For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SKLSDLPAQALATVSQTLGKSVGKYVERGSAELHYARKMFQAGALKLEPPQDIAAFVADMVRWGEFGMIP ALNARRHPHRTAVIDDFGEFTFGELDEAVNAVANGLLAKGVKGGDGVAILARNHRWFLVSVYAAGKVGAR IILLNSEFSGPQIKEVSHREGAKLVIYDDEYTAAVKAAEPELGKLRSLGVNPDKDAPSGSTDETLEELIA RTSSTPPPKATKHSSIIILTSGTTGTPKGANRSAPPSLAPIGGILSAVPFKSEEVTSLPAPMFHALGFLH ATIAMMLGSTLVLRRRFKPATVLADIEKHRATAIVVVPVMLSRMLDELDKTSPKPDLSSLRILFVSGSQL GAELATRALKDLGPIVYNLYGSTEVAFATIAGPQHLSINPATVGPVVKGMRVKILDDNGNELPRGEIGRI FVGNFFPFEGYTGGGGKQIIDGLLSSGDVGYFDDNDLLYVSGRDDEMIVSGGENVFPAEIEDLVSGHPEV VEATALGVEDKEWGHRLRCFVVKAEGATIDEDAIKAYVRDNLARYKVPREVIFLDELPRNPTGKILKREL REMDVPES*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0341 | - | - | 100% (569) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2427 | - | e-111 | 43.90% (492) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1993 | - | e-108 | 41.67% (492) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0276 | fadD2 | 0.0 | 75.35% (564) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0270 | fadD2 | 0.0 | 75.35% (564) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 0.0 | 75.79% (541) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4340c | - | 0.0 | 65.46% (553) | acyl-CoA synthetase |
| M. marinum M | MMAR_0528 | fadD2 | 0.0 | 74.38% (566) | fatty-acid-CoA ligase FadD2 |
| M. avium 104 | MAV_4891 | - | 0.0 | 76.86% (566) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0599 | - | 0.0 | 80.41% (541) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4533 | - | 0.0 | 77.92% (566) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 0.0 | 74.20% (566) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0397 | - | 0.0 | 91.02% (568) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0276|M.bovis_AF2122/97 MPNLTDLPG---QAVSKLQKS-IGQYVARGTAELHYLRKIIESGAIGLEP
Rv0270|M.tuberculosis_H37Rv MPNLTDLPG---QAVSKLQKS-IGQYVARGTAELHYLRKIIESGAIGLEP
MMAR_0528|M.marinum_M MPNLSDLPG-----VAKIQ-----QYVDRGAAELHYVRKIIESGAFRLES
MUL_1191|M.ulcerans_Agy99 MPNLSDLPG-----VAKIQ-----QYVDRGAAELHYVRKIIESGAFRLES
MAV_4891|M.avium_104 MPNLLGLPGQATKAVAKVQ-----QYVERGSAELHYLRRIIESGAFRLEP
MLBr_02546|M.leprae_Br4923 --------------MTKLR-----HYLERGAAEVHYLRSIFESGALGFEP
Mflv_0341|M.gilvum_PYR-GCK MSKLSDLPAQALATVSQTLGKSVGKYVERGSAELHYARKMFQAGALKLEP
Mvan_0397|M.vanbaalenii_PYR-1 MPKLSDLPLQAAAKLQQTVG----TYLERGSAELHYARKMFEAGALKLEP
MSMEG_0599|M.smegmatis_MC2_155 ---------------MTAKAK---EYAERGVAELHYARKMFEAGALRLEP
TH_4533|M.thermoresistible__bu MAKLTDLPRLAADKLPLSRLQ---LYAERGAAELHYLRKMLEAGALKIES
