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MLRPRRFSAEVDPGPVQIQARKVHFDVSDVPLHWIPGHPVASHVVSVLNILLPAGERWFVETFNEALPLV KDPKLADDIRGFIGQEATHADVHDQVLHDVMVRHGVDPAPILGQVDHLFGKSLAPLDDSADEARRLNHLC DRLWLIAAIEHYTAVMGDFALNCTWDDHGADPTLVDLFRWHGSEEVEHRSVAHDVAVYFHDSYFARIRAM TIAASMLFVFFQRVAWYLTSTDPSVDASWWKFNRMRMRDSKLGLLPLYRRLFGANTLSYFRPGYSPEQLG STAQAVAYLAASPAARAAHL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3425 | - | - | 100% (300) | hypothetical protein Mflv_3425 |
| M. gilvum PYR-GCK | Mflv_4629 | - | 9e-18 | 28.57% (266) | metal-dependent hydrolase |
| M. gilvum PYR-GCK | Mflv_4095 | - | 6e-13 | 27.47% (233) | hypothetical protein Mflv_4095 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2799c | - | 5e-55 | 39.59% (293) | hypothetical protein Mb2799c |
| M. tuberculosis H37Rv | Rv2777c | - | 5e-55 | 39.59% (293) | hypothetical protein Rv2777c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0089c | - | 7e-67 | 45.67% (289) | hypothetical protein MAB_0089c |
| M. marinum M | MMAR_1931 | - | 2e-56 | 40.27% (293) | hypothetical protein MMAR_1931 |
| M. avium 104 | MAV_3671 | - | 5e-59 | 40.75% (292) | FF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3675 | - | 1e-130 | 71.00% (300) | metal-dependent hydrolase |
| M. thermoresistible (build 8) | TH_2221 | - | 1e-133 | 72.33% (300) | metal-dependent hydrolase |
| M. ulcerans Agy99 | MUL_2157 | - | 2e-56 | 40.27% (293) | hypothetical protein MUL_2157 |
| M. vanbaalenii PYR-1 | Mvan_3179 | - | 1e-158 | 86.00% (300) | hypothetical protein Mvan_3179 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2799c|M.bovis_AF2122/97 MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
Rv2777c|M.tuberculosis_H37Rv MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
MMAR_1931|M.marinum_M --------------------------------------------------
MUL_2157|M.ulcerans_Agy99 --------------------------------------------------
MAV_3671|M.avium_104 --------------------------------------------------
Mflv_3425|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3179|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2221|M.thermoresistible__bu --------------------------------------------------
MSMEG_3675|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0089c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2799c|M.bovis_AF2122/97 AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTNLPFHYVPNEPMA
Rv2777c|M.tuberculosis_H37Rv AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTNLPFHYVPNEPMA
MMAR_1931|M.marinum_M -MFTVDNRAVGPHSGESGAADHERLVLEARDVEFDWANLPFHYVPNEPLP
MUL_2157|M.ulcerans_Agy99 -MFTVDNRAVGPHSGESGAADHERLVLEARDVEFDWANLPFHYVPNEPLP
MAV_3671|M.avium_104 -MVIIDNQAAGPHDAS---VDHERLVLEARDVDFDWAQLPFHYAPGEPFA
Mflv_3425|M.gilvum_PYR-GCK -MLRPRRFSA--------EVDPGPVQIQARKVHFDVSDVPLHWIPGHPVA
Mvan_3179|M.vanbaalenii_PYR-1 -MLRPRRFDA--------EIDPGPVQIQARKVHFDVADVPLHWIPGHPVA
TH_2221|M.thermoresistible__bu -MLRPRRFAT--------EVDPGPVQIQARQVHFDVSGIPLHWIPGHPVA
MSMEG_3675|M.smegmatis_MC2_155 -MLRPLRFDH--------EIDPGPVQIQARKVHFDLSDIPLHWIPGHPVA
MAB_0089c|M.abscessus_ATCC_199 -MVRNTTDTTG---VQVVPTEPGEVVLRPRNVQFDTSHTPLHWIPNEPIV
*. : : :..*.*.** : *:*: *..*.
