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MSVVSPREFFGGAAIQDPAPMYDMMRDRAAVNRIGESAFYAVCGWDAVQEAVNRVDDFSSNLTATMVFHD DGTVTPFEMGALGGPMHALATADDPLHASHRKLLLPHLSAKRIRVIEQFAEVTAHRLWSDALVDGHIEWM SAIANRVPMMVVARLLGLPEDDVDELIRLGYATTTLLDGIVSATQLEAAGTAAMELATYVLQHFEKATGD PQPGLMSDLAWRTQSGELEQLSALAIMLTLFSAAGESTASLLGSAAWILTDRPAVQEQLRADPGLLGAFI EETLRFESPFRGHYRHVVRDTALAGVELPADSRLLLMWGAANRDPRQFNSANDFRLDRSSAKGHVAFGKG AHFCVGAALARLEARIVLAMLLERTTWIEAADVGPWLPSILVRRLEHLRLKIR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3475 | - | - | 100% (403) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2474 | - | 5e-44 | 32.70% (422) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2431 | - | 6e-38 | 31.98% (369) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1806 | cyp144 | 1e-147 | 63.54% (395) | cytochrome p450 144 CYP144 |
| M. tuberculosis H37Rv | Rv1777 | cyp144 | 1e-148 | 63.80% (395) | cytochrome p450 144 CYP144 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-29 | 25.89% (394) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1939 | - | 2e-94 | 45.34% (397) | cytochrome P450 |
| M. marinum M | MMAR_2654 | cyp144A4 | 1e-143 | 62.03% (395) | cytochrome P450 144A4 Cyp144A4 |
| M. avium 104 | MAV_0011 | - | 1e-171 | 73.93% (399) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_0675 | - | 1e-139 | 61.38% (391) | putative cytochrome P450 144 |
| M. thermoresistible (build 8) | TH_3411 | - | 1e-133 | 59.59% (391) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3131 | cyp144A4 | 1e-143 | 62.03% (395) | cytochrome P450 144A4 Cyp144A4 |
| M. vanbaalenii PYR-1 | Mvan_3781 | - | 1e-128 | 56.99% (386) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3475|M.gilvum_PYR-GCK -------------------------------MSVVS-PREFFGGAAIQDP
MAV_0011|M.avium_104 -------------------------------MAVLDSATRFFGSEAIQDP
Mb1806|M.bovis_AF2122/97 -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
Rv1777|M.tuberculosis_H37Rv -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
MMAR_2654|M.marinum_M -------------------------------MKVASDAMTFFGPETLQNP
MUL_3131|M.ulcerans_Agy99 -------------------------------MKVASDAMTFFGTESLQNP
MSMEG_0675|M.smegmatis_MC2_155 ------------------------------MTPPEGLGLALFRPECIQDP
TH_3411|M.thermoresistible__bu -----------------------------MATTDAGLGLALFDDQFIQNP
Mvan_3781|M.vanbaalenii_PYR-1 -----------------------------MTVGHTDLGLALFHDEFLQDP
MAB_1939|M.abscessus_ATCC_1997 -----------------------------------MNTDELFDPQVLEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:: :*
Mflv_3475|M.gilvum_PYR-GCK APMYDMMRDRAAVNRIGESAFYAVCGWDAVQEAVNRVDDFSSNLTATMVF
