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TELSRRHVLLGGLSLFALTACSTQTVLADPARPLPPPEERIAALAARHDARIGLYAADLDSGATLAFGDT DTFAVCSTFKTYAAGAVLQRVQQGRLGLGDTVLIEAADIRPHSPVTEPRVGTAMTLAELCQAALQQSDNA AANGLLRVLGGPSAITEFARSIGDDRTRLDRWEVELNSAVPGDPRDTSTPRALATGYQALLTGDVLDPAG RRQLVDWMLANQTSSMRAGLPAGYTSADKTGSGDYGSTNDVGIAFGPAGQRLLLAVMTRSASDDPDAPSL RPLIGELATLVLSEL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4021 | - | - | 100% (296) | Beta-lactamase |
| M. gilvum PYR-GCK | Mflv_4179 | - | 2e-07 | 30.35% (201) | Serine-type D-Ala-D-Ala carboxypeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2094c | blaC | 8e-51 | 40.20% (301) | class A BETA-lactamase BLAC |
| M. tuberculosis H37Rv | Rv2068c | blaC | 8e-51 | 40.20% (301) | class A BETA-lactamase BLAC |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2875 | - | 2e-48 | 38.44% (294) | beta-lactamase |
| M. marinum M | MMAR_3050 | blaC | 2e-56 | 40.13% (299) | class a beta-lactamase, BlaC |
| M. avium 104 | MAV_3766 | - | 3e-08 | 32.68% (153) | D-alanyl-D-alanine carboxypeptidase |
| M. smegmatis MC2 155 | MSMEG_2658 | - | 8e-98 | 61.49% (296) | beta-lactamase |
| M. thermoresistible (build 8) | TH_1285 | - | 5e-96 | 60.40% (298) | beta-lactamase |
| M. ulcerans Agy99 | MUL_2294 | blaC | 8e-56 | 39.80% (299) | class a beta-lactamase, BlaC |
| M. vanbaalenii PYR-1 | Mvan_2352 | - | 1e-131 | 78.04% (296) | Beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4021|M.gilvum_PYR-GCK ------MTELSRRHVLLGGLSLFALTACSTQTVLADPARPLPP----PEE
Mvan_2352|M.vanbaalenii_PYR-1 ------MTEFSRRHVLFGGVSLAALAACSPQTVLADPVEPLPP----LDQ
MSMEG_2658|M.smegmatis_MC2_155 ------MTNLSRRSVLIGSLAVMAA--AGVRMP-TASAAP-------VDD
TH_1285|M.thermoresistible__bu ------VTGLSRRTLLIGGLAVAGAGLCGLAAPRIAHAAPA------IHQ
Mb2094c|M.bovis_AF2122/97 MR----NRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLAD
Rv2068c|M.tuberculosis_H37Rv MR----NRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLAD
MMAR_3050|M.marinum_M MRPSNPRSAVNRRQLLAAMAALLPLSACAKAASDQHMASTMAVPSPDLES
MUL_2294|M.ulcerans_Agy99 MRPSNPRSAVNRRQLLAAMAALVPLSACAKAASDQHLASTMAVPSPDLES
MAB_2875|M.abscessus_ATCC_1997 --------MISRRALLVGGVSAVGVVAAGCSRNGNRRPAP---------D
MAV_3766|M.avium_104 --MDRKLDFAAMRKLWTAAAALLLVGACGAPTAAADSTQP----------
* : . .. .
