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MISRRALLVGGVSAVGVVAAGCSRNGNRRPAPDELASLEKDFGGRIGVYALDTGSGDTVGHRADERFLMC STVKTFIVSAILRRRLSEPGLLDQRIQYTQSDVLEWAPITSQHVSTGMTVSELCDATLRYSDNTGANLLI TQLGGPKETEKFVRSLGDNVTRMDRTEVQLNIPDGDLDTSTPQQLVANLRRLVLDEGLDSRGRDLLTDWL KRNTTGDQSIRAAVPAGWTVADKTGGGFKGETNDIAVIWPPGRAPIVMAVLTVPEDPTSTKGKPTIAAAT RIVLRAFGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2875 | - | - | 100% (289) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2094c | blaC | 8e-56 | 44.57% (276) | class A BETA-lactamase BLAC |
| M. gilvum PYR-GCK | Mflv_4021 | - | 3e-48 | 38.44% (294) | Beta-lactamase |
| M. tuberculosis H37Rv | Rv2068c | blaC | 8e-56 | 44.57% (276) | class A BETA-lactamase BLAC |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_3050 | blaC | 4e-54 | 43.51% (262) | class a beta-lactamase, BlaC |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2658 | - | 2e-53 | 40.07% (292) | beta-lactamase |
| M. thermoresistible (build 8) | TH_1285 | - | 6e-50 | 38.97% (290) | beta-lactamase |
| M. ulcerans Agy99 | MUL_2294 | blaC | 7e-54 | 40.20% (296) | class a beta-lactamase, BlaC |
| M. vanbaalenii PYR-1 | Mvan_2352 | - | 2e-44 | 36.36% (297) | Beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2658|M.smegmatis_MC2_155 ------MTNLSRRSVLIG--SLAVMAA--AGVRMP-TASAAP-----VDD
TH_1285|M.thermoresistible__bu ------VTGLSRRTLLIG--GLAVAGAGLCGLAAPRIAHAAPA----IHQ
Mflv_4021|M.gilvum_PYR-GCK ------MTELSRRHVLLGGLSLFALTACSTQTVLADPARPLPP----PEE
Mvan_2352|M.vanbaalenii_PYR-1 ------MTEFSRRHVLFGGVSLAALAACSPQTVLADPVEPLPP----LDQ
Mb2094c|M.bovis_AF2122/97 MR----NRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLAD
Rv2068c|M.tuberculosis_H37Rv MR----NRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLAD
MMAR_3050|M.marinum_M MRPSNPRSAVNRRQLLAAMAALLPLSACAKAASDQHMASTMAVPSPDLES
MUL_2294|M.ulcerans_Agy99 MRPSNPRSAVNRRQLLAAMAALVPLSACAKAASDQHLASTMAVPSPDLES
MAB_2875|M.abscessus_ATCC_1997 --------MISRRALLVGGVSAVGVVAAGCSRNGNRRPAP---------D
..** :* . . . .
MSMEG_2658|M.smegmatis_MC2_155 RIADLERRNNASIGIYAVDLDSNRTVAHRADDSFAMCSTFKAYLAARILR
TH_1285|M.thermoresistible__bu RLTGLENDHDQLIGLYAVDLGSGRTIAHREHESFAMCSTFKTYLAAATLQ
Mflv_4021|M.gilvum_PYR-GCK RIAALAARHDARIGLYAADLDSGATLAFGDTDTFAVCSTFKTYAAGAVLQ
Mvan_2352|M.vanbaalenii_PYR-1 RIEALGQRHNAQIGLYALDLDTQRGIEFGADEPFAMCSTFKAYAAAAVLQ
Mb2094c|M.bovis_AF2122/97 RFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLH
Rv2068c|M.tuberculosis_H37Rv RFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLH
MMAR_3050|M.marinum_M RFAELEQKYEARLGVYVPGTDATAAVEHRGDERFAFCSTFKGLLGAAVLH
MUL_2294|M.ulcerans_Agy99 RFAELEQKYEARLGVYVPGTDATAAVEHRGDERFAFCSTFKGLLGAAVLH
MAB_2875|M.abscessus_ATCC_1997 ELASLEKDFGGRIGVYALDTGSGDTVGHRADERFLMCSTVKTFIVSAILR
.: * :*:*. .: : . : * .***.* . *:
MSMEG_2658|M.smegmatis_MC2_155 GAERGELSLDDRVFVDPAALLSNSPITETHAGGEMTLAELCQAALQRSDN
TH_1285|M.thermoresistible__bu RVQQGELQLDQRIFVPPAAIVTHSPRSEAAAGGHLTVAELCAAILQVSDN
Mflv_4021|M.gilvum_PYR-GCK RVQQGRLGLGDTVLIEAADIRPHSPVTEPRVGTAMTLAELCQAALQQSDN
Mvan_2352|M.vanbaalenii_PYR-1 RTQTGELTLNDAIPIEPGDIRPHSPVTEPRVGTSMSLAELCQAALQQSDN
Mb2094c|M.bovis_AF2122/97 Q--NPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDG
Rv2068c|M.tuberculosis_H37Rv Q--NPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDG
MMAR_3050|M.marinum_M R--YPIAHLGTVITYNSADIRSTSPITEQHLATGMSIGGLCDATIRYSDG
MUL_2294|M.ulcerans_Agy99 R--YSIAHLGTVITYNSADIRSTSPIIEQHLATGMSIGGLCDATIRYSDG
MAB_2875|M.abscessus_ATCC_1997 RRLSEPGLLDQRIQYTQSDVLEWAPITSQHVSTGMTVSELCDATLRYSDN
*. : : :* . :::. ** * :: **.
MSMEG_2658|M.smegmatis_MC2_155 AAANLLLKQIGG----PAEITAFARSIGDQRTRLDRWETELNSAVPGDPR
TH_1285|M.thermoresistible__bu GAANTLLQTLGG----PPAVTEFARSIGDERSRLDRWEVALNSAVPGDPR
Mflv_4021|M.gilvum_PYR-GCK AAANGLLRVLGG----PSAITEFARSIGDDRTRLDRWEVELNSAVPGDPR
Mvan_2352|M.vanbaalenii_PYR-1 AAANGLLRVLGG----PQAITAFARSIGDHRTRLDRWEVELNSALPGDPR
Mb2094c|M.bovis_AF2122/97 TAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDER
Rv2068c|M.tuberculosis_H37Rv TAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDER
MMAR_3050|M.marinum_M TAANLLLQDIGG----IAAFNEYLRSLGDSVSRLDQMEPELNRNPPGDVR
MUL_2294|M.ulcerans_Agy99 TAANLLLQDIGG----IAAFNEYLRSLGDSVSRLDQMEPELNRNPPGDVR
MAB_2875|M.abscessus_ATCC_1997 TGANLLITQLGG----PKETEKFVRSLGDNVTRMDRTEVQLN-IPDGD-L
.** *: :** : **:** :*:* * ** **
MSMEG_2658|M.smegmatis_MC2_155 DTSTPAALAGGFRAVLTGDVLAPPQRQLLDEWMRANETS--SLRAGLPDG
TH_1285|M.thermoresistible__bu DTSTPRALGEGYRTLLEGDVLAPPYREQLVEWMRTNETS--AMRPGLPPG
Mflv_4021|M.gilvum_PYR-GCK DTSTPRALATGYQALLTGDVLDPAGRRQLVDWMLANQTS--SMRAGLPAG
Mvan_2352|M.vanbaalenii_PYR-1 DTSTPRALGDGYRNILTGDVLNPPTRRQLLDWMLANQTS--SMRAGLPAG
Mb2094c|M.bovis_AF2122/97 DTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPAD
Rv2068c|M.tuberculosis_H37Rv DTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPAD
MMAR_3050|M.marinum_M DTTTPHAIAMDYQQVVLGDALLPEKRDKLIDWLGRSTTGAKRIRAGFPAD
MUL_2294|M.ulcerans_Agy99 DTTTPHAIAMDYQQVVLGDALLPEKRDKLIDWLGRSTTGAKRIRAGFPAD
MAB_2875|M.abscessus_ATCC_1997 DTSTPQQLVANLRRLVLDEGLDSRGRDLLTDWLKRNTTGDQSIRAAVPAG
**:** : : :: .: * . * * :*: . *. :*...* .
MSMEG_2658|M.smegmatis_MC2_155 WTSADKTGSGDYGSTNDVGIAYGPQGQRILLALMVRTRGDDPNADGFRPL
TH_1285|M.thermoresistible__bu WVSADKTGSGDYGTTNDVGLLYGPQGQRVVLAILTRSASDDPDAQNPRPL
Mflv_4021|M.gilvum_PYR-GCK YTSADKTGSGDYGSTNDVGIAFGPAGQRLLLAVMTRSASDDPDAPSLRPL
Mvan_2352|M.vanbaalenii_PYR-1 YTSADKTGSGDYGTTNDVGVAYGPAGQQVLLSLMTRSAIDDPDAPSLRPL
Mb2094c|M.bovis_AF2122/97 WKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREAL
Rv2068c|M.tuberculosis_H37Rv WKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREAL
MMAR_3050|M.marinum_M WRVIDKTGSGEYGRANDVAVVWSPGGTPYVVAIMTDRVGGGPEAPWCDPL
MUL_2294|M.ulcerans_Agy99 WRVIDKTGSGEYGRANDVAVVWSPGGTPYVVAIMTDRVGGGPEAPWCDPL
MAB_2875|M.abscessus_ATCC_1997 WTVADKTGGGFKGETNDIAVIWPPGRAPIVMAVLT--VPEDPTSTKGKPT
: **** * * :**:.: : * ::::: . : .
MSMEG_2658|M.smegmatis_MC2_155 IGELTALVLPELGVH----
TH_1285|M.thermoresistible__bu IGEITAAVLPELLGWPSAQ
Mflv_4021|M.gilvum_PYR-GCK IGELATLVLSEL-------
Mvan_2352|M.vanbaalenii_PYR-1 IGELAALALSELG------
Mb2094c|M.bovis_AF2122/97 LAEAATCVAGVLA------
Rv2068c|M.tuberculosis_H37Rv LAEAATCVAGVLA------
MMAR_3050|M.marinum_M VADAAKCVADVLAQWSA--
MUL_2294|M.ulcerans_Agy99 VADAAKCVADVLAQWSA--
MAB_2875|M.abscessus_ATCC_1997 IAAATRIVLRAFGA-----
:. : . :