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MTRFGYTLMTEQSGPKDLVRYAVSAENVGFDFEVSSDHYFPWLSSQGHAPYAWSVLGAVAHATERVELMT YVTCPTVRYHPAIVAQKAATLQILADGRFTLGLGSGENLNEHIVGKGWPTVARRQDMLSEAIQIIRELQT GEMVDWKGEYFEVDSARLWDVPDVPVRIAAAVSGERSVAQFAPLADHLIAVQPDKSIVDAWHETRRGTGL PGDVRVIGQIPICWDPDRDAAIDRAHDQFRWFAGGWAVNADLPTTAGFDGATQFVRKEDVAESIPCGPDL DAIVEAVREYWEAGFTDIALVQVGGDTQDQFLAEAATPLLDKLRSASH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1341 | - | - | 100% (328) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_3722 | - | 8e-39 | 36.07% (305) | putative dehydrogenase protein |
| M. gilvum PYR-GCK | Mflv_0211 | - | 2e-36 | 32.54% (338) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 2e-35 | 34.24% (295) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | 8e-36 | 34.58% (295) | putative f420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00269 | - | 6e-33 | 35.54% (242) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0947c | - | 1e-130 | 78.14% (279) | putative luciferase |
| M. marinum M | MMAR_0709 | fgd1 | 5e-37 | 33.04% (339) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. avium 104 | MAV_0425 | - | 1e-148 | 74.92% (327) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1794 | - | 1e-147 | 74.01% (327) | dehydrogenase |
| M. thermoresistible (build 8) | TH_1712 | - | 1e-156 | 76.76% (327) | dehydrogenase |
| M. ulcerans Agy99 | MUL_2814 | fgd1 | 4e-37 | 33.04% (339) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. vanbaalenii PYR-1 | Mvan_5448 | - | 1e-175 | 88.11% (328) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1341|M.gilvum_PYR-GCK ----------------------------------------MTRFGYTLMT
Mvan_5448|M.vanbaalenii_PYR-1 ----------------------------------------MTRFGYTLMT
TH_1712|M.thermoresistible__bu ----------------------------------------MTRFGYTLLT
MAV_0425|M.avium_104 --------------------------------MQPGIPVRMTNFGYTLMT
MSMEG_1794|M.smegmatis_MC2_155 ---------------------------------MHGYPQPMTRFGYTLMT
MAB_0947c|M.abscessus_ATCC_199 ----------------------------------------MTRFGYTLMT
Mb0137c|M.bovis_AF2122/97 MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
Rv0132c|M.tuberculosis_H37Rv MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
MMAR_0709|M.marinum_M --------------------------------------MAELKLGYKASA
MUL_2814|M.ulcerans_Agy99 --------------------------------------MAELKLGYKASA
MLBr_00269|M.leprae_Br4923 --------------------------------------MAELRLGYKASA
.*
Mflv_1341|M.gilvum_PYR-GCK EQSGPKDLVRYAVSAENVGFDFEVSSDHYFPWLSSQGHAPYAWSVLGAVA
Mvan_5448|M.vanbaalenii_PYR-1 EQSGPKDLVSYAVSAEQVGFDFEVSSDHYFPWLASQGHAPYAWSVLGAVA
TH_1712|M.thermoresistible__bu EQSGPKDLIRYAVAAERAGFDFELCSDHYSPWLAAQGHAPYAWSVLGAVA
MAV_0425|M.avium_104 EQSGPKELVRYAISAEERGFDFHVCSDHFSPWLTSQGHAPNAWAVLGAVA
MSMEG_1794|M.smegmatis_MC2_155 EQSGPKDLVHYAVAAEQAGFDFEVCSDHFSPWLTSQGHAPNAWAVLGAVA
MAB_0947c|M.abscessus_ATCC_199 EQSGPKDLVRYAVAAEKAGFDFEVSSDHYSPWLSSQGHAPYAWSVLGAVA
Mb0137c|M.bovis_AF2122/97 EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
Rv0132c|M.tuberculosis_H37Rv EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
MMAR_0709|M.marinum_M EQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVG
MUL_2814|M.ulcerans_Agy99 EQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVG
MLBr_00269|M.leprae_Br4923 EQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTAVG
** . *: . :** *: *** ** **: . : *.
Mflv_1341|M.gilvum_PYR-GCK HATERVELMTYVTCPTVRYHPAIVAQKAATLQILADGRFTLGLGSGENLN
Mvan_5448|M.vanbaalenii_PYR-1 HATDRVELMTYVTCPTMRYHPAIVAQKAATLQLLADGRFTLGLGSGENLN
TH_1712|M.thermoresistible__bu HATDRVELLTFITCPTMRYHPAVVAQKAATLQILADGRFTLGLGSGENLN
MAV_0425|M.avium_104 QATERVDLYTYVTCPTMRYHPAIVAQQAATVQILSDGRFTLGLGSGENLN
MSMEG_1794|M.smegmatis_MC2_155 HATESAHLYSYVTCPTMRYHPAVVAQQAATVQILSDGRFTLGLGSGENLN
MAB_0947c|M.abscessus_ATCC_199 QATERVDLATYVTCPTMRYHPAVVAQKAATMQILADGRFTLGLGSGENLN
Mb0137c|M.bovis_AF2122/97 NSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGKRLN
Rv0132c|M.tuberculosis_H37Rv NSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLN
MMAR_0709|M.marinum_M ERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGTGEALN
MUL_2814|M.ulcerans_Agy99 ERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGTGEALN
MLBr_00269|M.leprae_Br4923 ERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGEALN
. *. : : : * **:** :.* *:: * .*. **:*:*: **
Mflv_1341|M.gilvum_PYR-GCK EHIVG--KGWPTVARRQDMLSEAIQIIRELQTGEMVDWKGEYFEVDSARL
Mvan_5448|M.vanbaalenii_PYR-1 EHVVG--KGWPTVARRHAMLREAIQIIRELHSGDMVDWKGEYFEVDSARL
TH_1712|M.thermoresistible__bu EHVVG--RRWPTVARRHDMLREAITIIRGLFSGEVVDWKGEYFEVDSARL
MAV_0425|M.avium_104 EHVVG--KGWPTITRRQDMLREAIKIIRELFGGQLVDFTGDYFRVDSARV
MSMEG_1794|M.smegmatis_MC2_155 EHVVG--KGWPTVERRLDMLAEAIKIIRELFTGELIDFRGEYFEVDSARI
MAB_0947c|M.abscessus_ATCC_199 EHVVG--RGWPTVGRRQAMLREAIQIIRDLLCGEHVDGKGDYFEVDSARL
Mb0137c|M.bovis_AF2122/97 EQAA--TDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKL
Rv0132c|M.tuberculosis_H37Rv EQAA--TDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKL
MMAR_0709|M.marinum_M EVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLRGASI
MUL_2814|M.ulcerans_Agy99 EVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLRGASI
MLBr_00269|M.leprae_Br4923 EVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGASI
* . : .* * *:: ::* * *: :. *.*:. :
Mflv_1341|M.gilvum_PYR-GCK WDVPDVPVRIAAAVSGERSVAQFAPLADHLIAVQP------DKSIVDAWH
Mvan_5448|M.vanbaalenii_PYR-1 WDVPEVPVPIAAAVSGDRSVEQFALLADHLIAVEP------DKDLVDSWH
TH_1712|M.thermoresistible__bu WDIPEVPVAIAVAVSGDRSVEMFAPIADHLVTTEP------DAGLVGSWH
MAV_0425|M.avium_104 WDVPDVPVGIGVAIGGTRAVDKFAKLADHLIATEP------NADLVDAWH
MSMEG_1794|M.smegmatis_MC2_155 WDVPDEPVGIGVSLTGERALEKLAVSTDHLINVAP------DAAVVEGWR
MAB_0947c|M.abscessus_ATCC_199 WDLPDVPVPIGVAVSSGDTAARFAPTADHMIAVAP------ESDIVDAWR
Mb0137c|M.bovis_AF2122/97 YDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKLLAAFA
Rv0132c|M.tuberculosis_H37Rv YDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKLLAAFA
MMAR_0709|M.marinum_M YDVPEGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYSEKLMPAVR
MUL_2814|M.ulcerans_Agy99 YDVPEGGVPVYTAAGGPAVAKYAGRAGDGFICTSGKGEDLYSEKLMPAVR
MLBr_00269|M.leprae_Br4923 YDVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIPAVL
:* * : : . . : : :: .