MAB_4340c|M.abscessus_ATCC_199 MSITAERPL-----FSKLQ-----TLAKRGGAELHYLRKVIEAGMLKLDP
** **:** * ::::* : ::.
Mb0276|M.bovis_AF2122/97 PLNYAALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAA
Rv0270|M.tuberculosis_H37Rv PLNYAALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAA
MMAR_0528|M.marinum_M PLNYAAMATEIAKWGEFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEAA
MUL_1191|M.ulcerans_Agy99 PLNYAAMATEIAKWGEFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEAG
MAV_4891|M.avium_104 PQNYAAMAADIYKWGEFGMLPSLNARRTPDRAAVIDEEGELSYAELDRAA
MLBr_02546|M.leprae_Br4923 PLTYAAMAVAMRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAA
Mflv_0341|M.gilvum_PYR-GCK PQDIAAFVADMVRWGEFGMIPALNARRHPHRTAVIDDFGEFTFGELDEAV
Mvan_0397|M.vanbaalenii_PYR-1 PQDIAAFVADMRRWGEFGMIPALNARRYPHRAAVIDDFGEMTFKELDDAA
MSMEG_0599|M.smegmatis_MC2_155 PQHMLALVADIRTWGEIGMIPALNARRHPNRVAVIDDEGEFTFGELDAAA
TH_4533|M.thermoresistible__bu PTRIAALLADIRRWGEIGMIPALNARRWPDRVAVIDDEGEMTFAELNDAA
MAB_4340c|M.abscessus_ATCC_199 PNVLAGLVRDFYRFGEIGAVPAFGAHRSPSRTAIIDDEGSITYAELNDAV
* .: : :*:.. :*: *:* * *.* **: * ::: :*: *
Mb0276|M.bovis_AF2122/97 HAVANGLLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFS
Rv0270|M.tuberculosis_H37Rv HAVANGLLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFS
MMAR_0528|M.marinum_M HAVANALLAKGVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEFS
MUL_1191|M.ulcerans_Agy99 HAVANALLAKGVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEFS
MAV_4891|M.avium_104 HAVANGLIAKGVKAGDGVAILARNHRWFLIANYGAARVGARIILLNSEFS
MLBr_02546|M.leprae_Br4923 HALANGLIAKGVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFS
Mflv_0341|M.gilvum_PYR-GCK NAVANGLLAKGVKGGDGVAILARNHRWFLVSVYAAGKVGARIILLNSEFS
Mvan_0397|M.vanbaalenii_PYR-1 NAVANGLLAKGVKGGDGVAILARNHRWFLVSVYAAGKVGARIILLNSEFS
MSMEG_0599|M.smegmatis_MC2_155 HALANELLARGVRGGDGVGILARNHRWFLVSLYGAARVGARIIMLNTEFS
TH_4533|M.thermoresistible__bu HAVANALLAKGVRGGDGVAILARNHRWFLVSMYGAARVGARIILLNTEFS
MAB_4340c|M.abscessus_ATCC_199 NALAHGLNRLGIKGGDGVAILARNHRWFIIANYAAHRAGARVILLNTDFS
:*:*: * *: .***:.*********::: *.. :.***:*:**::**
Mb0276|M.bovis_AF2122/97 GPQIKEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSG
Rv0270|M.tuberculosis_H37Rv GPQIKEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSG
MMAR_0528|M.marinum_M GPQIKEVSEREGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEEDSG
MUL_1191|M.ulcerans_Agy99 GPQIKEVSEREGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEEDSG
MAV_4891|M.avium_104 GPQIKEVSEREGAKVIIYDDEYTKAVSKAEPPLGKLRALGSNPDADEPSG
MLBr_02546|M.leprae_Br4923 GPQIKEVSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPG
Mflv_0341|M.gilvum_PYR-GCK GPQIKEVSHREGAKLVIYDDEYTAAVKAAEPELGKLRSLGVNPDKDAPSG
Mvan_0397|M.vanbaalenii_PYR-1 GPQIKEVSEREGAKLVIYDDEYTAAVAAAEPELGKLRSLGVNPDKEEPSG
MSMEG_0599|M.smegmatis_MC2_155 GPQIKEVAAREGARVIIYDDEYTAAVAQAETELGKLRALGTNPDKEEPSG
TH_4533|M.thermoresistible__bu GPQICEVSDREGAKLIIYDDEYTAAVSGVEPELGKLRALGHNPDSDEPSG
