv_4868|M.gilvum_PYR-GCK MTDEVRVSCVTQHPARRTRVEELPKLLKGCPLFLVVLGSVLALMHFYVWK
TH_1617|M.thermoresistible__bu -------------------------------MFILVLTAILALIHLYLWK
Mvan_5813|M.vanbaalenii_PYR-1 -------MSDNPAEAVEEAATPPRRSRGRWRRSAVVLAVMLLLFGVPWST
Mb3708|M.bovis_AF2122/97 --------------------------MAAVLP-----------TLIRTGA
Rv3683|M.tuberculosis_H37Rv --------------------------MAAVLP-----------TLIRTGA
MMAR_5172|M.marinum_M -------------------MAYAQPPITKLLPGPLSGRHRAASVLLRGSA
MUL_4258|M.ulcerans_Agy99 -------------------MAYAQPPITKLLPGPLSGRHRAASVLLRGSA
MAV_0445|M.avium_104 -------------------MADAHVSIARRRSGPPRGRRRALPILLRTGA
MLBr_02309|M.leprae_Br4923 --------------------------------------------MIRTGA
MAB_0407c|M.abscessus_ATCC_199 --------------------------MSTSLN----------TVIKRAAA
MSMEG_6614|M.smegmatis_MC2_155 RLAKNTTTPGRSRRVATVLFLIPTALLFAGLIVPRVFDIREAAWLSWPGF
Mflv_4868|M.gilvum_PYR-GCK RTVKDTSQ-GRARRWLSAALVVLMLMLVAALVVPRTVGVPESRWIAWPGY
TH_1617|M.thermoresistible__bu RLVKDTTVAGRTRWLLTGVLGALFVVLIAALLLPRMIGVTATRWLAWPGY
Mvan_5813|M.vanbaalenii_PYR-1 LVVGGAAWPTAVAVAGTLVFVAAFAGLPVAMMLG--HGPARRDWAAVLGD
.
Mb3708|M.bovis_AF2122/97 VALGSAIAGIGYAALVERNAFVLR--------------------------
Rv3683|M.tuberculosis_H37Rv VALGSAIAGIGYAALVERNAFVLR--------------------------
MMAR_5172|M.marinum_M VALGTTVAGIGYASLIERNAFVLR--------------------------
MUL_4258|M.ulcerans_Agy99 VALGTTVAGIGYASLIERNAFVLR--------------------------
MAV_0445|M.avium_104 AALGSTVAGLGYAAIIERNAFVLR--------------------------
MLBr_02309|M.leprae_Br4923 LVLSSAATGVGYASIVERNAFVLR--------------------------
MAB_0407c|M.abscessus_ATCC_199 YSAGSAALGIGYASIIERNAFTVR--------------------------
MSMEG_6614|M.smegmatis_MC2_155 VWLALVFYLVLTLLVLEPVRLVLRRWVKRG------GAQEAAPEST-AVN
Mflv_4868|M.gilvum_PYR-GCK LWFGVLVYLFLVLLALEPVRLVLRRWTRPAPPPTPTDAETADPEMAPAVD
TH_1617|M.thermoresistible__bu LWFAVAGYLLLILLVLEPLRVVLRRRPRRE----------PTPEHSPVID
Mvan_5813|M.vanbaalenii_PYR-1 ALLGAAWVLFVWSVLGQLFEVVLLAAGVADP-------------------
. . : ..:
Mb3708|M.bovis_AF2122/97 ------EVTMPVLTPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPD
Rv3683|M.tuberculosis_H37Rv ------EVTMPVLTPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPD
MMAR_5172|M.marinum_M ------EVTMPVLSPGSTPLRVLHLSDLHMLPNQRRKQAWLRELASWEPD
MUL_4258|M.ulcerans_Agy99 ------EVTMPVLSPGSTPLRVLHLSDLHMLPNQRRKQAWLRELASWEPD
MAV_0445|M.avium_104 ------EITMPVLSPGSTPLRVLHISDLHMTPGQRRKQAWLRELAGWEPD
MLBr_02309|M.leprae_Br4923 ------ELTIPILTPGSTPLRVLHISDIHMMPHQRRKQAWLRDLATWQPD
MAB_0407c|M.abscessus_ATCC_199 ------EATMDVLDPGASPLRVLHISDIHMRPGQRLKQAWLRELAQWQPD
MSMEG_6614|M.smegmatis_MC2_155 RRMFLARGGAVAAGVASVALVGTGASIALGPPKMLQVPVRLGRIDPAFNG
Mflv_4868|M.gilvum_PYR-GCK RRVFLARTAAVTAGAAAVGLTGFGAARALGPPDVLRVPVRLSRLAPAFDG
TH_1617|M.thermoresistible__bu RRLFLARGAAALAGVAAAGVVGAGASRALGDPDLLDVTVRLRGLHPAMDG
Mvan_5813|M.vanbaalenii_PYR-1 ---TRSRLVAAVVVTVAVGLLAWGYVEAMRVPRVKNLDVAIRRLGRGLDG
. : : * . : : .
