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TDKPVEVTAERSREERRRRSPRRRRWVRTLIVLTIMLLLFGVPWWTLVMSGNAWPVPVLVAGTVVFAAAF VALPTTMLLGHGRRSDPASVAGDVLLGVGWVLFVWSVLGQLFGLVLLVGGVEDPARSRIVTTAVLVVSVG LLGWGHFEAMRVPQIRRLDVTLARLGPALDGLRVAVITDTHYGPINRARWSAAVVDRVNELDADVVCHVG DIADGTTDIRDAQAAPLAMVRAKAARVYVTGNHEYFSEAQGWLDYMERIGWDALHNRHIVVERGGDRLVV AGVDDATAAGSGVRGHGADLTAALDGADPSSPVLLLAHQPKQVVRAAAAGVDLQLSGHTHGGQMWPFNFL VRLEQPVVQGLSRHGERTQLYTSRGTGFWGPPFRVFAPSEITLLTLRRAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1023 | - | - | 100% (401) | metallophosphoesterase |
| M. gilvum PYR-GCK | Mflv_4868 | - | 3e-64 | 47.45% (274) | metallophosphoesterase |
| M. gilvum PYR-GCK | Mflv_1364 | - | 9e-11 | 30.25% (281) | metallophosphoesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3708 | - | 2e-09 | 28.24% (301) | hypothetical protein Mb3708 |
| M. tuberculosis H37Rv | Rv3683 | - | 2e-09 | 28.24% (301) | hypothetical protein Rv3683 |
| M. leprae Br4923 | MLBr_02309 | - | 9e-10 | 28.25% (308) | hypothetical protein MLBr_02309 |
| M. abscessus ATCC 19977 | MAB_0407c | - | 2e-12 | 28.72% (289) | hypothetical protein MAB_0407c |
| M. marinum M | MMAR_5172 | - | 7e-10 | 27.88% (312) | hypothetical protein MMAR_5172 |
| M. avium 104 | MAV_0445 | - | 3e-10 | 30.22% (278) | secreted protein |
| M. smegmatis MC2 155 | MSMEG_6614 | - | 2e-60 | 37.53% (397) | integral membrane protein |
| M. thermoresistible (build 8) | TH_1617 | - | 4e-62 | 36.13% (393) | integral membrane protein |
| M. ulcerans Agy99 | MUL_4258 | - | 4e-10 | 27.88% (312) | hypothetical protein MUL_4258 |
| M. vanbaalenii PYR-1 | Mvan_5813 | - | 1e-176 | 74.75% (400) | metallophosphoesterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3708|M.bovis_AF2122/97 --------------------------------------------------
Rv3683|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5172|M.marinum_M --------------------------------------------------
MUL_4258|M.ulcerans_Agy99 --------------------------------------------------
MAV_0445|M.avium_104 --------------------------------------------------
MLBr_02309|M.leprae_Br4923 --------------------------------------------------
MAB_0407c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1023|M.gilvum_PYR-GCK MTDKPVEVTAERSREERRRRSPRRRRWVRTLIVLTIMLLLFGVPWWTLVM
Mvan_5813|M.vanbaalenii_PYR-1 MSDNPAEAVEEAATPPRRSRG----RWRRSAVVLAVMLLLFGVPWSTLVV
MSMEG_6614|M.smegmatis_MC2_155 ----------------------------MFIVVLIVVLASMHFYVWTRLA
TH_1617|M.thermoresistible__bu ----------------------------MFILVLTAILALIHLYLWKRLV
Mb3708|M.bovis_AF2122/97 --------------------------------------------------
