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VRRRLAGLAFALGALLTASVSVAAPGIAQPAAQPAAAQPIPDGPAKAWLVADLDTGRVLASKDPYGTYAP ASTIKVLLAMTVLDHLRPDSFARANESHTKIECSCAGLTPGQAYTTAQLVSAILMVSGNDAATMLGDMLG GQRVAVAAMNRKAALVGARSTKASSTSGLDGPGWESVTTPHDLAVIMRAALKYPLIAQIMRSPTAPFPGK TLHNQNELLSRYPGDLGGKTGFTNLARKTYVGAAQRGNRRLVVVQMYGTGDLYGQAMQLLDYGFSQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4180 | - | - | 100% (277) | peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 |
| M. gilvum PYR-GCK | Mflv_4179 | - | 3e-77 | 54.04% (285) | Serine-type D-Ala-D-Ala carboxypeptidase |
| M. gilvum PYR-GCK | Mflv_4869 | - | 5e-46 | 43.50% (246) | Serine-type D-Ala-D-Ala carboxypeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2935 | dacB2 | 5e-73 | 52.88% (278) | D-alanyl-D-alanine carboxypeptidase |
| M. tuberculosis H37Rv | Rv2911 | dacB2 | 5e-73 | 52.88% (278) | D-alanyl-D-alanine carboxypeptidase |
| M. leprae Br4923 | MLBr_00691 | - | 3e-47 | 43.32% (247) | putative D-alanyl-D-alanine carboxypeptidase |
| M. abscessus ATCC 19977 | MAB_3234 | - | 3e-74 | 53.53% (269) | D-alanyl-D-alanine carboxypeptidase DacB |
| M. marinum M | MMAR_1797 | dacB | 2e-73 | 53.87% (271) | D-alanyl-D-alanine carboxypeptidase DacB |
| M. avium 104 | MAV_3766 | - | 6e-75 | 52.73% (275) | D-alanyl-D-alanine carboxypeptidase |
| M. smegmatis MC2 155 | MSMEG_2432 | - | 1e-119 | 77.17% (276) | D-alanyl-D-alanine carboxypeptidase |
| M. thermoresistible (build 8) | TH_2393 | - | 1e-75 | 53.02% (281) | D-alanyl-D-alanine carboxypeptidase |
| M. ulcerans Agy99 | MUL_2045 | dacB | 5e-73 | 53.33% (270) | D-alanyl-D-alanine carboxypeptidase DacB |
| M. vanbaalenii PYR-1 | Mvan_2183 | - | 1e-141 | 89.57% (278) | peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4180|M.gilvum_PYR-GCK -------------------------------------------MRRRLAG
Mvan_2183|M.vanbaalenii_PYR-1 -------------------------------------------MRRRLAG
MSMEG_2432|M.smegmatis_MC2_155 -------------------------------------------MRRLFAA
Mb2935|M.bovis_AF2122/97 ----------------------------------------------MRKL
Rv2911|M.tuberculosis_H37Rv ----------------------------------------------MRKL
MMAR_1797|M.marinum_M ----------------------------------------------MRKV
MUL_2045|M.ulcerans_Agy99 ----------------------------------------------MRKV
MAV_3766|M.avium_104 -------------------------------------MDRKLDFAAMRKL
MAB_3234|M.abscessus_ATCC_1997 ----------------------------------------------MSDP
TH_2393|M.thermoresistible__bu -------------------------------VRATTDRPRRPRLRSRPSR
MLBr_00691|M.leprae_Br4923 MSFLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEPNAGPNAGPATCPYQ
Mflv_4180|M.gilvum_PYR-GCK LAFALGALL-TASVSVAAPGIAQPAAQPAAAQPI--------PDGP----
Mvan_2183|M.vanbaalenii_PYR-1 LALALSAVLPAASMSIAPPTSAQPAAEPAAAQPL--------PDGP----
MSMEG_2432|M.smegmatis_MC2_155 AAFALSTAL--AAATFTPVAHAEPAAAPAGAAAV--------TDGP----
Mb2935|M.bovis_AF2122/97 MTATAALCACAVTVSAGAAW-ADADVQPAGSVPI--------PDGP----
Rv2911|M.tuberculosis_H37Rv MTATAALCACAVTVSAGAAW-ADADVQPAGSVPI--------PDGP----
MMAR_1797|M.marinum_M MAVAAALLT-AATISGATAS-ADTEMQPAGSVPI--------PDGP----
MUL_2045|M.ulcerans_Agy99 MAVAAVLLT-AATISGATAS-ADTEMQPAGSVPI--------PDGP----
