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LFTVPAVAEAVAAAIPDRPLIVQGERRHTYRQVMDRSNRLASYLHSQGLGVHTERDGLAGHEVGQDLLGI YAHNGPEYVESMLGSFRARVAPFNVNYRYVKNELHYLLTDAGATALVYHATFAPRIAEIRDELPTLRVLI QIADGSGNELLDGAVDYEQIVNFETAAPPVQPCPDDLYVLYTGGTTGMPKGVLWRQHDIFMTAFGGRNMM TGEAATSVDEIVDRAVENPGTRLMILPPLIHGAAQWAAMTAVTTGQTLVFPDVTDRFDAEDVVRTIEREQ VLVATVVGDAMARPLLDAIRSGIQNGTVDVSSLSVIANGGAQLTPHVKQQLIDSKPNLIVVDGVGSSETG AQMSHMSAPGAVSTGTFKAGPDTCVVAEDFSCVLPEAHDGLGWLAQRGYVPLGYKGDAAKTAATFPVIDG VRYAIPGDRARQLDGGMIELLGRDSVTINSGGEKVFAEEVEAAIASHPAVRDVVVAGRPSERWGQEVVAV VAVDDGAQVDADELIRHADGSIARYKLPKAVVFRPAIERSPAGKADYRWAREQALSETS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_2241 | - | - | 100% (550) | acyl-CoA synthetase |
M. smegmatis MC2 155 | MSMEG_3687 | - | e-170 | 56.78% (553) | acyl-CoA synthetase |
M. smegmatis MC2 155 | MSMEG_2231 | - | e-106 | 40.73% (550) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3544c | fadD19 | 1e-104 | 39.71% (549) | acyl-CoA synthetase |
M. gilvum PYR-GCK | Mflv_4335 | - | 0.0 | 74.91% (546) | acyl-CoA synthetase |
M. tuberculosis H37Rv | Rv3515c | fadD19 | 1e-104 | 39.71% (549) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_02546 | fadD2 | 5e-27 | 24.39% (537) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_4163c | - | 1e-102 | 38.63% (554) | acyl-CoA synthetase |
M. marinum M | MMAR_4007 | fadD19_2 | 0.0 | 74.82% (544) | fatty-acid-CoA ligase FadD19_2 |
M. avium 104 | MAV_1600 | - | 0.0 | 77.43% (545) | acyl-CoA synthetase |
M. thermoresistible (build 8) | TH_4443 | - | 0.0 | 73.59% (549) | PUTATIVE AMP-dependent synthetase and ligase |
M. ulcerans Agy99 | MUL_3870 | fadD19_2 | 0.0 | 73.71% (544) | acyl-CoA synthetase |
M. vanbaalenii PYR-1 | Mvan_2010 | - | 0.0 | 75.00% (548) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment Mb3544c|M.bovis_AF2122/97 -----------------------------------------MAVALNIAD Rv3515c|M.tuberculosis_H37Rv -----------------------------------------MAVALNIAD MAB_4163c|M.abscessus_ATCC_199 -------------------------------------------MALNIAD MSMEG_2241|M.smegmatis_MC2_155 -------------------------------------------MLFTVPA TH_4443|M.thermoresistible__bu -----------------------------------------MTTEFTVPQ MMAR_4007|M.marinum_M -----------------------------------------MTTQFTVPA MUL_3870|M.ulcerans_Agy99 -----------------------------------------MTTQFTVPA MAV_1600|M.avium_104 --------------------------------------MSDTTTAFTVPA Mflv_4335|M.gilvum_PYR-GCK ---------------------------------------MTEPNQFTVPA Mvan_2010|M.vanbaalenii_PYR-1 ---------------------------------------MTESIQFTVPA MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM :. Mb3544c|M.bovis_AF2122/97 LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD---- Rv3515c|M.tuberculosis_H37Rv LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD---- MAB_4163c|M.abscessus_ATCC_199 LIEHAIDTMPDRVAIISGDRKLTYAELEEQSNRLGHYLQSQGVGPG---- MSMEG_2241|M.smegmatis_MC2_155 VAEAVAAAIPDRPLIVQGERRHTYRQVMDRSNRLASYLHSQGLGVHTERD TH_4443|M.thermoresistible__bu VADTVAAVLPDRELVVHRDRRFTYTDIIARSNRLAAYLHSRGLGCHTERD MMAR_4007|M.marinum_M VASAVTAAIGDRELIVGGDRRHTYRQIHQRSNRLASYLHSQGLGCHTERS MUL_3870|M.ulcerans_Agy99 VASAVTAAIGDRELVVQGDRRHTYRQIHQRSNRLASYLHSQGLGCHTERS MAV_1600|M.avium_104 VAKAVAAAIPDRELIIQGDRRYSYRQVIERSNRLAAYLHSQGLGCHTERE Mflv_4335|M.gilvum_PYR-GCK AADAVAAVIGDREFIIQGERRYTYAQIVERSNRLAAFLHAQGLGCHTERS Mvan_2010|M.vanbaalenii_PYR-1 AADAVAAAIGDREFIVQGDRRYTYTQIVERSNRLAAYLHAQGLGCHTERT MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGG---- .* :: : :* :: :: *. * :*: Mb3544c|M.bovis_AF2122/97 ---------DKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY Rv3515c|M.tuberculosis_H37Rv ---------DKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY MAB_4163c|M.abscessus_ATCC_199 ---------DKVGLYCRNGIEIVIALTAIVKIRAISVNVNYRYVEAELHY MSMEG_2241|M.smegmatis_MC2_155 GLAGHEVGQDLLGIYAHNGPEYVESMLGSFRARVAPFNVNYRYVKNELHY TH_4443|M.thermoresistible__bu GLAPHECGQDLLGIYAYNGSEYLEGLLGAFRARVAPFNVNFRYVRAELEY MMAR_4007|M.marinum_M ELAGHEVGQDLLGIYAYNGNEFVEALFGSFAARVAPFNVNFRYVKNELQY MUL_3870|M.ulcerans_Agy99 ELAGHEVGQNLLGIYAYNGNEFVEALFGSFAARVAPFNVNFRYVKNEPQY MAV_1600|M.avium_104 ALAGHEVGQDLLGLYAYNGNEFVEALLGAFAARVAPFNVNFRYVKSELHY Mflv_4335|M.gilvum_PYR-GCK ELPGHEVGQDLLGIYAYNGPEYVEGMLGAWRARVAPFNVNYRYVKSELQY Mvan_2010|M.vanbaalenii_PYR-1 ALPGHEVGQDLLGIYSHNGPEYVEGMLGAWRARVAPFNVNYRYVKSELHY MLBr_02546|M.leprae_Br4923 ---------DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKE : :.: . * : . . . . :* .: : . Mb3544c|M.bovis_AF2122/97 LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV Rv3515c|M.tuberculosis_H37Rv LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV MAB_4163c|M.abscessus_ATCC_199 LFENSDMAALVHERRYSDKVANVLPSTPNVKTAIVVEDGADGSFDSYGGV MSMEG_2241|M.smegmatis_MC2_155 LLTDAGATALVYHATFAPRIAEIRDELPTLRVLIQIADGSGNELLD-GAV TH_4443|M.thermoresistible__bu LLTDAGATALLYHAAFAPRVAEILPNLPRRPVLIQIADDSGHELLE-GAV MMAR_4007|M.marinum_M LLADAGATALIYHATFAPRVAEVLPELPRLRVLIQIADDSGNGLLD-GAV MUL_3870|M.ulcerans_Agy99 LLADAGATALIYHATFAPRVAEVLPELPRLRVLIQIADDSGNGLLD-GAV MAV_1600|M.avium_104 LLADSEATALIYHAAFAPRVAEILPDLPRLRVLIQIADESGNELLD-GAV Mflv_4335|M.gilvum_PYR-GCK LLADAGATALLYHSAFAPRLAEVLADLPSLKVLIQIADDSGNELLP-GAV Mvan_2010|M.vanbaalenii_PYR-1 LLADSGATALLYHAAFAPRLAEVLADLPNLKVLIQIADDSGNELLP-GAV MLBr_02546|M.leprae_Br4923 VSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGST--DE : .:::. :: ::: . * Mb3544c|M.bovis_AF2122/97 EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF Rv3515c|M.tuberculosis_H37Rv EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF MAB_4163c|M.abscessus_ATCC_199 PFADALAQGSPERDFEERSPDDIFLIYTGGTTGFPKGVMWRHEDIYRSLF MSMEG_2241|M.smegmatis_MC2_155 DYEQIVNFETAAPP-VQPCPDDLYVLYTGGTTGMPKGVLWRQHDIFMTAF TH_4443|M.thermoresistible__bu DYESIVSNGPADPPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTAF MMAR_4007|M.marinum_M DYESIIANSSPEPLPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF MUL_3870|M.ulcerans_Agy99 DYESIIANSSPEPLPVQPSPDDLYVLYTGGTTGMTKGVLWRQHDIFMTSF MAV_1600|M.avium_104 DYEDALASVSAEPPPVRHCPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF Mflv_4335|M.gilvum_PYR-GCK DYESIVAEGPAEVPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMASF Mvan_2010|M.vanbaalenii_PYR-1 DYESIVAEGPADVPPVEPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF MLBr_02546|M.leprae_Br4923 TLAELIARSSSAPAPKVRKRASIIILTSG-TTGTPKGAN-RNTPASLAPL . : .. : :: :* *** .**. *: : Mb3544c|M.bovis_AF2122/97 GGTDFATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFS Rv3515c|M.tuberculosis_H37Rv GGTDFATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFS MAB_4163c|M.abscessus_ATCC_199 GGINYVTGEYIEGEWDLAKQGAEAAPFIGFPIPPMIHGATQAATFMALFQ MSMEG_2241|M.smegmatis_MC2_155 GGRNMMTGEAATSVDEIVDRAVENPGTRLMILPPLIHGAAQWAAMTAVTT TH_4443|M.thermoresistible__bu GGRSLYGGEAAGSYGEIAERAAANPGTKMMILPPLMHGAAQWAAMTALTT MMAR_4007|M.marinum_M GGRDLYSGQPVNSVDEIVARTTAGPGTKLLVLPPLIHGAAQWTVMTALTT MUL_3870|M.ulcerans_Agy99 GGRDLYSGQPVNSVDEIVARTTAGPGTKLLVLPPLIHGAAQWTVMTALTT MAV_1600|M.avium_104 GGRNLMTGEPSSSIDEIVQRAASGPGTKLMILPPLIHGAAQWSVMTAITT Mflv_4335|M.gilvum_PYR-GCK GGRSLYTGELISSLDDVAQRCVESPGTTLMVLPPLMHGAAQWAVFTAMNT Mvan_2010|M.vanbaalenii_PYR-1 GGRSLYTGELVSTYDDIAARCSESPGTKLMVLPPLMHGAAQWAVFTAMNT MLBr_02546|M.leprae_Br4923 GG--------------ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFL ** : . .*::*. . *: Mb3544c|M.bovis_AF2122/97 GQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL---VK Rv3515c|M.tuberculosis_H37Rv GQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL---VK MAB_4163c|M.abscessus_ATCC_199 GRTTVLAP---EFNPEEVWELIEKHKINMLFFAGDAIGRPLIDALDT-ET MSMEG_2241|M.smegmatis_MC2_155 GQTLVFPDVTDRFDAEDVVRTIEREQVLVATVVGDAMARPLLDAIRSGIQ TH_4443|M.thermoresistible__bu GQTVVFGSVVDRVDAVDALQTIKREDVSVVTVVGDAIARPLADAL----E MMAR_4007|M.marinum_M GQTVVFASVVDHLDPRDVVRTIERERVSVVTVVGDAIARPLVASI----E MUL_3870|M.ulcerans_Agy99 GQTVVFASVVDHLDPRDVVRTIERERVSVVTVVGNAIARPLVASI----E MAV_1600|M.avium_104 GQTVVFPTVVDHLDAEDVVRTIEREKVMVVTVVGDAMARPLVAAI----E Mflv_4335|M.gilvum_PYR-GCK GQSVVFSPVTEHLDVDDVVATIEREKVLAVTVVGDAMARPLADAF----E Mvan_2010|M.vanbaalenii_PYR-1 GQTVVFSPVTSHLDVDDVVATIEREQILAVTVVGDAMARPLAEAF----E MLBr_02546|M.leprae_Br4923 GSTLVLRR---RFKPATVLEDIEKHQATAMVVVPVMLSR-ILDTLEN--L * : *: ... . *.:. .. :.