MAB_4340c|M.abscessus_ATCC_199 GPQTKEVAEREGARVLIYDAEYAEFLDGYSPELGRIMALPTNPDNPDQPA
*** **: ****:::*** **: : .. **:: :* *** ..
Mb0276|M.bovis_AF2122/97 SSDETLAELIAHSSTAPAPKASRRASIIILTSGTTGTPKGANRNTPPTLA
Rv0270|M.tuberculosis_H37Rv SSDETLAELIAHSSTAPAPKASRRASIIILTSGTTGTPKGANRNTPPTLA
MMAR_0528|M.marinum_M STDETLAELIARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTPPTLA
MUL_1191|M.ulcerans_Agy99 STDETLAELIARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTPPTLA
MAV_4891|M.avium_104 STDETLAELIERSSSEPAPKADRHASIIILTSGTTGTPKGANRSTPPTLA
MLBr_02546|M.leprae_Br4923 STDETLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLA
Mflv_0341|M.gilvum_PYR-GCK STDETLEELIARTSSTPPPKATKHSSIIILTSGTTGTPKGANRSAPPSLA
Mvan_0397|M.vanbaalenii_PYR-1 STDETLEELIARTTSNPPPKATKHSSIIILTSGTTGTPKGANRSAPPSLA
MSMEG_0599|M.smegmatis_MC2_155 STDETLAEVIARSGKRPAPKASRHASIIILTSGTTGTPKGANRAAPPSLA
TH_4533|M.thermoresistible__bu STDETLADIIERVGAKPAPKATRHSSIIILTSGTTGTPKGATRKAPPSLA
MAB_4340c|M.abscessus_ATCC_199 STDETIASVIKRNSTSPAPRPSKYSSLVILTSGTTGTPKGAPRKLALTLA
*:***: .:* : *.*: : :*::************* * . :**
Mb0276|M.bovis_AF2122/97 PIGGILSHVPFKAGEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFKP
Rv0270|M.tuberculosis_H37Rv PIGGILSHVPFKAGEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFKP
MMAR_0528|M.marinum_M PVGGILSHVPFKANEVTSLPAPMFHALGYLHATIAMFLGSTLVLRRKFKP
MUL_1191|M.ulcerans_Agy99 PVGGILSHVPFKANEVTSLPAPMFHALGYLHATIAMFLGSTLVLRRKFKP
MAV_4891|M.avium_104 PVGGILSHVPFKAGEVTSLPSPMFHALGYLHATIAMFLGSTLVLRRKFKP
MLBr_02546|M.leprae_Br4923 PLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKP
Mflv_0341|M.gilvum_PYR-GCK PIGGILSAVPFKSEEVTSLPAPMFHALGFLHATIAMMLGSTLVLRRRFKP
Mvan_0397|M.vanbaalenii_PYR-1 PIGGILSSVPFKSQAVTSLPAPMFHALGFLHATIAMMLGTTLVLRRRFKP
MSMEG_0599|M.smegmatis_MC2_155 PIGGVLSHVPFKAGEVTALPAPMFHALGFLHATIAMMLGSTLVLRRRFKP
TH_4533|M.thermoresistible__bu PIGGVLSHVPFKSGEVTSLPAPMFHALGYLHATIAMMLGNTLLLRRRFKP
MAB_4340c|M.abscessus_ATCC_199 PVGGMFSHVPFRSGEVTSVPAPMFHALGYLHQSLALTLGCTLILRRKFKP
*:**::* ***:: ** :*:*******::* ::*: ** **:***:***
Mb0276|M.bovis_AF2122/97 ALVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGSQ
Rv0270|M.tuberculosis_H37Rv ALVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGSQ
MMAR_0528|M.marinum_M QLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFVSGSQ
MUL_1191|M.ulcerans_Agy99 QLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFVSGSQ
MAV_4891|M.avium_104 PLVLQDIEKYRPTAMVVVPVMLSRILDTLEKMDKKPDLSSLRIVFVSGSQ