MAV_3766|M.avium_104 WTAAAALLL--VGACGAPTA-AADSTQPAGSIPI--------PDGP----
MAB_3234|M.abscessus_ATCC_1997 MSTLRIRALAVLSVLFLSTL-PVGVARADMAAPP--------PEGP----
TH_2393|M.thermoresistible__bu NALLATLFAIALSVSGIAAPESSAQPEPVRAMSV--------PDGP----
MLBr_00691|M.leprae_Br4923 VSTPPAVDSSEVPQTGNPPMPLAVPPKPVGGAALNSCGIVTAPDTPPVPG
: . . . . .: *
Mflv_4180|M.gilvum_PYR-GCK ---AKAWLVADLDTGRVLASKDPYGTYAPASTIKVLLAMTVLDHLRPDSF
Mvan_2183|M.vanbaalenii_PYR-1 ---AEAWLVADLDTGRVLASKNPYGTYAPASTIKVLLAMTVLDHLRPDNF
MSMEG_2432|M.smegmatis_MC2_155 ---AKAWLVADMDTGRVLASKDPYGSYAPASTIKPLLAMVVLDHLRPDNF
Mb2935|M.bovis_AF2122/97 ---AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVLLALVALDELDLNST
Rv2911|M.tuberculosis_H37Rv ---AQTWIVADLDSGQVLAGRDQNVAHPPASTIKVLLALVALDELDLNST
MMAR_1797|M.marinum_M ---AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVLLALVALDELDLNST
MUL_2045|M.ulcerans_Agy99 ---AQTWIVADLDTGQVLAGRDQNVTHPPASTIKVLLALVALDELNLNST
MAV_3766|M.avium_104 ---AQTWIIADLDSGQVLAGRDPNVAHPPASTIKTLLAQVVLDEVSLDAT
MAB_3234|M.abscessus_ATCC_1997 ---AQAWLVADLDSGQILAARDPYATHAPASTIKVLLALVALDEVPMDAT
TH_2393|M.thermoresistible__bu ---APAWLLADLDTGQVLAAREPHVHRAPASTIKVLLAIVALDQLPLNAT
MLBr_00691|M.leprae_Br4923 DLSAEAWLVADLNSGAVIAARDPHGRHRPASIIKVLLAMASINTLNLNKS
* :*::**:::* ::*.:: *** ** *** . :: : :
Mflv_4180|M.gilvum_PYR-GCK ARANESHTKIECSCAGLTPGQAYTTAQLVSAILMVSGNDAATMLGDMLGG
Mvan_2183|M.vanbaalenii_PYR-1 ARANESHTRVECSCVGLQPGQAYTTAQLVAAILMVSGNDAANMLADMLGG
MSMEG_2432|M.smegmatis_MC2_155 ARANASHTKVECSCVGLKPGQPYTTRQLLDALLMVSGNDAANMLADMLGG
Mb2935|M.bovis_AF2122/97 VVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGG
Rv2911|M.tuberculosis_H37Rv VVADVADTQAECNCVGVKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGG
MMAR_1797|M.marinum_M VVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVSGNDAANTLAQMLGG
MUL_2045|M.ulcerans_Agy99 VVADEADTHVECNCVGVKAGHTYTARQLLDGLLLVSGNDAANTLAQLLGG
MAV_3766|M.avium_104 VVADAADTQVECNCVGIKPGRSYTARQLLDALLLVSGNDAANTLAHMLGG
MAB_3234|M.abscessus_ATCC_1997 VVADAADAKAECNCVGIKAGQTYTARELLDAALLESGNDAANTLAHLLGG
TH_2393|M.thermoresistible__bu VRAGAAAADEVCSCAGIRPGRVYSTRQLLDAVLLISGNDAANTLADMLGG
MLBr_00691|M.leprae_Br4923 VAGTAEDAAAEGTKVGVHDGGTYTINQLLHGLLMQSGNDAAHSLAMQLGG
. . : . .*: * *: :*: . *: ****** *. ***
Mflv_4180|M.gilvum_PYR-GCK QRVAVAAMNRKAALVGARSTKASSTSGLDGPGWESVTTPHDLAVIMRAAL
Mvan_2183|M.vanbaalenii_PYR-1 QRVAVAAMNRKAALVGARSTRASSPSGLDGPGWESVTTPHDLAVIMRAAL
MSMEG_2432|M.smegmatis_MC2_155 PRVAVAAMNRKAAAVGARNTRAASPSGLDGPGWESLTTPHDLAVIFRAAL
Mb2935|M.bovis_AF2122/97 QDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGASTAHDLVVIFRAAM
Rv2911|M.tuberculosis_H37Rv QDVTVAKMNAKAATLGATSTHATTPSGLDGPGGSGASTAHDLVVIFRAAM
MMAR_1797|M.marinum_M QDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGWSTAHDLAVIFRTAM
MUL_2045|M.ulcerans_Agy99 QDAAVAKMNAKAAALGAMNTHAATPSGLDGPGGSGWSTAHDLAVIFRTAM
MAV_3766|M.avium_104 PEATVAKMNAKAAALGATNTHASTPSGLDGPNGSGSSTAHDLAVIFRAAM
MAB_3234|M.abscessus_ATCC_1997 RQATVDKMNAKAAALGATSTHTDSPSGLDAPGMDMRTSPHDLAVIFRAAL
TH_2393|M.thermoresistible__bu RQVTVAKMNAKAYQIGARNTRVTSPSGLDVPGVDMVTTPHDLALIFRTAL
MLBr_00691|M.leprae_Br4923 MQQALQKINVLAAKLGGQDTRVATPSGLDGPGMS--TSAYDIGLFYRYAW
:: :* * :*. .*:. :.**** *. . ::.:*: :: * *