Mflv_4021|M.gilvum_PYR-GCK RIAALAARHDARIGLYAADLDSGATLAFGD-TDTFAVCSTFKTYAAGAVL
Mvan_2352|M.vanbaalenii_PYR-1 RIEALGQRHNAQIGLYALDLDTQRGIEFGA-DEPFAMCSTFKAYAAAAVL
MSMEG_2658|M.smegmatis_MC2_155 RIADLERRNNASIGIYAVDLDSNRTVAHRA-DDSFAMCSTFKAYLAARIL
TH_1285|M.thermoresistible__bu RLTGLENDHDQLIGLYAVDLGSGRTIAHRE-HESFAMCSTFKTYLAAATL
Mb2094c|M.bovis_AF2122/97 RFAELERRYDARLGVYVPATGTTAAIEYRA-DERFAFCSTFKAPLVAAVL
Rv2068c|M.tuberculosis_H37Rv RFAELERRYDARLGVYVPATGTTAAIEYRA-DERFAFCSTFKAPLVAAVL
MMAR_3050|M.marinum_M RFAELEQKYEARLGVYVPGTDATAAVEHRG-DERFAFCSTFKGLLGAAVL
MUL_2294|M.ulcerans_Agy99 RFAELEQKYEARLGVYVPGTDATAAVEHRG-DERFAFCSTFKGLLGAAVL
MAB_2875|M.abscessus_ATCC_1997 ELASLEKDFGGRIGVYALDTGSGDTVGHRA-DERFLMCSTVKTFIVSAIL
MAV_3766|M.avium_104 -AGSIPIPDGPAQTWIIADLDSGQVLAGRDPNVAHPPASTIKTLLAQVVL
: .: : . .**.* *
Mflv_4021|M.gilvum_PYR-GCK QRVQQGRLGLGDTVLIEAADIRPHSPVTEPRVGTAMTLAELCQAALQQSD
Mvan_2352|M.vanbaalenii_PYR-1 QRTQTGELTLNDAIPIEPGDIRPHSPVTEPRVGTSMSLAELCQAALQQSD
MSMEG_2658|M.smegmatis_MC2_155 RGAERGELSLDDRVFVDPAALLSNSPITETHAGGEMTLAELCQAALQRSD
TH_1285|M.thermoresistible__bu QRVQQGELQLDQRIFVPPAAIVTHSPRSEAAAGGHLTVAELCAAILQVSD
Mb2094c|M.bovis_AF2122/97 HQ--NPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSD
Rv2068c|M.tuberculosis_H37Rv HQ--NPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSD
MMAR_3050|M.marinum_M HR--YPIAHLGTVITYNSADIRSTSPITEQHLATGMSIGGLCDATIRYSD
MUL_2294|M.ulcerans_Agy99 HR--YSIAHLGTVITYNSADIRSTSPIIEQHLATGMSIGGLCDATIRYSD
MAB_2875|M.abscessus_ATCC_1997 RRRLSEPGLLDQRIQYTQSDVLEWAPITSQHVSTGMTVSELCDATLRYSD
MAV_3766|M.avium_104 DE-----VSLDATVVADAADTQVECNCVGIKPGRSYTARQLLDALLLVSG
*. : . : * * : *.
Mflv_4021|M.gilvum_PYR-GCK NAAANGLLRVLGG----PSAITEFARSIGDDRTRLDRWEVELNSAVPGDP
Mvan_2352|M.vanbaalenii_PYR-1 NAAANGLLRVLGG----PQAITAFARSIGDHRTRLDRWEVELNSALPGDP
MSMEG_2658|M.smegmatis_MC2_155 NAAANLLLKQIGG----PAEITAFARSIGDQRTRLDRWETELNSAVPGDP
TH_1285|M.thermoresistible__bu NGAANTLLQTLGG----PPAVTEFARSIGDERSRLDRWEVALNSAVPGDP
Mb2094c|M.bovis_AF2122/97 GTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDE
Rv2068c|M.tuberculosis_H37Rv GTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDE
MMAR_3050|M.marinum_M GTAANLLLQDIGG----IAAFNEYLRSLGDSVSRLDQMEPELNRNPPGDV
MUL_2294|M.ulcerans_Agy99 GTAANLLLQDIGG----IAAFNEYLRSLGDSVSRLDQMEPELNRNPPGDV