Mflv_1341|M.gilvum_PYR-GCK ETRRGTG-LPGDVRVIGQIPICWDPDRDAAIDRAHDQFRWFAGGWAVNAD
Mvan_5448|M.vanbaalenii_PYR-1 DARHATG-LPGEVRVIGQLPICWDTDRDAAIDRAHDQFRWFAGGWAVNSD
TH_1712|M.thermoresistible__bu HLRRATG-LPVETRVFGQVPICWDPDRDAAVERAHEQFRWFAGGWAVNSD
MAV_0425|M.avium_104 GARQAAN-LAGGGRVVGQIPVSWDPDPDTAVKRAHDQFRWFAGGWKVNAD
MSMEG_1794|M.smegmatis_MC2_155 KRREATG-ILPEGRVVGQIPVCWDPDKDAAIARAHDQFRWFAGGWAVNAD
MAB_0947c|M.abscessus_ATCC_199 QARRSAA-APEESRVIGQLPICWDTDREAAIKRAHDEFRWFAGGWPVNAD
Mb0137c|M.bovis_AF2122/97 AGAQAAGRDPTTLGKRAELFAVVGDD-KAAAR-AADLWRFTAGAVDQP--
Rv0132c|M.tuberculosis_H37Rv AGAQAAGRDPTTLGKRAELFAVVGDD-KAAAR-AADLWRFTAGAVDQP--
MMAR_0709|M.marinum_M EGAAINNRNIDDIDKMIEIKISYDPDPELALN-NTRFWAPLSLSAEQKRS
MUL_2814|M.ulcerans_Agy99 EGAAINNRNIDDIDKMIEIKISYDPDPELALN-NTRFWAPLSLSAEQKRS
MLBr_00269|M.leprae_Br4923 EGAAVAGRDADDIDKMIEIKMSYDPDPEQALS-NIRFWAPLSLAAEQKHS
:: . * . * : : .
Mflv_1341|M.gilvum_PYR-GCK LPTTAGFDGATQFVRKEDVAESIPCGPDLDAIVEAVREYWEAGFTDIALV
Mvan_5448|M.vanbaalenii_PYR-1 LPTTAGFDGATQFVRKDDVADSIPCGPDLDAIVDAVREYWEAGFTDIALI
TH_1712|M.thermoresistible__bu LPTTAGFAGATQFVRPEDTAAAIACGPDLDAIVEAVRAYWDAGFTDIGLI
MAV_0425|M.avium_104 LPTPAGFAGATQFVRPEDVADAIPCGPDLDAIVEGVRPYWEAGFTDIALV
MSMEG_1794|M.smegmatis_MC2_155 LPTPAGFAAATQFVRPEDVASAIPCGPDLDAIVAAVDEYRQAGFTDIALI
MAB_0947c|M.abscessus_ATCC_199 LPTPAGFAAATKFVRPEDVAGNIPCGSDSAPSSRTRAPTPTPGLP-----
Mb0137c|M.bovis_AF2122/97 --NPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGA--VPFL
Rv0132c|M.tuberculosis_H37Rv --NPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGA--VPFL
MMAR_0709|M.marinum_M IGDPIEMEAAAEALPIEQIAKRWIVASDPDEAVEKVGQYVAWGLN-HLVL
MUL_2814|M.ulcerans_Agy99 IGDPIEMEAAAEALPIEQIAKRWIVASDPDEAVEKVGQYVAWGLN-HLVL
MLBr_00269|M.leprae_Br4923 IDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQYVTWGLN-HLVF
. : .:. :. .* *
Mflv_1341|M.gilvum_PYR-GCK QVGGDTQDQFLAEAATPLLDKLRSASH-
Mvan_5448|M.vanbaalenii_PYR-1 QVGGDSQEAFLKEAAAPLLDKLRSASH-
TH_1712|M.thermoresistible__bu QIGDENQDLFLEKAAEALLDKLRAAAPR
MAV_0425|M.avium_104 QIGGDTQERFLKEAAEPLLAALRDAAK-
MSMEG_1794|M.smegmatis_MC2_155 QIGGDSQDQFLAEAATPLLAALRESAG-
MAB_0947c|M.abscessus_ATCC_199 ------ISRWCRWEAT-----ARTAS--
Mb0137c|M.bovis_AF2122/97 HFPQDDPITAIDFYRTNVLPELR-----
Rv0132c|M.tuberculosis_H37Rv HFPQDDPITAIDFYRTNVLPELR-----
MMAR_0709|M.marinum_M HAPGHDQLRFLELFEKDLAPRLRRLG--
MUL_2814|M.ulcerans_Agy99 HAPGHDQLRFLELFEKDLAPRLRRLG--
MLBr_00269|M.leprae_Br4923 HAPGHNQRRFLELFEKDLAPRLRRLG--
*