* : :: Mb3544c|M.bovis_AF2122/97 GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT Rv3515c|M.tuberculosis_H37Rv GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT MAB_4163c|M.abscessus_ATCC_199 GRARDLSSLWVLASSAALFSQTVKERYLELLPNRVITDAIGASETGTGGL MSMEG_2241|M.smegmatis_MC2_155 NGTVDVSSLSVIANGGAQLTPHVKQQLIDSKPNLIVVDGVGSSETGAQMS TH_4443|M.thermoresistible__bu QGVCETPSLAVIANGGAFLTPTTKQRLIDLLPDAIVVDGVGSSETGAQMT MMAR_4007|M.marinum_M KGTADVSSLVAVANGGALLTPYVKQRLIEALPNAVITDGVGSSETGAQMH MUL_3870|M.ulcerans_Agy99 KGTADVSSLVAVANGGALLTPYVKQRLIAALPNAVIIDGVGSSETGAQMH MAV_1600|M.avium_104 KGIADVSSLAVVANGGALLTPFVKQRLIEVLPNAVVVDGVGSSETGAQMH Mflv_4335|M.gilvum_PYR-GCK RTTADLSALAVVANGGAQLTPSAKQRLIDVKKNLMVVDGVGSSETGAQMT Mvan_2010|M.vanbaalenii_PYR-1 RTSADLSSLAVVANGGAQLTPTAKQRLIDAKQNLMVVDGVGSSETGAQMT MLBr_02546|M.leprae_Br4923 ETKSDLSSLRVVFVSGSQLGAELATRALEELG-PVIYNMYGSTEIAFATI : .:* : .: : : : :: : *::* . Mb3544c|M.bovis_AF2122/97 SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG Rv3515c|M.tuberculosis_H37Rv SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG MAB_4163c|M.abscessus_ATCC_199 STVTKGQMHPGGPTVKISSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVG MSMEG_2241|M.smegmatis_MC2_155 HMSAPGAVSTGTFKAGPD-TCVVAEDFSCVLPEAHDGLGWLAQRGYVPLG TH_4443|M.thermoresistible__bu HMSMNGAVATGTFNPGPD-TCVLAEDFSTVLPPGHAGLGWLGQRGYVPLG MMAR_4007|M.marinum_M HLSASGAVSTGTFNAGPD-TNVAAEDLSAILPAGHEGIGWLAQRGYVPLG MUL_3870|M.ulcerans_Agy99 HLSASGAISTGTFNAGPD-INVAAEDLSAILPAGHEGIGWLAQRGYVPLG MAV_1600|M.avium_104 HMSTPGAVATGTFNAGPD-TFVAAEDLSAILPPGHEGMGWLAQRGYVPLG Mflv_4335|M.gilvum_PYR-GCK HMSAPGAVSTGKFTAGPD-TFVASEDLSTILEPGHDGMGWLAQRGYVPLG Mvan_2010|M.vanbaalenii_PYR-1 HMSAPGAVSTGKFNAGPD-TFVAAEDLGSILEPGHDGIGWLAQRGYVPLG MLBr_02546|M.leprae_Br4923 AGPKDLQINSATVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEG . . . : . : . * Mb3544c|M.bovis_AF2122/97 YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE Rv3515c|M.tuberculosis_H37Rv YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE MAB_4163c|M.abscessus_ATCC_199 YFKDEKKTAETFKTFNGVRYAIPGDWATVEADGTVTMLGRGSVSINTGGE MSMEG_2241|M.smegmatis_MC2_155 YKGDAAKTAATFPVIDGVRYAIPGDRARQLDGGMIELLGRDSVTINSGGE TH_4443|M.thermoresistible__bu YKGDADKTARTFPVIDTVRYAVPGDRARHLDGGAIELLGRDSVTINSGGE MMAR_4007|M.marinum_M YKGDAAKTAATFPVINGVRYAVPGDRARHRADECIELLGRDSATINSGGE MUL_3870|M.ulcerans_Agy99 YKGDAAKTATTFPVINGVRYAVPGDRARHRADGCIELLGRDSATINSGGE MAV_1600|M.avium_104 YKGDAAKTAKTFPVIDGVRYAVPGDRARHHADGHIELLGRDSVCINSGGE Mflv_4335|M.gilvum_PYR-GCK YKGDATKTAATFPVIEGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE Mvan_2010|M.vanbaalenii_PYR-1 YKGDAAKTAATFPVIGGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE MLBr_02546|M.leprae_Br4923 YTGGGGK-----QIIDGLLS--SGDVGYFDEHDLLYISGRDDEMIVSGGE * . * : : .