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MSRLRRDLIGLMPTQVSGYSAFRVCYAFPARKAGTTAHRSTAAGCPSSTDGPRTDPRDVLDTEAVIPVHT QTLSPPARTASPRKRDGYDDVLDMFRELAVLDRDSAAFRRQREAIIARCLPLADHIARRFRGRGEGHEDL VQVARVGLLNAVNRFDVDSANDFLAFAVPTMMGEVRRYFRDHGWSLKVPRRLKELNVRLNAARADLTQEL NRAPTPSELAKYLGIDREEVVEGLVAANAYSTRSTEQPTTFSGDGEGLSLQDTFGAPDDNIQKVIDVNTV QPLLAALPERDRLVLKLRFFEDRTQSQIAEQIGVSQMHVSRLLARALATLRDQVGDEPATHS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3871 | - | - | 100% (342) | FliA/WhiG family RNA polymerase sigma factor |
| M. gilvum PYR-GCK | Mflv_4789 | - | 5e-84 | 62.20% (254) | RNA polymerase sigma factor SigF |
| M. gilvum PYR-GCK | Mflv_3872 | - | 1e-81 | 60.24% (254) | FliA/WhiG family RNA polymerase sigma factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3314c | sigF | 9e-78 | 56.59% (258) | RNA polymerase sigma factor SigF |
| M. tuberculosis H37Rv | Rv3286c | sigF | 9e-78 | 56.59% (258) | RNA polymerase sigma factor SigF |
| M. leprae Br4923 | MLBr_01022 | rpoT | 2e-19 | 27.63% (228) | RNA polymerase sigma factor |
| M. abscessus ATCC 19977 | MAB_2511 | - | 9e-77 | 59.52% (252) | RNA polymerase sigma factor SigF |
| M. marinum M | MMAR_1248 | sigF | 1e-81 | 59.62% (260) | alternate RNA polymerase sigma factor SigF |
| M. avium 104 | MAV_4256 | - | 6e-79 | 61.83% (241) | RNA polymerase sigma factor SigF |
| M. smegmatis MC2 155 | MSMEG_1804 | - | 5e-83 | 63.16% (247) | RNA polymerase sigma factor SigF |
| M. thermoresistible (build 8) | TH_0241 | sigF | 1e-80 | 61.41% (241) | ALTERNATE RNA POLYMERASE SIGMA FACTOR SIGF |
| M. ulcerans Agy99 | MUL_2640 | sigF | 8e-82 | 59.62% (260) | RNA polymerase sigma factor SigF |
| M. vanbaalenii PYR-1 | Mvan_2531 | - | 1e-113 | 82.64% (242) | FliA/WhiG family RNA polymerase sigma factor |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3871|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2531|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3314c|M.bovis_AF2122/97 --------------------------------------------------
Rv3286c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1248|M.marinum_M --------------------------------------------------
MUL_2640|M.ulcerans_Agy99 --------------------------------------------------
MAV_4256|M.avium_104 --------------------------------------------------
TH_0241|M.thermoresistible__bu --------------------------------------------------
MSMEG_1804|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2511|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 MEQSRRVPPLQWLSAVARPIARVLTLISTPTFDIADTFGYACPNPPEVSP
Mflv_3871|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2531|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3314c|M.bovis_AF2122/97 --------------------------------------------------
Rv3286c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1248|M.marinum_M --------------------------------------------------
MUL_2640|M.ulcerans_Agy99 --------------------------------------------------
MAV_4256|M.avium_104 --------------------------------------------------
TH_0241|M.thermoresistible__bu --------------------------------------------------
MSMEG_1804|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2511|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 TEGVYVVATKTSPATGQPVKRTATKTPATPAKRSTTKAANGSAPTKRATS
Mflv_3871|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2531|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3314c|M.bovis_AF2122/97 --------------------------------------------------
Rv3286c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1248|M.marinum_M --------------------------------------------------
MUL_2640|M.ulcerans_Agy99 --------------------------------------------------
MAV_4256|M.avium_104 --------------------------------------------------
TH_0241|M.thermoresistible__bu --------------------------------------------------
MSMEG_1804|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2511|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 TASRATKSTTPPKASGASDAAKKARTSVKSVDTKAPSAQDHTTKASAAKD
Mflv_3871|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2531|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3314c|M.bovis_AF2122/97 --------------------------------------------------
Rv3286c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1248|M.marinum_M --------------------------------------------------
MUL_2640|M.ulcerans_Agy99 --------------------------------------------------
MAV_4256|M.avium_104 --------------------------------------------------
TH_0241|M.thermoresistible__bu --------------------------------------------------
MSMEG_1804|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2511|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 TLNDPEATLNTLDSDATADDLDAEPDLDVEPSEDIDIDIEAADLGLDDLE
Mflv_3871|M.gilvum_PYR-GCK --------------MSRLRRDLIGLMPTQVSGYSAFRVCYAFPARKAGTT
Mvan_2531|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3314c|M.bovis_AF2122/97 --------------------------------------------------
Rv3286c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1248|M.marinum_M --------------------------------------------------
MUL_2640|M.ulcerans_Agy99 --------------------------------------------------
MAV_4256|M.avium_104 --------------------------------------------------
TH_0241|M.thermoresistible__bu --------------------------------------------------
MSMEG_1804|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2511|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 DDDVVTDIEPGETEDGEATAATKTDEASTDDDEEIVEPTEKDKASGDFVW
Mflv_3871|M.gilvum_PYR-GCK AHRSTAAGCPSSTDGPRTDPRDVLDTEAVIPVHTQTLSPPARTASPRKRD
Mvan_2531|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3314c|M.bovis_AF2122/97 ------------------------------------MTARAAGGSASRAN
Rv3286c|M.tuberculosis_H37Rv ------------------------------------MTARAAGGSASRAN
MMAR_1248|M.marinum_M ------------------------------------MTSRTAGGSSSRPN
MUL_2640|M.ulcerans_Agy99 ------------------------------------MTSRTAGGSSSRPN
MAV_4256|M.avium_104 --------------------------------------------------
TH_0241|M.thermoresistible__bu --------------------------------------------------
MSMEG_1804|M.smegmatis_MC2_155 ------------------------------------MTS-----------
MAB_2511|M.abscessus_ATCC_1997 --------------------------MECPVDVPETGHSQVKPRVGRPTD
MLBr_01022|M.leprae_Br4923 DEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIE
Mflv_3871|M.gilvum_PYR-GCK GYDDVLDMFRELAVLDRDSAAFRRQ------------REAIIARCLPLAD
Mvan_2531|M.vanbaalenii_PYR-1 -------MFRELALLDEGSAPYRRQ------------RDAIIERCLPLAD
Mb3314c|M.bovis_AF2122/97 EYADVPEMFRELVGLPAGSPEFQRH------------RDKIVQRCLPLAD
Rv3286c|M.tuberculosis_H37Rv EYADVPEMFRELVGLPAGSPEFQRH------------RDKIVQRCLPLAD
MMAR_1248|M.marinum_M EYADVPEMFRELATFDADSPNFQRH------------RDTIVERCLPLAD
MUL_2640|M.ulcerans_Agy99 EYADVPEMFRELATFDADSPNFQRH------------RDTIVERCLPLAD
MAV_4256|M.avium_104 -------MFRELATAEPDSMEFQRQ------------RDKIVERCLPLAD
TH_0241|M.thermoresistible__bu -------MFRELRKLPAESKEFQRQ------------RDRIVERCLPLAD
MSMEG_1804|M.smegmatis_MC2_155 EYADVLDMFRELAGTTEGSPSYVRQ------------REKIVERCLPLAD
MAB_2511|M.abscessus_ATCC_1997 DYADVPDMFRSLAGLAEHSDAYQRK------------HEEIVTRCLPLAD
MLBr_01022|M.leprae_Br4923 AGLYATQLMTELSERGTKLPTAQRRDMMWICRDGDRAKNHLLEANLRLVV
:: .* *: :: :: * *.
Mflv_3871|M.gilvum_PYR-GCK HIARRFRGRGEGHEDLVQVARVGLLNAVNRFDVDSANDFLAFAVPTMMGE
Mvan_2531|M.vanbaalenii_PYR-1 HIARRFRGRGEAHEDLVQVARVGLLNAVNRFDVDSANDFLAFAVPTMMGE
Mb3314c|M.bovis_AF2122/97 HIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGE
Rv3286c|M.tuberculosis_H37Rv HIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGE
MMAR_1248|M.marinum_M HIARRFEGRGEPRDDLVQVARVGLVNAVVRFDVETGSDFVSFAVPTIMGE
MUL_2640|M.ulcerans_Agy99 HIARRFEGRGEPRDDLVQVARVGLVNAVVRFDVETGSDFVSFAVPTIMGE
MAV_4256|M.avium_104 HIARRFEGRGEPRDDLVQVARVGLVNAVVRFDVDAGSDFVSFAVPTIMGE
TH_0241|M.thermoresistible__bu HIARRFDGRGEARDDLVQVARVGLVNAVIRFDVETGSDFVSFAVPTIMGE
MSMEG_1804|M.smegmatis_MC2_155 HIARRFDGRGEPREDLVQVARVGLVNAVNRFDVEAGSDFVSFAVPTIMGE
MAB_2511|M.abscessus_ATCC_1997 NVARHFDRRGEDLEDLIQVARVGLLNAVNRFDPEKGASFLGFAVPTMMGE
MLBr_01022|M.leprae_Br4923 SLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQA
:*::: ** **:* ..:**:.*. :** . .* :*. :
Mflv_3871|M.gilvum_PYR-GCK VRRYFRDHGWSLKVPRRLKELNVRLNAARADLTQELNRAPTPSELAKYLG
Mvan_2531|M.vanbaalenii_PYR-1 VRRYFRDHGWSLKVPRRLKELNVRLNSARSELTHQLNRAPTPSELAEFLG
Mb3314c|M.bovis_AF2122/97 VRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELG
Rv3286c|M.tuberculosis_H37Rv VRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELG
MMAR_1248|M.marinum_M VRRHFRDNSWSVKVPRRLKELHLRLGAATAELSQRLGRAPTATELAAELE
MUL_2640|M.ulcerans_Agy99 VRRHFRDNSWSVKVPRRLKELHLRLGAATAELSQRLGRAPTATELAAELE
MAV_4256|M.avium_104 VRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAHTATELAAELE
TH_0241|M.thermoresistible__bu VRRHFRDNSWSVKVPRRLKELHLRLGAATAELSQRLGRAPTASELAEELE
MSMEG_1804|M.smegmatis_MC2_155 VRRHFRDNSWSVKVPRRLKELHLRLGAATAELSQRLGRAPTASELAHELD
MAB_2511|M.abscessus_ATCC_1997 VRRHFRDHGWSLHVPRAIRDRHAQISRATAELTQELQRAPTAGELAAELG
MLBr_01022|M.leprae_Br4923 ITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMD
: * : *:. ::::* : : ::. :* : * * :. *** :
Mflv_3871|M.gilvum_PYR-GCK IDREEVVEGLVAANAYSTRSTEQPTTFSGDGEGLSLQDTFGAPDDNIQKV
Mvan_2531|M.vanbaalenii_PYR-1 MERDEIVEGLVAANAYSTRSTEQETMRTGDGDGLTLLDTIGGPDEGIQRV
Mb3314c|M.bovis_AF2122/97 MDRAEVIEGLLAGSSYHTLSIDSG-GGS-DDDARAITDTLGDVDAGLDQI
Rv3286c|M.tuberculosis_H37Rv MDRAEVIEGLLAGSSYHTLSIDSG-GGS-DDDARAITDTLGDVDAGLDQI
MMAR_1248|M.marinum_M MDRAEVVEGLVAGSSYNTLSIDSG-SGSEDDDARAIADTLGDMDAGLDRI
MUL_2640|M.ulcerans_Agy99 MDRAEVVEGLVAGSSYNTLSIDSG-SGSEDDDARAIADTLGDMDAGLDRI
MAV_4256|M.avium_104 MDREEVVEGLVAGSSYNTLSIDSG-GGSEEEEVRAIADTLGDVDTGLDRI
TH_0241|M.thermoresistible__bu MDRDEVIEGLVAGSSYNTLSIDSGGSGSGTEDAPAIADTLGDVDTGLDQI
MSMEG_1804|M.smegmatis_MC2_155 MDREEVVEGLIAGSSYNTLSIDSG--GGGDEEAPAIVDTLGDLDMGLDQI
MAB_2511|M.abscessus_ATCC_1997 IDREEVVESLIAADAYQPQSIEAP-LSHGDQESKHLSDLLGNEDPALEHV
MLBr_01022|M.leprae_Br4923 ITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFT
: :::* . . . . :.
Mflv_3871|M.gilvum_PYR-GCK IDVNTVQPLLAALPERDRLVLKLRFFED----RTQSQIAEQIGVSQMHVS
Mvan_2531|M.vanbaalenii_PYR-1 IDIQTVQPLLAKLPARDRLVLQLRFFDN----LTQSQIAERIGVSQMHVS
Mb3314c|M.bovis_AF2122/97 ENREVLRPLLEALPERERTVLVLRFFDS----MTQTQIAERVGISQMHVS
Rv3286c|M.tuberculosis_H37Rv ENREVLRPLLEALPERERTVLVLRFFDS----MTQTQIAERVGISQMHVS
MMAR_1248|M.marinum_M EDRESLRPLLEALPERERTVLVLRFFDS----MTQTQIAERVGISQMHVS
MUL_2640|M.ulcerans_Agy99 EDRESLRPLLEALPERERTVLVLRFFDS----MTQTQIAERVGISQMHVS
MAV_4256|M.avium_104 EDQESLRPLLEALPERERTVLVLRFFES----MTQTQIAERVGISQMHVS
TH_0241|M.thermoresistible__bu ENREALRPLLAALPERERTVLVLRFFES----LTQTQIAERVGISQMHVS
MSMEG_1804|M.smegmatis_MC2_155 DNRESLRPLLASLPERERTVLVLRFFES----MTQTQIAERVGISQMHVS
MAB_2511|M.abscessus_ATCC_1997 TNREAVRPLLANLPLRERTVLELRFFKG----MTQSQIAAQIGVSQMHVS
MLBr_01022|M.leprae_Br4923 LLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIR
: ::.:* *. *: *: *** * :*. *::: ::
Mflv_3871|M.gilvum_PYR-GCK RLLARALATLRDQVGDEPATHS--
Mvan_2531|M.vanbaalenii_PYR-1 RLLARALATLREQIG---------
Mb3314c|M.bovis_AF2122/97 RLLAKSLARLRDQLE---------
Rv3286c|M.tuberculosis_H37Rv RLLAKSLARLRDQLE---------
MMAR_1248|M.marinum_M RLLAKSLARLRDQLE---------
MUL_2640|M.ulcerans_Agy99 RLLAKSLARLRDQLE---------
MAV_4256|M.avium_104 RLLAKSLTRLRDQLQ---------
TH_0241|M.thermoresistible__bu RLLAKSLARLRDQLE---------
MSMEG_1804|M.smegmatis_MC2_155 RLLAKSLARLRDQLQ---------
MAB_2511|M.abscessus_ATCC_1997 RILSDTLRYLREQMA---------
MLBr_01022|M.leprae_Br4923 QIESKTMSKLRHPSRSQVLRDYLD
:: : :: **.