Mb3708|M.bovis_AF2122/97 LVVNTGDNLAHP---------KAVPAVVQTLSDLLSRPGVFVFGSNDYFG
Rv3683|M.tuberculosis_H37Rv LVVNTGDNLAHP---------KAVPAVVQTLSDLLSRPGVFVFGSNDYFG
MMAR_5172|M.marinum_M LVVNTGDNLAHP---------KAVPAVVQTLGDLLSRPGVFVFGSNDYFG
MUL_4258|M.ulcerans_Agy99 LVVNTGDNLAHP---------KAVPAVVQTLGDLLSRPGVFVFGSNDYFG
MAV_0445|M.avium_104 LVVNTGDNLAHP---------KAVPAVIQALGDLLSRPGVFVFGSNDYFG
MLBr_02309|M.leprae_Br4923 LVVNTGDNLAHP---------KAVPGVIQALGNLLSRPGVFVFGSNDYFG
MAB_0407c|M.abscessus_ATCC_199 LVINTGDNLAHP---------KAVSSVVQSLGDLLSIPGLFVFGSNDYFG
MSMEG_6614|M.smegmatis_MC2_155 FRIAVVSDIHLGPMLGRSHTERIVRMINETEPDLVAIVGDLVDGTVSELG
Mflv_4868|M.gilvum_PYR-GCK FRIAVVSDIHLGPLLGRAHTERIVRMINEAQPDLVAVVGDLVDGTVEELG
TH_1617|M.thermoresistible__bu FRVAMLSDLHLGPLLGRSFTERIVRLVNDTEPDLIVIVGDLVDGEVHELA
Mvan_5813|M.vanbaalenii_PYR-1 LRVAVITDTHYGPIDRARWSAGVVERVNELDADVVCHVGDIADGTADIRE
: : : * : : ::: * :. *
Mb3708|M.bovis_AF2122/97 PRLKNPMNYLTSP-DHRVRGAALPWQDLRAAFTER----GWLDLTHTRRE
Rv3683|M.tuberculosis_H37Rv PRLKNPMNYLTSP-DHRVRGAALPWQDLRAAFTER----GWLDLTHTRRE
MMAR_5172|M.marinum_M PRLKNPANYLINP-GHRVRGEPLPWQDLRAAFTER----GWLDLTHTRRE
MUL_4258|M.ulcerans_Agy99 PRLKNPANYLINP-GHRVRGEPLPWQDLRAAFTER----GWLDLTHTRRE
MAV_0445|M.avium_104 PHLKNPLNYVTNP-SHRVRGEPLPWQDLRAAFTER----GWLDLTHTRRE
MLBr_02309|M.leprae_Br4923 PHLKNPVNYLTNP-THRVRGKPLPWKDLRAAFTER----GWLDLTHTRRE
MAB_0407c|M.abscessus_ATCC_199 PRLKNPAKYLYKS-HERKHGEPLPWQDLRAAFTER----GWHDMTHTRRE
MSMEG_6614|M.smegmatis_MC2_155 AAVEPLQDLAAREGSFFVTGNHEYFTDETGEWLRELERLGVAPLRNENTP
Mflv_4868|M.gilvum_PYR-GCK AAAEPLQDLVAPEGAFFVTGNHEYFVDDTPAWLRELERFGLDVLSNENTL
TH_1617|M.thermoresistible__bu AATEPLHALRAAHGTFFATGNHEYYLTDTDAWIEQLDRLGVGTLRNAHTV
Mvan_5813|M.vanbaalenii_PYR-1 AQASPLARVRARSARVYVTGNHEYFS-EAQGWLDYMERIGWDVLHNRHVV
. . * : : * : : .