MAV_0011|M.avium_104 YPLYERMHAEAPVHRIGDSVFYAVCGWDAVHEAIERVEDFSSNLTATMVF
Mb1806|M.bovis_AF2122/97 YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
Rv1777|M.tuberculosis_H37Rv YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
MMAR_2654|M.marinum_M YPLYERMRAEGPVHRIADSDFYAVCGWDAVNDAISRPEDFSSNLTATMTY
MUL_3131|M.ulcerans_Agy99 YPLYERMRAEGPVHRIADSEFYAVCGWDAVNDAISRPGDFSSNLTATMTY
MSMEG_0675|M.smegmatis_MC2_155 YPLYRRMLDTAPVHPIADSGFYAVCGWDAVNDAIARPENFSSNLTATMTY
TH_3411|M.thermoresistible__bu HPLYARMHREGPVHRIGASDFYAVSSWAAVTEAVARPEDFSSNLTATMMY
Mvan_3781|M.vanbaalenii_PYR-1 HPLYARMHAEAPVHRVGDSDFYAVCGWDAITEAVARPGDFSSNLTGAMRY
MAB_1939|M.abscessus_ATCC_1997 YPFYRRLRETAPVWPVGDSGFYFVSRWDLVVEATERAEDFSSNLTAALMK
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
*.* : ..: . : .. : :* : . *..*..::
Mflv_3475|M.gilvum_PYR-GCK HDDGTVTPFEMGALGGPMHALATADDPLHASHRKLLLPHLSAKRIRVIEQ
MAV_0011|M.avium_104 HEDGTVTPFDMGAPGAPMHALATADDPVHAVHRKILLPHLSAKRIRIIEE
Mb1806|M.bovis_AF2122/97 TAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQ
Rv1777|M.tuberculosis_H37Rv TAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQ
MMAR_2654|M.marinum_M SPAGKIAAFEMDQLGGPTHVLATADDPAHAVHRKLLVRHLAARRIRSLER
MUL_3131|M.ulcerans_Agy99 SPDGKVAAFEMDQLGGPTHVLATADDPAHAVHRKLLVRHLAARRIRSLER
MSMEG_0675|M.smegmatis_MC2_155 QADGTVGAFEMESLGGKSHVLATADEPAHTAHRKALLPQLAARRIRAFEP
TH_3411|M.thermoresistible__bu EPGGEIRPIPIGEVGGPTQALATADEPSHTVHRKLLLPQLAARRIRAYQP
Mvan_3781|M.vanbaalenii_PYR-1 QADGTVSLLPLDTLGSPTQALATADDPAHAAHRKLLVPYLAAKRVRALET
MAB_1939|M.abscessus_ATCC_1997 SAEG-LAVAPMGPPADPTHVLATGDDPLHHAHRRLVLPTLVARRITALEP
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASS----FMFLDPPDHTRLRKLVSKAFAPKVVQALEG
. . : * * * *: : : .: : :
Mflv_3475|M.gilvum_PYR-GCK FAEVTAHRLWSDALVDGHIEWMSAIANRVPMMVVARLLGLPEDDVDELIR
MAV_0011|M.avium_104 FATQTADRLWDENLSDGRIEWMSAIANRLPMMVVCRLLGLPDDDVDKLIR
Mb1806|M.bovis_AF2122/97 FTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVK
Rv1777|M.tuberculosis_H37Rv FTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVK
MMAR_2654|M.marinum_M FVSETAERLWFDGLQGGRIEWMDAIANRLPMMVVAELIGLPDADIAQLVQ
MUL_3131|M.ulcerans_Agy99 FVSETAERLWFDGLQGGRIEWMDAIANRLPMMVVAELIGLPDADIAQLVQ
MSMEG_0675|M.smegmatis_MC2_155 FILETANSLWHSHLHDGHIEWMSAVANRLPMMIVGRLIGVPDADVDKLVR
TH_3411|M.thermoresistible__bu FIAETATALWNTGLGDGRIEWMGAMANRLPMMIVARIIGVPDTDVDKLIR
Mvan_3781|M.vanbaalenii_PYR-1 FAENTMHALWQQMPAGAPVEWMAVVADRLPMTVVCKLIGVPAEDVDRIAA
MAB_1939|M.abscessus_ATCC_1997 VMAQTGSCLWERGVNGDGIDWMAAMGDALPMTMVARLIGLPAGDVPQLVQ
MLBr_02088|M.leprae_Br4923 DIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
* .: : :. :.: :: .::*:* * .:
Mflv_3475|M.gilvum_PYR-GCK LGYATTTLLDGIVSAT-----QLEAAGTAAMELATYVLQHFEKATGDPQP
MAV_0011|M.avium_104 LGYATTTLLDGIVAPE-----QLEQAGMAAIELSGYVLEHFEKASEKPES
Mb1806|M.bovis_AF2122/97 WGYAATQLLEGLVEND-----QLVAAGVALMELSGYIFEQFDRAAADPRD
Rv1777|M.tuberculosis_H37Rv WGYAATQLLEGLVEND-----QLVAAGVALMELSGYIFEQFDRAAADPRD
MMAR_2654|M.marinum_M WGYGATQLLEGLVDQD-----QLADAGIAVMQLSGYITEQFARAAADPQE
MUL_3131|M.ulcerans_Agy99 WGYGATQLLEGLVDQD-----QLADAGIAVMQLSGCITEQFARAAADPQE
MSMEG_0675|M.smegmatis_MC2_155 WGYSATQVVEGLVGQD-----QLTQATVAVMELAGYITDQFRHAAQDPQD
TH_3411|M.thermoresistible__bu WGYAATQVVEGLVTQE-----KLDDAAAAVLELGGYITDQFRRAADDPQD
Mvan_3781|M.vanbaalenii_PYR-1 WAYASTQILEGRVDEH-----TLTAAGTAALELAGYISDKLGRASLDPGD
MAB_1939|M.abscessus_ATCC_1997 WGYSSTEMLGGLNTPQ-----RQAQVVTDTMHLVLYLREHLEEELAAPGD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
. . : : * : : . *
Mflv_3475|M.gilvum_PYR-GCK GLMSDLAWRTQSGE-LEQLSALAIMLTLFSAAGESTASLLGSAAWILTDR
MAV_0011|M.avium_104 SLMADLAARCAAGE-LEQLPALGIMLTLFSAAGESTASLLGSAAWILADR
Mb1806|M.bovis_AF2122/97 NLLGELATACASGE-LDTLTAQVMMVTLFAAGGESTAALLGSAVWILATR
Rv1777|M.tuberculosis_H37Rv NLLGELATACASGE-LDTLTAQVMMVTLFAAGGESTAALLGSAVWILATR
MMAR_2654|M.marinum_M NLLGELATACATGE-LDSLTANLMMVMLFAAGGESTASLLGSAVWILATR
MUL_3131|M.ulcerans_Agy99 NLLGELATACAAGE-LDSLTANLMMVMLFAAGGESTASLLGSAVWILATR
MSMEG_0675|M.smegmatis_MC2_155 NLLGDLATACATGE-MDELTAQSMMIILFSAGGESTASLIGSAAWILASR
TH_3411|M.thermoresistible__bu DLLGDLATACASGD-LDDVTALAMMVTLFSAGGESTASLIGSAAWILATR
Mvan_3781|M.vanbaalenii_PYR-1 NLLGCIATACAAGE-LNNLTAQVMLVTLFSAGGESTAALIGSATQIIATR
MAB_1939|M.abscessus_ATCC_1997 DLLGYLAQACNRGD-ISLDIGVMILVQLVGAGGESTAGLMGNAVRILGEN
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRN
.*:. : *: : *. *. *:*. *:..*. : .
Mflv_3475|M.gilvum_PYR-GCK PAVQEQLRADPGLLGAFIEETLRFESPFRGHYRHVVRDTALAGVELPADS
MAV_0011|M.avium_104 PAIQRQLRENPELLSTFIEETLRFEAPFRGHYRHVWRDTTLGGIELPEGA
Mb1806|M.bovis_AF2122/97 PDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVRNATTLDGTELPADS
Rv1777|M.tuberculosis_H37Rv PDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADS
MMAR_2654|M.marinum_M PDIQQQVRDNPQLLGAFVEETLRYEAPFRGHYRHVRNDTTLGGLTLPADS
MUL_3131|M.ulcerans_Agy99 PDIQQQVRDNPQLLGAFVEETLRYEAPFRAHYRHVRNDTTLGGLTLPADS
MSMEG_0675|M.smegmatis_MC2_155 PDIQEHLRAKPELLGAFVEEVLRYEPPFRGHYRHVVHDTTLGGVDLPAGS
TH_3411|M.thermoresistible__bu PDIQQRLRDAPDLLGAFLEEVLRYEPPFRGHYRHVLRDTELCGVELPAGS
Mvan_3781|M.vanbaalenii_PYR-1 PDVQRRLRADPGLIPAFLEEVLRFEPPFRGHYRHVVRDCALAGKELTAGS
MAB_1939|M.abscessus_ATCC_1997 PRLQQRIRENRALLPTFLEEALRLESPFRGHHRHVLTDTTLGGVQLPAGS
MLBr_02088|M.leprae_Br4923 PSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGD
* . : .:**.** :..:: * . : *. .