Mb2799c|M.bovis_AF2122/97 THVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMHSQ
Rv2777c|M.tuberculosis_H37Rv THVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMHSQ
MMAR_1931|M.marinum_M THVLNVLHLLLPAGEEFFVEVFKKTLPLIKDDQLRLDVQGFIGQEAMHSQ
MUL_2157|M.ulcerans_Agy99 THVLNVLHLLLPAGEEFFVEVFKKTLPLIKDDQLRLDVQGFIGQEAMHSQ
MAV_3671|M.avium_104 THVLNVLHLLLPAGEQFFVEVFKQALPLIRDDQLRLDVQGFIGQEGVHSR
Mflv_3425|M.gilvum_PYR-GCK SHVVSVLNILLPAGERWFVETFNEALPLVKDPKLADDIRGFIGQEATHAD
Mvan_3179|M.vanbaalenii_PYR-1 SHVVSVLNIVLPAGERWFVQTFNEALPLVKDPKLADDIRGFIGQEATHAD
TH_2221|M.thermoresistible__bu SNLISLLNVVLPDAERWFVATFNEALPYVKDPKLADDMRGFIGQEATHAD
MSMEG_3675|M.smegmatis_MC2_155 STMVNLFNVVLPVAEHWFVDTFNEALPYVRDPKLADDMRGFIGQEATHAE
MAB_0089c|M.abscessus_ATCC_199 SHFISAFNLLLPEGERAFVDTFTRALPYVKDDKIREAMIGFMGQEAVHAE
: .:. ::::** .*. ** .*..:** ::* :: : **:***. *:
Mb2799c|M.bovis_AF2122/97 AHSGVVDHFDAQ-GVDVTAFTNQIRWLFEKLLGE-SPRRSPRRQYSWLLE
Rv2777c|M.tuberculosis_H37Rv AHSGVVDHFDAQ-GVDVTAFTNQIRWLFEKLLGE-SPRRSPRRQYSWLLE
MMAR_1931|M.marinum_M AHSGVLAHFEAQ-GVDVTPYTDQIRWLFGKLLAE-KPGRNPRQRHRWLLE
MUL_2157|M.ulcerans_Agy99 AHSGVLAHFEAQ-GVDVTPYTDQIRWLFGKLLAE-KPGRNPRQRHRWLLE
MAV_3671|M.avium_104 AHANVLAHFAAR-GIDLRPYTGQIEWLFGTLLGP-RPNWSPRRRQSWLLE
Mflv_3425|M.gilvum_PYR-GCK VHDQVLHDVMVRHGVDPAPILGQVDHLFGKSLAPLDDSADEARRLNHLCD
Mvan_3179|M.vanbaalenii_PYR-1 VHDQVLHEFMVSHGVNPAPILAQIEHMFTGVLAPPDETVDESRRWSHLCD
TH_2221|M.thermoresistible__bu VHEQVMYDFMVEHGVNPEPILAQIEYMFTKVLTP-STSSDPKRRFNNLCE
MSMEG_3675|M.smegmatis_MC2_155 THDKVLEEFLTAHDVHYQPILELVDHVFNTMLAP-KPATDPRRRLNDLCD
MAB_0089c|M.abscessus_ATCC_199 THHKVLGDFLEKNGLDVRPALTQIEYIT-HMLERTNELRSEKLRYRVMVE
.* *: .. .:. . : : * . : : :
Mb2799c|M.bovis_AF2122/97 QVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHKA
Rv2777c|M.tuberculosis_H37Rv QVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHKA
MMAR_1931|M.marinum_M QVSFIAAIEHYTAVLGEWILNSPQLDVVGTDPVMLDMLRWHGAEEVEHKA
MUL_2157|M.ulcerans_Agy99 QVSFIAAIEHYTAVLGEWILNSPQLDVVGTDPVMLDMLRWHGAEEVEHKA
MAV_3671|M.avium_104 QISLVSAIEHYTAILGEWILDSPAHDRIGTDPVMLDMLRWHGAEEVEHKA
Mflv_3425|M.gilvum_PYR-GCK RLWLIAAIEHYTAVMGDFALNCT-WDDHGADPTLVDLFRWHGSEEVEHRS
Mvan_3179|M.vanbaalenii_PYR-1 RLWLIAAIEHYTAVMGDFALNCT-WDDHGADPTLVDLFRWHGSEEVEHRS
TH_2221|M.thermoresistible__bu RLWLIAALEHYTAVLGDFALNCR-WDDHGAHPTMVDLYRWHGAEEVEHRN
