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MTEDLTTVDFFRDSRLTDDPYTFYEALRNKCPVAKEDHYGITMVTGWQEAVDVYNDADTFSSCISVTGPF PGFPVSLEGRENDDITDLIKEHRDEIPFSDQLPTLDPPTHTDHRALLMRLITPKRLKENEDAMWQLADDN LDRFLAPGEGEFIKGFAGPFTLQVIADLLGVPEGDREELLERLARGTHGSGLGNADKALTKTPLEYLYDV FATYVEDRRAEPRDDVLTGLATATFPDGRLPEVGDVVRVATNVFSAGQETTVRLLSTALKVMGDQPEVQA KLRENRELLGNFIEECLRIESPVKGDFRLSRMPTTIGDQPLGAGCTVMVINGAANRDPRRFEDPDTFDPE RKNARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTTDIRISERKHGPVGNRRYEYIPTYILRGLTEL HLEFDLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2474 | - | - | 100% (427) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2517 | - | e-132 | 54.23% (426) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4149 | - | e-123 | 52.73% (421) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1806 | cyp144 | 8e-45 | 31.74% (419) | cytochrome p450 144 CYP144 |
| M. tuberculosis H37Rv | Rv1777 | cyp144 | 1e-44 | 31.74% (419) | cytochrome p450 144 CYP144 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-30 | 30.82% (331) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1939 | - | 2e-47 | 31.33% (415) | cytochrome P450 |
| M. marinum M | MMAR_4737 | cyp150A5 | 1e-176 | 71.02% (421) | cytochrome P450 150A5 Cyp150A5 |
| M. avium 104 | MAV_0912 | - | 1e-179 | 69.95% (426) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_4823 | - | 0.0 | 71.90% (427) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_4148 | - | 0.0 | 86.35% (425) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0314 | cyp150A6 | 1e-129 | 53.57% (420) | cytochrome P450 150A6 Cyp150A6 |
| M. vanbaalenii PYR-1 | Mvan_4180 | - | 0.0 | 88.99% (427) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1806|M.bovis_AF2122/97 -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
Rv1777|M.tuberculosis_H37Rv -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
MAB_1939|M.abscessus_ATCC_1997 -----------------------------------MNTDELFDPQVLEDP
Mflv_2474|M.gilvum_PYR-GCK ------------------------------MTEDLTTVDFFRDSRLTDDP
Mvan_4180|M.vanbaalenii_PYR-1 ------------------------------MAEDLTTVDFFRDSRLTDDP
TH_4148|M.thermoresistible__bu ------------------------------MAEDITAVDFFRDDRLTDDP
MSMEG_4823|M.smegmatis_MC2_155 ---------------------------MTHMAIDPAGIDWFKDPRLVDDP
MMAR_4737|M.marinum_M -------------------------------MNDCAEPDFFRDSGLVENP
MAV_0912|M.avium_104 ------------------------------MTNEFSELDFFRGSELIENP
MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . :*
Mb1806|M.bovis_AF2122/97 YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
Rv1777|M.tuberculosis_H37Rv YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
MAB_1939|M.abscessus_ATCC_1997 YPFYRRLRETAPVWPVGDSGFYFVSRWDLVVEATERAEDFSSNLTAALMK
Mflv_2474|M.gilvum_PYR-GCK YTFYEALRNKCPVAKEDHYGITMVTGWQEAVDVYNDADTFSSCISVTGPF
Mvan_4180|M.vanbaalenii_PYR-1 YTFYEALRNKCPVSREEHYGVTMVTGWQEAVDVYNDAESFSSCVSVTGPF
TH_4148|M.thermoresistible__bu YPFYAALRDKCPVTREKFYGVTMVTGWQEAVDVYNDAESFSSCISVTGPF
MSMEG_4823|M.smegmatis_MC2_155 YPYFNALRDKCPVQSEDHYGVTMVTGWEEAVSVYNDEKSFSSCTSVTGPF
MMAR_4737|M.marinum_M YPYYETLRQRCPVTGEGHHGVTMVTGWDEAVSVLNDAETFSSCISVTGPF
MAV_0912|M.avium_104 YPYYEALRQRCPVTKESHHNVTMITGWDEACAVLNDAETWSSCISVTGPF
MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKAT---
.. : : .: . . :. . *.
