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MAEAVIVEAVRSAVGKRNGALAGIHPAELSAQVLNGLVERAGVDPALVDDVIWGCVMQAGEQALDIARTA VLSAGWPETVPGVTVDRQCGSSQQSLHFAVAGVIAGHYDVVVAGGVESMSRTPMGSSLANGGNPYGESFK ARYAQTPNQGVGAEMIAEQWGLSRTQLDEFSLRSHEKAAAAQDSGAFKDQIVGIKTKDADGNDTVVLEDG GIRRGGTVESMAKIKPAFREDGVIHAGNSSQISDGSAALLLMSAEKAKDLGLKPLAKVHTAVLAGADPVI MLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPMAWLKDIGADETKLNPNGGAIALGHPLGGSGARI LTTLLYHMRDNNIQYGLQTMCEGGGQANATILELL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2116 | - | - | 100% (385) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2445 | - | e-141 | 64.36% (390) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_3782 | - | e-110 | 53.37% (401) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3586c | fadA6 | 1e-103 | 51.15% (393) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv3556c | fadA6 | 1e-103 | 51.15% (393) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 2e-72 | 40.99% (405) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3455c | - | 1e-110 | 53.77% (398) | putative acyl-CoA thiolase |
| M. marinum M | MMAR_4318 | fadA6_3 | 0.0 | 83.16% (386) | acetyl-CoA acetyltransferase FadA6_3 |
| M. avium 104 | MAV_1276 | - | 0.0 | 84.20% (386) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5199 | - | 0.0 | 95.84% (385) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0255 | - | 1e-143 | 66.06% (386) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0971 | fadA6_3 | 0.0 | 83.42% (386) | acetyl-CoA acetyltransferase FadA6_3 |
| M. vanbaalenii PYR-1 | Mvan_4589 | - | 0.0 | 96.10% (385) | acetyl-CoA acetyltransferases |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3586c|M.bovis_AF2122/97 -MTEAYVIDAVRTAVGKR--GGALAGIHPVDLGALAWRGLLDR-TDIDPA
Rv3556c|M.tuberculosis_H37Rv -MTEAYVIDAVRTAVGKR--GGALAGIHPVDLGALAWRGLLDR-TDIDPA
Mflv_2116|M.gilvum_PYR-GCK -MAEAVIVEAVRSAVGKR--NGALAGIHPAELSAQVLNGLVER-AGVDPA
Mvan_4589|M.vanbaalenii_PYR-1 -MAEAVIVEAVRAPVGKR--NGALSGVHPAELSAQVLNGLVER-AGVDPA
MSMEG_5199|M.smegmatis_MC2_155 -MAEAVIVEAVRSPVGKR--NGALSGIHPAELSAQVLNGLVER-AGVDPA
MMAR_4318|M.marinum_M -MAEAVIVEAVRSPVGKR--NGALSGVHPADLSAQVLNGLADK-AGIDPE
MUL_0971|M.ulcerans_Agy99 -MAEAVIVEAVRSPVGKR--NGALSGVHPADLSAQVLNGLADK-AGIDPE
MAV_1276|M.avium_104 -MAEAVIVEAVRSPIGKR--NGGLSGVHPAELSAQVLNGLVDK-AGVDPG
TH_0255|M.thermoresistible__bu -MRETVIVEAVRTAVGKR--NGALADVHAADLSAVVLSELVER-AGIDPE
MAB_3455c|M.abscessus_ATCC_199 -MRDAVIIDAVRTPVGKGKPGGSLSGVHPVDLHAHAIRELVER-AGIDPA
MLBr_02162|M.leprae_Br4923 MSEEAFIYEAIRTPRGKQK-NGSLHEVKPVSLVVGLVEELRKRNPDLDEN
:: : :*:*:. ** .*.* ::...* . * .: ..:*
Mb3586c|M.bovis_AF2122/97 AVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAI
Rv3556c|M.tuberculosis_H37Rv AVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAI
Mflv_2116|M.gilvum_PYR-GCK LVDDVIWGCVMQAGEQALDIARTAVLSAGWPETVPGVTVDRQCGSSQQSL
Mvan_4589|M.vanbaalenii_PYR-1 LVDDVIWGCVMQAGEQALDIARTAALSAGWPETVAGVTVDRQCGSSQQTL
MSMEG_5199|M.smegmatis_MC2_155 LVDDVIWGCVMQAGEQALDIARTAVLSAGWPETVPGVTVDRQCGSSQQSL
MMAR_4318|M.marinum_M IVDDVIWGCVMQAGEQALDIARTSLLTAGWPETVPGVTVDRQCGSSQQSV
MUL_0971|M.ulcerans_Agy99 IVDDVIWGCVMQAGEQALDIARTSLLTAGWPETVPGVTVDRQCGSSQQSV
MAV_1276|M.avium_104 IVDDVIWGCVMQAGEQALDIGRTALLTAGWPETVPGVTVDRQCGSSQQSI
TH_0255|M.thermoresistible__bu LIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQQAL
MAB_3455c|M.abscessus_ATCC_199 LIDDVISGAVGQVGEQSSNTARWAALAAGLPETVPAVTVDRQCGSSQQAI
MLBr_02162|M.leprae_Br4923 LISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGLEAV
:.*** *.* * *. : .* : *:** * .. ::* *.*. :::
Mb3586c|M.bovis_AF2122/97 SFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQW
Rv3556c|M.tuberculosis_H37Rv SFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQW
Mflv_2116|M.gilvum_PYR-GCK HFAVAGVIAGHYDVVVAGGVESMSRTPMGSSLANGG-----NPYGES--F
Mvan_4589|M.vanbaalenii_PYR-1 NFAVAGVIAGHYDVVVAGGVESMSRTPMGSSLANGG-----NPYGES--F
MSMEG_5199|M.smegmatis_MC2_155 HFAVAGVVAGHYDVVVAGGVESMSRTPMGSSLANGG-----NPYGES--F
MMAR_4318|M.marinum_M HFAAAGVVAGHYDVVVAGGVESMSRTPMGSSLANGG-----RPYSQT--F
MUL_0971|M.ulcerans_Agy99 HFAAAGVVAGHYDVVVAGGVESMSRTPMGSSLANGG-----RPYSQT--F
MAV_1276|M.avium_104 HFAAAGVIAGHYDVVVAGGVESMSRTPMGASLANGG-----RPYPQA--F
TH_0255|M.thermoresistible__bu DFAVHAVMSGQQDVVVAGGVEVMSRVPLGAARATG------MPYGPK--V
MAB_3455c|M.abscessus_ATCC_199 HFAAQGVIAGAYDVVIASGIESMSRVPMGS-QSLGK-----DFFGSE--V
MLBr_02162|M.leprae_Br4923 NTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMG-------LDPA---
.. : :* *:::*.*:: **: *:.:
Mb3586c|M.bovis_AF2122/97 LHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAGHFE
Rv3556c|M.tuberculosis_H37Rv LHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAGHFE
Mflv_2116|M.gilvum_PYR-GCK KARYA-QTPNQGVGAEMIAEQWGLSRTQLDEFSLRSHEKAAAAQDSGAFK
Mvan_4589|M.vanbaalenii_PYR-1 KARYA-QTPNQGVGAEMIAEQWGFSRTQLDEFSLRSHEKAAAAQDSGAFK
MSMEG_5199|M.smegmatis_MC2_155 KARYD-KTPNQGVGAEMIAEQWGFSRTQLDEFSLRSHEKAAAAQDSGAFS
MMAR_4318|M.marinum_M LERYDGRIPNQGLGAEMIAEQWGLSRTMLDEFSLMSHEKAAAAQDSGAFD
MUL_0971|M.ulcerans_Agy99 LERYDGRIPNQGLGAEMIAEQWGLSRTMLDEFSLMSHEKAAAAQDSGAFD
MAV_1276|M.avium_104 LDRYQGQIPNQGIGAEMIAEKWGFDRTALDEFSLASHEKAAAAQDSGAFD
TH_0255|M.thermoresistible__bu LERYDNFGFNQGISAELIAERWNLSRTRLDEYSAQSHERAAAAQSSGAFK
MAB_3455c|M.abscessus_ATCC_199 ARRYPEGLVPQGISAELIAAKWNLSREQLDTFAAESHRRAAQAWSEGRFA
MLBr_02162|M.leprae_Br4923 -TNYDVMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWSGGYFA
.* * .:::** .:.* :: :: *:.:* * * *
Mb3586c|M.bovis_AF2122/97 NEIITVETESG-----PFRVDEGPRE-SSLEKMAGLQP-LVEGG------
Rv3556c|M.tuberculosis_H37Rv NEIITVETESG-----PFRVDEGPRE-SSLEKMAGLQP-LVEGG------
Mflv_2116|M.gilvum_PYR-GCK DQIVGIKTKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFREDG------
Mvan_4589|M.vanbaalenii_PYR-1 DQIVGIKTKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFKEDG------
MSMEG_5199|M.smegmatis_MC2_155 DQIVGIKTKDADGNDTVVLEDGGIRRGGTIEAMAGIKPAFKEDG------
MMAR_4318|M.marinum_M DQIVGIK--DQDGN--PVLKDEGIRRGTPMEKMAALKPAFKEDG------
MUL_0971|M.ulcerans_Agy99 DQIVGIK--DQDGN--PVLKDEGIRRGTPMEKMAALKPAFKEDG------
MAV_1276|M.avium_104 DQIVGIK--DQDGN--VVLKDEGIRRGTPMEKMASLKPAFKEDG------
TH_0255|M.thermoresistible__bu DQIVPVFTDDA-----VVTEDEGIRRGTTVEKLATLKPAFTENG------
MAB_3455c|M.abscessus_ATCC_199 RDVVPIKAPDVNGDLVEVSTDESVRPSTTVEVLAGLKPAFRNELWQ----
MLBr_02162|M.leprae_Br4923 KSVVPVRDQNG---LLILDHDEHMRPDTSKEGLAKLKPAFEGLAAMGGFD
.:: : . . * * . * :* ::* :
Mb3586c|M.bovis_AF2122/97 ---------------RLTAAMASQISDGASAVLLASERAVKDHGLRPRAR
Rv3556c|M.tuberculosis_H37Rv ---------------RLTAAMASQISDGASAVLLASERAVKDHGLRPRAR
Mflv_2116|M.gilvum_PYR-GCK ---------------VIHAGNSSQISDGSAALLLMSAEKAKDLGLKPLAK
Mvan_4589|M.vanbaalenii_PYR-1 ---------------VIHAGNSSQISDGSAALLIMSAEKAKELGCKPLAK
MSMEG_5199|M.smegmatis_MC2_155 ---------------VIHAGNSSQISDGSAALLITSAEKAKELGLKPIAK
MMAR_4318|M.marinum_M ---------------VIHAGNSSQISDGSAALLFMSAEKAKSLGMKPIAR
MUL_0971|M.ulcerans_Agy99 ---------------VIHAGNSSQISDGSAALLFMSAEKAKSLGMKPIAK
MAV_1276|M.avium_104 ---------------VIHAGNSSQISDGSAAILFMSAEKAKELGLKPIAK
TH_0255|M.thermoresistible__bu ---------------VIHAGNSSQISDGAAALLVMTAETAVTLGLTPIVR
MAB_3455c|M.abscessus_ATCC_199 -------QRFPGLDWKVTAGNSSPINDGASAVLITSSETAHRLGLTPRAR
MLBr_02162|M.leprae_Br4923 DVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQGLTPRAR
.. :* * **:: ::. : * * .:
Mb3586c|M.bovis_AF2122/97 IHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVM
Rv3556c|M.tuberculosis_H37Rv IHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVM
Mflv_2116|M.gilvum_PYR-GCK VHTAVLAGADPVIMLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPM
Mvan_4589|M.vanbaalenii_PYR-1 VHTAVLAGADPVIMLTAPIPATQKALKKSGLSVDQIGAFEVNEAFAPVPM
MSMEG_5199|M.smegmatis_MC2_155 VHTAVLAGADPVIMLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPM
MMAR_4318|M.marinum_M VHTAVLAGADPVIMLTAPIPATQKVLKRSGLSIGDIGAYEVNEAFAPVPL
MUL_0971|M.ulcerans_Agy99 VHTAVLAGADPVIMLTAPIPATQKVLKRSGLSIGDIGAYEVNEAFAPVPL
MAV_1276|M.avium_104 VHTATLAGADPVIMLTAPIPATQKVLKKSGLSIDDIGVYEVNEAFAPVPM
TH_0255|M.thermoresistible__bu YRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIGVFEVNEAFAPVPL
MAB_3455c|M.abscessus_ATCC_199 VHSVAVVGDDPLYMLTGIIPATAKVLDRAGLSLADIDAFEVNEAFASVVL
MLBr_02162|M.leprae_Br4923 MVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVL
. **: ***. *** .* ::** : :*. *:*****.* :
Mb3586c|M.bovis_AF2122/97 AWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELERIGGRYGL
Rv3556c|M.tuberculosis_H37Rv AWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELERIGGRYGL
Mflv_2116|M.gilvum_PYR-GCK AWLKDIGADETKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGL
Mvan_4589|M.vanbaalenii_PYR-1 AWLKDIGADEKKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGL
MSMEG_5199|M.smegmatis_MC2_155 AWLKDIGADEKKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGL
MMAR_4318|M.marinum_M AWLRDIGADENRLNPNGGAIALGHPLGGSGARLMTTLLYHMRDNGIRYGL
MUL_0971|M.ulcerans_Agy99 AWLCDIGADENRLNPNGGAIALGHPLGGSGARVMTTLLYHMRDNGIRYGL
MAV_1276|M.avium_104 AWLKDIGADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDKGIRYGL
TH_0255|M.thermoresistible__bu AWQAETGADPAKLNPLGGAIALGHPLGASGAVLMTRMVHHMRANGIRYGL
MAB_3455c|M.abscessus_ATCC_199 AWQAETGADLSKVNVNGGATAIGHPLGASGGRLMTTLVSVLEQGGGRYGL
MLBr_02162|M.leprae_Br4923 KFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERCNARRAL
: : ::* *** *:*****.:*. :: :: :. . : .*
Mb3586c|M.bovis_AF2122/97 QTMCEGGGTANVTIIERL-
Rv3556c|M.tuberculosis_H37Rv QTMCEGGGTANVTIIERL-
Mflv_2116|M.gilvum_PYR-GCK QTMCEGGGQANATILELL-
Mvan_4589|M.vanbaalenii_PYR-1 QTMCEGGGQANATILELL-
MSMEG_5199|M.smegmatis_MC2_155 QTMCEGGGQANATILELL-
MMAR_4318|M.marinum_M QTMCEGGGQANATVLELL-
MUL_0971|M.ulcerans_Agy99 QTMCEGGGQANATVLELL-
MAV_1276|M.avium_104 QTMCEGGGQANATIVELL-
TH_0255|M.thermoresistible__bu QTMCEGGGTANATVVELLA
MAB_3455c|M.abscessus_ATCC_199 QTMCEAGGLANATILERL-
MLBr_02162|M.leprae_Br4923 VTLCIGAGMGVATIIERV-
*:* ..* . .*::* :