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MSRIPRASQAHPIDADVVLIGGGIMSATLGSMLSILAPEWRIVLLERSDALATESSGPWNNAGTGHTGFC ELNYMPDPGDGAQAAAIARQFHLSRQWWSYLADHALLRPDTFIHSAAHMDVVFGHRDANYLRQRYETLAA DPMFSGMRFSDDPATIERWAPLVMRGRTPGGPIAATLHPEGTDVDFGALTAALTRIVTDRGGQLRLGHEV RALRQSIDGSWMVTGRNAEGGFAVRTHKVFVGAGGHALRLLQRAHLAEVRGYAVLPVGAAFLRSANAAVA DAHTTKVYGQAPVGAPPMSVPHLDKRIVDGRPYVMFGPYATFSTKLLKHGRWTDFFSTVRWHNLHVIAAA LLQNLALIRYLIGQVVAGPRQRMGQLRRYYPTAAPDDWELVPAGQRAQLITPDPRQVGVLRHGTELVVSA DHSIAGLLGASPGASTAVPIMLDALRRCFPEQWRTTWQRTLTAAMPGAGDITWDEAAVTRSARSTARSLR LDQARPSN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2681 | - | - | 100% (498) | malate:quinone oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3159c | - | e-102 | 42.98% (463) | malate:quinone oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2877c | mqo | 1e-109 | 44.15% (487) | malate:quinone oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4052 | - | 1e-106 | 43.76% (489) | malate:quinone oxidoreductase |
| M. tuberculosis H37Rv | Rv2852c | mqo | 1e-109 | 44.15% (487) | malate:quinone oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1881 | mqo | 1e-112 | 45.15% (485) | malate:quinone oxidoreductase Mqo |
| M. avium 104 | MAV_3708 | mqo | 1e-113 | 45.00% (500) | malate:quinone oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2613 | mqo | 1e-109 | 44.87% (468) | malate:quinone oxidoreductase |
| M. thermoresistible (build 8) | TH_1387 | - | 1e-106 | 44.14% (478) | PROBABLE MALATE:QUINONE OXIDOREDUCTASE MQO (MALATE |
| M. ulcerans Agy99 | MUL_2109 | mqo | 1e-110 | 44.74% (485) | malate:quinone oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2300 | - | 1e-106 | 42.37% (498) | malate:quinone oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2877c|M.bovis_AF2122/97 ---MSDLAR-----TDVVLIGAGIMSATLGVLLRRLEPNWSITLIERLDA
Rv2852c|M.tuberculosis_H37Rv ---MSDLAR-----TDVVLIGAGIMSATLGVLLRRLEPNWSITLIERLDA
MMAR_1881|M.marinum_M ---MSESAR-----TDVVLVGAGIMSATLGAMLRRLEPDWSITLIERLDA
MUL_2109|M.ulcerans_Agy99 ---MSESAR-----TDVVLVGAGIMSATLGAMLRRLEPDWSITLIERLDA
MAV_3708|M.avium_104 ---MSSLART--TRTDVVLVGAGIMSATLGALLRRLQPDWSMTFVERLDA
Mflv_4052|M.gilvum_PYR-GCK ---MSEA-----EKTDVLLVGAGIMSATLCALLRLLEPNWSMTLVERLDG
Mvan_2300|M.vanbaalenii_PYR-1 ---MSEP-----HKTDVLLVGAGIMSATLSALLRLVEPNWSMTLVERLDG
TH_1387|M.thermoresistible__bu ------------------------MSATLGALLRLVEPNWSITLIERLDG