Mb3708|M.bovis_AF2122/97 FEVAGLHIAAAGVDDPHIDRD----RYDTIAGPASPAANLRLGLTHSPEP
Rv3683|M.tuberculosis_H37Rv FEVAGLHIAAAGVDDPHIDRD----RYDTIAGPASPAANLRLGLTHSPEP
MMAR_5172|M.marinum_M FEVAGLHIAAAGVDDPHINRD----RYDAIAGPASPAANLRLGLTHSPEP
MUL_4258|M.ulcerans_Agy99 FEVAGLHIAAAGVDDPHINRD----RYDAIAGPASPAANLRLGLTHSPEP
MAV_0445|M.avium_104 FEVAGLHVAAAGVDDPHIDRD----RYDTIAGPASPAANLRLGLTHSPEP
MLBr_02309|M.leprae_Br4923 FEVAGLHIAAAGVDDPHISRD----RYDTIAGPASPVANLRLGLTHSPEP
MAB_0407c|M.abscessus_ATCC_199 IEVGGVRIAAAGVDDPHLHRD----RYDTIAGMPNPLATLRLGLTHSPEP
MSMEG_6614|M.smegmatis_MC2_155 IRRGRASFALAGVNDVAGERS---SDPPDLDRALAGVAPSQATVLLAHQP
Mflv_4868|M.gilvum_PYR-GCK LTRGGAGLHLAGVNDIAGESR---SDPPDFDRALAGAGARGPTVLLAHQP
TH_1617|M.thermoresistible__bu IRRGPAAFTLAGVTDVAGARR---GDPPDFDRALSGTDPALPTVLLAHQP
Mvan_5813|M.vanbaalenii_PYR-1 VERGGDRMVVAGIDDATASGSGVSGHGADLDSALIGADRSLPVLLLAHQP
. . . **: * : : : :*
Mb3708|M.bovis_AF2122/97 RVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWG
Rv3683|M.tuberculosis_H37Rv RVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWG
MMAR_5172|M.marinum_M RVLDRFAADGYQLVMAGHTHGGQLCLPFYGALVTNCGLDRTRAKGASQWG
MUL_4258|M.ulcerans_Agy99 RVLDRFAADGYQLVMAGHTHGGQLCLPFYGALVTNCGLDRTRAKGASQWG
MAV_0445|M.avium_104 RVLDRFAADGYQLVMAGHTHGGQVCLPFYGALVTNCGLDRSRAKGPSRWG
MLBr_02309|M.leprae_Br4923 RVLDRFAADCYQLVMAGHTHGGQLCLPFYGALVTNCGLDRSRAKGLSRWD
MAB_0407c|M.abscessus_ATCC_199 RVLDRFAEDGYQLVMAGHTHGGQLCLPLYGAIVTNCELDRSRVKGPSQWG
MSMEG_6614|M.smegmatis_MC2_155 VQVTEAAERGVDLQLSGHTHGGQLWP-----FHYVVSAVQPSLAGLSTVG
Mflv_4868|M.gilvum_PYR-GCK IEVEKAADRGVDLQLSGHTHGGQMWP-----FHYAVELAQPTLAGLSRVG
TH_1617|M.thermoresistible__bu DLITEAAARGVDLQLSGHTHGGQVWP-----FHLAVRAVQPTLAGLAAVG
Mvan_5813|M.vanbaalenii_PYR-1 KQVVHAVRGGVDLQISGHTHGGQIWP-----FNFLVRLEQPVVHGLSTHG
: . . :* ::*******: : :. * : .
Mb3708|M.bovis_AF2122/97 ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSS---SNLG
Rv3683|M.tuberculosis_H37Rv ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSS---SNLG
MMAR_5172|M.marinum_M ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIAAPMGGRDSS---SNLD
MUL_4258|M.ulcerans_Agy99 ANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIAAPMGGRDSS---SNLD
MAV_0445|M.avium_104 AHMQLHVSAGMGTSPYAPVRFCCRPEATLLTLIATPMGDRDAV---SDLS
MLBr_02309|M.leprae_Br4923 ADMRLHVSAGIGTSPLAPMRFCCRPEATLLTLIATPMGSRVESPVRTGAV
MAB_0407c|M.abscessus_ATCC_199 SHMQLHVSAGIGTSPFAPMRFFCRPEATLLTLVPARTSGHGAD---AESG
MSMEG_6614|M.smegmatis_MC2_155 D-TQLYVTRGAGFWG-PPVRIGAPPDISVLTLRADQ--------------
Mflv_4868|M.gilvum_PYR-GCK D-TQLYVTRGAGFWG-PPLRIGAPPDISVLTLRSGD--------------
TH_1617|M.thermoresistible__bu D-TQLYVSRGAGFWG-PPARVGAPPDISVLTLRAAG--------------
Mvan_5813|M.vanbaalenii_PYR-1 DRTQLYTSRGTGFWG-PPFRVFAPSEITVLTLRRCSSDDDQAA-------
:*:.: * * .* *. . .: ::***
Mb3708|M.bovis_AF2122/97 RSQPTVSVR---------------
Rv3683|M.tuberculosis_H37Rv RSQPTVSVR---------------
MMAR_5172|M.marinum_M RSQPTMSIR---------------
MUL_4258|M.ulcerans_Agy99 RSQPTMSIR---------------
MAV_0445|M.avium_104 RSQPTASVR---------------
MLBr_02309|M.leprae_Br4923 RNQQLQCVERAHRDSGPRPPTQLD
MAB_0407c|M.abscessus_ATCC_199 DRSPSATVQ---------------
MSMEG_6614|M.smegmatis_MC2_155 ------------------------
Mflv_4868|M.gilvum_PYR-GCK ------------------------
TH_1617|M.thermoresistible__bu ------------------------
Mvan_5813|M.vanbaalenii_PYR-1 RHEPR-------------------