Rv3683|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5172|M.marinum_M --------------------------------------------MAYAQP
MUL_4258|M.ulcerans_Agy99 --------------------------------------------MAYAQP
MAV_0445|M.avium_104 --------------------------------------------MADAHV
MLBr_02309|M.leprae_Br4923 --------------------------------------------------
MAB_0407c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1023|M.gilvum_PYR-GCK SGNAWPVPVLVAGTVVFAAAFVALPTTMLLGHG---RRSDPASVAGDVLL
Mvan_5813|M.vanbaalenii_PYR-1 GGAAWPTAVAVAGTLVFVAAFAGLPVAMMLGHGP--ARRDWAAVLGDALL
MSMEG_6614|M.smegmatis_MC2_155 KNTTTPGRSRRVATVLFLIPTALLFAGLIVPRVFDIREAAWLSWPGFVWL
TH_1617|M.thermoresistible__bu KDTTVAGRTRWLLTGVLGALFVVLIAALLLPRMIGVTATRWLAWPGYLWF
Mb3708|M.bovis_AF2122/97 -MAAVLP-----------TLIRT---------------------------
Rv3683|M.tuberculosis_H37Rv -MAAVLP-----------TLIRT---------------------------
MMAR_5172|M.marinum_M PITKLLPGPLSGRHRAASVLLRG---------------------------
MUL_4258|M.ulcerans_Agy99 PITKLLPGPLSGRHRAASVLLRG---------------------------
MAV_0445|M.avium_104 SIARRRSGPPRGRRRALPILLRT---------------------------
MLBr_02309|M.leprae_Br4923 -------------------MIRT---------------------------
MAB_0407c|M.abscessus_ATCC_199 -MSTSLN----------TVIKRA---------------------------
Mflv_1023|M.gilvum_PYR-GCK GVGWVLFVWSVLGQLFGLVLLV---------GGVEDPAR------SRIVT
Mvan_5813|M.vanbaalenii_PYR-1 GAAWVLFVWSVLGQLFEVVLLA---------AGVADPTR------SRLVA
MSMEG_6614|M.smegmatis_MC2_155 ALVFYLVLTLLVLEPVRLVLRRWVKRGGAQEAAPESTAVNRRMFLARGGA
TH_1617|M.thermoresistible__bu AVAGYLLLILLVLEPLRVVLRRRPRR---EPTPEHSPVIDRRLFLARGAA
:
Mb3708|M.bovis_AF2122/97 -GAVALGSAIAGIGYAALVERNAFVLREVTMPVLTPGSTPLRVLHISDLH
Rv3683|M.tuberculosis_H37Rv -GAVALGSAIAGIGYAALVERNAFVLREVTMPVLTPGSTPLRVLHISDLH
MMAR_5172|M.marinum_M -SAVALGTTVAGIGYASLIERNAFVLREVTMPVLSPGSTPLRVLHLSDLH
MUL_4258|M.ulcerans_Agy99 -SAVALGTTVAGIGYASLIERNAFVLREVTMPVLSPGSTPLRVLHLSDLH
MAV_0445|M.avium_104 -GAAALGSTVAGLGYAAIIERNAFVLREITMPVLSPGSTPLRVLHISDLH
MLBr_02309|M.leprae_Br4923 -GALVLSSAATGVGYASIVERNAFVLRELTIPILTPGSTPLRVLHISDIH
MAB_0407c|M.abscessus_ATCC_199 -AAYSAGSAALGIGYASIIERNAFTVREATMDVLDPGASPLRVLHISDIH
Mflv_1023|M.gilvum_PYR-GCK TAVLVVSVGLLGWGHFEAMRVPQIRRLDVTLARLGPALDGLRVAVITDTH
Mvan_5813|M.vanbaalenii_PYR-1 AVVVTVAVGLLAWGYVEAMRVPRVKNLDVAIRRLGRGLDGLRVAVITDTH
MSMEG_6614|M.smegmatis_MC2_155 VAAGVASVALVGTGASIALGPPKMLQVPVRLGRIDPAFNGFRIAVVSDIH
TH_1617|M.thermoresistible__bu ALAGVAAAGVVGAGASRALGDPDLLDVTVRLRGLHPAMDGFRVAMLSDLH
. . . * : . : : . :*: ::* *
Mb3708|M.bovis_AF2122/97 MLPNQHR--KQAWLRELASWEPDLVVNTGDNLA-HPKAVPAVVQTLSDLL
