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GGTGRETVIVEAVRTAVGKRNGGLSGMHAADLSAVVLNELLERAGVGPEIVDDVIWGCVSQVGDQSSNIG RYAVLAAGWPETIPGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATGMPYGPK VLARYDNFSFNQGLSAELIAKKWGFSRDRLDEYSALSHQRAAAAQDRGAFTDQIVPVFPAAATVVDTDEG VRRGTTVEKLAGLKPAFVEDGLIHAGNSSQISDGSAALLVTTSEMALELGLTPIVRYRAGAVTGADPVLM LTGPIPATEKVLGKSGVSLDEVGVFEVNEAFAPVPLAWLAETGADPGRLNPLGGAIALGHPLGASGAVLM TRMVHHMRDNGIRYGLQTMCEGGGTANATLVELLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4740 | fadA6_2 | - | 100% (386) | acetyl-CoA acetyltransferase FadA6_2 |
| M. marinum M | MMAR_4318 | fadA6_3 | e-141 | 65.26% (380) | acetyl-CoA acetyltransferase FadA6_3 |
| M. marinum M | MMAR_1317 | fadA6_4 | e-107 | 52.67% (393) | acetyl-CoA acetyltransferase FadA6_4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3586c | fadA6 | 1e-101 | 49.35% (387) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2445 | - | 0.0 | 83.76% (388) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv3556c | fadA6 | 1e-101 | 49.35% (387) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 9e-74 | 42.18% (403) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3455c | - | 1e-109 | 54.29% (396) | putative acyl-CoA thiolase |
| M. avium 104 | MAV_0909 | - | 0.0 | 87.99% (383) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_4833 | - | 0.0 | 83.68% (380) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0255 | - | 0.0 | 85.83% (381) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0971 | fadA6_3 | 1e-141 | 64.74% (380) | acetyl-CoA acetyltransferase FadA6_3 |
| M. vanbaalenii PYR-1 | Mvan_4206 | - | 0.0 | 86.32% (380) | acetyl-CoA acetyltransferases |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3586c|M.bovis_AF2122/97 ----MTEAYVIDAVRTAVGKR--GGALAGIHPVDLGALAWRGLLDR-TDI
Rv3556c|M.tuberculosis_H37Rv ----MTEAYVIDAVRTAVGKR--GGALAGIHPVDLGALAWRGLLDR-TDI
MMAR_4740|M.marinum_M MGGTGRETVIVEAVRTAVGKR--NGGLSGMHAADLSAVVLNELLER-AGV
MAV_0909|M.avium_104 ----MRETVIVEAVRTPVGKR--NGALSGMHAADLSAIVLNELVER-TGI
Mflv_2445|M.gilvum_PYR-GCK ----MRETVIVGAVRTPVGKR--NGGLSEQHAADLSAVVLNEVVER-TGV
Mvan_4206|M.vanbaalenii_PYR-1 ----MRETVIVGAVRTPVGKR--NGGLSEQHAADLSAVVLNELVER-TGV
MSMEG_4833|M.smegmatis_MC2_155 ----MRETVIVEAVRTPVGKR--NGGLSGMHAADLSGLVLNALVEK-AGI
TH_0255|M.thermoresistible__bu ----MRETVIVEAVRTAVGKR--NGALADVHAADLSAVVLSELVER-AGI
MUL_0971|M.ulcerans_Agy99 ----MAEAVIVEAVRSPVGKR--NGALSGVHPADLSAQVLNGLADK-AGI
MAB_3455c|M.abscessus_ATCC_199 ----MRDAVIIDAVRTPVGKGKPGGSLSGVHPVDLHAHAIRELVER-AGI
MLBr_02162|M.leprae_Br4923 ---MSEEAFIYEAIRTPRGKQK-NGSLHEVKPVSLVVGLVEELRKRNPDL
:: : *:*:. ** .*.* :...* : .: ..:
Mb3586c|M.bovis_AF2122/97 DPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQ
Rv3556c|M.tuberculosis_H37Rv DPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQ
MMAR_4740|M.marinum_M GPEIVDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQ
MAV_0909|M.avium_104 GPELIDDVVWGCVSQVGDQSSNIGRYAVLAAGWPESIPGTTVNRACGSSQ
Mflv_2445|M.gilvum_PYR-GCK DPDLVDDVVWGCVSQVGDQSSNIGRYAVLAAGWPEHIPGTTVNRACGSSQ
Mvan_4206|M.vanbaalenii_PYR-1 DTDVIDDVIWGCVSQVGDQSSNIGRYSVLAAGWPEHIPGTTVNRACGSSQ
MSMEG_4833|M.smegmatis_MC2_155 GPDIIDDVIWGCVSQVGDQSSNIGRFAVLAAGWPEHIPGTTVNRACGSSQ
TH_0255|M.thermoresistible__bu DPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQ
MUL_0971|M.ulcerans_Agy99 DPEIVDDVIWGCVMQAGEQALDIARTSLLTAGWPETVPGVTVDRQCGSSQ
MAB_3455c|M.abscessus_ATCC_199 DPALIDDVISGAVGQVGEQSSNTARWAALAAGLPETVPAVTVDRQCGSSQ
MLBr_02162|M.leprae_Br4923 DENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGL
. :.**: *.* * *. : .* : *:** * .. ::* *.*.
Mb3586c|M.bovis_AF2122/97 QAISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNES
Rv3556c|M.tuberculosis_H37Rv QAISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNES
MMAR_4740|M.marinum_M QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
MAV_0909|M.avium_104 QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------TPYG
Mflv_2445|M.gilvum_PYR-GCK QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGSARSTG--------MPYG
Mvan_4206|M.vanbaalenii_PYR-1 QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
MSMEG_4833|M.smegmatis_MC2_155 QALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
TH_0255|M.thermoresistible__bu QALDFAVHAVMSGQQDVVVAGGVEVMSRVPLGAARATG--------MPYG
MUL_0971|M.ulcerans_Agy99 QSVHFAAAGVVAGHYDVVVAGGVESMSRTPMGSSLANGG-------RPYS
MAB_3455c|M.abscessus_ATCC_199 QAIHFAAQGVIAGAYDVVIASGIESMSRVPMGSQ-SLG-------KDFFG
MLBr_02162|M.leprae_Br4923 EAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDG-----------GAMG
::: .. : :* *:::*.*:: **: *:.: .
Mb3586c|M.bovis_AF2122/97 KQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAG
Rv3556c|M.tuberculosis_H37Rv KQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAG
MMAR_4740|M.marinum_M PKVLARYDNFSFNQGLSAELIAKKWGFSRDRLDEYSALSHQRAAAAQDRG
MAV_0909|M.avium_104 PKVLARYDDFSFNQGLSAEMIAKKWGFSRTQLDEYSVRSHERAAAAQDAG
Mflv_2445|M.gilvum_PYR-GCK PKVLARYDDFSFNQGISAEMISAQWGLSRTRLDEYSAQSHERAAAAQDAG
Mvan_4206|M.vanbaalenii_PYR-1 PKVFARYDDFSFNQGISAEMISQKWGFSRTQLDEYSALSHERAAAAQDAG
MSMEG_4833|M.smegmatis_MC2_155 PKVIDRYRDFSFNQGISAEMIAQKWGFTRTQLDEYSVASHERAAAAQDSG
TH_0255|M.thermoresistible__bu PKVLERYDNFGFNQGISAELIAERWNLSRTRLDEYSAQSHERAAAAQSSG
MUL_0971|M.ulcerans_Agy99 QTFLERYDGRIPNQGLGAEMIAEQWGLSRTMLDEFSLMSHEKAAAAQDSG
MAB_3455c|M.abscessus_ATCC_199 SEVARRYPEGLVPQGISAELIAAKWNLSREQLDTFAAESHRRAAQAWSEG
MLBr_02162|M.leprae_Br4923 LDPATNYDVMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWSGG
.* * .:::*: .::* :: :: *:.:* * *
Mb3586c|M.bovis_AF2122/97 HFENEIITVETESGP---------FRVDEGPRE-SSLEKMAGLQP-LVEG
Rv3556c|M.tuberculosis_H37Rv HFENEIITVETESGP---------FRVDEGPRE-SSLEKMAGLQP-LVEG
MMAR_4740|M.marinum_M AFTDQIVPVFPAAAT--------VVDTDEGVRRGTTVEKLAGLKPAFVED
MAV_0909|M.avium_104 AFTDQIVPVFVEDAEN------KVVAADEGVRRGSSVEKLAALKPAFAED
Mflv_2445|M.gilvum_PYR-GCK AFKDQIVPVFTEAADARSNSGGSVVTDDEGIRRGTTAEKLSGLKPAFTED
Mvan_4206|M.vanbaalenii_PYR-1 AFKDQIVPVFTD---------GGIVTDDEGIRRGTTVEKLAGLKPAFTED
MSMEG_4833|M.smegmatis_MC2_155 AFETQMITVFPDDGDP--------VVADEGVRRGTTVDKLANLKPAFKDD
TH_0255|M.thermoresistible__bu AFKDQIVPVFTDDA---------VVTEDEGIRRGTTVEKLATLKPAFTEN
MUL_0971|M.ulcerans_Agy99 AFDDQIVGIKDQDGNP--------VLKDEGIRRGTPMEKMAALKPAFKED
MAB_3455c|M.abscessus_ATCC_199 RFARDVVPIKAPDVNG----DLVEVSTDESVRPSTTVEVLAGLKPAFRNE
MLBr_02162|M.leprae_Br4923 YFAKSVVPVRDQNGLL-------ILDHDEHMRPDTSKEGLAKLKPAFEGL
* .:: : . ** * :. : :: *:* :
Mb3586c|M.bovis_AF2122/97 G---------------------RLTAAMASQISDGASAVLLASERAVKDH
Rv3556c|M.tuberculosis_H37Rv G---------------------RLTAAMASQISDGASAVLLASERAVKDH
MMAR_4740|M.marinum_M G---------------------LIHAGNSSQISDGSAALLVTTSEMALEL
MAV_0909|M.avium_104 G---------------------VIHAGNSSQISDGAAALLVTTAEMAVEL
Mflv_2445|M.gilvum_PYR-GCK G---------------------VIHAGNSSQISDGAAALLVMTAENAVNL
Mvan_4206|M.vanbaalenii_PYR-1 G---------------------VIHAGNSSQISDGAAALLVTTMENAVNL
MSMEG_4833|M.smegmatis_MC2_155 G---------------------VIHAGNSSQISDGAAALLVMTAENAVAM
TH_0255|M.thermoresistible__bu G---------------------VIHAGNSSQISDGAAALLVMTAETAVTL
MUL_0971|M.ulcerans_Agy99 G---------------------VIHAGNSSQISDGSAALLFMSAEKAKSL
MAB_3455c|M.abscessus_ATCC_199 LWQ-----------QRFPGLDWKVTAGNSSPINDGASAVLITSSETAHRL
MLBr_02162|M.leprae_Br4923 AAMGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQ
.. :* * **:: ::. :
Mb3586c|M.bovis_AF2122/97 GLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINE
Rv3556c|M.tuberculosis_H37Rv GLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINE
MMAR_4740|M.marinum_M GLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLGKSGVSLDEVGVFEVNE
MAV_0909|M.avium_104 GLTPIVRYVAGAVTGADPVLMLTGPIPATEKVLKKAGVALSDVGVFEVNE
Mflv_2445|M.gilvum_PYR-GCK GLTPLVRYRAGAVTGADPKLMLTGPIPATAKVLHKAGVTLDEVGVYEVNE
Mvan_4206|M.vanbaalenii_PYR-1 GLTPLVRYRAGAVTGADPRLMLTGPIPATEKVLHKAGVTLDEVGVYEVNE
MSMEG_4833|M.smegmatis_MC2_155 GLSPIVRYRAGAVAGADPVLMLTGPIPATEKVLHKAGVRLDEIGVFEVNE
TH_0255|M.thermoresistible__bu GLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIGVFEVNE
MUL_0971|M.ulcerans_Agy99 GMKPIAKVHTAVLAGADPVIMLTAPIPATQKVLKRSGLSIGDIGAYEVNE
MAB_3455c|M.abscessus_ATCC_199 GLTPRARVHSVAVVGDDPLYMLTGIIPATAKVLDRAGLSLADIDAFEVNE
MLBr_02162|M.leprae_Br4923 GLTPRARMVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNE
*: * .: . ** ***. *** .* ::*: : ::. *:**
Mb3586c|M.bovis_AF2122/97 AFAPVVMAWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELER
Rv3556c|M.tuberculosis_H37Rv AFAPVVMAWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELER
MMAR_4740|M.marinum_M AFAPVPLAWLAETGADPGRLNPLGGAIALGHPLGASGAVLMTRMVHHMRD
MAV_0909|M.avium_104 AFAPVPLAWLAETGADAARTNPLGGAIALGHPLGASGAVLMTRMAHHMRD
Mflv_2445|M.gilvum_PYR-GCK AFAPVPLAWLADTGADEAKLNPLGGAIALGHPLGASGAVLMTRMIHHMRD
Mvan_4206|M.vanbaalenii_PYR-1 AFAPVPLAWLADTGADAAKLNPLGGAIALGHPLGASGAVLMTRMIHHMRD
MSMEG_4833|M.smegmatis_MC2_155 AFAPVPLAWQAETGADPAKLNPLGGAIALGHPLGASGAVLMTRMINHMRD
TH_0255|M.thermoresistible__bu AFAPVPLAWQAETGADPAKLNPLGGAIALGHPLGASGAVLMTRMVHHMRA
MUL_0971|M.ulcerans_Agy99 AFAPVPLAWLCDIGADENRLNPNGGAIALGHPLGGSGARVMTTLLYHMRD
MAB_3455c|M.abscessus_ATCC_199 AFASVVLAWQAETGADLSKVNVNGGATAIGHPLGASGGRLMTTLVSVLEQ
MLBr_02162|M.leprae_Br4923 AFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELER
***.* : : : : * *** *:*****.:*. :: : :.
Mb3586c|M.bovis_AF2122/97 IGGRYGLQTMCEGGGTANVTIIERL-
Rv3556c|M.tuberculosis_H37Rv IGGRYGLQTMCEGGGTANVTIIERL-
MMAR_4740|M.marinum_M NGIRYGLQTMCEGGGTANATLVELLS
MAV_0909|M.avium_104 NGIRYGLQTMCEGGGTANATLVELVS
Mflv_2445|M.gilvum_PYR-GCK NGIRYGLQTMCEGGGTANATLVELVK
Mvan_4206|M.vanbaalenii_PYR-1 NGIRYGLQTMCEGGGTANATLIELVK
MSMEG_4833|M.smegmatis_MC2_155 NGIQYGLQTMCEGGGTANATIVELLG
TH_0255|M.thermoresistible__bu NGIRYGLQTMCEGGGTANATVVELLA
MUL_0971|M.ulcerans_Agy99 NGIRYGLQTMCEGGGQANATVLELL-
MAB_3455c|M.abscessus_ATCC_199 GGGRYGLQTMCEAGGLANATILERL-
MLBr_02162|M.leprae_Br4923 CNARRALVTLCIGAGMGVATIIERV-
. : .* *:* ..* . .*::* :