For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTGATTGRLSPHNVRRALRLAGMRPLPSRPLRTPIDLRGKRILLTGASSGIGELAAEKLAAHGAQVIVVA RREHLLADLVDRITARGGDATAMPVNLADLDAVDDLVLRAGPVDILINNAGRSIRRPLLESLDRWHDVER TIALNYYAPLRLIRGVAPQMVARGDGHIINVSSWRVMPESSPLFGVYNASKAALSAVSRVIDNELAESGV QSTTIYYPLVATPMIAPTRAYDGLAALSADEAAQWMVDAAQRRPVRIAPRKLIPLRALDVVSPRLLNGVM KRSTPQPSRAADAH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3466 | - | - | 100% (294) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0026 | - | 1e-94 | 63.38% (284) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4896 | - | 3e-42 | 42.67% (225) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0561c | - | 9e-95 | 63.08% (279) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0547c | - | 9e-95 | 63.08% (279) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 5e-17 | 31.96% (194) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3947 | - | 3e-78 | 56.63% (279) | short chain dehydrogenase |
| M. marinum M | MMAR_0894 | - | 4e-91 | 62.01% (279) | dehydrogenase |
| M. avium 104 | MAV_4597 | - | 2e-98 | 64.34% (286) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1073 | - | 1e-92 | 61.30% (292) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3707 | - | 1e-65 | 61.46% (205) | PUTATIVE oxidoreductase, short-chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0647 | - | 3e-91 | 62.01% (279) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0944 | - | 7e-93 | 61.97% (284) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1073|M.smegmatis_MC2_155 -MSKHPL-RRLTDNLFLASMRPPVTDQLIQLRAARDA-VDLTGKRVLITG
TH_3707|M.thermoresistible__bu --------------------------------------VRADGR------
Mvan_0944|M.vanbaalenii_PYR-1 MTSRNPL-RRLADQVVLTSMRPPILPALLN-RPNRET-IELKGKRVLLTG
Mb0561c|M.bovis_AF2122/97 -MSKRPL-RWLTEQITLAGMRPPISPQLLINRPAMQP-VDLTGKRILLTG
Rv0547c|M.tuberculosis_H37Rv -MSKRPL-RWLTEQITLAGMRPPISPQLLINRPAMQP-VDLTGKRILLTG
MMAR_0894|M.marinum_M -MSKSPL-RRLTEQITLAGMRPPIAPQLLVNRPPIKP-VALDGKRVMITG
MUL_0647|M.ulcerans_Agy99 -MSKSPL-RRLTEQITLAGMRPPIAPQLLVNRPPIKP-VALDGKRVMITG
MAV_4597|M.avium_104 -MSKSPL-RRFADQLVLATMRPPMAPQVLVNRPLIKP-VELAGKRVLLTG
MAB_3947|M.abscessus_ATCC_1997 -MSKNSFGKRVSTTLARAAMQPFPSLPLVRARLDPNYGAPIKGKRVLITG
Mflv_3466|M.gilvum_PYR-GCK -MTGATT-GRLSPHNVRRALR-LAGMRPLPSRPLRTP-IDLRGKRILLTG
MLBr_01740|M.leprae_Br4923 ---------------------------------MVKTAQYFVGKRCFVTG
*:
MSMEG_1073|M.smegmatis_MC2_155 ASSGIGAAAARKFAERGARVIVVARRAELLDEVAGGITASGGDAKAR-PC
TH_3707|M.thermoresistible__bu ADQGLDAARX------------------------------GGTGRAL-AC
Mvan_0944|M.vanbaalenii_PYR-1 ASSGIGEAAAEKLARRGATVVAVARRGDLLDDLVARITDAGGRARAH-AC
Mb0561c|M.bovis_AF2122/97 ASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSL-PC
Rv0547c|M.tuberculosis_H37Rv ASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSL-PC
MMAR_0894|M.marinum_M ASSGIGEAAAEQFARQGATVIAVARRKDLLDAVADRITTSGGVAMSA-PC
MUL_0647|M.ulcerans_Agy99 ASSGIGEAAAEQFARQGATVIAVARRKDLLDAVADRITTSGGVAMSA-PC
MAV_4597|M.avium_104 ASSGIGEAAAEQFAREGARVVVVARRKDLLDALAEGITRAGGEAIAM-PC
MAB_3947|M.abscessus_ATCC_1997 ASSGIGEEAAYQFGKLGAKVIVVARREDLLAEVAARIIAEGGEAEAI-AC
Mflv_3466|M.gilvum_PYR-GCK ASSGIGELAAEKLAAHGAQVIVVARREHLLADLVDRITARGGDATAM-PV
MLBr_01740|M.leprae_Br4923 AASGIGRATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQVPEYRAL
* .*:. *. .
MSMEG_1073|M.smegmatis_MC2_155 DLTDLDAIDALVAEIESDHGGLDILVNNAGHSIRRPLADSLERWHDIERT
TH_3707|M.thermoresistible__bu DLTDLDAIDELVLKIEQDLGGVDILINNAGKSIRRPLAESLERWHDVERT
Mvan_0944|M.vanbaalenii_PYR-1 DLSDLDAIDALVATVEDELGGVDILVNNAGRSIRRPLEESLDRWHDVERT
Mb0561c|M.bovis_AF2122/97 DLSDMEAIDALVEDVEKRIGGIDILINNAGRSIRRPLAESLERWHDVERT
Rv0547c|M.tuberculosis_H37Rv DLSDMEAIDALVEDVEKRIGGIDILINNAGRSIRRPLAESLERWHDVERT
MMAR_0894|M.marinum_M DISDLDAVDALVADVENRLGGVDILINNAGRSIRRPLAESLQRWHDVERT
MUL_0647|M.ulcerans_Agy99 DISDLDAVDALVADVENRLGGVDILINNAGRSIRRPLAESLQRWHDVERT
MAV_4597|M.avium_104 DISDLDAADALVADVQQQLGGVDILINNAGRSIRRPLAESLERWHDVERT
MAB_3947|M.abscessus_ATCC_1997 DLSDLDAIDKLVETVNEKHGGVDILVNNAGRSIRRKTYESLDRWHDAERT
Mflv_3466|M.gilvum_PYR-GCK NLADLDAVDDLVL----RAGPVDILINNAGRSIRRPLLESLDRWHDVERT
MLBr_01740|M.leprae_Br4923 DISDYDEVAAFGADIHARHPSMDIVMNIAGVSVWGTVDR--LTHDQWSNV
:::* : : :**::* ** *: .: ...
MSMEG_1073|M.smegmatis_MC2_155 MTLNYYSPLRLIRGFAPGMRERGAGHIINVSTWGVLSEASPLFSVYQASK
TH_3707|M.thermoresistible__bu MNLNYYAPLRLIRGLAPGMRE----------TWGVLSEASPLFSVYNASK
Mvan_0944|M.vanbaalenii_PYR-1 MTLNYYGPLRLIRGLAPGMLERGDGHVINVSTWGVKTESPPLFGVYNASK
Mb0561c|M.bovis_AF2122/97 MVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASK
Rv0547c|M.tuberculosis_H37Rv MVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASK
MMAR_0894|M.marinum_M MVLNYYGPLRLIRGLAPGMLERGDGHIINVTTWGVLSEASPLFSVYNASK
MUL_0647|M.ulcerans_Agy99 MVLNYYGPLRLIRGLAPGMLERGDGHIINVTTWGVLSEASPLFSVYNASK
MAV_4597|M.avium_104 MVLNYYAPLRLIRGIAPGMIERGDGHIINVSTWGVLSEASPLFAVYNASK
MAB_3947|M.abscessus_ATCC_1997 MQLNYFSPLRLIRGFAPGMVERRSGHIINVATWGVLTDVVPQFAVYNASK
Mflv_3466|M.gilvum_PYR-GCK IALNYYAPLRLIRGVAPQMVARGDGHIINVSSWRVMPESSPLFGVYNASK
MLBr_01740|M.leprae_Br4923 VAINLMGPIHIIETFVPAILAAGRGGHLVNVSSAAGLVALPWHAAYSASK
: :* .*:::*. ..* : : . * ...*.***
MSMEG_1073|M.smegmatis_MC2_155 AALSAVSRVIETEWGDGGVHSTTLYYPLVDTPMIKP--------------
TH_3707|M.thermoresistible__bu AALTAVSRVVETEWSQFGVHSTTLFYPLVKTPMIAP--------------
Mvan_0944|M.vanbaalenii_PYR-1 AALSSISRIMETEWADRGVHSTTLYYPLVKTPMIAP--------------
Mb0561c|M.bovis_AF2122/97 AALSAVSRIIETEWGSQGVHSTTLYYPLVATPMIAP--------------
Rv0547c|M.tuberculosis_H37Rv AALSAVSRIIETEWGSQGVHSTTLYYPLVATPMIAP--------------
MMAR_0894|M.marinum_M AALSAVSRTIETEWGRGGVHSTTLYYPLVATPMIAP--------------
MUL_0647|M.ulcerans_Agy99 AALSAVSRTIETEWGRGGVHSTTLYYPLVATPMIAP--------------
MAV_4597|M.avium_104 AALSTVSRVVETEWGDKGVHSTTLYYPLVATPMIAP--------------
MAB_3947|M.abscessus_ATCC_1997 AALSTVSRIVDAEYGKYNVHTTTLYFPLVRTPMIAP--------------
Mflv_3466|M.gilvum_PYR-GCK AALSAVSRVIDNELAESGVQSTTIYYPLVATPMIAP--------------
MLBr_01740|M.leprae_Br4923 YGLRGLSEVLRFDLARYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFS
.* :*. : : . : :.: * **:: .
MSMEG_1073|M.smegmatis_MC2_155 --TRAFDGLPALSADEAADWMITAARHRPVQIAPRVAVGARALNAVAPGV
TH_3707|M.thermoresistible__bu --TREYDNLPALSAEEAADWMISAARYRPIQIAPRMAVTARALNVVAPGV
Mvan_0944|M.vanbaalenii_PYR-1 --TRAYDGLPGLSAEEAAGWIITAARHRPVSIAPRIAVTAHAINSIAPAA
Mb0561c|M.bovis_AF2122/97 --TKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPRW
Rv0547c|M.tuberculosis_H37Rv --TKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPRW
MMAR_0894|M.marinum_M --TKAYSGMPALTPQEAAEWMITAARTRPVRIAPRIALMAKALNTLGPRW
MUL_0647|M.ulcerans_Agy99 --TKAYSGMPALTPQEAAEWMITAARTRPVRIAPRIALMAKALNTLGPRW
MAV_4597|M.avium_104 --TKAYQGVPALTPEEAGRWMITAARTRPVRIAPRMAIAAKALDTFGPRW
MAB_3947|M.abscessus_ATCC_1997 --TEAYTNAAALTSAEAAEWMVLAARTRVVRIAPRISVMSAATNAVAPDL
Mflv_3466|M.gilvum_PYR-GCK --TRAYDGLAALSADEAAQWMVDAAQRRPVRIAPRKLIPLRALDVVSPRL
MLBr_01740|M.leprae_Br4923 RWVDRFRGHAVSAERAAEKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWP
. : . . : * : .*: * : :.: . . ..
MSMEG_1073|M.smegmatis_MC2_155 VNAVMKRQSAQPDGVGRRPIFPAG-----------------------
TH_3707|M.thermoresistible__bu VNAVMKRQRIQP-------VFV-------------------------
Mvan_0944|M.vanbaalenii_PYR-1 VDTIMKRQRMQPKD---------------------------------
Mb0561c|M.bovis_AF2122/97 VNALMQRRNEQLNP---------------------------------
Rv0547c|M.tuberculosis_H37Rv VNALMQRRNEQLNP---------------------------------
MMAR_0894|M.marinum_M VNTLMQQRDDQLNDR--------------------------------
MUL_0647|M.ulcerans_Agy99 VNTLMQQRDDQLNDR--------------------------------
MAV_4597|M.avium_104 VNAVMQRQTVQPNREAGA-----------------------------
MAB_3947|M.abscessus_ATCC_1997 VTRVARNGRETLG----------------------------------
Mflv_3466|M.gilvum_PYR-GCK LNGVMKRSTPQPSRAADAH----------------------------
MLBr_01740|M.leprae_Br4923 YGVVMKQVNVVFTRALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN
: :.