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TPPEGLGLALFRPECIQDPYPLYRRMLDTAPVHPIADSGFYAVCGWDAVNDAIARPENFSSNLTATMTYQ ADGTVGAFEMESLGGKSHVLATADEPAHTAHRKALLPQLAARRIRAFEPFILETANSLWHSHLHDGHIEW MSAVANRLPMMIVGRLIGVPDADVDKLVRWGYSATQVVEGLVGQDQLTQATVAVMELAGYITDQFRHAAQ DPQDNLLGDLATACATGEMDELTAQSMMIILFSAGGESTASLIGSAAWILASRPDIQEHLRAKPELLGAF VEEVLRYEPPFRGHYRHVVHDTTLGGVDLPAGSRLLLLWGAANRDPSHFDAPDEFRLDRSSAKSHLSFGK GTHFCVGAALARLEALVVLRHLLHNTANITAGDTGPWLPSLLVRRLAHLELVTT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0675 | - | - | 100% (405) | putative cytochrome P450 144 |
| M. smegmatis MC2 155 | MSMEG_4823 | - | 6e-48 | 30.27% (413) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_4780 | - | 6e-45 | 29.93% (411) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1806 | cyp144 | 1e-155 | 67.52% (391) | cytochrome p450 144 CYP144 |
| M. gilvum PYR-GCK | Mflv_3475 | - | 1e-139 | 61.38% (391) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1777 | cyp144 | 1e-156 | 67.77% (391) | cytochrome p450 144 CYP144 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-36 | 28.71% (404) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1939 | - | 1e-105 | 49.36% (393) | cytochrome P450 |
| M. marinum M | MMAR_2654 | cyp144A4 | 1e-162 | 69.54% (394) | cytochrome P450 144A4 Cyp144A4 |
| M. avium 104 | MAV_0011 | - | 1e-145 | 62.92% (391) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3411 | - | 1e-163 | 69.90% (402) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3131 | cyp144A4 | 1e-159 | 68.78% (394) | cytochrome P450 144A4 Cyp144A4 |
| M. vanbaalenii PYR-1 | Mvan_3781 | - | 1e-140 | 59.90% (399) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0675|M.smegmatis_MC2_155 ------------------------------MTPPEGLGLALFRPECIQDP
TH_3411|M.thermoresistible__bu -----------------------------MATTDAGLGLALFDDQFIQNP
Mb1806|M.bovis_AF2122/97 -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
Rv1777|M.tuberculosis_H37Rv -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
MMAR_2654|M.marinum_M -------------------------------MKVASDAMTFFGPETLQNP
MUL_3131|M.ulcerans_Agy99 -------------------------------MKVASDAMTFFGTESLQNP
Mflv_3475|M.gilvum_PYR-GCK -------------------------------MSVVS-PREFFGGAAIQDP
MAV_0011|M.avium_104 -------------------------------MAVLDSATRFFGSEAIQDP
Mvan_3781|M.vanbaalenii_PYR-1 -----------------------------MTVGHTDLGLALFHDEFLQDP
MAB_1939|M.abscessus_ATCC_1997 -----------------------------------MNTDELFDPQVLEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:: :*
MSMEG_0675|M.smegmatis_MC2_155 YPLYRRMLDTAPVHPIADSGFYAVCGWDAVNDAIARPENFSSNLTATMTY