MAB_2875|M.abscessus_ATCC_1997 NTGANLLITQLGG----PKETEKFVRSLGDNVTRMDRTEVQLN-IPDGD-
MAV_3766|M.avium_104 NDAANTLAHMLGG----PEATVAKMNAKAAALGATNTHASTPSGLDGPNG
. .** * :** .: . : . :
Mflv_4021|M.gilvum_PYR-GCK RDTSTPRALATGYQALLTGDVLDPAGRRQLVDWMLANQTS--SMRAGLPA
Mvan_2352|M.vanbaalenii_PYR-1 RDTSTPRALGDGYRNILTGDVLNPPTRRQLLDWMLANQTS--SMRAGLPA
MSMEG_2658|M.smegmatis_MC2_155 RDTSTPAALAGGFRAVLTGDVLAPPQRQLLDEWMRANETS--SLRAGLPD
TH_1285|M.thermoresistible__bu RDTSTPRALGEGYRTLLEGDVLAPPYREQLVEWMRTNETS--AMRPGLPP
Mb2094c|M.bovis_AF2122/97 RDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPA
Rv2068c|M.tuberculosis_H37Rv RDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPA
MMAR_3050|M.marinum_M RDTTTPHAIAMDYQQVVLGDALLPEKRDKLIDWLGRSTTGAKRIRAGFPA
MUL_2294|M.ulcerans_Agy99 RDTTTPHAIAMDYQQVVLGDALLPEKRDKLIDWLGRSTTGAKRIRAGFPA
MAB_2875|M.abscessus_ATCC_1997 LDTSTPQQLVANLRRLVLDEGLDSRGRDLLTDWLKRNTTGDQSIRAAVPA
MAV_3766|M.avium_104 SGSSTAHDLAVIFRAAMANPVFAQITAEPSAMFPGDNGLQPITNQDELLQ
.::*. : : : . : : . : .
Mflv_4021|M.gilvum_PYR-GCK GYT--SADKTGSGDYGSTNDVGIAFGPAGQRLLLAVMTRSASDDPDAPSL
Mvan_2352|M.vanbaalenii_PYR-1 GYT--SADKTGSGDYGTTNDVGVAYGPAGQQVLLSLMTRSAIDDPDAPSL
MSMEG_2658|M.smegmatis_MC2_155 GWT--SADKTGSGDYGSTNDVGIAYGPQGQRILLALMVRTRGDDPNADGF
TH_1285|M.thermoresistible__bu GWV--SADKTGSGDYGTTNDVGLLYGPQGQRVVLAILTRSASDDPDAQNP
Mb2094c|M.bovis_AF2122/97 DWK--VIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPR
Rv2068c|M.tuberculosis_H37Rv DWK--VIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPR
MMAR_3050|M.marinum_M DWR--VIDKTGSGEYGRANDVAVVWSPGGTPYVVAIMTDRVGGGPEAPWC
MUL_2294|M.ulcerans_Agy99 DWR--VIDKTGSGEYGRANDVAVVWSPGGTPYVVAIMTDRVGGGPEAPWC
MAB_2875|M.abscessus_ATCC_1997 GWT--VADKTGGGFKGETNDIAVIWPPGRAPIVMAVLT--VPEDPTSTKG
MAV_3766|M.avium_104 RYPGAIGGKTGFTNAARKTFVGAAARGGRRLVIAMMYGLIKEGGPSYWDQ
: .*** . . :. : : .
Mflv_4021|M.gilvum_PYR-GCK RPLIGELATLVLSEL-------
Mvan_2352|M.vanbaalenii_PYR-1 RPLIGELAALALSELG------
MSMEG_2658|M.smegmatis_MC2_155 RPLIGELTALVLPELGVH----
TH_1285|M.thermoresistible__bu RPLIGEITAAVLPELLGWPSAQ
Mb2094c|M.bovis_AF2122/97 EALLAEAATCVAGVLA------
Rv2068c|M.tuberculosis_H37Rv EALLAEAATCVAGVLA------
MMAR_3050|M.marinum_M DPLVADAAKCVADVLAQWSA--
MUL_2294|M.ulcerans_Agy99 DPLVADAAKCVADVLAQWSA--
MAB_2875|M.abscessus_ATCC_1997 KPTIAAATRIVLRAFGA-----
MAV_3766|M.avium_104 AATLFDWGFAQSPQASIGSL--
. :