** . : : **.. * :*** Mb3544c|M.bovis_AF2122/97 KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE Rv3515c|M.tuberculosis_H37Rv KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE MAB_4163c|M.abscessus_ATCC_199 KVFPEEVESVLKGHPAVFDAVVVGVPDEKWGQHVGAVIAVREGVELTFED MSMEG_2241|M.smegmatis_MC2_155 KVFAEEVEAAIASHPAVRDVVVAGRPSERWGQEVVAVVAVDDGAQVDADE TH_4443|M.thermoresistible__bu KIFAEEVEMALASHPAVADVVVTGRPSDRWGQEVVAVVALAEGATADAEA MMAR_4007|M.marinum_M KIFAEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALDPDAAADAEE MUL_3870|M.ulcerans_Agy99 KIFAEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALDPDAAADAEE MAV_1600|M.avium_104 KIFVEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALSDGAAVDAGE Mflv_4335|M.gilvum_PYR-GCK KIFAEEVESAIASHPAVADVVVAGRPSERWGQEVVAVVALDSGATATAEE Mvan_2010|M.vanbaalenii_PYR-1 KIFAEEVESAIASHPAVADVVVAGRPSDRWGQEVVAVVALADGAQATADE MLBr_02546|M.leprae_Br4923 NVFPAEVEDLISGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDA ::: *** : .** * :. . * . .:* .: *.: . Mb3544c|M.bovis_AF2122/97 LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH Rv3515c|M.tuberculosis_H37Rv LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH MAB_4163c|M.abscessus_ATCC_199 LDAHARKEIAGYKVPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVN MSMEG_2241|M.smegmatis_MC2_155 LIRHADGSIARYKLPKAVVFRPAIERSPAGKADYRWAREQALSETS---- TH_4443|M.thermoresistible__bu LIEHAAGALARYKLPKAIVFRPVIQRSPAGKADYRWAREQATASVAAE-- MMAR_4007|M.marinum_M LVAHAAKSLARYKLPKAIVFRAGIQRSPSGKADYRWAKEQAADG------ MUL_3870|M.ulcerans_Agy99 LVAHAAKSLARYKLPKAIVFRAGIQRSPSGKADYRWAKEQAADG------ MAV_1600|M.avium_104 LIAHASNSLARYKLPKAIVFRPVIERSPSGKADYRWAREQAVDG------ Mflv_4335|M.gilvum_PYR-GCK LIDHASAVIARYKLPKAVVFRPAIERSPAGKADYRWAREQAISGS----- Mvan_2010|M.vanbaalenii_PYR-1 LVEHASSVIARYKLPKAVVFRPVIERSPAGKADYRWAREQAISGS----- MLBr_02546|M.leprae_Br4923 IKAYVRDHLARYKVPREVIFLEELPRNPTGKVLKRELRDFEVH------- : .. :* **:*: : : : *.*:** * :: Mb3544c|M.bovis_AF2122/97 AGHVTSGG Rv3515c|M.tuberculosis_H37Rv AGHVTSGG MAB_4163c|M.abscessus_ATCC_199 SKHVNTGA MSMEG_2241|M.smegmatis_MC2_155 -------- TH_4443|M.thermoresistible__bu -------- MMAR_4007|M.marinum_M -------- MUL_3870|M.ulcerans_Agy99 -------- MAV_1600|M.avium_104 -------- Mflv_4335|M.gilvum_PYR-GCK -------- Mvan_2010|M.vanbaalenii_PYR-1 -------- MLBr_02546|M.leprae_Br4923 --------