Mflv_4180|M.gilvum_PYR-GCK KYPLIAQIMRSPTAPFP--GKT----LHNQNELLSRYPGDLGGKTGFTNL
Mvan_2183|M.vanbaalenii_PYR-1 KYPLIAQIMRSPSAPFP--GKT----LHNQNELLSRYPGDLAGKTGFTNL
MSMEG_2432|M.smegmatis_MC2_155 NYPVIAQILRQTTAQFP--GKT----LTYQNELLTRYPGDIGGKTGYTNL
Mb2935|M.bovis_AF2122/97 ANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQRYPGAIGGKTGYTNA
Rv2911|M.tuberculosis_H37Rv ANPVFAQITAEPSAMFP--SDNGEQLIVNQDELLQRYPGAIGGKTGYTNA
MMAR_1797|M.marinum_M ANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQRYPGAIGGKTGYTNA
MUL_2045|M.ulcerans_Agy99 ANPVFAHITAEPSAMFP--GEDGEHPIVNQDELLQRYPGAIGGKTGYTNA
MAV_3766|M.avium_104 ANPVFAQITAEPSAMFP--GDNGLQPITNQDELLQRYPGAIGGKTGFTNA
MAB_3234|M.abscessus_ATCC_1997 ANPVFAEITAQPSAPFP--GRG----LHNQNELMYRYPGVIGGKTGFTDI
TH_2393|M.thermoresistible__bu RYPAFVNIISQPWTMFP--SDNGFRQIVNQNELLKRYPGTIGGKTGYTKI
MLBr_00691|M.leprae_Br4923 QNPSFSNIVATRTFNFPGPGDHPGYQLENDNQLLYQYPGALGGKTGYTDD
* : .* ** . : :::*: :*** :.****:*.
Mflv_4180|M.gilvum_PYR-GCK ARKTYVGAAQRGNRRLVVVQMYGTG-----DLYGQAMQLLDYGFSQP---
Mvan_2183|M.vanbaalenii_PYR-1 ARKTYVGAAQRGNRRLVVVQMYGTG-----DLYGHAIRLLDYGFSQP---
MSMEG_2432|M.smegmatis_MC2_155 ARKTYVGAAQRGNRRLVVVQMYGTG-----DLYDQAIRLFDYGFSQ----
Mb2935|M.bovis_AF2122/97 ARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLFDWGFALNPQA
Rv2911|M.tuberculosis_H37Rv ARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLFDWGFALNPQA
MMAR_1797|M.marinum_M ARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQAGSLFDWGFALNPQS
MUL_2045|M.ulcerans_Agy99 ARKTFVGAAARNGRRLVIAMMYGLVKEGGPTYWDQAGSLFDWGFALNPQS
MAV_3766|M.avium_104 ARKTFVGAAARGGRRLVIAMMYGLIKEGGPSYWDQAATLFDWGFAQSPQA
MAB_3234|M.abscessus_ATCC_1997 ARKTYVVAAERDGKRLVVSMMYGLVHEGGPTYWDQAASLFDWGFVNDGSS
TH_2393|M.thermoresistible__bu ARKTYVGAAQRNGRRLVIVQMGGMDQPGR-TYWDQAVDLFNWGFSQYR--
MLBr_00691|M.leprae_Br4923 AGQTFVGAANRNGRRLMAVLLHGTRQP--IAPWEQAAHLLDYGFSTAVGT
* :*:* ** *..:**: : * : :* *:::**
Mflv_4180|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2183|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2432|M.smegmatis_MC2_155 --------------------------------------------------
Mb2935|M.bovis_AF2122/97 SVGSL---------------------------------------------
Rv2911|M.tuberculosis_H37Rv SVGSL---------------------------------------------
MMAR_1797|M.marinum_M GIGSL---------------------------------------------
MUL_2045|M.ulcerans_Agy99 GIGSL---------------------------------------------
MAV_3766|M.avium_104 SIGSL---------------------------------------------
MAB_3234|M.abscessus_ATCC_1997 SVGSL---------------------------------------------
TH_2393|M.thermoresistible__bu --------------------------------------------------
MLBr_00691|M.leprae_Br4923 QIGTLIEPDPTVAGNADRHGHGLQAAGIMSSNDTLPVRIGVAVVGTLIVF
Mflv_4180|M.gilvum_PYR-GCK ---------------
Mvan_2183|M.vanbaalenii_PYR-1 ---------------
MSMEG_2432|M.smegmatis_MC2_155 ---------------
Mb2935|M.bovis_AF2122/97 ---------------
Rv2911|M.tuberculosis_H37Rv ---------------
MMAR_1797|M.marinum_M ---------------
MUL_2045|M.ulcerans_Agy99 ---------------
MAV_3766|M.avium_104 ---------------
MAB_3234|M.abscessus_ATCC_1997 ---------------
TH_2393|M.thermoresistible__bu ---------------
MLBr_00691|M.leprae_Br4923 GLIMITRSLNRRPQH