MSMEG_2613|M.smegmatis_MC2_155 ---MSEANAGTNAKTDVVLVGAGIMSATLGTLIKLLEPNWSITMIERLDG
MAB_2681|M.abscessus_ATCC_1997 MSRIPRASQAHPIDADVVLIGGGIMSATLGSMLSILAPEWRIVLLERSDA
***** :: : *:* :.::** *.
Mb2877c|M.bovis_AF2122/97 VAAESSGPWNNAGTGHSALCEMNYTPEMPDGSIDITKAVRVNEQFQVTRQ
Rv2852c|M.tuberculosis_H37Rv VAAESSGPWNNAGTGHSALCEMNYTPEMPDGSIDITKAVRVNEQFQVTRQ
MMAR_1881|M.marinum_M VAAESSGPWNNAGTGHSALCELNYTPQRPDGSIDISKAVRINEEFQVTRQ
MUL_2109|M.ulcerans_Agy99 VAAESSGPWNNAGTGHSALCELNYTPQRPDGSIDISKAVRINEEFQVTRQ
MAV_3708|M.avium_104 VAAESSSPWNNAGTGHSALCELNYTPQRADGSIDIAKAVRINEQFQVTRQ
Mflv_4052|M.gilvum_PYR-GCK AAAESSDPWNNAGTGHSALCELNYTPARPDGSIDIAKAVNVNEQFQVSRQ
Mvan_2300|M.vanbaalenii_PYR-1 AAAESSDPWNNAGTGHSALCELNYTPARPDGSIDITKAVSVNEQFQVSRQ
TH_1387|M.thermoresistible__bu AAAESSDPWNNAGTGHSALCELNYTPQRPDGSIDTTKAIHVNEQFQVSRQ
MSMEG_2613|M.smegmatis_MC2_155 AAAESSDPWNNAGTGHSALCELNYTPALPDGTIDISKAVNVNEQFQVSRQ
MAB_2681|M.abscessus_ATCC_1997 LATESSGPWNNAGTGHTGFCELNYMPDPGDG----AQAAAIARQFHLSRQ
*:***.*********:.:**:** * ** ::* : .:*:::**
Mb2877c|M.bovis_AF2122/97 FWAYAAENGILTDVRSFLNPVPHVSFVHGSRGVEYLRRRQKALAGNPLFA
Rv2852c|M.tuberculosis_H37Rv FWAYAAENGILTDVRSFLNPVPHVSFVHGSRGVEYLRRRQKALAGNPLFA
MMAR_1881|M.marinum_M FWAYAAENGILNDVRSFLNPLPHVSFVHGAERVHQLRRRRDALAGNPLFA
MUL_2109|M.ulcerans_Agy99 FWAYAAENGILNDVRSFLNPLPHVSFVHGAERVHQLRRRRDALAGNPLFA
MAV_3708|M.avium_104 FWAYAVEDGMLTD-RGFVTPIPHASFVRGARAVEYLRRRQQALAPNPLFA
Mflv_4052|M.gilvum_PYR-GCK FWTYAVENGVLPDVRSFLNPIPHVSFVTGADNVQYLRKRYEALVGNPLFG
Mvan_2300|M.vanbaalenii_PYR-1 FWTYAVENGVLPDVRSFLNPIPHVSFVTGADNVQYLRRRYDALVTNPLFA
TH_1387|M.thermoresistible__bu FWAYAVENGVLPDVRSFLNPIPHVSFVQGAENIDYLRRRYEALVTNPLFA
MSMEG_2613|M.smegmatis_MC2_155 FWAHAVENGVLPDVRSFLNPVPHVSFVYGADNVQYLKARYNALVTNPLFA
MAB_2681|M.abscessus_ATCC_1997 WWSYLADHALLRP-DTFIHSAAHMDVVFGHRDANYLRQRYETLAADPMFS
:*:: .:..:* *: . .* ..* * . *: * .:*. :*:*.