MSMEG_3675|M.smegmatis_MC2_155 RLWLIAAIEHYTAVLGDFVLNCA-WDDHHADPTLTDLFRWHGAEEVEHRS
MAB_0089c|M.abscessus_ATCC_199 KLALIAGIEHFTAVLGDWVLNHP-FEKFNADPEMVDLFRWHGAEEVEHRS
:: :::.:**:**::*:: *: : :.* : *: ****:*****:
Mb2799c|M.bovis_AF2122/97 VAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYL-PPGT
Rv2777c|M.tuberculosis_H37Rv VAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYL-PPGT
MMAR_1931|M.marinum_M VAFDTMKHLRAGYWRQVRAQLAVTPVMLLLWIRGVRFMYTVDPLL-APGT
MUL_2157|M.ulcerans_Agy99 VAFDTMKHLRAGYWRQVRAQLAVTPVMLLLWIRGVRFMYTVDPLL-APGT
MAV_3671|M.avium_104 VAFDTMKHLRAGYWRQVRTQLVVTPAMLLLWIRGVRFMYSRDPYL-PPHT
Mflv_3425|M.gilvum_PYR-GCK VAHDVAVYFHDSYFARIRAMTIAASMLFVFFQRVAWYLTSTDPSV-DASW
Mvan_3179|M.vanbaalenii_PYR-1 VAHDVAMYFHDSYLARIRAMSVAATMLFVFFQRTAWYLVKHDPGV-DANW
TH_2221|M.thermoresistible__bu VAHDVAVYFRDSYVDRIRAMCIAMPLMWAFFERGMWYLVKTDPSV-ELSW
MSMEG_3675|M.smegmatis_MC2_155 VAHDVAVYFQDSYLARVRAMTIAATAVYMFFQRGTWAMIRKDPTV-DIGW
MAB_0089c|M.abscessus_ATCC_199 VAYDVARYFQIRRGHMMLTFVLATMLLVGVMLRYTKFLVRQDPSLPNYGV
**.*. ::: : : . : . * : ** :
Mb2799c|M.bovis_AF2122/97 KPRWRDYFKAARRGLVPGLPRLL-RVVGHYYKPGFHPSQLGGLGAAVDYL
Rv2777c|M.tuberculosis_H37Rv KPRWRDYFKAARRGLVPGLPRLL-RVVGHYYKPGFHPSQLGGLGAAVDYL
MMAR_1931|M.marinum_M KPRWRDYVRSARRGLTPGPWRLI-RVVGDYYKPGFHPSQLGGLERAVDYL
MUL_2157|M.ulcerans_Agy99 KPRWRDYVRSARRGLTPGPWRLI-RVVGDYYKPGFHPSQLGGLERAVDYL
MAV_3671|M.avium_104 KPRWRDYFRAAWRGLVPGPLRFV-RAVANYYRPGFHPSQLGGLQRAVDYL
Mflv_3425|M.gilvum_PYR-GCK WKFNRMRMRDSKLGLLPLYRRLFGANTLSYFRPGYSPEQLGSTAQAVAYL
Mvan_3179|M.vanbaalenii_PYR-1 WAFNRMRMRDSKLGLLPKYRKLFGSSTLGYFRPGYAPEQLGSTAQAVAYL
TH_2221|M.thermoresistible__bu WQTQRQRCRDSGLGLLPKWRTLFFTNTLDYFRPGFTPEQMGSTAQAVAYL
MSMEG_3675|M.smegmatis_MC2_155 WKMHRLRMRDSKLGLLPKFSTLFGTNTLAYCRPSFTPDQMGSTAQAVAYL
MAB_0089c|M.abscessus_ATCC_199 FGVLRQMNKAMKRGAFLRWRELG-KSALEFMRPGFSPDQVGSTAQAVAYL
* : * : . : :*.: *.*:*. ** **
Mb2799c|M.bovis_AF2122/97 AVSPAARASH--
Rv2777c|M.tuberculosis_H37Rv AVSPAARASH--
MMAR_1931|M.marinum_M AVSPAARASH--
MUL_2157|M.ulcerans_Agy99 AVSPAARASH--
MAV_3671|M.avium_104 AVSPAARASH--
Mflv_3425|M.gilvum_PYR-GCK AASPAARAAHL-
Mvan_3179|M.vanbaalenii_PYR-1 ASSPAARAAHL-
TH_2221|M.thermoresistible__bu ASSPAARSARL-
MSMEG_3675|M.smegmatis_MC2_155 ASSPAARAAHL-
MAB_0089c|M.abscessus_ATCC_199 STSPAAKAAAGY
: ****:::