Rv3683|M.tuberculosis_H37Rv MLPNQHR--KQAWLRELASWEPDLVVNTGDNLA-HPKAVPAVVQTLSDLL
MMAR_5172|M.marinum_M MLPNQRR--KQAWLRELASWEPDLVVNTGDNLA-HPKAVPAVVQTLGDLL
MUL_4258|M.ulcerans_Agy99 MLPNQRR--KQAWLRELASWEPDLVVNTGDNLA-HPKAVPAVVQTLGDLL
MAV_0445|M.avium_104 MTPGQRR--KQAWLRELAGWEPDLVVNTGDNLA-HPKAVPAVIQALGDLL
MLBr_02309|M.leprae_Br4923 MMPHQRR--KQAWLRDLATWQPDLVVNTGDNLA-HPKAVPGVIQALGNLL
MAB_0407c|M.abscessus_ATCC_199 MRPGQRL--KQAWLRELAQWQPDLVINTGDNLA-HPKAVSSVVQSLGDLL
Mflv_1023|M.gilvum_PYR-GCK YGPINRARWSAAVVDRVNELDADVVCHVGDIADGTTDIRDAQAAPLAMVR
Mvan_5813|M.vanbaalenii_PYR-1 YGPIDRARWSAGVVERVNELDADVVCHVGDIADGTADIREAQASPLARVR
MSMEG_6614|M.smegmatis_MC2_155 LGPMLGRSHTERIVRMINETEPDLVAIVGDLVDGTVSELGAAVEPLQDLA
TH_1617|M.thermoresistible__bu LGPLLGRSFTERIVRLVNDTEPDLIVIVGDLVDGEVHELAAATEPLHALR
* . : : :.*:: .** . .* :
Mb3708|M.bovis_AF2122/97 SRPG-VFVFGSNDYFGPRLKNPMNYLTSPDHRVRGAALPWQDLRAAFTER
Rv3683|M.tuberculosis_H37Rv SRPG-VFVFGSNDYFGPRLKNPMNYLTSPDHRVRGAALPWQDLRAAFTER
MMAR_5172|M.marinum_M SRPG-VFVFGSNDYFGPRLKNPANYLINPGHRVRGEPLPWQDLRAAFTER
MUL_4258|M.ulcerans_Agy99 SRPG-VFVFGSNDYFGPRLKNPANYLINPGHRVRGEPLPWQDLRAAFTER
MAV_0445|M.avium_104 SRPG-VFVFGSNDYFGPHLKNPLNYVTNPSHRVRGEPLPWQDLRAAFTER
MLBr_02309|M.leprae_Br4923 SRPG-VFVFGSNDYFGPHLKNPVNYLTNPTHRVRGKPLPWKDLRAAFTER
MAB_0407c|M.abscessus_ATCC_199 SIPG-LFVFGSNDYFGPRLKNPAKYLYKSHERKHGEPLPWQDLRAAFTER
Mflv_1023|M.gilvum_PYR-GCK AKAARVYVTGNHEYFS-EAQGWLDYMER---------IGWDALHNRHIV-
Mvan_5813|M.vanbaalenii_PYR-1 ARSARVYVTGNHEYFS-EAQGWLDYMER---------IGWDVLHNRHVV-
MSMEG_6614|M.smegmatis_MC2_155 AREGSFFVTGNHEYFTDETGEWLRELER---------LGVAPLRNENTP-
TH_1617|M.thermoresistible__bu AAHGTFFATGNHEYYLTDTDAWIEQLDR---------LGVGTLRNAHTV-
: . .:. *.::*: : : *:
Mb3708|M.bovis_AF2122/97 GWLDLTHTRREFEVAGLHIAAAGVDDPHIDRDRYDTIAGPASPAANLRLG
Rv3683|M.tuberculosis_H37Rv GWLDLTHTRREFEVAGLHIAAAGVDDPHIDRDRYDTIAGPASPAANLRLG
MMAR_5172|M.marinum_M GWLDLTHTRREFEVAGLHIAAAGVDDPHINRDRYDAIAGPASPAANLRLG
MUL_4258|M.ulcerans_Agy99 GWLDLTHTRREFEVAGLHIAAAGVDDPHINRDRYDAIAGPASPAANLRLG
MAV_0445|M.avium_104 GWLDLTHTRREFEVAGLHVAAAGVDDPHIDRDRYDTIAGPASPAANLRLG
MLBr_02309|M.leprae_Br4923 GWLDLTHTRREFEVAGLHIAAAGVDDPHISRDRYDTIAGPASPVANLRLG
MAB_0407c|M.abscessus_ATCC_199 GWHDMTHTRREIEVGGVRIAAAGVDDPHLHRDRYDTIAGMPNPLATLRLG
Mflv_1023|M.gilvum_PYR-GCK ----VERGGDRLVVAGVDDATAAGSGVRGHGADLTAALDGADPSSPVLL-
Mvan_5813|M.vanbaalenii_PYR-1 ----VERGGDRMVVAGIDDATASGSGVSGHGADLDSALIGADRSLPVLL-
MSMEG_6614|M.smegmatis_MC2_155 ----IRRGRASFALAGVNDVAGER---SSDPPDLDRALAGVAPSQATVL-
TH_1617|M.thermoresistible__bu ----IRRGPAAFTLAGVTDVAGAR---RGDPPDFDRALSGTDPALPTVL-