Mb1806|M.bovis_AF2122/97 T-----------AEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRH
Rv1777|M.tuberculosis_H37Rv T-----------AEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRH
MAB_1939|M.abscessus_ATCC_1997 S-----------AEGLAV-APMGPPADPTHVLATGDDPLHHAHRRLVLPT
Mflv_2474|M.gilvum_PYR-GCK PGFPVSLEGRENDDITDLIKEHRDEIPFSDQLPTLDPPTHTDHRALLMRL
Mvan_4180|M.vanbaalenii_PYR-1 PGFPVSLEGRQDDDITALIEQHRDEIPFSDQLPTLDPPTHTNHRALLMRL
TH_4148|M.thermoresistible__bu PGFPVSLEGKENEDITELINEHRDEIPFSDQLPTLDPPTHTNHRALLMRL
MSMEG_4823|M.smegmatis_MC2_155 PGFPVPLEGR--DDVAELIEKHRDELPFSDQLPTLDPPVHTNHRSLMMRL
MMAR_4737|M.marinum_M PGFPVPLEGD---DVTELIERHRSELPFSDQLPTLDPPTHTNHRALLMRL
MAV_0912|M.avium_104 PGFPVPLEGD---DVTELIERHRDELPFSDQLPTLDPPTHTNHRSLLMRL
MUL_0314|M.ulcerans_Agy99 PPLPFTPNGD---DVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRL
MLBr_02088|M.leprae_Br4923 ------------LAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKA
: * * * * ::
Mb1806|M.bovis_AF2122/97 LAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIG
Rv1777|M.tuberculosis_H37Rv LAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIG
MAB_1939|M.abscessus_ATCC_1997 LVARRITALEPVMAQTGSCLWERGVNGDGIDWMAAMGDALPMTMVARLIG
Mflv_2474|M.gilvum_PYR-GCK ITPKRLKENEDAMWQLADDNLDRFLAPGEGEFIKGFAGPFTLQVIADLLG
Mvan_4180|M.vanbaalenii_PYR-1 ITPKRLKENEDAMWQLADDILDDYLAQGEGEFIKGFAGPFTLRVIADLLG
TH_4148|M.thermoresistible__bu ITPKRLKENEDAMWQIADDILDDFLAPGHGEFINGFAGPFTLRVIADLLG
MSMEG_4823|M.smegmatis_MC2_155 ITPKRLKENEDAMWQLADEVLDDFLAPGKGEFIKGFASPFTLLVIADLLG
MMAR_4737|M.marinum_M ITPKRLKENEDAMWVLADRVLDDYLAAGEGEFIKGFASPFTLLVIADLLG
MAV_0912|M.avium_104 ITPKRLKENEDAMWVLADQALDTFLAPGHGEFIKGFAGPFTLLVIADLLG
MUL_0314|M.ulcerans_Agy99 LTPSRLKQNEEFMWRLADRQLDEFLGAAECEFISEYAKPFATLVIADLLG
MLBr_02088|M.leprae_Br4923 FAPKVVQALEGDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLG
:.. : * . : : . :. ::. *:*
Mb1806|M.bovis_AF2122/97 LPDPDIAQLVKWGYAATQLLEGLVENDQLV-----AAGVALMELSGYIFE
Rv1777|M.tuberculosis_H37Rv LPDPDIAQLVKWGYAATQLLEGLVENDQLV-----AAGVALMELSGYIFE
MAB_1939|M.abscessus_ATCC_1997 LPAGDVPQLVQWGYSSTEMLGGLNTPQRQA-----QVVTDTMHLVLYLRE
Mflv_2474|M.gilvum_PYR-GCK VPEGDREELLER--LARGTHGSGLGNADKA-----LTKTPLEYLYDVFAT
Mvan_4180|M.vanbaalenii_PYR-1 VPEEDRPELLER--LAKGTHGGGLGNADKT-----LTKTPLEYLYDVFAT
TH_4148|M.thermoresistible__bu VPEEDRPELLER--LARGTHGSGLGNADKT-----LAKTPLEYLYDVFAE