Mb2877c|M.bovis_AF2122/97 GTEFIESPDEFARRLPFMAAKRAFSEPVALNWAADGTDVDFGALAKQLIG
Rv2852c|M.tuberculosis_H37Rv GTEFIESPDEFARRLPFMAAKRAFSEPVALNWAADGTDVDFGALAKQLIG
MMAR_1881|M.marinum_M GAEWIDDPDEFARRLPLMAAKRVFSEPIALNWAADGTDVDFGALSRQLIG
MUL_2109|M.ulcerans_Agy99 GAEWIDDPDEFARRLPLMAAKRVFSEPIALNWAADGTDVDFGALSRQLIG
MAV_3708|M.avium_104 GIELIEDADEFARRLPLMADRRDFSEPTALNWARHGTDVDFGALSRQLIG
Mflv_4052|M.gilvum_PYR-GCK TMEFIDDAGEFARRLPLMAEGRDLREPVGLNWTQDGTDVDFGALSRQLLG
Mvan_2300|M.vanbaalenii_PYR-1 TMEYIDDSDEFARRLPLMAEKRDFSNPVGLNWTQDGTDVDFGSLSRQLLG
TH_1387|M.thermoresistible__bu SMEFIDDHDEFSRRLPLMAYQRDFSEPVALNWTQDGTDVDFGSLSRQLIA
MSMEG_2613|M.smegmatis_MC2_155 SMEFIDDKDEFTRRLPLMAEKRDFSEPVALNWSQHGTDVDFGSLSRQLIG
MAB_2681|M.abscessus_ATCC_1997 GMRFSDDPATIERWAPLVMRGRTPGGPIAATLHPEGTDVDFGALTAALTR
. :. : * *:: * * . . .*******:*: *
Mb2877c|M.bovis_AF2122/97 YCVQNGTTALFGHEVRNLSRQSDGSWTVTMCNRRTGEKRKLNTKFVFVGA
Rv2852c|M.tuberculosis_H37Rv YCVQNGTTALFGHEVRNLSRQSDGSWTVTMCNRRTGEKRKLNTKFVFVGA
MMAR_1881|M.marinum_M YCVRNGAVALFGQEVRNLVRQPDGGWMLTVVNRRTGEKRKLKTKFVFVGA
MUL_2109|M.ulcerans_Agy99 YCVRNGAVALFGQEVRNLVRQPDGGWMLTVVNRRTGEKRKLKTKFVFVGA
MAV_3708|M.avium_104 FCVRGGATALFGHQVHNLTRESDGSWTLLIRNRRTGEKHRCNAKFVFVGA
Mflv_4052|M.gilvum_PYR-GCK FGAQQGMDTLFGHDVTNLSQNSDSTWTVKVVNRRTGRKRTFNAKFVFVGA
Mvan_2300|M.vanbaalenii_PYR-1 FGAKHGMTTLFGHEVVNLTQGSDGTWTVKIANRRTGQKRTINAKFVFVGA
TH_1387|M.thermoresistible__bu YVAEHGMTTMFGHEVRDLVKQRDGGWLVKVVNRRTGARRRIKAKFVFVGA
MSMEG_2613|M.smegmatis_MC2_155 FAAGNGMTTMFGHDVRDLSKNSDGSWTVKVRNRRTGNNFKINAKFVFVGA
MAB_2681|M.abscessus_ATCC_1997 IVTDRGGQLRLGHEVRALRQSIDGSWMVTGRNAEGG--FAVRTHKVFVGA
. * :*::* * : *. * : * . * .:: *****
Mb2877c|M.bovis_AF2122/97 GGDTLPVLQKSGIKEVKGFAGFPIGGRFLRAGNPALTASHRAKVYGFPAP
Rv2852c|M.tuberculosis_H37Rv GGDTLPVLQKSGIKEVKGFAGFPIGGRFLRAGNPALTASHRAKVYGFPAP
MMAR_1881|M.marinum_M GGNALSLLQRSGIKEINGFAGFPIGGRFLRTANPALTAAHRAKVYGVPAP
MUL_2109|M.ulcerans_Agy99 GGNALSLLQRSGIKEINGFAGFPIGGRFSRTANTALTAAHRAKVYGVPAP
MAV_3708|M.avium_104 GGDALPLLQKSGIGEARGFAGFPIGGRFLRADNPVLTAAHRAKVYGAPAP
Mflv_4052|M.gilvum_PYR-GCK GGGALPLLQKAGIKEAKGFGGFPVGGQWLRTGNPELTAKHQAKVYGLPPL
Mvan_2300|M.vanbaalenii_PYR-1 GGGALPLLQKAGIKEAKGFGGFPVGGQWLRTGNQDLTARHQAKVYGLPPL
TH_1387|M.thermoresistible__bu GGGALPLLQKAGIPEVKGFGGFPVGGQFLRTNDPALTAAHKAKVYGLPPL
