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DNPPGSESLAAEAVGLGDGTHRAVLGIAGSPGAGKSTLVELLAARIRQMRGPGWVAHVPMDGFHLADAQL RRLGLLDRKGAPETFDAVGYAHALHRIRTDVDSDVYVPGFDRDLEQPLAAALVVPASARLVLTEGNYLLL DQPAWRRVRRSLDQTWFVSADDSLRVERLIARHVEFGKTAAAARAWADTVDEANAALVTSTAASADRIVV NGTRGWSFGACLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4273 | frcK | - | 100% (224) | putative fructose transport system kinase |
| M. gilvum PYR-GCK | Mflv_2058 | - | 7e-08 | 28.00% (150) | pantothenate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1122c | coaA | 1e-06 | 37.50% (80) | pantothenate kinase |
| M. tuberculosis H37Rv | Rv1092c | coaA | 1e-06 | 37.50% (80) | pantothenate kinase |
| M. leprae Br4923 | MLBr_01954 | coaA | 1e-06 | 37.50% (80) | pantothenate kinase |
| M. abscessus ATCC 19977 | MAB_1234c | - | 2e-06 | 32.56% (86) | pantothenate kinase |
| M. marinum M | MMAR_4376 | coaA | 2e-06 | 37.50% (80) | pantothenate kinase CoaA |
| M. avium 104 | MAV_1214 | coaA | 2e-06 | 38.75% (80) | pantothenate kinase |
| M. smegmatis MC2 155 | MSMEG_6800 | frcK | 2e-41 | 47.37% (190) | putative fructose transport system kinase |
| M. thermoresistible (build 8) | TH_2624 | - | 8e-47 | 50.25% (203) | PUTATIVE phosphoribulokinase/uridine kinase |
| M. ulcerans Agy99 | MUL_0189 | coaA | 1e-06 | 37.50% (80) | pantothenate kinase |
| M. vanbaalenii PYR-1 | Mvan_2086 | frcK | 6e-82 | 69.16% (214) | putative fructose transport system kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1122c|M.bovis_AF2122/97 MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVE
Rv1092c|M.tuberculosis_H37Rv MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVE
MMAR_4376|M.marinum_M MSRLSEPSPYVEFDRRQWRALRMSTPLALTEAELIGLRGLGEQIDLLEVE
MUL_0189|M.ulcerans_Agy99 MSRLSEPSPYVEFDRRQWRALRMSTPLALTEAELIGLRGLGEQIDLLEVE
MLBr_01954|M.leprae_Br4923 MPRLSEPSPYVEFDRKQWRALRMSTPLALTEEELIGLRGLGEQIDLLEVE
MAV_1214|M.avium_104 ----------MEFDRKQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVE
MAB_1234c|M.abscessus_ATCC_199 MPRLSEPSPYVEFDRKQWRALRKSTPLVLTEEELIGLRGLGEQIDLTEVA
Mflv_4273|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2086|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2624|M.thermoresistible__bu --------------------------------------------------
MSMEG_6800|M.smegmatis_MC2_155 --------------------------------------------------
Mb1122c|M.bovis_AF2122/97 EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
Rv1092c|M.tuberculosis_H37Rv EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
MMAR_4376|M.marinum_M EVFLPLARLLHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
MUL_0189|M.ulcerans_Agy99 EVFLPLARLLHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
MLBr_01954|M.leprae_Br4923 EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPGRPVPFIIGVAGSVA
MAV_1214|M.avium_104 EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFVIGVAGSVA
MAB_1234c|M.abscessus_ATCC_199 EVYLPLARLIHLQVAARQRLFAATATFLG--DQHPDRLVPFVIGVAGSVA
Mflv_4273|M.gilvum_PYR-GCK -------------MDNPPGSESLAAEAVGLGDGTH----RAVLGIAGSPG
Mvan_2086|M.vanbaalenii_PYR-1 ------------------MLESLAADAVALGERVP----RAVLGIAGCPG
TH_2624|M.thermoresistible__bu ------------VRTTADAVAELTDDVHRLLNAHPG---RVVLGLVGPPG
MSMEG_6800|M.smegmatis_MC2_155 ------------MTNVQDVQEATLDQMVEWAKALVVPGKRRILGLTGAPA
. ::*:.* .
Mb1122c|M.bovis_AF2122/97 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFP
Rv1092c|M.tuberculosis_H37Rv VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFP
MMAR_4376|M.marinum_M VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELERRNLMHRKGFP
MUL_0189|M.ulcerans_Agy99 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELERRNLMHRKGFP
MLBr_01954|M.leprae_Br4923 VGKSTTARVLQALLARWDHHTRVDLVTTDGFLYPNAELGRRNLMHRKGFP
MAV_1214|M.avium_104 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELDRRNLMHRKGFP
MAB_1234c|M.abscessus_ATCC_199 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELSRRNIMHRKGFP
Mflv_4273|M.gilvum_PYR-GCK AGKSTLVELLAARIRQMRGPGWVAHVPMDGFHLADAQLRRLGLLDRKGAP
Mvan_2086|M.vanbaalenii_PYR-1 AGKSTLVQWLLERIGQLRGAGWVAHVPMDGFHLADDQLRRLGRLGRKGAP
TH_2624|M.thermoresistible__bu AGKSTLAQRLVREFGPG-APEGVGYVPMDGFHLSNAQLDRLGRRHRKGAP
MSMEG_6800|M.smegmatis_MC2_155 AGKSTVAEQLVAAL----GPEVAVLVPMDGFHLANEVLIDLGRRDRKGAH
.**** .. * : . *. *** .: * . ***
Mb1122c|M.bovis_AF2122/97 ESYNRRALMRFVTSVKSG---SDYACAPVYSHLHYDIIPGAEQVVRHPDI
Rv1092c|M.tuberculosis_H37Rv ESYNRRALMRFVTSVKSG---SDYACAPVYSHLHYDIIPGAEQVVRHPDI
MMAR_4376|M.marinum_M ESYNRRALMRFVTSVKSG---SDYACAPVYSHLHYNIIPGAKQVVRHPDI
MUL_0189|M.ulcerans_Agy99 ESYNRRALMRFVTSVKSG---SDYACAPVYSHLHYNIIPGAKQVVRHPDI
MLBr_01954|M.leprae_Br4923 ESYNRRALMRFVTSVKSG---ADYACAPVYSHLRYDTIPGAKHVVRHPDI
MAV_1214|M.avium_104 ESYNRRALMRFVTSVKSG---SDYACAPVYSHLKYDIIPGAKHVVRHPDI
MAB_1234c|M.abscessus_ATCC_199 ESYNRRGLLRFVTEVKSG---AREVTAPVYSHLLYDIIKNEKHVVQQPDI
Mflv_4273|M.gilvum_PYR-GCK ETFDAVGYAHALHRIRTD-VDS-DVYVPGFDRDLEQPLAAALVVPASARL
Mvan_2086|M.vanbaalenii_PYR-1 DTFDAAGYARLLDRVRED-TDI-DVYVPGFDRTLEQPLAAALVVHPTARL
TH_2624|M.thermoresistible__bu DTFDVDGYLAVLQQISHS-HRIRDVYVPGFDRTLDEPVAARHVVPADARV
MSMEG_6800|M.smegmatis_MC2_155 DTFDDGGYARLIATLRAQRLGDPVVYAPRFHREIEESIASSIPVASTVPL
:::: . : : . .* : : : : * :
Mb1122c|M.bovis_AF2122/97 LILEGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAF
Rv1092c|M.tuberculosis_H37Rv LILEGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAF
MMAR_4376|M.marinum_M LILEGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRSTAF
MUL_0189|M.ulcerans_Agy99 LILEGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRSTAF
MLBr_01954|M.leprae_Br4923 LILEGLNVLQTGPTLMVSDLFDFSLYVDARIQDIEQWYVSRFLAMRGTAF
MAV_1214|M.avium_104 LILEGLNVLQTGPTLMVSDLFDFGIYVDARIEDIEQWYISRFLAMRSTAF
MAB_1234c|M.abscessus_ATCC_199 LILEGLNVLQTGPTLMVSDLFDFSIYVDARIEDIEQWYISRFLAMRSTSF
Mflv_4273|M.gilvum_PYR-GCK VLTEGNYLLLDQP-----------AWRRVRRSLDQTWFVSADDSLRVERL
Mvan_2086|M.vanbaalenii_PYR-1 VITEGNYLLLGTA-----------DWVRARQAMDQVWFVSADDQTRTARL
TH_2624|M.thermoresistible__bu IVTEGNYLALPSP-----------GWAAVRDLLDWVVYLDSPAPLRRRRL
MSMEG_6800|M.smegmatis_MC2_155 VVTEGNYLLLDRD-----------AWPTARSCIDEVWFLTLDTEVRRARL
:: ** : : .* :: * :
Mb1122c|M.bovis_AF2122/97 ADPESHFHHYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLR
Rv1092c|M.tuberculosis_H37Rv ADPESHFHHYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLR
MMAR_4376|M.marinum_M ANPESHFHHYSALPDPEAVVAAREIWRTINRPNLVENILPTRPRATLVLR
MUL_0189|M.ulcerans_Agy99 ANPESHFHHYSALPDPEAVVAAREIWRTINRPNLVENILPTRPRATLVLR
MLBr_01954|M.leprae_Br4923 ADPESHFHHYSALTDSKAIIAAREIWRSINRPNLVENILPTRPRATLVLR
MAV_1214|M.avium_104 ADPESHFHHYAALNDTKAVAAAREIWRSINRPNLVENILPTRPRATLVLR
MAB_1234c|M.abscessus_ATCC_199 ANPSSHFHHYAKLSDKQATLAAQEIWHSINLPNLLENILPTRPRATLVLR
Mflv_4273|M.gilvum_PYR-GCK IARHVEFGKTAAAARA---------WADTVDEANAALVTSTAASADRIVV
Mvan_2086|M.vanbaalenii_PYR-1 TARHVEFGKSPDAARA---------WVTTVDQRNAELVSQTATAADRVIL
TH_2624|M.thermoresistible__bu IERHIRGGRGAAEAAR---------WVDTVDDPNAELIAAGRGRCDRVLE
MSMEG_6800|M.smegmatis_MC2_155 RRRHEAFGKSPRDAER---------WALGPDERNAQLIESTAGRADRIVR
: . * : . ::
Mb1122c|M.bovis_AF2122/97 KDADHSINRLRLRKL
Rv1092c|M.tuberculosis_H37Rv KDADHSINRLRLRKL
MMAR_4376|M.marinum_M KDADHSIKRLRLRKL
MUL_0189|M.ulcerans_Agy99 KDADHSIKRLRLRKL
MLBr_01954|M.leprae_Br4923 KDADHSINRLRLRKL
MAV_1214|M.avium_104 KDADHSINRLRLRKL
MAB_1234c|M.abscessus_ATCC_199 KDADHSINRLRLRKL
Mflv_4273|M.gilvum_PYR-GCK NGTRGWSFGACLR--
Mvan_2086|M.vanbaalenii_PYR-1 NGAQGWAISA-----
TH_2624|M.thermoresistible__bu IGDTGVQSAGS----
MSMEG_6800|M.smegmatis_MC2_155 VP-------------