TH_3411|M.thermoresistible__bu HPLYARMHREGPVHRIGASDFYAVSSWAAVTEAVARPEDFSSNLTATMMY
Mb1806|M.bovis_AF2122/97 YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
Rv1777|M.tuberculosis_H37Rv YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
MMAR_2654|M.marinum_M YPLYERMRAEGPVHRIADSDFYAVCGWDAVNDAISRPEDFSSNLTATMTY
MUL_3131|M.ulcerans_Agy99 YPLYERMRAEGPVHRIADSEFYAVCGWDAVNDAISRPGDFSSNLTATMTY
Mflv_3475|M.gilvum_PYR-GCK APMYDMMRDRAAVNRIGESAFYAVCGWDAVQEAVNRVDDFSSNLTATMVF
MAV_0011|M.avium_104 YPLYERMHAEAPVHRIGDSVFYAVCGWDAVHEAIERVEDFSSNLTATMVF
Mvan_3781|M.vanbaalenii_PYR-1 HPLYARMHAEAPVHRVGDSDFYAVCGWDAITEAVARPGDFSSNLTGAMRY
MAB_1939|M.abscessus_ATCC_1997 YPFYRRLRETAPVWPVGDSGFYFVSRWDLVVEATERAEDFSSNLTAALMK
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
*.* : ..: . : .. : :* : . *..*..::
MSMEG_0675|M.smegmatis_MC2_155 QADGTVGAFEMESLGGKSHVLATADEPAHTAHRKALLPQLAARRIRAFEP
TH_3411|M.thermoresistible__bu EPGGEIRPIPIGEVGGPTQALATADEPSHTVHRKLLLPQLAARRIRAYQP
Mb1806|M.bovis_AF2122/97 TAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQ
Rv1777|M.tuberculosis_H37Rv TAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQ
MMAR_2654|M.marinum_M SPAGKIAAFEMDQLGGPTHVLATADDPAHAVHRKLLVRHLAARRIRSLER
MUL_3131|M.ulcerans_Agy99 SPDGKVAAFEMDQLGGPTHVLATADDPAHAVHRKLLVRHLAARRIRSLER
Mflv_3475|M.gilvum_PYR-GCK HDDGTVTPFEMGALGGPMHALATADDPLHASHRKLLLPHLSAKRIRVIEQ
MAV_0011|M.avium_104 HEDGTVTPFDMGAPGAPMHALATADDPVHAVHRKILLPHLSAKRIRIIEE
Mvan_3781|M.vanbaalenii_PYR-1 QADGTVSLLPLDTLGSPTQALATADDPAHAAHRKLLVPYLAAKRVRALET
MAB_1939|M.abscessus_ATCC_1997 SAEG-LAVAPMGPPADPTHVLATGDDPLHHAHRRLVLPTLVARRITALEP
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASS----FMFLDPPDHTRLRKLVSKAFAPKVVQALEG
. . : * * * *: : : .: : :
MSMEG_0675|M.smegmatis_MC2_155 FILETANSLWHSHLHDGHIEWMSAVANRLPMMIVGRLIGVPDADVDKLVR
TH_3411|M.thermoresistible__bu FIAETATALWNTGLGDGRIEWMGAMANRLPMMIVARIIGVPDTDVDKLIR
Mb1806|M.bovis_AF2122/97 FTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVK
Rv1777|M.tuberculosis_H37Rv FTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVK
MMAR_2654|M.marinum_M FVSETAERLWFDGLQGGRIEWMDAIANRLPMMVVAELIGLPDADIAQLVQ
MUL_3131|M.ulcerans_Agy99 FVSETAERLWFDGLQGGRIEWMDAIANRLPMMVVAELIGLPDADIAQLVQ
Mflv_3475|M.gilvum_PYR-GCK FAEVTAHRLWSDALVDGHIEWMSAIANRVPMMVVARLLGLPEDDVDELIR
MAV_0011|M.avium_104 FATQTADRLWDENLSDGRIEWMSAIANRLPMMVVCRLLGLPDDDVDKLIR
Mvan_3781|M.vanbaalenii_PYR-1 FAENTMHALWQQMPAGAPVEWMAVVADRLPMTVVCKLIGVPAEDVDRIAA
MAB_1939|M.abscessus_ATCC_1997 VMAQTGSCLWERGVNGDGIDWMAAMGDALPMTMVARLIGLPAGDVPQLVQ
MLBr_02088|M.leprae_Br4923 DIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
* .: : :. :.: :: .::*:* * .:
MSMEG_0675|M.smegmatis_MC2_155 WGYSATQVVEGLVGQD-----QLTQATVAVMELAGYITDQFRHAAQDPQD
TH_3411|M.thermoresistible__bu WGYAATQVVEGLVTQE-----KLDDAAAAVLELGGYITDQFRRAADDPQD
Mb1806|M.bovis_AF2122/97 WGYAATQLLEGLVEND-----QLVAAGVALMELSGYIFEQFDRAAADPRD
Rv1777|M.tuberculosis_H37Rv WGYAATQLLEGLVEND-----QLVAAGVALMELSGYIFEQFDRAAADPRD
MMAR_2654|M.marinum_M WGYGATQLLEGLVDQD-----QLADAGIAVMQLSGYITEQFARAAADPQE
MUL_3131|M.ulcerans_Agy99 WGYGATQLLEGLVDQD-----QLADAGIAVMQLSGCITEQFARAAADPQE
Mflv_3475|M.gilvum_PYR-GCK LGYATTTLLDGIVSAT-----QLEAAGTAAMELATYVLQHFEKATGDPQP
MAV_0011|M.avium_104 LGYATTTLLDGIVAPE-----QLEQAGMAAIELSGYVLEHFEKASEKPES
Mvan_3781|M.vanbaalenii_PYR-1 WAYASTQILEGRVDEH-----TLTAAGTAALELAGYISDKLGRASLDPGD
MAB_1939|M.abscessus_ATCC_1997 WGYSSTEMLGGLNTPQ-----RQAQVVTDTMHLVLYLREHLEEELAAPGD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
. . : : * : : . *
MSMEG_0675|M.smegmatis_MC2_155 NLLGDLATACATGE-MDELTAQSMMIILFSAGGESTASLIGSAAWILASR
TH_3411|M.thermoresistible__bu DLLGDLATACASGD-LDDVTALAMMVTLFSAGGESTASLIGSAAWILATR
Mb1806|M.bovis_AF2122/97 NLLGELATACASGE-LDTLTAQVMMVTLFAAGGESTAALLGSAVWILATR
Rv1777|M.tuberculosis_H37Rv NLLGELATACASGE-LDTLTAQVMMVTLFAAGGESTAALLGSAVWILATR
MMAR_2654|M.marinum_M NLLGELATACATGE-LDSLTANLMMVMLFAAGGESTASLLGSAVWILATR
MUL_3131|M.ulcerans_Agy99 NLLGELATACAAGE-LDSLTANLMMVMLFAAGGESTASLLGSAVWILATR
Mflv_3475|M.gilvum_PYR-GCK GLMSDLAWRTQSGE-LEQLSALAIMLTLFSAAGESTASLLGSAAWILTDR
MAV_0011|M.avium_104 SLMADLAARCAAGE-LEQLPALGIMLTLFSAAGESTASLLGSAAWILADR
Mvan_3781|M.vanbaalenii_PYR-1 NLLGCIATACAAGE-LNNLTAQVMLVTLFSAGGESTAALIGSATQIIATR
MAB_1939|M.abscessus_ATCC_1997 DLLGYLAQACNRGD-ISLDIGVMILVQLVGAGGESTAGLMGNAVRILGEN
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRN
.*:. : *: : *. *. *:*. *:..*. : .
MSMEG_0675|M.smegmatis_MC2_155 PDIQEHLRAKPELLGAFVEEVLRYEPPFRGHYRHVVHDTTLGGVDLPAGS
TH_3411|M.thermoresistible__bu PDIQQRLRDAPDLLGAFLEEVLRYEPPFRGHYRHVLRDTELCGVELPAGS
Mb1806|M.bovis_AF2122/97 PDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVRNATTLDGTELPADS
Rv1777|M.tuberculosis_H37Rv PDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADS
MMAR_2654|M.marinum_M PDIQQQVRDNPQLLGAFVEETLRYEAPFRGHYRHVRNDTTLGGLTLPADS
MUL_3131|M.ulcerans_Agy99 PDIQQQVRDNPQLLGAFVEETLRYEAPFRAHYRHVRNDTTLGGLTLPADS
Mflv_3475|M.gilvum_PYR-GCK PAVQEQLRADPGLLGAFIEETLRFESPFRGHYRHVVRDTALAGVELPADS
MAV_0011|M.avium_104 PAIQRQLRENPELLSTFIEETLRFEAPFRGHYRHVWRDTTLGGIELPEGA
Mvan_3781|M.vanbaalenii_PYR-1 PDVQRRLRADPGLIPAFLEEVLRFEPPFRGHYRHVVRDCALAGKELTAGS
MAB_1939|M.abscessus_ATCC_1997 PRLQQRIRENRALLPTFLEEALRLESPFRGHHRHVLTDTTLGGVQLPAGS
MLBr_02088|M.leprae_Br4923 PSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGD
* . : .:**.** :..:: * . : *. .
MSMEG_0675|M.smegmatis_MC2_155 RLLLLWGAANRDPSHFDAPDEFRLDRSSAKSHLSFGKGTHFCVGAALARL
TH_3411|M.thermoresistible__bu RLLLLWGAANRDPARFADPDEFSLDRADGKAHISFGKGIHFCVGAALARL
Mb1806|M.bovis_AF2122/97 HLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARL
Rv1777|M.tuberculosis_H37Rv HLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARL
MMAR_2654|M.marinum_M HLLLMWGAANRDPVQFDAPEEFRLDRPGGKGHISFGKGAHFCVGAALARL
MUL_3131|M.ulcerans_Agy99 HLLLMWGAANRDPVQFDAPEEFRLDRPGGKGHISFGKGAHFCVGAALARL
Mflv_3475|M.gilvum_PYR-GCK RLLLMWGAANRDPRQFNSANDFRLDRSSAKGHVAFGKGAHFCVGAALARL
MAV_0011|M.avium_104 HLLLMWGAANRDPTHFKDPNEFRLDRAAAKSHLSFGKGVHFCVGAALARL
Mvan_3781|M.vanbaalenii_PYR-1 RLLLLWGAANRDPARFDAPNEFQIERPNSKAHIAFGKGAHFCIGAALARF
MAB_1939|M.abscessus_ATCC_1997 HLTLLWGAANRDPAIFEDPDVLRLDRPSPRGHITFGKGLHFCVGAALARL
MLBr_02088|M.leprae_Br4923 TMVLLLAAANRDPAVYSRPDEFDPDRPSSR-HLAFAVGSHFCLGAALARL
: *: .****** : . : :*. : *::*. * ***:******:
MSMEG_0675|M.smegmatis_MC2_155 EALVVLRHLLHNT-ANITAGDTGPWLPSLLVRRLAHLELVTT--
TH_3411|M.thermoresistible__bu EARIVLERLLEHT-TTITAARTGRWLPSLLVRRLEELHLVCG--
Mb1806|M.bovis_AF2122/97 EARIVLRLLLDRT-SVIEAADVGGWLPSILVRRIERLELAVQ--
Rv1777|M.tuberculosis_H37Rv EARIVLRLLLDRT-SVIEAADVGGWLPSILVRRIERLELAVQ--
MMAR_2654|M.marinum_M EAQIVLRLLLERT-TVIEAADVGRWLPSMLVRRLENLELAVR--
MUL_3131|M.ulcerans_Agy99 EAQIVLRLLLERT-TVIEAADVGRWLPSMLVRRLENLELAVR--
Mflv_3475|M.gilvum_PYR-GCK EARIVLAMLLERT-TWIEAADVGPWLPSILVRRLEHLRLKIR--
MAV_0011|M.avium_104 EAHIVLRRLLERT-SWIDATDVGDWLPSILVRRRERLGLAVR--
Mvan_3781|M.vanbaalenii_PYR-1 EARIVIDLLLRHT-SWVDAAGPGWWLPSLLVRRLDELPLTMT--
MAB_1939|M.abscessus_ATCC_1997 EARTAINLLLDRTREFAIKPDGAHWVPSIMVRRHQKLELEVSAA
MLBr_02088|M.leprae_Br4923 EATVTLSAISARF-PQVQLAGELVYKPNVAMRGMSALPVQV---
** .: : . : *.: :* * :