: : : :.*: .:. *
Mb3708|M.bovis_AF2122/97 LTHSPEPRVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRA
Rv3683|M.tuberculosis_H37Rv LTHSPEPRVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRA
MMAR_5172|M.marinum_M LTHSPEPRVLDRFAADGYQLVMAGHTHGGQLCLPFYGALVTNCGLDRTRA
MUL_4258|M.ulcerans_Agy99 LTHSPEPRVLDRFAADGYQLVMAGHTHGGQLCLPFYGALVTNCGLDRTRA
MAV_0445|M.avium_104 LTHSPEPRVLDRFAADGYQLVMAGHTHGGQVCLPFYGALVTNCGLDRSRA
MLBr_02309|M.leprae_Br4923 LTHSPEPRVLDRFAADCYQLVMAGHTHGGQLCLPFYGALVTNCGLDRSRA
MAB_0407c|M.abscessus_ATCC_199 LTHSPEPRVLDRFAEDGYQLVMAGHTHGGQLCLPLYGAIVTNCELDRSRV
Mflv_1023|M.gilvum_PYR-GCK LAHQPKQ--VVRAAAAGVDLQLSGHTHGGQMWP--FNFLVR---LEQPVV
Mvan_5813|M.vanbaalenii_PYR-1 LAHQPKQ--VVHAVRGGVDLQISGHTHGGQIWP--FNFLVR---LEQPVV
MSMEG_6614|M.smegmatis_MC2_155 LAHQPVQ--VTEAAERGVDLQLSGHTHGGQLWP--FHYVVS---AVQPSL
TH_1617|M.thermoresistible__bu LAHQPDL--ITEAAARGVDLQLSGHTHGGQVWP--FHLAVR---AVQPTL
*:*.* : . . :* ::*******: : * :.
Mb3708|M.bovis_AF2122/97 KGASHWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSS
Rv3683|M.tuberculosis_H37Rv KGASHWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSS
MMAR_5172|M.marinum_M KGASQWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIAAPMGGRDSS
MUL_4258|M.ulcerans_Agy99 KGASQWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIAAPMGGRDSS
MAV_0445|M.avium_104 KGPSRWGAHMQLHVSAGMGTSPYAPVRFCCRPEATLLTLIATPMGDRDAV
MLBr_02309|M.leprae_Br4923 KGLSRWDADMRLHVSAGIGTSPLAPMRFCCRPEATLLTLIATPMGSRVES
MAB_0407c|M.abscessus_ATCC_199 KGPSQWGSHMQLHVSAGIGTSPFAPMRFFCRPEATLLTLVPARTSGHGAD
Mflv_1023|M.gilvum_PYR-GCK QGLSRHGERTQLYTSRGTGFWG-PPFRVFAPSEITLLTLRRAR-------
Mvan_5813|M.vanbaalenii_PYR-1 HGLSTHGDRTQLYTSRGTGFWG-PPFRVFAPSEITVLTLRRCSSDDDQAA
MSMEG_6614|M.smegmatis_MC2_155 AGLSTVGD-TQLYVTRGAGFWG-PPVRIGAPPDISVLTLRADQ-------
TH_1617|M.thermoresistible__bu AGLAAVGD-TQLYVSRGAGFWG-PPARVGAPPDISVLTLRAAG-------
* : . :*:.: * * .* *. . .: ::***
Mb3708|M.bovis_AF2122/97 ---SNLGRSQPTVSVR---------------
Rv3683|M.tuberculosis_H37Rv ---SNLGRSQPTVSVR---------------
MMAR_5172|M.marinum_M ---SNLDRSQPTMSIR---------------
MUL_4258|M.ulcerans_Agy99 ---SNLDRSQPTMSIR---------------
MAV_0445|M.avium_104 ---SDLSRSQPTASVR---------------
MLBr_02309|M.leprae_Br4923 PVRTGAVRNQQLQCVERAHRDSGPRPPTQLD
MAB_0407c|M.abscessus_ATCC_199 ---AESGDRSPSATVQ---------------
Mflv_1023|M.gilvum_PYR-GCK -------------------------------
Mvan_5813|M.vanbaalenii_PYR-1 -------RHEPR-------------------
MSMEG_6614|M.smegmatis_MC2_155 -------------------------------
TH_1617|M.thermoresistible__bu -------------------------------