Mflv_3475|M.gilvum_PYR-GCK RLLLMWGAANRDPRQFNSANDFRLDRSSAKGHVAFGKGAHFCVGAALARL
MAV_0011|M.avium_104 HLLLMWGAANRDPTHFKDPNEFRLDRAAAKSHLSFGKGVHFCVGAALARL
Mb1806|M.bovis_AF2122/97 HLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARL
Rv1777|M.tuberculosis_H37Rv HLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARL
MMAR_2654|M.marinum_M HLLLMWGAANRDPVQFDAPEEFRLDRPGGKGHISFGKGAHFCVGAALARL
MUL_3131|M.ulcerans_Agy99 HLLLMWGAANRDPVQFDAPEEFRLDRPGGKGHISFGKGAHFCVGAALARL
MSMEG_0675|M.smegmatis_MC2_155 RLLLLWGAANRDPSHFDAPDEFRLDRSSAKSHLSFGKGTHFCVGAALARL
TH_3411|M.thermoresistible__bu RLLLLWGAANRDPARFADPDEFSLDRADGKAHISFGKGIHFCVGAALARL
Mvan_3781|M.vanbaalenii_PYR-1 RLLLLWGAANRDPARFDAPNEFQIERPNSKAHIAFGKGAHFCIGAALARF
MAB_1939|M.abscessus_ATCC_1997 HLTLLWGAANRDPAIFEDPDVLRLDRPSPRGHITFGKGLHFCVGAALARL
MLBr_02088|M.leprae_Br4923 TMVLLLAAANRDPAVYSRPDEFDPDRPSSR-HLAFAVGSHFCLGAALARL
: *: .****** : . : :*. : *::*. * ***:******:
Mflv_3475|M.gilvum_PYR-GCK EARIVLAMLLERT-TWIEAADVGPWLPSILVRRLEHLRLKIR--
MAV_0011|M.avium_104 EAHIVLRRLLERT-SWIDATDVGDWLPSILVRRRERLGLAVR--
Mb1806|M.bovis_AF2122/97 EARIVLRLLLDRT-SVIEAADVGGWLPSILVRRIERLELAVQ--
Rv1777|M.tuberculosis_H37Rv EARIVLRLLLDRT-SVIEAADVGGWLPSILVRRIERLELAVQ--
MMAR_2654|M.marinum_M EAQIVLRLLLERT-TVIEAADVGRWLPSMLVRRLENLELAVR--
MUL_3131|M.ulcerans_Agy99 EAQIVLRLLLERT-TVIEAADVGRWLPSMLVRRLENLELAVR--
MSMEG_0675|M.smegmatis_MC2_155 EALVVLRHLLHNT-ANITAGDTGPWLPSLLVRRLAHLELVTT--
TH_3411|M.thermoresistible__bu EARIVLERLLEHT-TTITAARTGRWLPSLLVRRLEELHLVCG--
Mvan_3781|M.vanbaalenii_PYR-1 EARIVIDLLLRHT-SWVDAAGPGWWLPSLLVRRLDELPLTMT--
MAB_1939|M.abscessus_ATCC_1997 EARTAINLLLDRTREFAIKPDGAHWVPSIMVRRHQKLELEVSAA
MLBr_02088|M.leprae_Br4923 EATVTLSAISARF-PQVQLAGELVYKPNVAMRGMSALPVQV---
** .: : . : *.: :* * :