MSMEG_2613|M.smegmatis_MC2_155 GGGALPLLQKSGIPEAKGFGGFPVGGAFLRTNKQHLTSRHNAKVYGLPPL
MAB_2681|M.abscessus_ATCC_1997 GGHALRLLQRAHLAEVRGYAVLPVGAAFLRSANAAVADAHTTKVYGQAPV
** :* :**:: : * .*:. :*:*. : *: . :: * :**** ..
Mb2877c|M.bovis_AF2122/97 GAPPLGALHLDLRFVNGKSWLVFGPYAGWSPKFLKHGQISDLPRSIRPDN
Rv2852c|M.tuberculosis_H37Rv GAPPLGALHLDLRFVNGKSWLVFGPYAGWSPKFLKHGQISDLPRSIRPDN
MMAR_1881|M.marinum_M GAPPLGALHLDLRYVNGKSWLMFGPFAGWSPKFLKRGHLRDLPGSIKPNN
MUL_2109|M.ulcerans_Agy99 GAPPLGALHLDLRYVNGKSWLMFGPFAGWSPKFLKRGHLRDLPGSIKPNN
MAV_3708|M.avium_104 GAPPLGALHLDLRYVNGKPWLVFGPYAGWSPKFLKHGHFTDLPRSVRPHN
Mflv_4052|M.gilvum_PYR-GCK GAPPMSVPHLDTRVINDKSWLLFGPFAGWSPKFLKQGKVTDLPFSVKPDN
Mvan_2300|M.vanbaalenii_PYR-1 GAPPMSVPHLDTRVINEKSWLLFGPFAGWSPKFLKQGKVTDLPFSVRPDN
TH_1387|M.thermoresistible__bu GAPPMSVPHLDARVINRKSWLLFGPFAGWSPKFLKHGKITDLPFSVKPNN
MSMEG_2613|M.smegmatis_MC2_155 GAPPMSVPHLDTRVINGRQWLLFGPFAGWSPKFLKQGKVTDLPLSVKPNN
MAB_2681|M.abscessus_ATCC_1997 GAPPMSVPHLDKRIVDGRPYVMFGPYATFSTKLLKHGRWTDFFSTVRWHN
****:.. *** * :: : :::***:* :*.*:**:*: *: ::: .*
Mb2877c|M.bovis_AF2122/97 LLSVLGVGLTERRLLNYLISQLRLSEPERVSALREFAPSAIDSDWELTIA
Rv2852c|M.tuberculosis_H37Rv LLSVLGVGLTERRLLNYLISQLRLSEPERVSALREFAPSAIDSDWELTIA
MMAR_1881|M.marinum_M ILSMVGVGVTQVTLLNYLIGQLRLSEPDRVAVLRKFVPSAADSDWELIVA
MUL_2109|M.ulcerans_Agy99 ILSMVGVGVTQVTLLNYLIGQLRLSEPDRVAVLREFVPSAADSDWELIVA
MAV_3708|M.avium_104 LVALLGVGVTQLTLLRYLIGQLRLSAPDRMRMLREFAPTAVDSDWELTVA
Mflv_4052|M.gilvum_PYR-GCK LVSMLGVGLTEMGLLKYLIGQLLLSEAARVENLREFAPSAKDSDWELDIA
Mvan_2300|M.vanbaalenii_PYR-1 LVSMLGVGLTEMGLLKYLIGQLLLSESARVENLRDFAPSARDSDWELDIA
TH_1387|M.thermoresistible__bu LASMIGVGLTEMGLLKYLIGQLLMSEADRVEALREFAPSARDSDWELDIA
MSMEG_2613|M.smegmatis_MC2_155 LASMLGVGLTEVGLLKYLIGQLLLSEPARVETLREFAPSAVDSDWELDIA
MAB_2681|M.abscessus_ATCC_1997 LHVIAAALLQNLALIRYLIGQVVAGPRQRMGQLRRYYPTAAPDDWELVPA
: : .. : : *:.***.*: . *: ** : *:* .**** *
Mb2877c|M.bovis_AF2122/97 GQRVQVIRRDERNGGVLEFGTTVIGDADGSIAGLLGGSPGASTAVAIMLD
Rv2852c|M.tuberculosis_H37Rv GQRVQVIRRDERNGGVLEFGTTVIGDADGSIAGLLGGSPGASTAVAIMLD
MMAR_1881|M.marinum_M GQRVQVIRRDKRKGGVLEFGTTVVGEADGSIAGLLGGSPGASTAVPIMLE
MUL_2109|M.ulcerans_Agy99 GQRVQVIRRDKRKGGVLEFDTTVVGEADGSIAGLLGGSPGASTAVPIMLE
MAV_3708|M.avium_104 GQRVQVIRRDRRRGGVLDFDTTVVAAGDGSIAGLLGGSPGASTAVPIMLD
Mflv_4052|M.gilvum_PYR-GCK GQRVQVIRKAKGKGGVLEFGTTVLSAADGSIAGLLGASPGASTAVPAMFD
Mvan_2300|M.vanbaalenii_PYR-1 GQRVQVIRKAKGKGGVLEFGTTVLAAADGSIAGLLGASPGASTAVPAMFD
TH_1387|M.thermoresistible__bu GQRVQVIRR-KGRGGVLEFGTTVLSAADGSIAGLLGASPGASTAVPAMIE
MSMEG_2613|M.smegmatis_MC2_155 GQRVQVIRR-KGAGGVLEFGTTVLAAADGSIAGLLGASPGASTAVPAMLD
MAB_2681|M.abscessus_ATCC_1997 GQRAQLITPDPRQVGVLRHGTELVVSADHSIAGLLGASPGASTAVPIMLD
***.*:* *** ..* :: .* *******.********. *::
Mb2877c|M.bovis_AF2122/97 VLQKCFANRYQS-WLPTLKEMVPSLGVQLSNEPALFDEVWSWSTKALKLG
Rv2852c|M.tuberculosis_H37Rv VLQKCFANRYQS-WLPTLKEMVPSLGVQLSNEPALFDEVWSWSTKALKLG
MMAR_1881|M.marinum_M VLQRCFTHRYQS-WLPALKEMVPSLGANLSEEPVLYDEVRSWSSRALQLD
MUL_2109|M.ulcerans_Agy99 VLQRCFTHRYQS-WLPALKEMVPSLGANLSEEPVLYDEVRSWSSRALQLD
MAV_3708|M.avium_104 VLQRCFADRYRS-WLPALKEMVPSLGVTLSDEPALYEEVYSWGTKILGLD
Mflv_4052|M.gilvum_PYR-GCK VMKRCFADRYPS-WEPKLKEMVPSLGVTLSDEPKLFEEVWARGTKVLKLD
Mvan_2300|M.vanbaalenii_PYR-1 VMKRCFSDRYPS-WEPKLKEMVPSLGTALSDEPKLFEEVWAHGTAVLKLD
TH_1387|M.thermoresistible__bu VMERCFSDRYQS-WLPKLKEMVPSLGVELSKEPALFREVWAHGTKVLKLD
MSMEG_2613|M.smegmatis_MC2_155 VLQRCFADRYQA-WTPKLKEMVPSLGTKLSDEPKLFEEVWSWGTKVLKLD
MAB_2681|M.abscessus_ATCC_1997 ALRRCFPEQWRTTWQRTLTAAMPGAGDITWDEAAVTRSARST-ARSLRLD
.:.:**..:: : * *. :*. * .*. : .. : : * *.
Mb2877c|M.bovis_AF2122/97 AA------------------------------------------------
Rv2852c|M.tuberculosis_H37Rv AA------------------------------------------------
MMAR_1881|M.marinum_M AS------------------------------------------------
MUL_2109|M.ulcerans_Agy99 ASGAKRCAVSGPKTLTYQPFTNCSSCGSRCSWSSRPAAIRSWTAVICSPR
MAV_3708|M.avium_104 ELDEERPK------------------------------------------
Mflv_4052|M.gilvum_PYR-GCK KPAGAIPATTDGQSTAGTEHTPTAATV-----------------------
Mvan_2300|M.vanbaalenii_PYR-1 KPASSIPATTADESTAGTEHSPAAATV-----------------------
TH_1387|M.thermoresistible__bu QPASGLPSSSTEP--AGTEHTPTAATG-----------------------
MSMEG_2613|M.smegmatis_MC2_155 VQAN------------TAEAANAPATV-----------------------
MAB_2681|M.abscessus_ATCC_1997 QARPSN--------------------------------------------
Mb2877c|M.bovis_AF2122/97 ------------
Rv2852c|M.tuberculosis_H37Rv ------------
MMAR_1881|M.marinum_M ------------
MUL_2109|M.ulcerans_Agy99 PATSGWKPPMAK
MAV_3708|M.avium_104 ------------
Mflv_4052|M.gilvum_PYR-GCK ------------
Mvan_2300|M.vanbaalenii_PYR-1 ------------
TH_1387|M.thermoresistible__bu ------------
MSMEG_2613|M.smegmatis_MC2_155 ------------
MAB_2681|M.abscessus_ATCC_1997 ------------