MLBr_02546|M.leprae_Br4923 ATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQ
Mflv_0341|M.gilvum_PYR-GCK ATVLADIEKHRATAIVVVPVMLSRMLDELDKTSPKPDLSSLRILFVSGSQ
Mvan_0397|M.vanbaalenii_PYR-1 ATVLADIEKHRATAIVVVPVMLSRMLDELDKTSPKPDLSSLRIVFVSGSQ
MSMEG_0599|M.smegmatis_MC2_155 ATVLEDIEKHKVTAAVVVPVMLSRMLDHLEKMPQKPDLSSLRIMFVSGSQ
TH_4533|M.thermoresistible__bu ATVLTDIEKHNVSAVIVVPVMLSRMLDEWEKMRPKPDLSSLRIVFVSGSQ
MAB_4340c|M.abscessus_ATCC_199 ENVLADVEKFKVTAIVVVPVMLNRLLNALDELSVKPDLSSLRIVFVSGSQ
** *:**.. :: :******.*:*: :: *.*****:::******
Mb0276|M.bovis_AF2122/97 LGAELATRALGDLGPVIYNMYGSTEVAFATIAGPKDLQFNPSTVGPVVKG
Rv0270|M.tuberculosis_H37Rv LGAELATRALGDLGPVIYNMYGSTEVAFATIAGPKDLQFNPSTVGPVVKG
MMAR_0528|M.marinum_M LGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATVGPVVKG
MUL_1191|M.ulcerans_Agy99 LGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATVGPVVKG
MAV_4891|M.avium_104 LGAELAARALKDIGPVIYNMYGSTEIAFATIAGPKDLERNAATVGPVVKG
MLBr_02546|M.leprae_Br4923 LGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVGPVVKG
Mflv_0341|M.gilvum_PYR-GCK LGAELATRALKDLGPIVYNLYGSTEVAFATIAGPQHLSINPATVGPVVKG
Mvan_0397|M.vanbaalenii_PYR-1 LGAELATRALKELGPVVYNLYGSTEVAFATIAGPQHLSINPATVGPVVKG
MSMEG_0599|M.smegmatis_MC2_155 LGAELATRALKELGPVIYNLYGSTEIAFATIARPQDLSRNPATVGPVVKG
TH_4533|M.thermoresistible__bu LGAELASRAMRDLGPVIYNLYGSTEIAFATIARPQDLSINPATVGPVVKG
MAB_4340c|M.abscessus_ATCC_199 LGGELASRAMDTLGPVIYNLYGSTEVAFATIARPQDLAINPSTVGPVVKG
**.***:**: :**::**:*****:****** *:.* *.:********
Mb0276|M.bovis_AF2122/97 VTVKILDENGNEVPQGAVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSGDV
Rv0270|M.tuberculosis_H37Rv VTVKILDENGNEVPQGAVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSGDV
MMAR_0528|M.marinum_M VKVKILDDNGNEVSQGQVGRIFVGNAFPFEGYTGGGHKQIIDGLMSSGDV
MUL_1191|M.ulcerans_Agy99 VKVKILDDNGNEVSQGQVGRIFVGNAFPFEGYTGGGHKQIIDGLMSSGDV
MAV_4891|M.avium_104 VKVKIFDDNGKELPQGEVGRIFVGNTFPFAGYTGGGNKQIIDGLLSSGDV
MLBr_02546|M.leprae_Br4923 VKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSGDV
Mflv_0341|M.gilvum_PYR-GCK MRVKILDDNGNELPRGEIGRIFVGNFFPFEGYTGGGGKQIIDGLLSSGDV
Mvan_0397|M.vanbaalenii_PYR-1 MKVRILDDNGNDVPRGQVGRIFVGNFFPFQGYTGGGGKQIIDGLLSSGDV
MSMEG_0599|M.smegmatis_MC2_155 ITVKILDDNGKELPQGEVGRIFVRNTFPFKGYTGGGGKQIIDGMMSSGDV
TH_4533|M.thermoresistible__bu VTVKLFDENGKEVPRGEVGRIFVRNTFPFEGYTGGGHKQIIDGLMSSGDV
MAB_4340c|M.abscessus_ATCC_199 ATVKILDDEGKPVSQGTVGRIFVSNAIPFDGYTGGGHKQIIDGLMSSGDV
*:::*:.*: :.:* :***** * :** ****** ******::*****
Mb0276|M.bovis_AF2122/97 GYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEAAAIGVD
Rv0270|M.tuberculosis_H37Rv GYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEAAAIGVD
MMAR_0528|M.marinum_M GYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEATALGVD
MUL_1191|M.ulcerans_Agy99 GYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGHPDVVEATALGVD
MAV_4891|M.avium_104 GYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEATAIGVE
MLBr_02546|M.leprae_Br4923 GYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVD
Mflv_0341|M.gilvum_PYR-GCK GYFDDNDLLYVSGRDDEMIVSGGENVFPAEIEDLVSGHPEVVEATALGVE
Mvan_0397|M.vanbaalenii_PYR-1 GYFDENDLLYVSGRDDEMIVSGGENVFPAEIEDLVSGHPEVVEATAIGVE
MSMEG_0599|M.smegmatis_MC2_155 GYFDEHGLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVIEATAIGVD
TH_4533|M.thermoresistible__bu GYFDEHGLLYVSGRDDEMIVSGGENVFPAEIEDLLSGHPEIVEATAIGVE
MAB_4340c|M.abscessus_ATCC_199 GYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPEVIEATALGVD
****:..***:*******************:* *:****:::**:*:**:
Mb0276|M.bovis_AF2122/97 DKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLARYKVPREVIFLDELPR
Rv0270|M.tuberculosis_H37Rv DKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLARYKVPREVIFLDELPR
MMAR_0528|M.marinum_M DKEWGARLRAFVVKKPDTDLDEETVKHYVRDHLARYKVPREVIFLEELPR
MUL_1191|M.ulcerans_Agy99 DKEWGARLRAFVVKKPDTDLDEETVKHYVRDHLARYKVPREVIFLEELPR
MAV_4891|M.avium_104 DKEWGHRLRAFVVKKEGADLDEDTIKHYVRDHLARYKVPREVIFLDELPR
MLBr_02546|M.leprae_Br4923 DKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEELPR
Mflv_0341|M.gilvum_PYR-GCK DKEWGHRLRCFVVKAEGATIDEDAIKAYVRDNLARYKVPREVIFLDELPR
Mvan_0397|M.vanbaalenii_PYR-1 DKEWGARLRCFVVKIEGAAVDEDAIKAYVRDNLARYKVPREVVFLDELPR
MSMEG_0599|M.smegmatis_MC2_155 DKEWGARLRAFVVKAAGSSLTEDDVKAYVRDHLARYKVPREVIFLDELPR
TH_4533|M.thermoresistible__bu DKEWGQRLRAFVVKAEGSDLDEDEVKRYVREHLARYKVPRDVIFLDELPR
MAB_4340c|M.abscessus_ATCC_199 DPEWGARLRAFVVRHPDSTVDADGIRAYVRDNLARYKVPRDVVFLDVLPR
* *:* ***.***: .: : : :: ***::********:*:**: ***
Mb0276|M.bovis_AF2122/97 NPTGKVLKRELRKL-----
Rv0270|M.tuberculosis_H37Rv NPTGKVLKRELRKL-----
MMAR_0528|M.marinum_M NPTGKILKRELREMEIE--
MUL_1191|M.ulcerans_Agy99 NPTGKILKRELREMEIE--
MAV_4891|M.avium_104 NPTGKILKRELREMEV---
MLBr_02546|M.leprae_Br4923 NPTGKVLKRELRDFEVH--
Mflv_0341|M.gilvum_PYR-GCK NPTGKILKRELREMDVPES
Mvan_0397|M.vanbaalenii_PYR-1 NPTGKILKRQLREMEIPD-
MSMEG_0599|M.smegmatis_MC2_155 NPTGKILKRELRNIDA---
TH_4533|M.thermoresistible__bu NPTGKILKRELRELEVS--
MAB_4340c|M.abscessus_ATCC_199 NPSGKILKRELRELEV---
**:**:***:**.: