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MTVIGFHCSHEQIPPGQLLHDVQHAEQAGFTAAMSSDHFSPWSERQNESGFAWAFLGAALATTKLPFGVV NAPGQRYHPAIIAQAIATLAQMFPGRIWAALGSGEASNERITGDVWPRKEIRDQRLVECVDVIRRLLKGE EVSVDGLIHVNRARLWTLPETVPDLVGPAVTPATAARHAAWADALITVNQPAETLRQVLDSYRDAGGRGP ARLQIHLSWAPTDEEALAIAHDQWRTNVLGPPVSWDIETVEAFDTIGEAVTPEQMEPSVRISSDLGRHAA WLQEYLDQGWDELYLHFVGQHQRSFIDAFGEHVLPQLSPSAPAVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3722 | - | - | 100% (325) | putative dehydrogenase protein |
| M. gilvum PYR-GCK | Mflv_1341 | - | 7e-39 | 36.07% (305) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_0211 | - | 9e-29 | 30.09% (329) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 5e-32 | 31.15% (321) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | 2e-32 | 31.46% (321) | putative f420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00269 | - | 6e-28 | 28.05% (328) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0947c | - | 4e-39 | 37.50% (280) | putative luciferase |
| M. marinum M | MMAR_0709 | fgd1 | 5e-28 | 29.08% (337) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. avium 104 | MAV_0425 | - | 2e-37 | 33.84% (328) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1794 | - | 4e-39 | 34.65% (329) | dehydrogenase |
| M. thermoresistible (build 8) | TH_1712 | - | 4e-38 | 33.43% (329) | dehydrogenase |
| M. ulcerans Agy99 | MUL_2814 | fgd1 | 2e-28 | 29.08% (337) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. vanbaalenii PYR-1 | Mvan_5448 | - | 2e-37 | 33.64% (327) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1712|M.thermoresistible__bu ----------------------------------------MTRFGYTLLT
Mvan_5448|M.vanbaalenii_PYR-1 ----------------------------------------MTRFGYTLMT
MAV_0425|M.avium_104 --------------------------------MQPGIPVRMTNFGYTLMT
MSMEG_1794|M.smegmatis_MC2_155 ---------------------------------MHGYPQPMTRFGYTLMT
MAB_0947c|M.abscessus_ATCC_199 ----------------------------------------MTRFGYTLMT
Mflv_3722|M.gilvum_PYR-GCK ----------------------------------------MTVIGFHCSH
Mb0137c|M.bovis_AF2122/97 MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
Rv0132c|M.tuberculosis_H37Rv MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
MMAR_0709|M.marinum_M --------------------------------------MAELKLGYKASA
MUL_2814|M.ulcerans_Agy99 --------------------------------------MAELKLGYKASA
MLBr_00269|M.leprae_Br4923 --------------------------------------MAELRLGYKASA
.*
TH_1712|M.thermoresistible__bu EQSGPKDLIRYAVAAERAGFDFELCSDHYSPWLAAQGHAPYAWSVLGAVA
Mvan_5448|M.vanbaalenii_PYR-1 EQSGPKDLVSYAVSAEQVGFDFEVSSDHYFPWLASQGHAPYAWSVLGAVA
MAV_0425|M.avium_104 EQSGPKELVRYAISAEERGFDFHVCSDHFSPWLTSQGHAPNAWAVLGAVA
MSMEG_1794|M.smegmatis_MC2_155 EQSGPKDLVHYAVAAEQAGFDFEVCSDHFSPWLTSQGHAPNAWAVLGAVA
MAB_0947c|M.abscessus_ATCC_199 EQSGPKDLVRYAVAAEKAGFDFEVSSDHYSPWLSSQGHAPYAWSVLGAVA
Mflv_3722|M.gilvum_PYR-GCK EQIPPGQLLHDVQHAEQAGFTAAMSSDHFSPWSERQNESGFAWAFLGAAL
Mb0137c|M.bovis_AF2122/97 EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
Rv0132c|M.tuberculosis_H37Rv EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
MMAR_0709|M.marinum_M EQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVG
MUL_2814|M.ulcerans_Agy99 EQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVG
MLBr_00269|M.leprae_Br4923 EQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTAVG
** . *: ** *: *** ** ..: . : .
TH_1712|M.thermoresistible__bu HATDRVELLTFITCPTMRYHPAVVAQKAATLQILADGRFTLGLGSGENLN
Mvan_5448|M.vanbaalenii_PYR-1 HATDRVELMTYVTCPTMRYHPAIVAQKAATLQLLADGRFTLGLGSGENLN
MAV_0425|M.avium_104 QATERVDLYTYVTCPTMRYHPAIVAQQAATVQILSDGRFTLGLGSGENLN
MSMEG_1794|M.smegmatis_MC2_155 HATESAHLYSYVTCPTMRYHPAVVAQQAATVQILSDGRFTLGLGSGENLN
MAB_0947c|M.abscessus_ATCC_199 QATERVDLATYVTCPTMRYHPAVVAQKAATMQILADGRFTLGLGSGENLN
Mflv_3722|M.gilvum_PYR-GCK ATTK--LPFGVVNAPGQRYHPAIIAQAIATLAQMFPGRIWAALGSGEASN
Mb0137c|M.bovis_AF2122/97 NSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGKRLN
Rv0132c|M.tuberculosis_H37Rv NSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLN
MMAR_0709|M.marinum_M ERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGTGEALN
MUL_2814|M.ulcerans_Agy99 ERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGTGEALN
MLBr_00269|M.leprae_Br4923 ERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGEALN
*. : * **:** :.* *:: : .*. .:*:*: *
TH_1712|M.thermoresistible__bu EHVVG--RRWPTVARRHDMLREAITIIRGLFSGEVVDWKGEYFEVDSARL
Mvan_5448|M.vanbaalenii_PYR-1 EHVVG--KGWPTVARRHAMLREAIQIIRELHSGDMVDWKGEYFEVDSARL
MAV_0425|M.avium_104 EHVVG--KGWPTITRRQDMLREAIKIIRELFGGQLVDFTGDYFRVDSARV
MSMEG_1794|M.smegmatis_MC2_155 EHVVG--KGWPTVERRLDMLAEAIKIIRELFTGELIDFRGEYFEVDSARI
MAB_0947c|M.abscessus_ATCC_199 EHVVG--RGWPTVGRRQAMLREAIQIIRDLLCGEHVDGKGDYFEVDSARL
Mflv_3722|M.gilvum_PYR-GCK ERITG--DVWPRKEIRDQRLVECVDVIRRLLKGEEVSVDG-LIHVNRARL
Mb0137c|M.bovis_AF2122/97 EQAA--TDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKL
Rv0132c|M.tuberculosis_H37Rv EQAA--TDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKL
MMAR_0709|M.marinum_M EVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLRGASI
MUL_2814|M.ulcerans_Agy99 EVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLRGASI
MLBr_00269|M.leprae_Br4923 EVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGASI
* . : * * *.: ::* * *: :. * . :
TH_1712|M.thermoresistible__bu WDIPEVPVAIAVAVSGDRSVEMFAPIADHLVTTEP------DAGLVGSWH
Mvan_5448|M.vanbaalenii_PYR-1 WDVPEVPVPIAAAVSGDRSVEQFALLADHLIAVEP------DKDLVDSWH
MAV_0425|M.avium_104 WDVPDVPVGIGVAIGGTRAVDKFAKLADHLIATEP------NADLVDAWH
MSMEG_1794|M.smegmatis_MC2_155 WDVPDEPVGIGVSLTGERALEKLAVSTDHLINVAP------DAAVVEGWR
MAB_0947c|M.abscessus_ATCC_199 WDLPDVPVPIGVAVSSGDTAARFAPTADHMIAVAP------ESDIVDAWR
Mflv_3722|M.gilvum_PYR-GCK WTLPETVPDLVGPAVTPATAARHAAWADALITVNQ------PAETLRQVL
Mb0137c|M.bovis_AF2122/97 YDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKLLAAFA
Rv0132c|M.tuberculosis_H37Rv YDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKLLAAFA
MMAR_0709|M.marinum_M YDVPEGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYSEKLMPAVR
MUL_2814|M.ulcerans_Agy99 YDVPEGGVPVYTAAGGPAVAKYAGRAGDGFICTSGKGEDLYSEKLMPAVR
MLBr_00269|M.leprae_Br4923 YDVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIPAVL
: * : . . : : :
TH_1712|M.thermoresistible__bu HLRRATGL-PVETRVFGQVPICWDPDRDAAVERAHEQFRWFAGGWAVNSD
Mvan_5448|M.vanbaalenii_PYR-1 DARHATGL-PGEVRVIGQLPICWDTDRDAAIDRAHDQFRWFAGGWAVNSD
MAV_0425|M.avium_104 GARQAANL-AGGGRVVGQIPVSWDPDPDTAVKRAHDQFRWFAGGWKVNAD
MSMEG_1794|M.smegmatis_MC2_155 KRREATGI-LPEGRVVGQIPVCWDPDKDAAIARAHDQFRWFAGGWAVNAD
MAB_0947c|M.abscessus_ATCC_199 QARRSAAA-PEESRVIGQLPICWDTDREAAIKRAHDEFRWFAGGWPVNAD
Mflv_3722|M.gilvum_PYR-GCK DSYRDAGG-RGPARLQ--IHLSWAPTDEEALAIAHDQWRTNVLGPPVSWD
Mb0137c|M.bovis_AF2122/97 AGAQAAGRDPTTLGKRAELFAVVGDD-KAAAR-AADLWRFTAGAVDQP--
Rv0132c|M.tuberculosis_H37Rv AGAQAAGRDPTTLGKRAELFAVVGDD-KAAAR-AADLWRFTAGAVDQP--
MMAR_0709|M.marinum_M EGAAINNRNIDDIDKMIEIKISYDPDPELALN-NTRFWAPLSLSAEQKRS
MUL_2814|M.ulcerans_Agy99 EGAAINNRNIDDIDKMIEIKISYDPDPELALN-NTRFWAPLSLSAEQKRS
MLBr_00269|M.leprae_Br4923 EGAAVAGRDADDIDKMIEIKMSYDPDPEQALS-NIRFWAPLSLAAEQKHS
: . * : .
TH_1712|M.thermoresistible__bu LPTTAGFAGATQFVRPEDTAAAIACGPDLDAIVEAVRAYWDAGFTDIGLI
Mvan_5448|M.vanbaalenii_PYR-1 LPTTAGFDGATQFVRKDDVADSIPCGPDLDAIVDAVREYWEAGFTDIALI
MAV_0425|M.avium_104 LPTPAGFAGATQFVRPEDVADAIPCGPDLDAIVEGVRPYWEAGFTDIALV
MSMEG_1794|M.smegmatis_MC2_155 LPTPAGFAAATQFVRPEDVASAIPCGPDLDAIVAAVDEYRQAGFTDIALI
MAB_0947c|M.abscessus_ATCC_199 LPTPAGFAAATKFVRPEDVAGNIPCGSDSAPSSRTRAPTPTPGLP-----
Mflv_3722|M.gilvum_PYR-GCK IETVEAFDTIGEAVTPEQMEPSVRISSDLGRHAAWLQEYLDQGWDELYLH
Mb0137c|M.bovis_AF2122/97 --NPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGA-VPFLH
Rv0132c|M.tuberculosis_H37Rv --NPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGA-VPFLH
MMAR_0709|M.marinum_M IGDPIEMEAAAEALPIEQIAKRWIVASDPDEAVEKVGQYVAWGLNHLVLH
MUL_2814|M.ulcerans_Agy99 IGDPIEMEAAAEALPIEQIAKRWIVASDPDEAVEKVGQYVAWGLNHLVLH
MLBr_00269|M.leprae_Br4923 IDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQYVTWGLNHLVFH
: . :. .* *
TH_1712|M.thermoresistible__bu QIGDENQDLFLEKAAEALLDKLRAAAPR--
Mvan_5448|M.vanbaalenii_PYR-1 QVGGDSQEAFLKEAAAPLLDKLRSASH---
MAV_0425|M.avium_104 QIGGDTQERFLKEAAEPLLAALRDAAK---
MSMEG_1794|M.smegmatis_MC2_155 QIGGDSQDQFLAEAATPLLAALRESAG---
MAB_0947c|M.abscessus_ATCC_199 ------ISRWCRWEATARTAS---------
Mflv_3722|M.gilvum_PYR-GCK FVG-QHQRSFIDAFGEHVLPQLSPSAPAVP
Mb0137c|M.bovis_AF2122/97 FPQ-DDPITAIDFYRTNVLPELR-------
Rv0132c|M.tuberculosis_H37Rv FPQ-DDPITAIDFYRTNVLPELR-------
MMAR_0709|M.marinum_M APG-HDQLRFLELFEKDLAPRLRRLG----
MUL_2814|M.ulcerans_Agy99 APG-HDQLRFLELFEKDLAPRLRRLG----
MLBr_00269|M.leprae_Br4923 APG-HNQRRFLELFEKDLAPRLRRLG----