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REFVTVAVSGEGAVPDDGERRIATLLLSRPPTNALTRQMNREIADAVAEVGGRDDICAVIVFGGHEMFSV GADVPELKTLDADEAGTADAVAAQAVAALAALPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATE ILAGLAPAGDGAGRLAEAVGPSRAKDLVFSGRFVDAREAHTLGLVDELVAPDGVYDAALAWAGRFREHPP EVLAAAKAAFSAPRSVAGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4270 | - | - | 100% (230) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2036 | - | 8e-31 | 39.04% (187) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4354 | - | 7e-22 | 33.17% (199) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3065c | echA17 | 5e-79 | 67.86% (224) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv3039c | echA17 | 5e-79 | 67.86% (224) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01724 | - | 1e-73 | 65.77% (222) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3382c | - | 7e-61 | 56.42% (218) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_1662 | echA17 | 3e-76 | 65.77% (222) | enoyl-CoA hydratase EchA17 |
| M. avium 104 | MAV_3904 | - | 4e-74 | 64.44% (225) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2328 | - | 4e-77 | 62.17% (230) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3663 | - | 5e-34 | 47.98% (173) | PUTATIVE Enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_1899 | echA17 | 1e-75 | 65.32% (222) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_2089 | - | 3e-86 | 74.77% (222) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4270|M.gilvum_PYR-GCK ---MREFVTVAVSGEGAVPDDGERRIATLLLSRPPTNALTRQMNREIADA
Mvan_2089|M.vanbaalenii_PYR-1 ---MREFVSSVLP-------EGGPGIATLLLSRPPTNALTRQVHREIVEA
Mb3065c|M.bovis_AF2122/97 ---MPEFVNVVVSD-----GSQDAGLAMLLLSRPPTNAMTRQVYREVVAA
Rv3039c|M.tuberculosis_H37Rv ---MPEFVNVVVSD-----GSQDAGLAMLLLSRPPTNAMTRQVYREVVAA
MLBr_01724|M.leprae_Br4923 ---MSEFVNIVVSD-----GSQDAGLAILLLSRPPTNAMTRQFYREIAMA
MAV_3904|M.avium_104 MAALNEFVSVVVSD-----GSRDAGLAMLLVSRPPTNALSRQVYREVIAA
MMAR_1662|M.marinum_M ---MNEFVSVVA----------DQGLATLVVSRPPTNAMTRQVYREIVAA
MUL_1899|M.ulcerans_Agy99 ---MNEFVSVVA----------DQGLATLVVFRPPTNAMTRQVYREIVAA
MSMEG_2328|M.smegmatis_MC2_155 ---MNEFIKIVLGS-----APEQTGVATLLLSRPPTNALTRQMYREISIA
MAB_3382c|M.abscessus_ATCC_199 -MIEPEFVSVRTAP-------EHPGIGTIALSRPPTNTFTRQMYRELAQA
TH_3663|M.thermoresistible__bu ---MREFVSIHTGD-------EQPGVATLTWSRPPSNALTRQLYRELAAA
**:. :. : ***:*:::**. **: *
Mflv_4270|M.gilvum_PYR-GCK VAEVGGRDDICAVIVFGGHEMFSVGADVPELKTLDADEAGTADAVAAQAV
Mvan_2089|M.vanbaalenii_PYR-1 TAELGPRDDVFAVIVYGGHEIFSAGEDMPELDTLTADEAAVAARVCAEAV
Mb3065c|M.bovis_AF2122/97 ANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEADTAARIRQQAV
Rv3039c|M.tuberculosis_H37Rv ANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEADTAARIRQQAV
MLBr_01724|M.leprae_Br4923 ADELGRRDDVAAVILFGGHDIFSAGDDMQELRTLTAVEAGVAAEVRRQAV
MAV_3904|M.avium_104 ADELGRRDDVAAVILFGGHEIFSAGDDMPELRTLRGAEAETAARVRRDAI
MMAR_1662|M.marinum_M ADELGRRDDIGAVVLFGGHEIFSAGDDMPELRTLNAPEADTAARVRLEAI
MUL_1899|M.ulcerans_Agy99 ADELGRRDDIGAVVLFGGHEIFSAGDDMPELRTLNAPEADTAARVRLEAI
MSMEG_2328|M.smegmatis_MC2_155 ANELAQRADVSSVIVYGGHEIFCAGDDIPELRTLDAEETAAADHALQRCI
MAB_3382c|M.abscessus_ATCC_199 AAEVNARADIRVVIVYGGHEIFCAGDDLAELSELSADEMARSAGDRQAAL
TH_3663|M.thermoresistible__bu AAEVGRHDGIAAVILFGGPEIFSAGDDAAELRTLAPRRVAAADRMCRAAF
. *: : .: *:::** ::*..* * ** * . : ..
Mflv_4270|M.gilvum_PYR-GCK AALAALPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLA
Mvan_2089|M.vanbaalenii_PYR-1 EALAALPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGRA
Mb3065c|M.bovis_AF2122/97 DAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLI
Rv3039c|M.tuberculosis_H37Rv DAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLI
MLBr_01724|M.leprae_Br4923 DAVATIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILADLV
MAV_3904|M.avium_104 DAVAAIPKPTVAAITGYALGAGLTLALAADWRISGDNVKFGATEILAGLV
MMAR_1662|M.marinum_M DAVAAIPKPTVAAVTGYALGAGLTLALAADWRVSGDNVKFGATEILAGLI
MUL_1899|M.ulcerans_Agy99 DAVAAIPKPTVAAVTGYALGAGLTLALAADWRVSGDNVKFGATEILAGLI
MSMEG_2328|M.smegmatis_MC2_155 EAVAAIPKPTVAAVTGYALGSGMNLALAADWRVSGDNAKFGATEILAGLA
MAB_3382c|M.abscessus_ATCC_199 TAVAELAKPTIAAITGYALGSGLELALTADWRIAGDNVKVGSPEILVGMI
TH_3663|M.thermoresistible__bu DALAAIPRPTVAAITGYALGSGLTLALTADWRVXXX--RDAGTASAFQIP
*:* :.:**:**:******:*: ***:****: : ...
Mflv_4270|M.gilvum_PYR-GCK PAGDGAGRLAEAVGPSRAKDLVFSGRFVDAREAHTLGLVDELVAPDGVYD
Mvan_2089|M.vanbaalenii_PYR-1 PAGGAATRLAGAIGQSKARDLVFSGRFVDAREALKLGLVDELVAPDTVYD
Mb3065c|M.bovis_AF2122/97 PSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGLIDDMVAPDDVYD
Rv3039c|M.tuberculosis_H37Rv PSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGLIDDMVAPDDVYD
MLBr_01724|M.leprae_Br4923 PDGDGLARLTRVAGVSRAKDLVFSGRFFDAAEALALGLIDDMVAPDDVYD
MAV_3904|M.avium_104 PGGDALARLTRVAGASKAKELVFSGRFFDAEEALALGLIDEMVAPDDVYD
MMAR_1662|M.marinum_M PGGGGMGRLTRVVGSSRAKELVFSGRFFDAEEALALGLIDDMVAPDDVYD
MUL_1899|M.ulcerans_Agy99 PGGGGMGRLTRVVGSSRAKELVFSGRFFDAEEALALGLIDDMVAPDDVYD
MSMEG_2328|M.smegmatis_MC2_155 PRGGGGVRLADAIGTSKAKELVFSGRFVGAEEALEIGLVDEMVAPDHVYE
MAB_3382c|M.abscessus_ATCC_199 PGGGGTVRLARVVGLSRAKEMVFSGRFVGADEARGAGLIDQVVAPDDVYT
TH_3663|M.thermoresistible__bu PSPASAPRVPNPGSARAANAATPVASDDDSDPASAGATSHGSATGTAVPS
* . *:. . *. . . .: * . . .: *
Mflv_4270|M.gilvum_PYR-GCK AALAWAGRFREHP-----PEVLAAAKA----AFS--APRSVAGP------
Mvan_2089|M.vanbaalenii_PYR-1 AALAWAGRFADYP-----PEVLAAAKS----SFARDMWAGVDGR------
Mb3065c|M.bovis_AF2122/97 AAAAWARRFLDGP-----PHALAAAKAGISDVYELAPAERIAAERRRYVE
Rv3039c|M.tuberculosis_H37Rv AAAAWARRFLDGP-----PHALAAAKAGISDVYELAPAERIAAERRRYVE
MLBr_01724|M.leprae_Br4923 IAAAWARRFLDGL-----PHALAAAKAGINEVFDLEPAERIAAERRRYVE
MAV_3904|M.avium_104 AAAAWARRFLDGP-----RHALAAAKAGVDAVFELPRAERLAAGQRRYVE
MMAR_1662|M.marinum_M SAVAWARRYLECP-----PRALAAAKAVINDVFELEATERAAAERRRYVE
MUL_1899|M.ulcerans_Agy99 SAVAWARRYLECP-----PRALAAAKAVINNVFELEATERAAAERRRYVE
MSMEG_2328|M.smegmatis_MC2_155 AALAWARRFSDHP-----VDVLAAAKASLNGPVNWRGPRPTDRMVDRP--
MAB_3382c|M.abscessus_ATCC_199 EAASWARRFVDGP-----PLALAAAKEAIDHGFDGPLAAGLDKERELFCQ
TH_3663|M.thermoresistible__bu VTVAHHRRGRPSPGTATHTSATVAASIRPVGVSPATATASTSGAHPRASD
: : * . .**.
Mflv_4270|M.gilvum_PYR-GCK ----------------------------------
Mvan_2089|M.vanbaalenii_PYR-1 ----------------------------------
Mb3065c|M.bovis_AF2122/97 VFAAGQ--------GGGSKGDRGGR---------
Rv3039c|M.tuberculosis_H37Rv VFAAGQ--------GGGSKGDRGGR---------
MLBr_01724|M.leprae_Br4923 VFAAAQ--------PSLLLGGCD-----------
MAV_3904|M.avium_104 VFSAGQ--------GGDAGADPHGG---------
MMAR_1662|M.marinum_M LFAAGQRGPDGRGPGGGNTGDQDGR---------
MUL_1899|M.ulcerans_Agy99 LFAAGQRGPDGRGPGGGNTDDQDGR---------
MSMEG_2328|M.smegmatis_MC2_155 ----------------------------------
MAB_3382c|M.abscessus_ATCC_199 VFATQDRADGVTAQLEIGPGTARFRGA-------
TH_3663|M.thermoresistible__bu PVRRRTGVESVRRRTGVESVRRRTMAAATQGSAP