MSMEG_4823|M.smegmatis_MC2_155 IPAEDRNAFVDG--ISQNSGGGVGSTGDES-----LSHSPLEFLYGQFEA
MMAR_4737|M.marinum_M VPPEDRQTFVNN--IHHHAGGGVGGTGKEA-----LAHNPLEFLYGAFAD
MAV_0912|M.avium_104 VPEEDRDKFVKG--IRQHSGGGVGGTGEET-----LAHSPLEFLYGLFSD
MUL_0314|M.ulcerans_Agy99 VPEDDRKDFRVV--LGADRMGRVGALDHES-----VGVNPLQWLDDKFSA
MLBr_02088|M.leprae_Br4923 VPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQ
:* * : * :
Mb1806|M.bovis_AF2122/97 QFDRAAADPRDNLLGELATACASGELDTLTAQVMMVT--LFAAGGESTAA
Rv1777|M.tuberculosis_H37Rv QFDRAAADPRDNLLGELATACASGELDTLTAQVMMVT--LFAAGGESTAA
MAB_1939|M.abscessus_ATCC_1997 HLEEELAAPGDDLLGYLAQACNRGDISLDIGVMILVQ--LVGAGGESTAG
Mflv_2474|M.gilvum_PYR-GCK YVEDRRAEPRDDVLTGLATATFPDGRLPEVGDVVRVATNVFSAGQETTVR
Mvan_4180|M.vanbaalenii_PYR-1 YVEERRAEPRDDVLTGLATANFPDGTVPEVGDVVRVATNVFSAGQETTVR
TH_4148|M.thermoresistible__bu YVEDRRRNPRDDVLTGLATATFPGGTTPEVGDVVRVATNVFSAGQETTVR
MSMEG_4823|M.smegmatis_MC2_155 YIEDRRSNPREDILTGMATALFPDGTTPSPGDVARVATNVFSAGQETTVR
MMAR_4737|M.marinum_M YVRDRRREPREDVLTGLATATFPDGTVPDVEDVARVACNVFSAGQETTVR
MAV_0912|M.avium_104 YVRDRRRQPREDVLTGLATATYPDGSIPEVEDVARVASNVFSAGQETTVR
MUL_0314|M.ulcerans_Agy99 YIEDRRRRPRNDVLTALATATYPDGSTPEIIDVVRWATFLFAAGQETTAK
MLBr_02088|M.leprae_Br4923 LVKCRRGTPGEDLISRLIELDESGD-QLTEEEIIATCGLLLVAGHETTVN
. * :::: : . : :. ** *:*.
Mb1806|M.bovis_AF2122/97 LLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVRNA
Rv1777|M.tuberculosis_H37Rv LLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNA
MAB_1939|M.abscessus_ATCC_1997 LMGNAVRILGENPRLQQRIRENRALLPTFLEEALRLESPFRGHHRHVLTD
Mflv_2474|M.gilvum_PYR-GCK LLSTALKVMGDQPEVQAKLRENRELLGNFIEECLRIESPVKGDFRLSRMP
Mvan_4180|M.vanbaalenii_PYR-1 LLSTALKVIGDRPDIQERLRADRSLLPNFIEECLRIESPVKGDFRLSRVP
TH_4148|M.thermoresistible__bu LLSTALKVLGDRPDIQERVRADRSLLPNFIEECLRIESPVKGDFRLSRVP
MSMEG_4823|M.smegmatis_MC2_155 LLGTALKVLGDRPDVQKMVREDRSLLPNFIEEALRHESPVKGDFRLSRCP
MMAR_4737|M.marinum_M LLGAALQIIGERADIQQQLRRDRSLIPNFIEEALRIESPVKGDFRLSRVP
MAV_0912|M.avium_104 LLGAALQTLGERPDIQAQLRKDRSLIPNFIEESLRHESPVKGDFRLNRRP
MUL_0314|M.ulcerans_Agy99 QLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLARKR
MLBr_02088|M.leprae_Br4923 LIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKD
: *: : .. : : .:** ** :...: *
Mb1806|M.bovis_AF2122/97 TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKG
Rv1777|M.tuberculosis_H37Rv TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKG
MAB_1939|M.abscessus_ATCC_1997 TTLGGVQLPAGSHLTLLWGAANRDPAIFEDPDVLRLDRPSPRGHITFGKG
Mflv_2474|M.gilvum_PYR-GCK TTIGDQPLGAGCTVMVINGAANRDPRRFEDPDTFDPERKNARQHLAFGRG
Mvan_4180|M.vanbaalenii_PYR-1 TTIGDQALGAGCTVMVINGAANRDPRRFEDPDAFDPERKNARQHLAFGRG
TH_4148|M.thermoresistible__bu TTVGGQPLGAGCTVMVINGAANRDPRRFENPDEFDPDRKNARQHLAFGRG
MSMEG_4823|M.smegmatis_MC2_155 VTVGDKDLPSGRTVMVVNGAANRDPRRFENPDDFDPARKNARQHLAFGRG
MMAR_4737|M.marinum_M TTVGEVDLPAGTTVMVLQAAANRDPRRFVEPATFDPARKNARQHLSFGRG
MAV_0912|M.avium_104 VTVGGVDLPAGTTVMVVQAAANRDPRRFDDPATFDPARKNARQHISFGRG
MUL_0314|M.ulcerans_Agy99 TTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFARG
MLBr_02088|M.leprae_Br4923 MTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSR-HLAFAVG
*:. : . : :: .****** : * : * . : *::*. *
Mb1806|M.bovis_AF2122/97 AHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------WLPSIL
Rv1777|M.tuberculosis_H37Rv AHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------WLPSIL
MAB_1939|M.abscessus_ATCC_1997 LHFCVGAALARLEARTAINLLLDRTREFAIKPDGAH--------WVPSIM
Mflv_2474|M.gilvum_PYR-GCK IHSCPGAPLARAETRVGLERLLDRTTDIRISERKHGPVGNRRYEYIPTYI
Mvan_4180|M.vanbaalenii_PYR-1 IHSCPGAPLARAETRVGLERLLDRTSDIRISESKHGPAGNRRYDYIPTYI
TH_4148|M.thermoresistible__bu IHSCPGAPLARAETRVGLERLLDRTSDIRISEAHHGPPENRRYSYIPTYI
MSMEG_4823|M.smegmatis_MC2_155 IHSCPGAPLARAETRVGLERLLDRTTDIRISEEHHGPAANRDYKYIPTFI
MMAR_4737|M.marinum_M IHSCPGAPLARAETRVAIERLLDRTADITISERVHGPANDRRYQYVPTYI
MAV_0912|M.avium_104 IHSCPGAPLARAETRVAIERLLDRTTDIRINENIHGPANDRRYQYVPTYI
MUL_0314|M.ulcerans_Agy99 VHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTYI
MLBr_02088|M.leprae_Br4923 SHFCLGAALARLEATVTLSAISARFPQVQLAGELV---------YKPNVA
* * *..*** * : : * . : *.
Mb1806|M.bovis_AF2122/97 VRRIERLELAVQ-------
Rv1777|M.tuberculosis_H37Rv VRRIERLELAVQ-------
MAB_1939|M.abscessus_ATCC_1997 VRRHQKLELEVSAA-----
Mflv_2474|M.gilvum_PYR-GCK LRGLTELHLEFD-----LR
Mvan_4180|M.vanbaalenii_PYR-1 LRGLTELHLEYD-----VR
TH_4148|M.thermoresistible__bu LRGLTELHLEFDGVSGGAR
MSMEG_4823|M.smegmatis_MC2_155 LRGLTHLHLEFD-----VK
MMAR_4737|M.marinum_M LRGLTELHLDFT-----PA
MAV_0912|M.avium_104 LRGLTELHLEFT-----LA
MUL_0314|M.ulcerans_Agy99 LRGLTELHITFTP----AG
MLBr_02088|M.leprae_Br4923 MRGMSALPVQV--------
:* * :